Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9JI03 (CO5A1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(V) chain
Gene names
Name:Col5a1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1840 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin By similarity.

Subunit structure

Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

A high molecular weight form was detected in Schwann cells and peripheral nerve. A lower, probably processed form, is detected in all other tissues tested (at protein level). Ref.1

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains By similarity.

Sulfated on 40% of tyrosines By similarity.

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.

Sequence similarities

Belongs to the fibrillar collagen family.

Contains 1 fibrillar collagen NC1 domain.

Contains 1 laminin G-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 18401810Collagen alpha-1(V) chain
PRO_0000041762

Regions

Domain72 – 244173Laminin G-like
Domain1611 – 1839229Fibrillar collagen NC1
Region231 – 445215Nonhelical region By similarity
Region446 – 560115Interrupted collagenous region By similarity
Region561 – 15721012Triple-helical region By similarity
Region1573 – 160735Nonhelical region By similarity

Amino acid modifications

Modified residue2341Sulfotyrosine Potential
Modified residue2361Sulfotyrosine Potential
Modified residue2401Sulfotyrosine Potential
Modified residue2621Sulfotyrosine Potential
Modified residue2631Sulfotyrosine Potential
Modified residue3361Sulfotyrosine Potential
Modified residue3381Sulfotyrosine Potential
Modified residue3441Sulfotyrosine Potential
Modified residue57214-hydroxyproline By similarity
Modified residue57814-hydroxyproline By similarity
Modified residue62314-hydroxyproline By similarity
Modified residue62915-hydroxylysine By similarity
Modified residue64114-hydroxyproline By similarity
Modified residue64415-hydroxylysine By similarity
Modified residue65014-hydroxyproline By similarity
Modified residue65614-hydroxyproline By similarity
Modified residue65914-hydroxyproline By similarity
Modified residue67714-hydroxyproline By similarity
Modified residue68014-hydroxyproline By similarity
Modified residue68213-hydroxyproline By similarity
Modified residue68813-hydroxyproline By similarity
Modified residue69214-hydroxyproline By similarity
Modified residue69814-hydroxyproline By similarity
Modified residue70714-hydroxyproline By similarity
Modified residue71015-hydroxylysine By similarity
Modified residue71914-hydroxyproline By similarity
Modified residue72214-hydroxyproline By similarity
Modified residue72814-hydroxyproline By similarity
Modified residue73414-hydroxyproline By similarity
Modified residue74615-hydroxylysine By similarity
Modified residue75214-hydroxyproline By similarity
Modified residue75814-hydroxyproline By similarity
Modified residue76414-hydroxyproline By similarity
Modified residue76714-hydroxyproline By similarity
Modified residue77314-hydroxyproline By similarity
Modified residue77615-hydroxylysine By similarity
Modified residue78214-hydroxyproline By similarity
Modified residue79114-hydroxyproline By similarity
Modified residue79715-hydroxylysine By similarity
Modified residue80615-hydroxylysine By similarity
Modified residue80915-hydroxylysine By similarity
Modified residue81215-hydroxylysine By similarity
Modified residue81814-hydroxyproline By similarity
Modified residue82115-hydroxylysine By similarity
Modified residue83614-hydroxyproline By similarity
Modified residue84815-hydroxylysine By similarity
Modified residue86615-hydroxylysine By similarity
Modified residue87214-hydroxyproline By similarity
Modified residue87514-hydroxyproline By similarity
Modified residue87814-hydroxyproline By similarity
Modified residue88415-hydroxylysine By similarity
Modified residue89014-hydroxyproline By similarity
Modified residue89314-hydroxyproline By similarity
Modified residue89915-hydroxylysine By similarity
Modified residue90514-hydroxyproline By similarity
Modified residue90814-hydroxyproline By similarity
Modified residue93214-hydroxyproline By similarity
Modified residue94714-hydroxyproline By similarity
Modified residue101914-hydroxyproline By similarity
Modified residue102214-hydroxyproline By similarity
Modified residue102514-hydroxyproline By similarity
Modified residue103114-hydroxyproline By similarity
Modified residue122314-hydroxyproline By similarity
Modified residue122614-hydroxyproline By similarity
Modified residue146914-hydroxyproline By similarity
Modified residue147214-hydroxyproline By similarity
Modified residue16031Sulfotyrosine Potential
Modified residue16061Sulfotyrosine Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JI03 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AD38F5FF886B923C

