Collagen alpha-1(V) chain precursor - Rattus norvegicus (Rat)

Sequence or UniProt identifier

>sp|Q9JI03|CO5A1_RAT Collagen alpha-1(V) chain OS=Rattus norvegicus GN=Col5a1 PE=1 SV=1 MDVHTRWKAPRPGAPLLSSPLLLLLLLLWAPPPSRAAQPTDLLEMLDFHNLPSGVTKTTG FCATRRSSKEPDVAYRVSKDAQLSMPTKQLYPESDFPEDFSILTTVKAKKGSQAFLVSVY NEQGIQQLGLELGRSPVFLYEDHTGKPGPEEYPLFPGINLSDGKWHRIAISVYKKNVTLI LDCKKKITKFLNRGDHPIIDVNGIIMFGSRILDDEIFEGDIQQLLFVSDHRAAYDYCEHY SPDCDTAVPDTPQSQDPNPDEYYPEGEGETYYYEYPYYEDPEDPGKEPAPSQKPVEAARE TTEVPEEQTQPPSEAPTVPETSDTAGKEDNPGIGDYDYVPTDDYYTTSPYEDFGYGEGVE NPDQPTNPDSGAEIPTSTSVTSNSSNPAPSPEEGKDDLGGEFTEETIKNLDENYYDPYFD PDSDSNVSPSEIGPGMPANQDTIYEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAG LPGPPGTTGPTGQMGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPM VSAQESQAQAILQQARLALRGPAGPMGLTGRPGPMGPPGSGGLKGEPGDMGPQGPRGVQG PPGPTGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGLPG DDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPG PPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQG PPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRG EDGPEGPKGRGGPNGDPGPLGPTGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKG GRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTG FPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPG PPGPPGEQGLPGAAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGSEG PPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGVPGEEGPQGPAGRDGLQG PVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPTGQPGPSGADG EPGPRGQQGLFGQKGDEGSRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRG PSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPLGPKGERGEKGEAGPSG AAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPG PTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDG LRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQG EKGDRGLPGPQGSSGPKGEQGITGPSGPLGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAG HPGLPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGAGESYVDYADGMEEIFGSLNSL KLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGS TCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVGVVQMTFLRLLSASA QQNITYNCYQSVAWQDAATGSYDKAIRFLGSNDEEMSYDNNPYIRALVDGCATKKGYQKT VLEIDTPKVEQVPIVDIMFTDFGEASQKFGFEVGPACFLG

Options »

Help

For a sequence similarity search, enter:
• a protein or nucleotide sequence
• a UniProt identifier, e.g.
P00750 or A4_HUMAN or UPI0000000001
More...

Contribute

Send feedback

Read comments (?) or add your own

Q9JI03 (CO5A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Collagen alpha-1(V) chain

Gene names

Name:

Col5a1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1840 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin By similarity.
Subunit structure	Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4 By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	A high molecular weight form was detected in Schwann cells and peripheral nerve. A lower, probably processed form, is detected in all other tissues tested (at protein level). Ref.1
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity. Sulfated on 40% of tyrosines By similarity. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
Sequence similarities	Belongs to the fibrillar collagen family. Contains 1 fibrillar collagen NC1 domain. Contains 1 laminin G-like domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Collagen Repeat Signal
Ligand	Heparin-binding
PTM	Hydroxylation Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	collagen type V Traceable author statement Ref.1. Source: RGD
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro heparin binding Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 1840

