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Q9JHX3

- IL21R_MOUSE

UniProt

Q9JHX3 - IL21R_MOUSE

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Protein

Interleukin-21 receptor

Gene

Il21r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for interleukin-21.

GO - Molecular functioni

  1. cytokine receptor activity Source: MGI
  2. transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21 receptor
Short name:
IL-21 receptor
Short name:
IL-21R
Alternative name(s):
Lymphocyte receptor beta
Short name:
LR-beta
Novel cytokine receptor 8
Short name:
NR8
Novel interleukin receptor
CD_antigen: CD360
Gene namesi
Name:Il21r
Synonyms:Nilr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1890475. Il21r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 237218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Topological domaini259 – 529271CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 529510Interleukin-21 receptorPRO_0000010882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 109By similarity
Disulfide bondi25 ↔ 35By similarity
Disulfide bondi65 ↔ 81By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi214 – 2141C-linked (Man)By similarity

Post-translational modificationi

C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JHX3.

PTM databases

PhosphoSiteiQ9JHX3.

Expressioni

Tissue specificityi

Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.

Gene expression databases

BgeeiQ9JHX3.
CleanExiMM_IL21R.
ExpressionAtlasiQ9JHX3. baseline and differential.
GenevestigatoriQ9JHX3.

Interactioni

Subunit structurei

Heterodimer with the common gamma subunit. Associates with JAK1.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033000.

Structurei

3D structure databases

ProteinModelPortaliQ9JHX3.
SMRiQ9JHX3. Positions 20-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 11898Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 228110Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi214 – 2185WSXWS motif
Motifi266 – 2749Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40447.
GeneTreeiENSGT00510000048783.
HOGENOMiHOG000013192.
HOVERGENiHBG052105.
InParanoidiQ9JHX3.
KOiK05075.
OMAiRDRPYGL.
OrthoDBiEOG767398.
PhylomeDBiQ9JHX3.
TreeFamiTF337874.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHX3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPRGPVAALL LLILHGAWSC LDLTCYTDYL WTITCVLETR SPNPSILSLT
60 70 80 90 100
WQDEYEELQD QETFCSLHRS GHNTTHIWYT CHMRLSQFLS DEVFIVNVTD
110 120 130 140 150
QSGNNSQECG SFVLAESIKP APPLNVTVAF SGRYDISWDS AYDEPSNYVL
160 170 180 190 200
RGKLQYELQY RNLRDPYAVR PVTKLISVDS RNVSLLPEEF HKDSSYQLQV
210 220 230 240 250
RAAPQPGTSF RGTWSEWSDP VIFQTQAGEP EAGWDPHMLL LLAVLIIVLV
260 270 280 290 300
FMGLKIHLPW RLWKKIWAPV PTPESFFQPL YREHSGNFKK WVNTPFTASS
310 320 330 340 350
IELVPQSSTT TSALHLSLYP AKEKKFPGLP GLEEQLECDG MSEPGHWCII
360 370 380 390 400
PLAAGQAVSA YSEERDRPYG LVSIDTVTVG DAEGLCVWPC SCEDDGYPAM
410 420 430 440 450
NLDAGRESGP NSEDLLLVTD PAFLSCGCVS GSGLRLGGSP GSLLDRLRLS
460 470 480 490 500
FAKEGDWTAD PTWRTGSPGG GSESEAGSPP GLDMDTFDSG FAGSDCGSPV
510 520
ETDEGPPRSY LRQWVVRTPP PVDSGAQSS
Length:529
Mass (Da):58,355
Last modified:October 1, 2000 - v1
Checksum:i8B41816B0D426581
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691R → K in strain: BALB/c and SJL/J.
Natural varianti200 – 2001V → M in strain: BALB/c and SJL/J.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254068 mRNA. Translation: AAG29347.1.
AF269134 mRNA. Translation: AAG23420.1.
AF279436 mRNA. Translation: AAF86350.1.
AB049137 mRNA. Translation: BAB13736.1.
AF477982 mRNA. Translation: AAL82632.1.
AF477983 mRNA. Translation: AAL82633.1.
AF477984 mRNA. Translation: AAL82634.1.
AF477985 mRNA. Translation: AAL82635.1.
AF477986 mRNA. Translation: AAL82636.1.
CCDSiCCDS21823.1.
RefSeqiNP_068687.1. NM_021887.2.
UniGeneiMm.155643.

Genome annotation databases

EnsembliENSMUST00000033000; ENSMUSP00000033000; ENSMUSG00000030745.
GeneIDi60504.
KEGGimmu:60504.
UCSCiuc012ftn.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254068 mRNA. Translation: AAG29347.1 .
AF269134 mRNA. Translation: AAG23420.1 .
AF279436 mRNA. Translation: AAF86350.1 .
AB049137 mRNA. Translation: BAB13736.1 .
AF477982 mRNA. Translation: AAL82632.1 .
AF477983 mRNA. Translation: AAL82633.1 .
AF477984 mRNA. Translation: AAL82634.1 .
AF477985 mRNA. Translation: AAL82635.1 .
AF477986 mRNA. Translation: AAL82636.1 .
CCDSi CCDS21823.1.
RefSeqi NP_068687.1. NM_021887.2.
UniGenei Mm.155643.

3D structure databases

ProteinModelPortali Q9JHX3.
SMRi Q9JHX3. Positions 20-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033000.

PTM databases

PhosphoSitei Q9JHX3.

Proteomic databases

PRIDEi Q9JHX3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033000 ; ENSMUSP00000033000 ; ENSMUSG00000030745 .
GeneIDi 60504.
KEGGi mmu:60504.
UCSCi uc012ftn.1. mouse.

Organism-specific databases

CTDi 50615.
MGIi MGI:1890475. Il21r.

Phylogenomic databases

eggNOGi NOG40447.
GeneTreei ENSGT00510000048783.
HOGENOMi HOG000013192.
HOVERGENi HBG052105.
InParanoidi Q9JHX3.
KOi K05075.
OMAi RDRPYGL.
OrthoDBi EOG767398.
PhylomeDBi Q9JHX3.
TreeFami TF337874.

Miscellaneous databases

NextBioi 314905.
PROi Q9JHX3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHX3.
CleanExi MM_IL21R.
ExpressionAtlasi Q9JHX3. baseline and differential.
Genevestigatori Q9JHX3.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain."
    Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J.
    Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen and Thymus.
  3. "Chromosome 16p12 encodes a biologically active IL-2Rb related receptor with lymphoid restricted expression."
    Donaldson D.D., Whitters M.J., Fitz L., Unger M., Finnerty H., Dagdigian C., Lowe L., Wood C.R., Young D.A., Collins M.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "A novel cytokine receptor NR8 is closely mapped to IL-4R: polymorphism in Balb/c mouse."
    Nomura H., Yaguchi N., Maeda M., Hasegawa M.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  5. "Mus musculus interleukin 21 receptor gene Il21r mRNA."
    Gao J., Teuscher C.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J, B10.S/DvTe, C57BL/6J, NOD/LtJ and SJL/J.
    Tissue: Spleen.

Entry informationi

Entry nameiIL21R_MOUSE
AccessioniPrimary (citable) accession number: Q9JHX3
Secondary accession number(s): Q9ESM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3