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Q9JHX0 (RGS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 2

Short name=RGS2
Gene names
Name:Rgs2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein By similarity.

Subunit structure

Interacts with EIF2B5 By similarity. Interacts with PRKG1 (isoform alpha) By similarity.

Subcellular location

Cell membrane By similarity. Cytoplasm By similarity. Nucleusnucleolus By similarity.

Post-translational modification

Phosphorylated by protein kinase C By similarity. Phosphorylation by PRKG1 leads to activation of RGS2 activity By similarity.

Sequence similarities

Contains 1 RGS domain.

Ontologies

Keywords
   Biological processCell cycle
Translation regulation
   Cellular componentCell membrane
Cytoplasm
Membrane
Nucleus
   Molecular functionSignal transduction inhibitor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrown fat cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of G-protein coupled receptor protein signaling pathway

Inferred from mutant phenotype PubMed 21798518. Source: RGD

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of cardiac muscle hypertrophy

Inferred from electronic annotation. Source: Ensembl

negative regulation of phospholipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of GTPase activity

Inferred from mutant phenotype PubMed 21798518. Source: RGD

positive regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of microtubule polymerization

Inferred from direct assay PubMed 16820281. Source: RGD

regulation of adrenergic receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

relaxation of cardiac muscle

Inferred from electronic annotation. Source: Ensembl

relaxation of vascular smooth muscle

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

termination of G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytoplasmic side of plasma membrane

Inferred from direct assay PubMed 21291891. Source: BHF-UCL

cytosol

Inferred from electronic annotation. Source: Ensembl

neuron projection

Inferred from direct assay PubMed 16820281. Source: RGD

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionGTPase activator activity

Inferred from mutant phenotype PubMed 21798518. Source: RGD

beta-tubulin binding

Inferred from physical interaction PubMed 16820281. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Regulator of G-protein signaling 2
PRO_0000204181

Regions

Domain83 – 199117RGS
Region32 – 6635Necessary for membrane association By similarity
Region79 – 11638Necessary to inhibit protein synthesis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JHX0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 84B5525CB41EA964

FASTA21124,323
        10         20         30         40         50         60 
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT 

        70         80         90        100        110        120 
GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK 

       130        140        150        160        170        180 
KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL 

       190        200        210 
MENNSYPRFL ESEFYQDLCK KPQITTEPHA T 

« Hide

References

« Hide 'large scale' references
[1]"Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells."
Grant S.L., Lassegue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., Alexander R.W.
Mol. Pharmacol. 57:460-467(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Thoracic aorta.
[2]"A detailed distribution study of RGS2 messenger RNA and protein in the rat brain."
Taymans J.-M., Wintmolders C., Te Riele P., Jurzak M., Groenewegen H.J., Leysen J.E., Langlois X.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.
[3]"PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell."
Ko J.K., Kim I.S., Park D.H.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[5]"Different regulation of RGS2 mRNA by haloperidol and clozapine."
Robinet E.A., Wurch T., Pauwels P.J.
NeuroReport 12:1731-1735(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF279918 mRNA. Translation: AAF85981.1.
AF321837 mRNA. Translation: AAK09375.1.
AY043246 mRNA. Translation: AAK85309.1.
BC061969 mRNA. Translation: AAH61969.1.
AJ318489 mRNA. Translation: CAC44900.1.
RefSeqNP_445905.1. NM_053453.2.
UniGeneRn.1892.

3D structure databases

ProteinModelPortalQ9JHX0.
SMRQ9JHX0. Positions 70-203.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
GeneID84583.
KEGGrno:84583.
UCSCRGD:621665. rat.

Organism-specific databases

CTD5997.
RGD621665. Rgs2.

Phylogenomic databases

eggNOGNOG252352.
GeneTreeENSGT00750000117382.
HOGENOMHOG000233512.
HOVERGENHBG013233.
InParanoidQ9JHX0.
KOK18154.
OMAQQAFIKP.
OrthoDBEOG7VHSZ5.
PhylomeDBQ9JHX0.
TreeFamTF315837.

Gene expression databases

GenevestigatorQ9JHX0.

Family and domain databases

Gene3D1.10.196.10. 2 hits.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617163.
PROQ9JHX0.

Entry information

Entry nameRGS2_RAT
AccessionPrimary (citable) accession number: Q9JHX0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families