FASTA1,840183,987
        10         20         30         40         50         60 
MDVHTRWKAP RPGAPLLSSP LLLLLLLLWA PPPSRAAQPT DLLEMLDFHN LPSGVTKTTG 

        70         80         90        100        110        120 
FCATRRSSKE PDVAYRVSKD AQLSMPTKQL YPESDFPEDF SILTTVKAKK GSQAFLVSVY 

       130        140        150        160        170        180 
NEQGIQQLGL ELGRSPVFLY EDHTGKPGPE EYPLFPGINL SDGKWHRIAI SVYKKNVTLI 

       190        200        210        220        230        240 
LDCKKKITKF LNRGDHPIID VNGIIMFGSR ILDDEIFEGD IQQLLFVSDH RAAYDYCEHY 

       250        260        270        280        290        300 
SPDCDTAVPD TPQSQDPNPD EYYPEGEGET YYYEYPYYED PEDPGKEPAP SQKPVEAARE 

       310        320        330        340        350        360 
TTEVPEEQTQ PPSEAPTVPE TSDTAGKEDN PGIGDYDYVP TDDYYTTSPY EDFGYGEGVE 

       370        380        390        400        410        420 
NPDQPTNPDS GAEIPTSTSV TSNSSNPAPS PEEGKDDLGG EFTEETIKNL DENYYDPYFD 

       430        440        450        460        470        480 
PDSDSNVSPS EIGPGMPANQ DTIYEGIGGP RGEKGQKGEP AIIEPGMLIE GPPGPEGPAG 

       490        500        510        520        530        540 
LPGPPGTTGP TGQMGDPGER GPPGRPGLPG ADGLPGPPGT MLMLPFRFGG GGDAGSKGPM 

       550        560        570        580        590        600 
VSAQESQAQA ILQQARLALR GPAGPMGLTG RPGPMGPPGS GGLKGEPGDM GPQGPRGVQG 

       610        620        630        640        650        660 
PPGPTGKPGR RGRAGSDGAR GMPGQTGPKG DRGFDGLAGL PGEKGHRGDP GPSGPPGLPG 

       670        680        690        700        710        720 
DDGERGDDGE VGPRGLPGEP GPRGLLGPKG PPGPPGPPGV TGMDGQPGPK GNVGPQGEPG 

       730        740        750        760        770        780 
PPGQQGNPGA QGLPGPQGAI GPPGEKGPLG KPGLPGMPGA DGPPGHPGKE GPPGEKGGQG 

       790        800        810        820        830        840 
PPGPQGPIGY PGPRGVKGAD GIRGLKGTKG EKGEDGFPGF KGDMGIKGDR GEIGPPGPRG 

       850        860        870        880        890        900 
EDGPEGPKGR GGPNGDPGPL GPTGEKGKLG VPGLPGYPGR QGPKGSIGFP GFPGANGEKG 

       910        920        930        940        950        960 
GRGTPGKPGP RGQRGPTGPR GERGPRGITG KPGPKGNSGG DGPAGPPGER GPNGPQGPTG 

       970        980        990       1000       1010       1020 
FPGPKGPPGP PGKDGLPGHP GQRGETGFQG KTGPPGPPGV VGPQGPTGET GPMGERGHPG 

      1030       1040       1050       1060       1070       1080 
PPGPPGEQGL PGAAGKEGTK GDPGPAGLPG KDGPPGLRGF PGDRGLPGPV GALGLKGSEG 

