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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine and asparagine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

  • asparagine transport Source: UniProtKB
  • brain development Source: RGD
  • cellular response to potassium ion starvation Source: Ensembl
  • female pregnancy Source: RGD
  • glutamine transport Source: UniProtKB
  • histidine transport Source: UniProtKB
  • positive regulation of glutamine transport Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: Ensembl
  • sodium ion transport Source: UniProtKB-KW

Keywordsi

Biological processAmino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-352230 Amino acid transport across the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
System N amino acid transporter 1
Gene namesi
Name:Slc38a3Imported
Synonyms:Snat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi628620 Slc38a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei324 – 344HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938301 – 504Sodium-coupled neutral amino acid transporter 3Add BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi239 ↔ 275PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JHZ9
PRIDEiQ9JHZ9

PTM databases

iPTMnetiQ9JHZ9
PhosphoSitePlusiQ9JHZ9

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, kidney, heart and brain. Not detected in gut, lung or spleen. Expressed ubiquitously in hepatocytes in liver whereas in kidney expression is restricted to the medulla. Within brain, expressed in glial cells. In the cerebellum, expressed on Bergmann glial fibers in the molecular layer and astrocytes in the granule layer.2 Publications

Gene expression databases

BgeeiENSRNOG00000016827
GenevisibleiQ9JHZ9 RN

Interactioni

Protein-protein interaction databases

BioGridi251668, 1 interactor
STRINGi10116.ENSRNOP00000023623

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOGENOMiHOG000013088
HOVERGENiHBG059571
InParanoidiQ9JHZ9
KOiK13576
OMAiKKKMQHV
OrthoDBiEOG091G0GP8
PhylomeDBiQ9JHZ9
TreeFamiTF328787

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGMPTA DTQRAEDAQH CGEGKGFLQQ
60 70 80 90 100
SSSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP TPVWYMDGNY LVILVSVIII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLVNATG
260 270 280 290 300
NFSHMVVVEE KSQLQSEPDT AEAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKRKMQH ISNLSIAVMY VMYFLAALFG YLTFYDGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLIAVTLT VPIVLFPVRR AIQQMLFQNQ
410 420 430 440 450
EFSWLRHVLI ATGLLTCINL LVIFAPNILG IFGIIGATSA PCLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPVRSTPKIL ALCFAAVGFL LMTMSLSFII TDWVSGTSQH

GGNH
Length:504
Mass (Da):55,637
Last modified:October 1, 2000 - v1
Checksum:iD8C19AED34A791DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273025 mRNA Translation: AAF81797.1
BC081717 mRNA Translation: AAH81717.1
RefSeqiNP_665719.1, NM_145776.1
UniGeneiRn.32067

Genome annotation databases

EnsembliENSRNOT00000023623; ENSRNOP00000023623; ENSRNOG00000016827
GeneIDi252919
KEGGirno:252919
UCSCiRGD:628620 rat

Similar proteinsi

Entry informationi

Entry nameiS38A3_RAT
AccessioniPrimary (citable) accession number: Q9JHZ9
Secondary accession number(s): Q66HS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health