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Q9JHX3 (IL21R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-21 receptor
Short name=IL-21 receptor
Short name=IL-21R
Alternative name(s):
Lymphocyte receptor beta
Short name=LR-beta
Novel cytokine receptor 8
Short name=NR8
Novel interleukin receptor
CD_antigen=CD360
Gene names
Name:Il21r
Synonyms:Nilr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for interleukin-21.

Subunit structure

Heterodimer with the common gamma subunit. Associates with JAK1.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Post-translational modification

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame By similarity.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Contains 2 fibronectin type-III domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine receptor activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 529510Interleukin-21 receptor
PRO_0000010882

Regions

Topological domain20 – 237218Extracellular Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 529271Cytoplasmic Potential
Domain21 – 11898Fibronectin type-III 1
Domain124 – 20986Fibronectin type-III 2
Motif214 – 2185WSXWS motif
Motif266 – 2749Box 1 motif

Amino acid modifications

Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation2141C-linked (Man) By similarity
Disulfide bond20 ↔ 109 By similarity
Disulfide bond25 ↔ 35 By similarity
Disulfide bond65 ↔ 81 By similarity

Natural variations

Natural variant691R → K in strain: BALB/c and SJL/J.
Natural variant2001V → M in strain: BALB/c and SJL/J.

Sequences

Sequence LengthMass (Da)Tools
Q9JHX3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8B41816B0D426581

FASTA52958,355
        10         20         30         40         50         60 
MPRGPVAALL LLILHGAWSC LDLTCYTDYL WTITCVLETR SPNPSILSLT WQDEYEELQD 

        70         80         90        100        110        120 
QETFCSLHRS GHNTTHIWYT CHMRLSQFLS DEVFIVNVTD QSGNNSQECG SFVLAESIKP 

       130        140        150        160        170        180 
APPLNVTVAF SGRYDISWDS AYDEPSNYVL RGKLQYELQY RNLRDPYAVR PVTKLISVDS 

       190        200        210        220        230        240 
RNVSLLPEEF HKDSSYQLQV RAAPQPGTSF RGTWSEWSDP VIFQTQAGEP EAGWDPHMLL 

       250        260        270        280        290        300 
LLAVLIIVLV FMGLKIHLPW RLWKKIWAPV PTPESFFQPL YREHSGNFKK WVNTPFTASS 

       310        320        330        340        350        360 
IELVPQSSTT TSALHLSLYP AKEKKFPGLP GLEEQLECDG MSEPGHWCII PLAAGQAVSA 

       370        380        390        400        410        420 
YSEERDRPYG LVSIDTVTVG DAEGLCVWPC SCEDDGYPAM NLDAGRESGP NSEDLLLVTD 

       430        440        450        460        470        480 
PAFLSCGCVS GSGLRLGGSP GSLLDRLRLS FAKEGDWTAD PTWRTGSPGG GSESEAGSPP 

       490        500        510        520 
GLDMDTFDSG FAGSDCGSPV ETDEGPPRSY LRQWVVRTPP PVDSGAQSS

« Hide

References

[1]"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function."
Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R. expand/collapse author list , Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C., Moore M., Grant F.J., Lofton-Day C., Gilbert T., Raymond F., Ching A., Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K., Holly R.D., Foster D.
Nature 408:57-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain."
Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J.
Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Spleen and Thymus.
[3]"Chromosome 16p12 encodes a biologically active IL-2Rb related receptor with lymphoid restricted expression."
Donaldson D.D., Whitters M.J., Fitz L., Unger M., Finnerty H., Dagdigian C., Lowe L., Wood C.R., Young D.A., Collins M.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"A novel cytokine receptor NR8 is closely mapped to IL-4R: polymorphism in Balb/c mouse."
Nomura H., Yaguchi N., Maeda M., Hasegawa M.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[5]"Mus musculus interleukin 21 receptor gene Il21r mRNA."
Gao J., Teuscher C.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A/J, B10.S/DvTe, C57BL/6J, NOD/LtJ and SJL/J.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF254068 mRNA. Translation: AAG29347.1.
AF269134 mRNA. Translation: AAG23420.1.
AF279436 mRNA. Translation: AAF86350.1.
AB049137 mRNA. Translation: BAB13736.1.
AF477982 mRNA. Translation: AAL82632.1.
AF477983 mRNA. Translation: AAL82633.1.
AF477984 mRNA. Translation: AAL82634.1.
AF477985 mRNA. Translation: AAL82635.1.
AF477986 mRNA. Translation: AAL82636.1.
IPIIPI00119976.
RefSeqNP_068687.1. NM_021887.2.
UniGeneMm.155643.

3D structure databases

ProteinModelPortalQ9JHX3.
SMRQ9JHX3. Positions 20-227.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033000.

PTM databases

PhosphoSiteQ9JHX3.

Proteomic databases

PRIDEQ9JHX3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033000; ENSMUSP00000033000; ENSMUSG00000030745.
GeneID60504.
KEGGmmu:60504.
UCSCuc012ftn.1. mouse.

Organism-specific databases

CTD50615.
MGIMGI:1890475. Il21r.

Phylogenomic databases

eggNOGNOG40447.
GeneTreeENSGT00510000048783.
HOGENOMHOG000013192.
HOVERGENHBG052105.
InParanoidQ9JHX3.
KOK05075.
OMARDRPYGL.
OrthoDBEOG4NZTTW.

Gene expression databases

ArrayExpressQ9JHX3.
BgeeQ9JHX3.
CleanExMM_IL21R.
GenevestigatorQ9JHX3.
GermOnlineENSMUSG00000030745. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 1 hit.
PROSITEPS50853. FN3. False negative.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314905.
SOURCESearch...

Entry information

Entry nameIL21R_MOUSE
AccessionPrimary (citable) accession number: Q9JHX3
Secondary accession number(s): Q9ESM1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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