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Protein

Transcription factor Sp5

Gene

Sp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI

GO - Biological processi

  • bone morphogenesis Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • post-anal tail morphogenesis Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp5
Gene namesi
Name:Sp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927715. Sp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471471 – 398Transcription factor Sp5Add BLAST398

Proteomic databases

MaxQBiQ9JHX2.
PaxDbiQ9JHX2.
PRIDEiQ9JHX2.

PTM databases

PhosphoSitePlusiQ9JHX2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075304.
CleanExiMM_SP5.
GenevisibleiQ9JHX2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097620.

Structurei

3D structure databases

ProteinModelPortaliQ9JHX2.
SMRiQ9JHX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 51Poly-Ala4
Compositional biasi164 – 173Poly-Pro10
Compositional biasi224 – 235Poly-AlaAdd BLAST12

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri326 – 350C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri356 – 378C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG014797.
InParanoidiQ9JHX2.
KOiK09195.
OMAiAYVPYAT.
OrthoDBiEOG091G0HX6.
PhylomeDBiQ9JHX2.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVAVLRND SLQAFLQDRT PSASPDLGKH SPLALLAATC SRIGQPGAAA
60 70 80 90 100
APDFLQVPYD PALGSPSRLF HPWTADMPAH SPGALPPPHP SLGLTPQKTH
110 120 130 140 150
LQPSFGAAHE LPLTPPADPS YPYEFSPVKM LPSSMAALPA SCAPAYVPYA
160 170 180 190 200
AQAALPPGYS NLLPPPPPPP PPPTCRQLSP APAPDDLPWW SIPQSGAGPG
210 220 230 240 250
SSGVPGTSLS SACAGPPHAP RFPASAAAAA AAAAALQRGL VLGPSDFAQY
260 270 280 290 300
QSQIAALLQT KAPLAATARR CRRCRCPNCQ AAGGAPEAEP GKKKQHVCHV
310 320 330 340 350
PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKSFTRS DELQRHLRTH
360 370 380 390
TGEKRFACPE CGKRFMRSDH LAKHVKTHQN KKLKVAEAGV KRENPRDL
Length:398
Mass (Da):42,052
Last modified:October 1, 2000 - v1
Checksum:iB359853755B6B5C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279479 mRNA. Translation: AAF87798.1.
AK036234 mRNA. Translation: BAC29355.1.
BC116691 mRNA. Translation: AAI16692.1.
BC117505 mRNA. Translation: AAI17506.1.
CCDSiCCDS16106.1.
RefSeqiNP_071880.1. NM_022435.2.
UniGeneiMm.423397.

Genome annotation databases

EnsembliENSMUST00000100043; ENSMUSP00000097620; ENSMUSG00000075304.
GeneIDi64406.
KEGGimmu:64406.
UCSCiuc008jzg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279479 mRNA. Translation: AAF87798.1.
AK036234 mRNA. Translation: BAC29355.1.
BC116691 mRNA. Translation: AAI16692.1.
BC117505 mRNA. Translation: AAI17506.1.
CCDSiCCDS16106.1.
RefSeqiNP_071880.1. NM_022435.2.
UniGeneiMm.423397.

3D structure databases

ProteinModelPortaliQ9JHX2.
SMRiQ9JHX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097620.

PTM databases

PhosphoSitePlusiQ9JHX2.

Proteomic databases

MaxQBiQ9JHX2.
PaxDbiQ9JHX2.
PRIDEiQ9JHX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100043; ENSMUSP00000097620; ENSMUSG00000075304.
GeneIDi64406.
KEGGimmu:64406.
UCSCiuc008jzg.1. mouse.

Organism-specific databases

CTDi389058.
MGIiMGI:1927715. Sp5.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000231067.
HOVERGENiHBG014797.
InParanoidiQ9JHX2.
KOiK09195.
OMAiAYVPYAT.
OrthoDBiEOG091G0HX6.
PhylomeDBiQ9JHX2.
TreeFamiTF350150.

Miscellaneous databases

PROiQ9JHX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075304.
CleanExiMM_SP5.
GenevisibleiQ9JHX2. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSP5_MOUSE
AccessioniPrimary (citable) accession number: Q9JHX2
Secondary accession number(s): Q149T2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.