1810

Collagen alpha-1(V) chain

PRO_0000041762

Regions

Domain

72 – 244

173

Laminin G-like

Domain

1611 – 1839

229

Fibrillar collagen NC1

Region

231 – 445

215

Nonhelical region By similarity

Region

446 – 560

115

Interrupted collagenous region By similarity

Region

561 – 1572

1012

Triple-helical region By similarity

Region

1573 – 1607

Nonhelical region By similarity

Amino acid modifications

Modified residue

234

Sulfotyrosine Potential

Modified residue

236

Sulfotyrosine Potential

Modified residue

240

Sulfotyrosine Potential

Modified residue

262

Sulfotyrosine Potential

Modified residue

263

Sulfotyrosine Potential

Modified residue

336

Sulfotyrosine Potential

Modified residue

338

Sulfotyrosine Potential

Modified residue

344

Sulfotyrosine Potential

Modified residue

572

4-hydroxyproline By similarity

Modified residue

578

4-hydroxyproline By similarity

Modified residue

623

4-hydroxyproline By similarity

Modified residue

629

5-hydroxylysine By similarity

Modified residue

641

4-hydroxyproline By similarity

Modified residue

644

5-hydroxylysine By similarity

Modified residue

650

4-hydroxyproline By similarity

Modified residue

656

4-hydroxyproline By similarity

Modified residue

659

4-hydroxyproline By similarity

Modified residue

677

4-hydroxyproline By similarity

Modified residue

680

4-hydroxyproline By similarity

Modified residue

682

3-hydroxyproline By similarity

Modified residue

688

3-hydroxyproline By similarity

Modified residue

692

4-hydroxyproline By similarity

Modified residue

698

4-hydroxyproline By similarity

Modified residue

707

4-hydroxyproline By similarity

Modified residue

710

5-hydroxylysine By similarity

Modified residue

719

4-hydroxyproline By similarity

Modified residue

722

4-hydroxyproline By similarity

Modified residue

728

4-hydroxyproline By similarity

Modified residue

734

4-hydroxyproline By similarity

Modified residue

746

5-hydroxylysine By similarity

Modified residue

752

4-hydroxyproline By similarity

Modified residue

758

4-hydroxyproline By similarity

Modified residue

764

4-hydroxyproline By similarity

Modified residue

767

4-hydroxyproline By similarity

Modified residue

773

4-hydroxyproline By similarity

Modified residue

776

5-hydroxylysine By similarity

Modified residue

782

4-hydroxyproline By similarity

Modified residue

791

4-hydroxyproline By similarity

Modified residue

797

5-hydroxylysine By similarity

Modified residue

806

5-hydroxylysine By similarity

Modified residue

809

5-hydroxylysine By similarity

Modified residue

812

5-hydroxylysine By similarity

Modified residue

818

4-hydroxyproline By similarity

Modified residue

821

5-hydroxylysine By similarity

Modified residue

836

4-hydroxyproline By similarity

Modified residue

848

5-hydroxylysine By similarity

Modified residue

866

5-hydroxylysine By similarity

Modified residue

872

4-hydroxyproline By similarity

Modified residue

875

4-hydroxyproline By similarity

Modified residue

878

4-hydroxyproline By similarity

Modified residue

884

5-hydroxylysine By similarity

Modified residue

890

4-hydroxyproline By similarity

Modified residue

893

4-hydroxyproline By similarity

Modified residue

899

5-hydroxylysine By similarity

Modified residue

905

4-hydroxyproline By similarity

Modified residue

908

4-hydroxyproline By similarity

Modified residue

932

4-hydroxyproline By similarity

Modified residue

947

4-hydroxyproline By similarity

Modified residue

1019

4-hydroxyproline By similarity

Modified residue

1022

4-hydroxyproline By similarity

Modified residue

1025

4-hydroxyproline By similarity

Modified residue

1031

4-hydroxyproline By similarity

Modified residue

1223

4-hydroxyproline By similarity

Modified residue

1226

4-hydroxyproline By similarity

Modified residue

1469

4-hydroxyproline By similarity

Modified residue

1472

4-hydroxyproline By similarity

Modified residue

1603

Sulfotyrosine Potential

Modified residue

1606

Sulfotyrosine Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JI03 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AD38F5FF886B923C
Show »