      1090       1100       1110       1120       1130       1140 
PPGPPGPAGS PGERGPAGAA GPIGIPGRPG PQGPPGPAGE KGVPGEEGPQ GPAGRDGLQG 

      1150       1160       1170       1180       1190       1200 
PVGLPGPAGP VGPPGEDGDK GEIGEPGQKG SKGDKGEQGP PGPTGPQGPT GQPGPSGADG 

      1210       1220       1230       1240       1250       1260 
EPGPRGQQGL FGQKGDEGSR GFPGPPGPVG LQGLPGPPGE KGETGDVGQM GPPGPPGPRG 

      1270       1280       1290       1300       1310       1320 
PSGAPGADGP QGPPGGIGNP GAVGEKGEPG EAGEPGLPGE GGPLGPKGER GEKGEAGPSG 

      1330       1340       1350       1360       1370       1380 
AAGPPGPKGP PGDDGPKGSP GPVGFPGDPG PPGEPGPAGQ DGPPGDKGDD GEPGQTGSPG 

      1390       1400       1410       1420       1430       1440 
PTGEPGPSGP PGKRGPPGPA GPEGRQGEKG AKGEAGLEGP PGKTGPIGPQ GAPGKPGPDG 

      1450       1460       1470       1480       1490       1500 
LRGIPGPVGE QGLPGSPGPD GPPGPMGPPG LPGLKGDSGP KGEKGHPGLI GLIGPPGEQG 

      1510       1520       1530       1540       1550       1560 
EKGDRGLPGP QGSSGPKGEQ GITGPSGPLG PPGPPGLPGP PGPKGAKGSS GPTGPKGEAG 

      1570       1580       1590       1600       1610       1620 
HPGLPGPPGP PGEVIQPLPI QASRTRRNID ASQLLDDGAG ESYVDYADGM EEIFGSLNSL 

      1630       1640       1650       1660       1670       1680 
KLEIEQMKRP LGTQQNPART CKDLQLCHPD FPDGEYWVDP NQGCSRDSFK VYCNFTAGGS 

      1690       1700       1710       1720       1730       1740 
TCVFPDKKSE GARITSWPKE NPGSWFSEFK RGKLLSYVDA EGNPVGVVQM TFLRLLSASA 

      1750       1760       1770       1780       1790       1800 
QQNITYNCYQ SVAWQDAATG SYDKAIRFLG SNDEEMSYDN NPYIRALVDG CATKKGYQKT 

      1810       1820       1830       1840 
VLEIDTPKVE QVPIVDIMFT DFGEASQKFG FEVGPACFLG 

« Hide

References

[1]"Schwann cells synthesize type V collagen that contains a novel alpha 4 chain. Molecular cloning, biochemical characterization, and high affinity heparin binding of alpha 4(V) collagen."
Chernousov M.A., Rothblum K., Tyler W.A., Stahl R.C., Carey D.J.
J. Biol. Chem. 275:28208-28215(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, HEPARIN-BINDING.
Strain: Sprague-Dawley.
Tissue: Schwann cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF272662 mRNA. Translation: AAF76433.1.
RefSeqNP_604447.1. NM_134452.1.
UniGeneRn.117.

3D structure databases

ProteinModelPortalQ9JI03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JI03. 1 interaction.

Proteomic databases

PaxDbQ9JI03.
PRIDEQ9JI03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID85490.
KEGGrno:85490.
UCSCRGD:70920. rat.

Organism-specific databases

CTD1289.
RGD70920. Col5a1.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000085654.
HOVERGENHBG004933.
InParanoidQ9JI03.
KOK06236.
PhylomeDBQ9JI03.

Gene expression databases

GenevestigatorQ9JI03.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamPF01410. COLFI. 1 hit.
PF01391. Collagen. 6 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51461. NC1_FIB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617576.

Entry information

Entry nameCO5A1_RAT
AccessionPrimary (citable) accession number: Q9JI03
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families