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Q9JHY1

- JAM1_RAT

UniProt

Q9JHY1 - JAM1_RAT

Protein

Junctional adhesion molecule A

Gene

F11r

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: RGD

    GO - Biological processi

    1. cell adhesion Source: Ensembl
    2. cell differentiation Source: RGD
    3. epithelial cell differentiation Source: Ensembl
    4. positive regulation of blood pressure Source: RGD
    5. response to radiation Source: RGD
    6. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Junctional adhesion molecule A
    Short name:
    JAM-A
    Alternative name(s):
    Junctional adhesion molecule 1
    Short name:
    JAM-1
    CD_antigen: CD321
    Gene namesi
    Name:F11r
    Synonyms:Jam1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi621842. F11r.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Localized at tight junctions of both epithelial and endothelial cells.By similarity

    GO - Cellular componenti

    1. cell-cell junction Source: RGD
    2. cytoplasmic vesicle Source: RGD
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell
    5. slit diaphragm Source: RGD
    6. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 300274Junctional adhesion molecule APRO_0000015068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 108PROSITE-ProRule annotation
    Disulfide bondi152 ↔ 212PROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Modified residuei282 – 2821PhosphoserineBy similarity
    Modified residuei285 – 2851PhosphoserineBy similarity
    Modified residuei288 – 2881PhosphoserineBy similarity

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9JHY1.
    PRIDEiQ9JHY1.

    PTM databases

    PhosphoSiteiQ9JHY1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JHY1.

    Interactioni

    Subunit structurei

    Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9JHY1. 1 interaction.
    MINTiMINT-135629.
    STRINGi10116.ENSRNOP00000006141.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHY1.
    SMRiQ9JHY1. Positions 27-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 238212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 30041CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 12295Ig-like V-type 1Add
    BLAST
    Domaini134 – 22895Ig-like V-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150281.
    GeneTreeiENSGT00730000110678.
    HOGENOMiHOG000247041.
    HOVERGENiHBG000518.
    InParanoidiQ9JHY1.
    KOiK06089.
    OMAiSCSYSGF.
    OrthoDBiEOG7MH0Z1.
    PhylomeDBiQ9JHY1.
    TreeFamiTF331459.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JHY1-1 [UniParc]FASTAAdd to Basket

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    MGTEGKAGSK LLFLFTSMIL GSLVQGKGSV YSPQTAVQVP ENDSVKLPCI    50
    YSGFSSPRVE WKFVQGSTTA LVCYNNQITV PYADRVTFSS SGITFSSVTR 100
    KDNGEYTCMV SEDGGQNYGE VSIHLTVLVP PSKPTVSIPS SVTIGNRAVL 150
    TCSEHDGSPP SEYSWFKDGV PMLTADAKKT RAFINSSYTI DPKSGDLVFD 200
    PVSAFDSGEY YCEAQNGYGT AMRSEAVRME AVELNVGGIV AAVLVTLILL 250
    GLLIFGIWFA YSRGYFERTK KGTAPGKKVI YSQPSARSEG EFKQTSSFLV 300
    Length:300
    Mass (Da):32,370
    Last modified:October 1, 2000 - v1
    Checksum:i45AE362A96158BFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276998 mRNA. Translation: AAF78250.1.
    BC065309 mRNA. Translation: AAH65309.1.
    RefSeqiNP_446248.1. NM_053796.1.
    UniGeneiRn.107273.

    Genome annotation databases

    EnsembliENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414.
    GeneIDi116479.
    KEGGirno:116479.
    UCSCiRGD:621842. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276998 mRNA. Translation: AAF78250.1 .
    BC065309 mRNA. Translation: AAH65309.1 .
    RefSeqi NP_446248.1. NM_053796.1.
    UniGenei Rn.107273.

    3D structure databases

    ProteinModelPortali Q9JHY1.
    SMRi Q9JHY1. Positions 27-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JHY1. 1 interaction.
    MINTi MINT-135629.
    STRINGi 10116.ENSRNOP00000006141.

    PTM databases

    PhosphoSitei Q9JHY1.

    Proteomic databases

    PaxDbi Q9JHY1.
    PRIDEi Q9JHY1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006141 ; ENSRNOP00000006141 ; ENSRNOG00000004414 .
    GeneIDi 116479.
    KEGGi rno:116479.
    UCSCi RGD:621842. rat.

    Organism-specific databases

    CTDi 50848.
    RGDi 621842. F11r.

    Phylogenomic databases

    eggNOGi NOG150281.
    GeneTreei ENSGT00730000110678.
    HOGENOMi HOG000247041.
    HOVERGENi HBG000518.
    InParanoidi Q9JHY1.
    KOi K06089.
    OMAi SCSYSGF.
    OrthoDBi EOG7MH0Z1.
    PhylomeDBi Q9JHY1.
    TreeFami TF331459.

    Enzyme and pathway databases

    Reactomei REACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).

    Miscellaneous databases

    NextBioi 619047.
    PROi Q9JHY1.

    Gene expression databases

    Genevestigatori Q9JHY1.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mashima H., Kojima I.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiJAM1_RAT
    AccessioniPrimary (citable) accession number: Q9JHY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3