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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine and asparagine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.1 Publication2 Publications

GO - Molecular functioni

GO - Biological processi

  • asparagine transport Source: UniProtKB
  • brain development Source: RGD
  • cellular response to potassium ion starvation Source: Ensembl
  • female pregnancy Source: RGD
  • glutamine transport Source: UniProtKB
  • histidine transport Source: UniProtKB
  • positive regulation of glutamine transport Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: Ensembl
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
System N amino acid transporter 1
Gene namesi
Name:Slc38a3Imported
Synonyms:Snat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi628620. Slc38a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Transmembranei408 – 42821HelicalSequence analysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence analysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Sodium-coupled neutral amino acid transporter 3PRO_0000093830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence analysis
Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JHZ9.
PRIDEiQ9JHZ9.

PTM databases

iPTMnetiQ9JHZ9.
PhosphoSiteiQ9JHZ9.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, liver, kidney, heart and brain. Not detected in gut, lung or spleen. Expressed ubiquitously in hepatocytes in liver whereas in kidney expression is restricted to the medulla. Within brain, expressed in glial cells. In the cerebellum, expressed on Bergmann glial fibers in the molecular layer and astrocytes in the granule layer.2 Publications

Gene expression databases

GenevisibleiQ9JHZ9. RN.

Interactioni

Protein-protein interaction databases

BioGridi251668. 1 interaction.
STRINGi10116.ENSRNOP00000023623.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9JHZ9.
KOiK13576.
OMAiHEWEYDS.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ9JHZ9.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGMPTA DTQRAEDAQH CGEGKGFLQQ
60 70 80 90 100
SSSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP TPVWYMDGNY LVILVSVIII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLVNATG
260 270 280 290 300
NFSHMVVVEE KSQLQSEPDT AEAFCTPSYF TLNSQTAYTI PIMAFAFVCH
310 320 330 340 350
PEVLPIYTEL KDPSKRKMQH ISNLSIAVMY VMYFLAALFG YLTFYDGVES
360 370 380 390 400
ELLHTYSKVD PFDVLILCVR VAVLIAVTLT VPIVLFPVRR AIQQMLFQNQ
410 420 430 440 450
EFSWLRHVLI ATGLLTCINL LVIFAPNILG IFGIIGATSA PCLIFIFPAI
460 470 480 490 500
FYFRIMPTEK EPVRSTPKIL ALCFAAVGFL LMTMSLSFII TDWVSGTSQH

GGNH
Length:504
Mass (Da):55,637
Last modified:October 1, 2000 - v1
Checksum:iD8C19AED34A791DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273025 mRNA. Translation: AAF81797.1.
BC081717 mRNA. Translation: AAH81717.1.
RefSeqiNP_665719.1. NM_145776.1.
UniGeneiRn.32067.

Genome annotation databases

EnsembliENSRNOT00000023623; ENSRNOP00000023623; ENSRNOG00000016827.
GeneIDi252919.
KEGGirno:252919.
UCSCiRGD:628620. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273025 mRNA. Translation: AAF81797.1.
BC081717 mRNA. Translation: AAH81717.1.
RefSeqiNP_665719.1. NM_145776.1.
UniGeneiRn.32067.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251668. 1 interaction.
STRINGi10116.ENSRNOP00000023623.

PTM databases

iPTMnetiQ9JHZ9.
PhosphoSiteiQ9JHZ9.

Proteomic databases

PaxDbiQ9JHZ9.
PRIDEiQ9JHZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023623; ENSRNOP00000023623; ENSRNOG00000016827.
GeneIDi252919.
KEGGirno:252919.
UCSCiRGD:628620. rat.

Organism-specific databases

CTDi10991.
RGDi628620. Slc38a3.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9JHZ9.
KOiK13576.
OMAiHEWEYDS.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ9JHZ9.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

NextBioi624061.
PROiQ9JHZ9.

Gene expression databases

GenevisibleiQ9JHZ9. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission."
    Chaudhry F.A., Reimer R.J., Krizaj D., Barber D., Storm-Mathisen J., Copenhagen D.R., Edwards R.H.
    Cell 99:769-780(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain1 Publication.
  2. "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter."
    Fei Y.-J., Sugawara M., Nakanishi T., Huang W., Wang H., Prasad P.D., Leibach F.H., Ganapathy V.
    J. Biol. Chem. 275:23707-23717(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Skeletal muscle1 Publication.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS38A3_RAT
AccessioniPrimary (citable) accession number: Q9JHZ9
Secondary accession number(s): Q66HS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.