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Q9JHY1 (JAM1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Junctional adhesion molecule A

Short name=JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name=JAM-1
CD_antigen=CD321
Gene names
Name:F11r
Synonyms:Jam1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus By similarity.

Subunit structure

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity. Note: Localized at tight junctions of both epithelial and endothelial cells By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 300274Junctional adhesion molecule A
PRO_0000015068

Regions

Topological domain27 – 238212Extracellular Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 30041Cytoplasmic Potential
Domain28 – 12295Ig-like V-type 1
Domain134 – 22895Ig-like V-type 2

Amino acid modifications

Modified residue2821Phosphoserine By similarity
Modified residue2851Phosphoserine By similarity
Modified residue2881Phosphoserine By similarity
Glycosylation1851N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 108 By similarity
Disulfide bond152 ↔ 212 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JHY1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 45AE362A96158BFA

FASTA30032,370
        10         20         30         40         50         60 
MGTEGKAGSK LLFLFTSMIL GSLVQGKGSV YSPQTAVQVP ENDSVKLPCI YSGFSSPRVE 

        70         80         90        100        110        120 
WKFVQGSTTA LVCYNNQITV PYADRVTFSS SGITFSSVTR KDNGEYTCMV SEDGGQNYGE 

       130        140        150        160        170        180 
VSIHLTVLVP PSKPTVSIPS SVTIGNRAVL TCSEHDGSPP SEYSWFKDGV PMLTADAKKT 

       190        200        210        220        230        240 
RAFINSSYTI DPKSGDLVFD PVSAFDSGEY YCEAQNGYGT AMRSEAVRME AVELNVGGIV 

       250        260        270        280        290        300 
AAVLVTLILL GLLIFGIWFA YSRGYFERTK KGTAPGKKVI YSQPSARSEG EFKQTSSFLV 

« Hide

References

« Hide 'large scale' references
[1]Mashima H., Kojima I.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF276998 mRNA. Translation: AAF78250.1.
BC065309 mRNA. Translation: AAH65309.1.
RefSeqNP_446248.1. NM_053796.1.
UniGeneRn.107273.

3D structure databases

ProteinModelPortalQ9JHY1.
SMRQ9JHY1. Positions 27-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JHY1. 1 interaction.
MINTMINT-135629.
STRING10116.ENSRNOP00000006141.

PTM databases

PhosphoSiteQ9JHY1.

Proteomic databases

PaxDbQ9JHY1.
PRIDEQ9JHY1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414.
GeneID116479.
KEGGrno:116479.
UCSCRGD:621842. rat.

Organism-specific databases

CTD50848.
RGD621842. F11r.

Phylogenomic databases

eggNOGNOG150281.
GeneTreeENSGT00730000110678.
HOGENOMHOG000247041.
HOVERGENHBG000518.
InParanoidQ9JHY1.
KOK06089.
OMASCSYSGF.
OrthoDBEOG7MH0Z1.
PhylomeDBQ9JHY1.
TreeFamTF331459.

Gene expression databases

GenevestigatorQ9JHY1.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio619047.
PROQ9JHY1.

Entry information

Entry nameJAM1_RAT
AccessionPrimary (citable) accession number: Q9JHY1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families