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Protein

Regulator of G-protein signaling 2

Gene

Rgs2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).By similarity

GO - Molecular functioni

  • beta-tubulin binding Source: RGD
  • GTPase activator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Signal transduction inhibitor

Keywords - Biological processi

Cell cycle, Translation regulation

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 2
Short name:
RGS2
Gene namesi
Name:Rgs2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi621665. Rgs2.

Subcellular locationi

  • Cell membrane By similarity
  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytoplasmic side of plasma membrane Source: BHF-UCL
  • cytosol Source: Ensembl
  • neuron projection Source: RGD
  • nucleolus Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Regulator of G-protein signaling 2PRO_0000204181Add
BLAST

Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JHX0.

Expressioni

Gene expression databases

GenevisibleiQ9JHX0. RN.

Interactioni

Subunit structurei

Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).By similarity

GO - Molecular functioni

  • beta-tubulin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005156.

Structurei

3D structure databases

ProteinModelPortaliQ9JHX0.
SMRiQ9JHX0. Positions 70-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 199117RGSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 6635Necessary for membrane associationBy similarityAdd
BLAST
Regioni79 – 11638Necessary to inhibit protein synthesisBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ9JHX0.
KOiK18154.
OMAiAVQHDCV.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ9JHX0.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ
60 70 80 90 100
NSSTPGKPKT GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF
110 120 130 140 150
LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI
160 170 180 190 200
DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK
210
KPQITTEPHA T
Length:211
Mass (Da):24,323
Last modified:October 1, 2000 - v1
Checksum:i84B5525CB41EA964
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279918 mRNA. Translation: AAF85981.1.
AF321837 mRNA. Translation: AAK09375.1.
AY043246 mRNA. Translation: AAK85309.1.
BC061969 mRNA. Translation: AAH61969.1.
AJ318489 mRNA. Translation: CAC44900.1.
RefSeqiNP_445905.1. NM_053453.2.
UniGeneiRn.1892.

Genome annotation databases

EnsembliENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
GeneIDi84583.
KEGGirno:84583.
UCSCiRGD:621665. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF279918 mRNA. Translation: AAF85981.1.
AF321837 mRNA. Translation: AAK09375.1.
AY043246 mRNA. Translation: AAK85309.1.
BC061969 mRNA. Translation: AAH61969.1.
AJ318489 mRNA. Translation: CAC44900.1.
RefSeqiNP_445905.1. NM_053453.2.
UniGeneiRn.1892.

3D structure databases

ProteinModelPortaliQ9JHX0.
SMRiQ9JHX0. Positions 70-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005156.

Proteomic databases

PaxDbiQ9JHX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
GeneIDi84583.
KEGGirno:84583.
UCSCiRGD:621665. rat.

Organism-specific databases

CTDi5997.
RGDi621665. Rgs2.

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233512.
HOVERGENiHBG013233.
InParanoidiQ9JHX0.
KOiK18154.
OMAiAVQHDCV.
OrthoDBiEOG7VHSZ5.
PhylomeDBiQ9JHX0.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi617163.
PROiQ9JHX0.

Gene expression databases

GenevisibleiQ9JHX0. RN.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells."
    Grant S.L., Lassegue B., Griendling K.K., Ushio-Fukai M., Lyons P.R., Alexander R.W.
    Mol. Pharmacol. 57:460-467(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Thoracic aorta.
  2. "A detailed distribution study of RGS2 messenger RNA and protein in the rat brain."
    Taymans J.-M., Wintmolders C., Te Riele P., Jurzak M., Groenewegen H.J., Leysen J.E., Langlois X.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  3. "PTH induced RGS cDNA sequence in rat osteoblast-like UMR106 cell."
    Ko J.K., Kim I.S., Park D.H.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. "Different regulation of RGS2 mRNA by haloperidol and clozapine."
    Robinet E.A., Wurch T., Pauwels P.J.
    NeuroReport 12:1731-1735(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-100.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiRGS2_RAT
AccessioniPrimary (citable) accession number: Q9JHX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.