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Q9JHX0

- RGS2_RAT

UniProt

Q9JHX0 - RGS2_RAT

Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein By similarity.By similarity

    GO - Molecular functioni

    1. beta-tubulin binding Source: RGD
    2. GTPase activator activity Source: RGD

    GO - Biological processi

    1. brown fat cell differentiation Source: Ensembl
    2. cell cycle Source: UniProtKB-KW
    3. negative regulation of cardiac muscle hypertrophy Source: Ensembl
    4. negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
    5. negative regulation of MAP kinase activity Source: Ensembl
    6. negative regulation of phospholipase activity Source: Ensembl
    7. positive regulation of cardiac muscle contraction Source: Ensembl
    8. positive regulation of GTPase activity Source: RGD
    9. positive regulation of microtubule polymerization Source: RGD
    10. regulation of adrenergic receptor signaling pathway Source: Ensembl
    11. regulation of translation Source: UniProtKB-KW
    12. relaxation of cardiac muscle Source: Ensembl
    13. relaxation of vascular smooth muscle Source: Ensembl
    14. spermatogenesis Source: Ensembl
    15. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Cell cycle, Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 2
    Short name:
    RGS2
    Gene namesi
    Name:Rgs2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi621665. Rgs2.

    Subcellular locationi

    Cell membrane By similarity. Cytoplasm By similarity. Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytoplasmic side of plasma membrane Source: BHF-UCL
    3. cytosol Source: Ensembl
    4. neuron projection Source: RGD
    5. nucleolus Source: UniProtKB-SubCell
    6. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211Regulator of G-protein signaling 2PRO_0000204181Add
    BLAST

    Post-translational modificationi

    Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JHX0.

    Interactioni

    Subunit structurei

    Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHX0.
    SMRiQ9JHX0. Positions 70-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 199117RGSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 6635Necessary for membrane associationBy similarityAdd
    BLAST
    Regioni79 – 11638Necessary to inhibit protein synthesisBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252352.
    GeneTreeiENSGT00750000117382.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    InParanoidiQ9JHX0.
    KOiK18154.
    OMAiQQAFIKP.
    OrthoDBiEOG7VHSZ5.
    PhylomeDBiQ9JHX0.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JHX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ    50
    NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF 100
    LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI 150
    DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK 200
    KPQITTEPHA T 211
    Length:211
    Mass (Da):24,323
    Last modified:October 1, 2000 - v1
    Checksum:i84B5525CB41EA964
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279918 mRNA. Translation: AAF85981.1.
    AF321837 mRNA. Translation: AAK09375.1.
    AY043246 mRNA. Translation: AAK85309.1.
    BC061969 mRNA. Translation: AAH61969.1.
    AJ318489 mRNA. Translation: CAC44900.1.
    RefSeqiNP_445905.1. NM_053453.2.
    UniGeneiRn.1892.

    Genome annotation databases

    EnsembliENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
    GeneIDi84583.
    KEGGirno:84583.
    UCSCiRGD:621665. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF279918 mRNA. Translation: AAF85981.1 .
    AF321837 mRNA. Translation: AAK09375.1 .
    AY043246 mRNA. Translation: AAK85309.1 .
    BC061969 mRNA. Translation: AAH61969.1 .
    AJ318489 mRNA. Translation: CAC44900.1 .
    RefSeqi NP_445905.1. NM_053453.2.
    UniGenei Rn.1892.

    3D structure databases

    ProteinModelPortali Q9JHX0.
    SMRi Q9JHX0. Positions 70-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005156 ; ENSRNOP00000005156 ; ENSRNOG00000003687 .
    GeneIDi 84583.
    KEGGi rno:84583.
    UCSCi RGD:621665. rat.

    Organism-specific databases

    CTDi 5997.
    RGDi 621665. Rgs2.

    Phylogenomic databases

    eggNOGi NOG252352.
    GeneTreei ENSGT00750000117382.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    InParanoidi Q9JHX0.
    KOi K18154.
    OMAi QQAFIKP.
    OrthoDBi EOG7VHSZ5.
    PhylomeDBi Q9JHX0.
    TreeFami TF315837.

    Miscellaneous databases

    NextBioi 617163.
    PROi Q9JHX0.

    Gene expression databases

    Genevestigatori Q9JHX0.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells."
      Grant S.L., Lassegue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., Alexander R.W.
      Mol. Pharmacol. 57:460-467(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Thoracic aorta.
    2. "A detailed distribution study of RGS2 messenger RNA and protein in the rat brain."
      Taymans J.-M., Wintmolders C., Te Riele P., Jurzak M., Groenewegen H.J., Leysen J.E., Langlois X.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    3. "PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell."
      Ko J.K., Kim I.S., Park D.H.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. "Different regulation of RGS2 mRNA by haloperidol and clozapine."
      Robinet E.A., Wurch T., Pauwels P.J.
      NeuroReport 12:1731-1735(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiRGS2_RAT
    AccessioniPrimary (citable) accession number: Q9JHX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3