FASTA

1,840

183,987

        10         20         30         40         50         60 
MDVHTRWKAP RPGAPLLSSP LLLLLLLLWA PPPSRAAQPT DLLEMLDFHN LPSGVTKTTG 

        70         80         90        100        110        120 
FCATRRSSKE PDVAYRVSKD AQLSMPTKQL YPESDFPEDF SILTTVKAKK GSQAFLVSVY 

       130        140        150        160        170        180 
NEQGIQQLGL ELGRSPVFLY EDHTGKPGPE EYPLFPGINL SDGKWHRIAI SVYKKNVTLI 

       190        200        210        220        230        240 
LDCKKKITKF LNRGDHPIID VNGIIMFGSR ILDDEIFEGD IQQLLFVSDH RAAYDYCEHY 

       250        260        270        280        290        300 
SPDCDTAVPD TPQSQDPNPD EYYPEGEGET YYYEYPYYED PEDPGKEPAP SQKPVEAARE 

       310        320        330        340        350        360 
TTEVPEEQTQ PPSEAPTVPE TSDTAGKEDN PGIGDYDYVP TDDYYTTSPY EDFGYGEGVE 

       370        380        390        400        410        420 
NPDQPTNPDS GAEIPTSTSV TSNSSNPAPS PEEGKDDLGG EFTEETIKNL DENYYDPYFD 

       430        440        450        460        470        480 
PDSDSNVSPS EIGPGMPANQ DTIYEGIGGP RGEKGQKGEP AIIEPGMLIE GPPGPEGPAG 

       490        500        510        520        530        540 
LPGPPGTTGP TGQMGDPGER GPPGRPGLPG ADGLPGPPGT MLMLPFRFGG GGDAGSKGPM 

       550        560        570        580        590        600 
VSAQESQAQA ILQQARLALR GPAGPMGLTG RPGPMGPPGS GGLKGEPGDM GPQGPRGVQG 

       610        620        630        640        650        660 
PPGPTGKPGR RGRAGSDGAR GMPGQTGPKG DRGFDGLAGL PGEKGHRGDP GPSGPPGLPG 

       670        680        690        700        710        720 
DDGERGDDGE VGPRGLPGEP GPRGLLGPKG PPGPPGPPGV TGMDGQPGPK GNVGPQGEPG 

       730        740        750        760        770        780 
PPGQQGNPGA QGLPGPQGAI GPPGEKGPLG KPGLPGMPGA DGPPGHPGKE GPPGEKGGQG 

       790        800        810        820        830        840 
PPGPQGPIGY PGPRGVKGAD GIRGLKGTKG EKGEDGFPGF KGDMGIKGDR GEIGPPGPRG 

       850        860        870        880        890        900 
EDGPEGPKGR GGPNGDPGPL GPTGEKGKLG VPGLPGYPGR QGPKGSIGFP GFPGANGEKG 

       910        920        930        940        950        960 
GRGTPGKPGP RGQRGPTGPR GERGPRGITG KPGPKGNSGG DGPAGPPGER GPNGPQGPTG 

       970        980        990       1000       1010       1020 
FPGPKGPPGP PGKDGLPGHP GQRGETGFQG KTGPPGPPGV VGPQGPTGET GPMGERGHPG 

      1030       1040       1050       1060       1070       1080 
PPGPPGEQGL PGAAGKEGTK GDPGPAGLPG KDGPPGLRGF PGDRGLPGPV GALGLKGSEG 

      1090       1100       1110       1120       1130       1140 
PPGPPGPAGS PGERGPAGAA GPIGIPGRPG PQGPPGPAGE KGVPGEEGPQ GPAGRDGLQG 

      1150       1160       1170       1180       1190       1200 
PVGLPGPAGP VGPPGEDGDK GEIGEPGQKG SKGDKGEQGP PGPTGPQGPT GQPGPSGADG 

