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Q9JHX0

- RGS2_RAT

UniProt

Q9JHX0 - RGS2_RAT

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Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity

GO - Molecular functioni

  1. beta-tubulin binding Source: RGD
  2. GTPase activator activity Source: RGD

GO - Biological processi

  1. brown fat cell differentiation Source: Ensembl
  2. cell cycle Source: UniProtKB-KW
  3. negative regulation of cAMP-mediated signaling Source: Ensembl
  4. negative regulation of cardiac muscle hypertrophy Source: Ensembl
  5. negative regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  6. negative regulation of MAP kinase activity Source: Ensembl
  7. negative regulation of phospholipase activity Source: Ensembl
  8. positive regulation of cardiac muscle contraction Source: Ensembl
  9. positive regulation of GTPase activity Source: RGD
  10. positive regulation of microtubule polymerization Source: RGD
  11. regulation of adrenergic receptor signaling pathway Source: Ensembl
  12. regulation of translation Source: UniProtKB-KW
  13. relaxation of cardiac muscle Source: Ensembl
  14. relaxation of vascular smooth muscle Source: Ensembl
  15. spermatogenesis Source: Ensembl
  16. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Cell cycle, Translation regulation

Enzyme and pathway databases

ReactomeiREACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Short name:
RGS2
Gene namesi
Name:Rgs2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi621665. Rgs2.

Subcellular locationi

Cell membrane By similarity. Cytoplasm By similarity. Nucleusnucleolus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytoplasmic side of plasma membrane Source: BHF-UCL
  3. cytosol Source: Ensembl
  4. neuron projection Source: RGD
  5. nucleus Source: UniProtKB-KW
  6. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Regulator of G-protein signaling 2PRO_0000204181Add
BLAST

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriQ9JHX0.

Interactioni

Subunit structurei

Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005156.

Structurei

3D structure databases

ProteinModelPortaliQ9JHX0.
SMRiQ9JHX0. Positions 70-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 199117RGSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 6635Necessary for membrane associationBy similarityAdd
BLAST
Regioni79 – 11638Necessary to inhibit protein synthesisBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252352.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ9JHX0.
KOiK18154.
OMAiQQAFIKP.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ9JHX0.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Length:211
Mass (Da):24,323
Last modified:October 1, 2000 - v1
Checksum:i84B5525CB41EA964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279918 mRNA. Translation: AAF85981.1.
AF321837 mRNA. Translation: AAK09375.1.
AY043246 mRNA. Translation: AAK85309.1.
BC061969 mRNA. Translation: AAH61969.1.
AJ318489 mRNA. Translation: CAC44900.1.
RefSeqiNP_445905.1. NM_053453.2.
UniGeneiRn.1892.

Genome annotation databases

EnsembliENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
GeneIDi84583.
KEGGirno:84583.
UCSCiRGD:621665. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279918 mRNA. Translation: AAF85981.1 .
AF321837 mRNA. Translation: AAK09375.1 .
AY043246 mRNA. Translation: AAK85309.1 .
BC061969 mRNA. Translation: AAH61969.1 .
AJ318489 mRNA. Translation: CAC44900.1 .
RefSeqi NP_445905.1. NM_053453.2.
UniGenei Rn.1892.

3D structure databases

ProteinModelPortali Q9JHX0.
SMRi Q9JHX0. Positions 70-203.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005156 ; ENSRNOP00000005156 ; ENSRNOG00000003687 .
GeneIDi 84583.
KEGGi rno:84583.
UCSCi RGD:621665. rat.

Organism-specific databases

CTDi 5997.
RGDi 621665. Rgs2.

Phylogenomic databases

eggNOGi NOG252352.
GeneTreei ENSGT00760000118903.
HOGENOMi HOG000233512.
HOVERGENi HBG013233.
InParanoidi Q9JHX0.
KOi K18154.
OMAi QQAFIKP.
OrthoDBi EOG7VHSZ5.
PhylomeDBi Q9JHX0.
TreeFami TF315837.

Enzyme and pathway databases

Reactomei REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 617163.
PROi Q9JHX0.

Gene expression databases

Genevestigatori Q9JHX0.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view ]
Pfami PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
PROSITEi PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells."
    Grant S.L., Lassegue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., Alexander R.W.
    Mol. Pharmacol. 57:460-467(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Thoracic aorta.
  2. "A detailed distribution study of RGS2 messenger RNA and protein in the rat brain."
    Taymans J.-M., Wintmolders C., Te Riele P., Jurzak M., Groenewegen H.J., Leysen J.E., Langlois X.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  3. "PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell."
    Ko J.K., Kim I.S., Park D.H.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "Different regulation of RGS2 mRNA by haloperidol and clozapine."
    Robinet E.A., Wurch T., Pauwels P.J.
    NeuroReport 12:1731-1735(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiRGS2_RAT
AccessioniPrimary (citable) accession number: Q9JHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3