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Protein

Junctional adhesion molecule A

Gene

F11r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: Ensembl
  2. cell differentiation Source: RGD
  3. epithelial cell differentiation Source: Ensembl
  4. positive regulation of blood pressure Source: RGD
  5. response to radiation Source: RGD
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_234191. Cell surface interactions at the vascular wall.
REACT_247497. Tight junction interactions.
REACT_252097. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule A
Short name:
JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name:
JAM-1
CD_antigen: CD321
Gene namesi
Name:F11r
Synonyms:Jam1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi621842. F11r.

Subcellular locationi

Cell junctiontight junction By similarity. Cell membrane By similarity; Single-pass type I membrane protein By similarity
Note: Localized at tight junctions of both epithelial and endothelial cells.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 238212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 30041CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: RGD
  2. cytoplasmic vesicle Source: RGD
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. microtubule cytoskeleton Source: Ensembl
  6. plasma membrane Source: UniProtKB-SubCell
  7. slit diaphragm Source: RGD
  8. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 300274Junctional adhesion molecule APRO_0000015068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 108PROSITE-ProRule annotation
Disulfide bondi152 ↔ 212PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Modified residuei282 – 2821PhosphoserineBy similarity
Modified residuei285 – 2851PhosphoserineBy similarity
Modified residuei288 – 2881PhosphoserineBy similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JHY1.
PRIDEiQ9JHY1.

PTM databases

PhosphoSiteiQ9JHY1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9JHY1. baseline.
GenevestigatoriQ9JHY1.

Interactioni

Subunit structurei

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9JHY1. 1 interaction.
MINTiMINT-135629.
STRINGi10116.ENSRNOP00000006141.

Structurei

3D structure databases

ProteinModelPortaliQ9JHY1.
SMRiQ9JHY1. Positions 27-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 12295Ig-like V-type 1Add
BLAST
Domaini134 – 22895Ig-like V-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150281.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9JHY1.
KOiK06089.
OMAiSCSYSGF.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ9JHY1.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTEGKAGSK LLFLFTSMIL GSLVQGKGSV YSPQTAVQVP ENDSVKLPCI
60 70 80 90 100
YSGFSSPRVE WKFVQGSTTA LVCYNNQITV PYADRVTFSS SGITFSSVTR
110 120 130 140 150
KDNGEYTCMV SEDGGQNYGE VSIHLTVLVP PSKPTVSIPS SVTIGNRAVL
160 170 180 190 200
TCSEHDGSPP SEYSWFKDGV PMLTADAKKT RAFINSSYTI DPKSGDLVFD
210 220 230 240 250
PVSAFDSGEY YCEAQNGYGT AMRSEAVRME AVELNVGGIV AAVLVTLILL
260 270 280 290 300
GLLIFGIWFA YSRGYFERTK KGTAPGKKVI YSQPSARSEG EFKQTSSFLV
Length:300
Mass (Da):32,370
Last modified:October 1, 2000 - v1
Checksum:i45AE362A96158BFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276998 mRNA. Translation: AAF78250.1.
BC065309 mRNA. Translation: AAH65309.1.
RefSeqiNP_446248.1. NM_053796.1.
UniGeneiRn.107273.

Genome annotation databases

EnsembliENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414.
GeneIDi116479.
KEGGirno:116479.
UCSCiRGD:621842. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276998 mRNA. Translation: AAF78250.1.
BC065309 mRNA. Translation: AAH65309.1.
RefSeqiNP_446248.1. NM_053796.1.
UniGeneiRn.107273.

3D structure databases

ProteinModelPortaliQ9JHY1.
SMRiQ9JHY1. Positions 27-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JHY1. 1 interaction.
MINTiMINT-135629.
STRINGi10116.ENSRNOP00000006141.

PTM databases

PhosphoSiteiQ9JHY1.

Proteomic databases

PaxDbiQ9JHY1.
PRIDEiQ9JHY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006141; ENSRNOP00000006141; ENSRNOG00000004414.
GeneIDi116479.
KEGGirno:116479.
UCSCiRGD:621842. rat.

Organism-specific databases

CTDi50848.
RGDi621842. F11r.

Phylogenomic databases

eggNOGiNOG150281.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9JHY1.
KOiK06089.
OMAiSCSYSGF.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ9JHY1.
TreeFamiTF331459.

Enzyme and pathway databases

ReactomeiREACT_198828. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_234191. Cell surface interactions at the vascular wall.
REACT_247497. Tight junction interactions.
REACT_252097. Integrin cell surface interactions.

Miscellaneous databases

NextBioi619047.
PROiQ9JHY1.

Gene expression databases

ExpressionAtlasiQ9JHY1. baseline.
GenevestigatoriQ9JHY1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mashima H., Kojima I.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiJAM1_RAT
AccessioniPrimary (citable) accession number: Q9JHY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.