      1210       1220       1230       1240       1250       1260 
EPGPRGQQGL FGQKGDEGSR GFPGPPGPVG LQGLPGPPGE KGETGDVGQM GPPGPPGPRG 

      1270       1280       1290       1300       1310       1320 
PSGAPGADGP QGPPGGIGNP GAVGEKGEPG EAGEPGLPGE GGPLGPKGER GEKGEAGPSG 

      1330       1340       1350       1360       1370       1380 
AAGPPGPKGP PGDDGPKGSP GPVGFPGDPG PPGEPGPAGQ DGPPGDKGDD GEPGQTGSPG 

      1390       1400       1410       1420       1430       1440 
PTGEPGPSGP PGKRGPPGPA GPEGRQGEKG AKGEAGLEGP PGKTGPIGPQ GAPGKPGPDG 

      1450       1460       1470       1480       1490       1500 
LRGIPGPVGE QGLPGSPGPD GPPGPMGPPG LPGLKGDSGP KGEKGHPGLI GLIGPPGEQG 

      1510       1520       1530       1540       1550       1560 
EKGDRGLPGP QGSSGPKGEQ GITGPSGPLG PPGPPGLPGP PGPKGAKGSS GPTGPKGEAG 

      1570       1580       1590       1600       1610       1620 
HPGLPGPPGP PGEVIQPLPI QASRTRRNID ASQLLDDGAG ESYVDYADGM EEIFGSLNSL 

      1630       1640       1650       1660       1670       1680 
KLEIEQMKRP LGTQQNPART CKDLQLCHPD FPDGEYWVDP NQGCSRDSFK VYCNFTAGGS 

      1690       1700       1710       1720       1730       1740 
TCVFPDKKSE GARITSWPKE NPGSWFSEFK RGKLLSYVDA EGNPVGVVQM TFLRLLSASA 

      1750       1760       1770       1780       1790       1800 
QQNITYNCYQ SVAWQDAATG SYDKAIRFLG SNDEEMSYDN NPYIRALVDG CATKKGYQKT 

      1810       1820       1830       1840 
VLEIDTPKVE QVPIVDIMFT DFGEASQKFG FEVGPACFLG

« Hide

References

[1]

"Schwann cells synthesize type V collagen that contains a novel alpha 4 chain. Molecular cloning, biochemical characterization, and high affinity heparin binding of alpha 4(V) collagen."
Chernousov M.A., Rothblum K., Tyler W.A., Stahl R.C., Carey D.J.
J. Biol. Chem. 275:28208-28215(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, HEPARIN-BINDING.
Strain: Sprague-Dawley.
Tissue: Schwann cell.

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF272662 mRNA. Translation: AAF76433.1.
IPI	IPI00201608.
RefSeq	NP_604447.1. NM_134452.1.
UniGene	Rn.117.
3D structure databases
ProteinModelPortal	Q9JI03.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JI03. 1 interaction.
Proteomic databases
PaxDb	Q9JI03.
PRIDE	Q9JI03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	85490.
KEGG	rno:85490.
UCSC	RGD:70920. rat.
Organism-specific databases
CTD	1289.
RGD	70920. Col5a1.
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000085654.
HOVERGEN	HBG004933.
InParanoid	Q9JI03.
KO	K06236.
OrthoDB	EOG49GKHM.
Gene expression databases
ArrayExpress	Q9JI03.
Genevestigator	Q9JI03.
GermOnline	ENSRNOG00000008749. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000885. Fib_collagen_C. IPR001791. Laminin_G. [Graphical view]
Pfam	PF01410. COLFI. 1 hit. PF01391. Collagen. 6 hits. PF02210. Laminin_G_2. 1 hit. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00282. LamG. 1 hit. SM00210. TSPN. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50025. LAM_G_DOMAIN. False negative. PS51461. NC1_FIB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	617576.

Entry information

Entry name

CO5A1_RAT

Accession

Primary (citable) accession number: Q9JI03

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents