Q9JHX0 (RGS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Regulator of G-protein signaling 2
Short name=RGS2

Gene names

Name:

Rgs2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein By similarity.
Subunit structure	Interacts with EIF2B5 By similarity. Interacts with PRKG1 (isoform alpha) By similarity.
Subcellular location	Cell membrane By similarity. Cytoplasm By similarity. Nucleus › nucleolus By similarity.
Post-translational modification	Phosphorylated by protein kinase C By similarity. Phosphorylation by PRKG1 leads to activation of RGS2 activity By similarity.
Sequence similarities	Contains 1 RGS domain.

Ontologies

Keywords
Biological process	Cell cycle Translation regulation
Cellular component	Cell membrane Cytoplasm Membrane Nucleus
Molecular function	Signal transduction inhibitor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from electronic annotation. Source: Compara cell cycle Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of G-protein coupled receptor protein signaling pathway Inferred from mutant phenotype PubMed 21798518. Source: RGD negative regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara negative regulation of cardiac muscle hypertrophy Inferred from electronic annotation. Source: Compara negative regulation of phospholipase activity Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara positive regulation of microtubule polymerization Inferred from direct assay PubMed 16820281. Source: RGD regulation of adrenergic receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW relaxation of cardiac muscle Inferred from electronic annotation. Source: Compara relaxation of vascular smooth muscle Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara termination of G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome cytosol Inferred from electronic annotation. Source: Compara internal side of plasma membrane Inferred from direct assay PubMed 21291891. Source: BHF-UCL neuron projection Inferred from direct assay PubMed 16820281. Source: RGD nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTPase activator activity Inferred from mutant phenotype PubMed 21798518. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Regulator of G-protein signaling 2		PRO_0000204181
Regions
	Domain	83 – 199	117	RGS
	Region	32 – 66	35	Necessary for membrane association By similarity
	Region	79 – 116	38	Necessary to inhibit protein synthesis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JHX0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 84B5525CB41EA964	FASTA	211	24,323
	10 20 30 40 50 60 MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT 70 80 90 100 110 120 GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK 130 140 150 160 170 180 KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL 190 200 210 MENNSYPRFL ESEFYQDLCK KPQITTEPHA T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells." Grant S.L., Lassegue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., Alexander R.W. Mol. Pharmacol. 57:460-467(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Thoracic aorta.
[2]	"A detailed distribution study of RGS2 messenger RNA and protein in the rat brain." Taymans J.-M., Wintmolders C., Te Riele P., Jurzak M., Groenewegen H.J., Leysen J.E., Langlois X. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[3]	"PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell." Ko J.K., Kim I.S., Park D.H. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"Different regulation of RGS2 mRNA by haloperidol and clozapine." Robinet E.A., Wurch T., Pauwels P.J. NeuroReport 12:1731-1735(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF279918 mRNA. Translation: AAF85981.1. AF321837 mRNA. Translation: AAK09375.1. AY043246 mRNA. Translation: AAK85309.1. BC061969 mRNA. Translation: AAH61969.1. AJ318489 mRNA. Translation: CAC44900.1.
IPI	IPI00200023.
RefSeq	NP_445905.1. NM_053453.2.
UniGene	Rn.1892.
3D structure databases
ProteinModelPortal	Q9JHX0.
SMR	Q9JHX0. Positions 70-203.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
GeneID	84583.
KEGG	rno:84583.
UCSC	RGD:621665. rat.
Organism-specific databases
CTD	5997.
RGD	621665. Rgs2.
Phylogenomic databases
eggNOG	NOG252352.
GeneTree	ENSGT00700000104212.
HOGENOM	HOG000233512.
HOVERGEN	HBG013233.
InParanoid	Q9JHX0.
KO	K16449.
OMA	KSKQQAF.
OrthoDB	EOG4ZGPD8.
Gene expression databases
Genevestigator	Q9JHX0.
GermOnline	ENSRNOG00000003687. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.196.10. 2 hits.
InterPro	IPR000342. Regulat_G_prot_signal. IPR024066. Regulat_G_prot_signal_dom1. IPR016137. Regulat_G_prot_signal_superfam. [Graphical view]
Pfam	PF00615. RGS. 1 hit. [Graphical view]
PRINTS	PR01301. RGSPROTEIN.
SMART	SM00315. RGS. 1 hit. [Graphical view]
SUPFAM	SSF48097. Regulat_G_prot_signal_superfam. 1 hit.
PROSITE	PS50132. RGS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	617163.

Entry information

Entry name

RGS2_RAT

Accession

Primary (citable) accession number: Q9JHX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program