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Q9JHX3

- IL21R_MOUSE

UniProt

Q9JHX3 - IL21R_MOUSE

Protein

Interleukin-21 receptor

Gene

Il21r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    This is a receptor for interleukin-21.

    GO - Molecular functioni

    1. cytokine receptor activity Source: MGI
    2. transmembrane signaling receptor activity Source: MGI

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. signal transduction Source: GOC

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21 receptor
    Short name:
    IL-21 receptor
    Short name:
    IL-21R
    Alternative name(s):
    Lymphocyte receptor beta
    Short name:
    LR-beta
    Novel cytokine receptor 8
    Short name:
    NR8
    Novel interleukin receptor
    CD_antigen: CD360
    Gene namesi
    Name:Il21r
    Synonyms:Nilr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1890475. Il21r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 529510Interleukin-21 receptorPRO_0000010882Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 109By similarity
    Disulfide bondi25 ↔ 35By similarity
    Disulfide bondi65 ↔ 81By similarity
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi214 – 2141C-linked (Man)By similarity

    Post-translational modificationi

    C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JHX3.

    PTM databases

    PhosphoSiteiQ9JHX3.

    Expressioni

    Tissue specificityi

    Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

    Gene expression databases

    ArrayExpressiQ9JHX3.
    BgeeiQ9JHX3.
    CleanExiMM_IL21R.
    GenevestigatoriQ9JHX3.

    Interactioni

    Subunit structurei

    Heterodimer with the common gamma subunit. Associates with JAK1.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033000.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHX3.
    SMRiQ9JHX3. Positions 20-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 237218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini259 – 529271CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 11898Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini119 – 228110Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi214 – 2185WSXWS motif
    Motifi266 – 2749Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40447.
    GeneTreeiENSGT00510000048783.
    HOGENOMiHOG000013192.
    HOVERGENiHBG052105.
    InParanoidiQ9JHX3.
    KOiK05075.
    OMAiRDRPYGL.
    OrthoDBiEOG767398.
    PhylomeDBiQ9JHX3.
    TreeFamiTF337874.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JHX3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGPVAALL LLILHGAWSC LDLTCYTDYL WTITCVLETR SPNPSILSLT    50
    WQDEYEELQD QETFCSLHRS GHNTTHIWYT CHMRLSQFLS DEVFIVNVTD 100
    QSGNNSQECG SFVLAESIKP APPLNVTVAF SGRYDISWDS AYDEPSNYVL 150
    RGKLQYELQY RNLRDPYAVR PVTKLISVDS RNVSLLPEEF HKDSSYQLQV 200
    RAAPQPGTSF RGTWSEWSDP VIFQTQAGEP EAGWDPHMLL LLAVLIIVLV 250
    FMGLKIHLPW RLWKKIWAPV PTPESFFQPL YREHSGNFKK WVNTPFTASS 300
    IELVPQSSTT TSALHLSLYP AKEKKFPGLP GLEEQLECDG MSEPGHWCII 350
    PLAAGQAVSA YSEERDRPYG LVSIDTVTVG DAEGLCVWPC SCEDDGYPAM 400
    NLDAGRESGP NSEDLLLVTD PAFLSCGCVS GSGLRLGGSP GSLLDRLRLS 450
    FAKEGDWTAD PTWRTGSPGG GSESEAGSPP GLDMDTFDSG FAGSDCGSPV 500
    ETDEGPPRSY LRQWVVRTPP PVDSGAQSS 529
    Length:529
    Mass (Da):58,355
    Last modified:October 1, 2000 - v1
    Checksum:i8B41816B0D426581
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691R → K in strain: BALB/c and SJL/J.
    Natural varianti200 – 2001V → M in strain: BALB/c and SJL/J.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254068 mRNA. Translation: AAG29347.1.
    AF269134 mRNA. Translation: AAG23420.1.
    AF279436 mRNA. Translation: AAF86350.1.
    AB049137 mRNA. Translation: BAB13736.1.
    AF477982 mRNA. Translation: AAL82632.1.
    AF477983 mRNA. Translation: AAL82633.1.
    AF477984 mRNA. Translation: AAL82634.1.
    AF477985 mRNA. Translation: AAL82635.1.
    AF477986 mRNA. Translation: AAL82636.1.
    CCDSiCCDS21823.1.
    RefSeqiNP_068687.1. NM_021887.2.
    UniGeneiMm.155643.

    Genome annotation databases

    EnsembliENSMUST00000033000; ENSMUSP00000033000; ENSMUSG00000030745.
    GeneIDi60504.
    KEGGimmu:60504.
    UCSCiuc012ftn.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254068 mRNA. Translation: AAG29347.1 .
    AF269134 mRNA. Translation: AAG23420.1 .
    AF279436 mRNA. Translation: AAF86350.1 .
    AB049137 mRNA. Translation: BAB13736.1 .
    AF477982 mRNA. Translation: AAL82632.1 .
    AF477983 mRNA. Translation: AAL82633.1 .
    AF477984 mRNA. Translation: AAL82634.1 .
    AF477985 mRNA. Translation: AAL82635.1 .
    AF477986 mRNA. Translation: AAL82636.1 .
    CCDSi CCDS21823.1.
    RefSeqi NP_068687.1. NM_021887.2.
    UniGenei Mm.155643.

    3D structure databases

    ProteinModelPortali Q9JHX3.
    SMRi Q9JHX3. Positions 20-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033000.

    PTM databases

    PhosphoSitei Q9JHX3.

    Proteomic databases

    PRIDEi Q9JHX3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033000 ; ENSMUSP00000033000 ; ENSMUSG00000030745 .
    GeneIDi 60504.
    KEGGi mmu:60504.
    UCSCi uc012ftn.1. mouse.

    Organism-specific databases

    CTDi 50615.
    MGIi MGI:1890475. Il21r.

    Phylogenomic databases

    eggNOGi NOG40447.
    GeneTreei ENSGT00510000048783.
    HOGENOMi HOG000013192.
    HOVERGENi HBG052105.
    InParanoidi Q9JHX3.
    KOi K05075.
    OMAi RDRPYGL.
    OrthoDBi EOG767398.
    PhylomeDBi Q9JHX3.
    TreeFami TF337874.

    Miscellaneous databases

    NextBioi 314905.
    PROi Q9JHX3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHX3.
    Bgeei Q9JHX3.
    CleanExi MM_IL21R.
    Genevestigatori Q9JHX3.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR003531. Hempt_rcpt_S_F1_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    PS01355. HEMATOPO_REC_S_F1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain."
      Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J.
      Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen and Thymus.
    3. "Chromosome 16p12 encodes a biologically active IL-2Rb related receptor with lymphoid restricted expression."
      Donaldson D.D., Whitters M.J., Fitz L., Unger M., Finnerty H., Dagdigian C., Lowe L., Wood C.R., Young D.A., Collins M.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "A novel cytokine receptor NR8 is closely mapped to IL-4R: polymorphism in Balb/c mouse."
      Nomura H., Yaguchi N., Maeda M., Hasegawa M.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    5. "Mus musculus interleukin 21 receptor gene Il21r mRNA."
      Gao J., Teuscher C.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A/J, B10.S/DvTe, C57BL/6J, NOD/LtJ and SJL/J.
      Tissue: Spleen.

    Entry informationi

    Entry nameiIL21R_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHX3
    Secondary accession number(s): Q9ESM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3