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Q9JHY1

- JAM1_RAT

UniProt

Q9JHY1 - JAM1_RAT

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Protein
Junctional adhesion molecule A
Gene
F11r, Jam1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus By similarity.

GO - Molecular functioni

  1. protein binding Source: RGD
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: Ensembl
  2. cell differentiation Source: RGD
  3. epithelial cell differentiation Source: Ensembl
  4. positive regulation of blood pressure Source: RGD
  5. response to radiation Source: RGD
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule A
Short name:
JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name:
JAM-1
CD_antigen: CD321
Gene namesi
Name:F11r
Synonyms:Jam1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi621842. F11r.

Subcellular locationi

Cell junctiontight junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity
Note: Localized at tight junctions of both epithelial and endothelial cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 238212Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 30041Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: RGD
  2. cytoplasmic vesicle Source: RGD
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
  5. slit diaphragm Source: RGD
  6. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 300274Junctional adhesion molecule A
PRO_0000015068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 108 By similarity
Disulfide bondi152 ↔ 212 By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Modified residuei282 – 2821Phosphoserine By similarity
Modified residuei285 – 2851Phosphoserine By similarity
Modified residuei288 – 2881Phosphoserine By similarity

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JHY1.
PRIDEiQ9JHY1.

PTM databases

PhosphoSiteiQ9JHY1.

Expressioni

Gene expression databases

GenevestigatoriQ9JHY1.

Interactioni

Subunit structurei

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein By similarity.

Protein-protein interaction databases

IntActiQ9JHY1. 1 interaction.
MINTiMINT-135629.
STRINGi10116.ENSRNOP00000006141.

Structurei

3D structure databases

ProteinModelPortaliQ9JHY1.
SMRiQ9JHY1. Positions 27-238.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 12295Ig-like V-type 1
Add
BLAST
Domaini134 – 22895Ig-like V-type 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150281.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9JHY1.
KOiK06089.
OMAiSCSYSGF.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ9JHY1.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHY1-1 [UniParc]FASTAAdd to Basket

« Hide

MGTEGKAGSK LLFLFTSMIL GSLVQGKGSV YSPQTAVQVP ENDSVKLPCI    50
YSGFSSPRVE WKFVQGSTTA LVCYNNQITV PYADRVTFSS SGITFSSVTR 100
KDNGEYTCMV SEDGGQNYGE VSIHLTVLVP PSKPTVSIPS SVTIGNRAVL 150
TCSEHDGSPP SEYSWFKDGV PMLTADAKKT RAFINSSYTI DPKSGDLVFD 200
PVSAFDSGEY YCEAQNGYGT AMRSEAVRME AVELNVGGIV AAVLVTLILL 250
GLLIFGIWFA YSRGYFERTK KGTAPGKKVI YSQPSARSEG EFKQTSSFLV 300
Length:300
Mass (Da):32,370
Last modified:October 1, 2000 - v1
Checksum:i45AE362A96158BFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF276998 mRNA. Translation: AAF78250.1.
BC065309 mRNA. Translation: AAH65309.1.
RefSeqiNP_446248.1. NM_053796.1.
UniGeneiRn.107273.

Genome annotation databases

EnsembliENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414.
GeneIDi116479.
KEGGirno:116479.
UCSCiRGD:621842. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF276998 mRNA. Translation: AAF78250.1 .
BC065309 mRNA. Translation: AAH65309.1 .
RefSeqi NP_446248.1. NM_053796.1.
UniGenei Rn.107273.

3D structure databases

ProteinModelPortali Q9JHY1.
SMRi Q9JHY1. Positions 27-238.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9JHY1. 1 interaction.
MINTi MINT-135629.
STRINGi 10116.ENSRNOP00000006141.

PTM databases

PhosphoSitei Q9JHY1.

Proteomic databases

PaxDbi Q9JHY1.
PRIDEi Q9JHY1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006141 ; ENSRNOP00000006141 ; ENSRNOG00000004414 .
GeneIDi 116479.
KEGGi rno:116479.
UCSCi RGD:621842. rat.

Organism-specific databases

CTDi 50848.
RGDi 621842. F11r.

Phylogenomic databases

eggNOGi NOG150281.
GeneTreei ENSGT00730000110678.
HOGENOMi HOG000247041.
HOVERGENi HBG000518.
InParanoidi Q9JHY1.
KOi K06089.
OMAi SCSYSGF.
OrthoDBi EOG7MH0Z1.
PhylomeDBi Q9JHY1.
TreeFami TF331459.

Enzyme and pathway databases

Reactomei REACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

Miscellaneous databases

NextBioi 619047.
PROi Q9JHY1.

Gene expression databases

Genevestigatori Q9JHY1.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mashima H., Kojima I.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiJAM1_RAT
AccessioniPrimary (citable) accession number: Q9JHY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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