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Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity

GO - Molecular functioni

  • beta-tubulin binding Source: RGD
  • G-protein alpha-subunit binding Source: RGD
  • GTPase activator activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Signal transduction inhibitor
Biological processCell cycle, Translation regulation

Enzyme and pathway databases

ReactomeiR-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Short name:
RGS2
Gene namesi
Name:Rgs2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi621665 Rgs2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041811 – 211Regulator of G-protein signaling 2Add BLAST211

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JHX0
PRIDEiQ9JHX0

Expressioni

Gene expression databases

BgeeiENSRNOG00000003687
GenevisibleiQ9JHX0 RN

Interactioni

Subunit structurei

Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

GO - Molecular functioni

  • beta-tubulin binding Source: RGD
  • G-protein alpha-subunit binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005156

Structurei

3D structure databases

ProteinModelPortaliQ9JHX0
SMRiQ9JHX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 199RGSPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 66Necessary for membrane associationBy similarityAdd BLAST35
Regioni79 – 116Necessary to inhibit protein synthesisBy similarityAdd BLAST38

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233512
HOVERGENiHBG013233
InParanoidiQ9JHX0
KOiK18154
OMAiAVQHDCV
OrthoDBiEOG091G0BDG
PhylomeDBiQ9JHX0
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034947 RGS2
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF43 PTHR10845:SF43, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Length:211
Mass (Da):24,323
Last modified:October 1, 2000 - v1
Checksum:i84B5525CB41EA964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279918 mRNA Translation: AAF85981.1
AF321837 mRNA Translation: AAK09375.1
AY043246 mRNA Translation: AAK85309.1
BC061969 mRNA Translation: AAH61969.1
AJ318489 mRNA Translation: CAC44900.1
RefSeqiNP_445905.1, NM_053453.2
UniGeneiRn.1892

Genome annotation databases

EnsembliENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687
GeneIDi84583
KEGGirno:84583
UCSCiRGD:621665 rat

Similar proteinsi

Entry informationi

Entry nameiRGS2_RAT
AccessioniPrimary (citable) accession number: Q9JHX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health