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Q9JHW9

- AL1A3_MOUSE

UniProt

Q9JHW9 - AL1A3_MOUSE

Protein

Aldehyde dehydrogenase family 1 member A3

Gene

Aldh1a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.4 Publications

    Catalytic activityi

    An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei181 – 1811Transition state stabilizerBy similarity
    Active sitei280 – 2801Proton acceptorPROSITE-ProRule annotation
    Active sitei314 – 3141NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi257 – 2626NADBy similarity

    GO - Molecular functioni

    1. 3-chloroallyl aldehyde dehydrogenase activity Source: MGI
    2. aldehyde dehydrogenase (NAD) activity Source: MGI
    3. aldehyde dehydrogenase [NAD(P)+] activity Source: MGI
    4. NAD+ binding Source: MGI
    5. thyroid hormone binding Source: MGI

    GO - Biological processi

    1. embryonic camera-type eye development Source: MGI
    2. embryonic eye morphogenesis Source: MGI
    3. face development Source: MGI
    4. inner ear morphogenesis Source: MGI
    5. locomotory behavior Source: MGI
    6. neuromuscular process controlling balance Source: MGI
    7. nucleus accumbens development Source: MGI
    8. olfactory pit development Source: MGI
    9. optic cup morphogenesis involved in camera-type eye development Source: MGI
    10. positive regulation of apoptotic process Source: MGI
    11. positive regulation of retinoic acid receptor signaling pathway Source: MGI
    12. retinal metabolic process Source: Ensembl
    13. retinoic acid biosynthetic process Source: MGI
    14. retinoic acid metabolic process Source: MGI
    15. retinol metabolic process Source: UniProtKB-UniPathway
    16. righting reflex Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.2.1.36. 3474.
    SABIO-RKQ9JHW9.
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 1 member A3 (EC:1.2.1.5)
    Alternative name(s):
    Aldehyde dehydrogenase 6
    Retinaldehyde dehydrogenase 3
    Short name:
    RALDH-3
    Short name:
    RalDH3
    Gene namesi
    Name:Aldh1a3
    Synonyms:Aldh6, Raldh3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1861722. Aldh1a3.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 512511Aldehyde dehydrogenase family 1 member A3PRO_0000056479Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9JHW9.
    PaxDbiQ9JHW9.
    PRIDEiQ9JHW9.

    PTM databases

    PhosphoSiteiQ9JHW9.

    Expressioni

    Tissue specificityi

    Ventral retina.4 Publications

    Developmental stagei

    In mouse embryos, RALDH3 expression is first noticed in the ventral optic eminence at E8.75, then in the optic vesicle/cup, otic vesicle and olfactory placode/pit from E9.5 to E11.5.1 Publication

    Gene expression databases

    ArrayExpressiQ9JHW9.
    BgeeiQ9JHW9.
    CleanExiMM_ALDH1A3.
    GenevestigatoriQ9JHW9.

    Interactioni

    Protein-protein interaction databases

    BioGridi208193. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHW9.
    SMRiQ9JHW9. Positions 20-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00550000074289.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ9JHW9.
    KOiK00129.
    OMAiHAQTPFG.
    OrthoDBiEOG7PS1F7.
    PhylomeDBiQ9JHW9.
    TreeFamiTF300455.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JHW9-1 [UniParc]FASTAAdd to Basket

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    MATTNGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HESKSGRKFA    50
    TYNPSTLEKI CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL 100
    HQLADLVERD RAILATLETM DTGKPFLHAF FVDLEGCIKT FRYFAGWADK 150
    IQGRTIPTDD NVVCFTRHEP IGVCGAITPW NFPLLMLAWK LAPALCCGNT 200
    VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV GAAISSHPQI 250
    NKIAFTGSTE VGKLVREAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE 300
    CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK 350
    TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD 400
    VTDNMRIAKE EIFGPVQPIL KFKNLEEVIK RANSTDYGLT AAVFTKNLDK 450
    ALKLAAALES GTVWINCYNA FYAQAPFGGF KMSGNGRELG EYALAEYTEV 500
    KTVTIKLEEK NP 512
    Length:512
    Mass (Da):56,157
    Last modified:October 1, 2000 - v1
    Checksum:i5BBC6DEE41E58CFE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911L → V in AAF67736. (PubMed:10906479)Curated
    Sequence conflicti208 – 2081Q → R in AAG33935. (PubMed:11013254)Curated
    Sequence conflicti223 – 2231V → E in AAF67736. (PubMed:10906479)Curated
    Sequence conflicti341 – 3411R → S in AAG33935. (PubMed:11013254)Curated
    Sequence conflicti407 – 4071I → R in AAF67736. (PubMed:10906479)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF253409 mRNA. Translation: AAF67736.1.
    AF280404 mRNA. Translation: AAF86980.1.
    AF246711 mRNA. Translation: AAG38488.1.
    AF152359 mRNA. Translation: AAG33935.1.
    BC058277 mRNA. Translation: AAH58277.1.
    CCDSiCCDS21345.1.
    RefSeqiNP_444310.3. NM_053080.3.
    UniGeneiMm.140988.

    Genome annotation databases

    EnsembliENSMUST00000015278; ENSMUSP00000015278; ENSMUSG00000015134.
    GeneIDi56847.
    KEGGimmu:56847.
    UCSCiuc009hhi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF253409 mRNA. Translation: AAF67736.1 .
    AF280404 mRNA. Translation: AAF86980.1 .
    AF246711 mRNA. Translation: AAG38488.1 .
    AF152359 mRNA. Translation: AAG33935.1 .
    BC058277 mRNA. Translation: AAH58277.1 .
    CCDSi CCDS21345.1.
    RefSeqi NP_444310.3. NM_053080.3.
    UniGenei Mm.140988.

    3D structure databases

    ProteinModelPortali Q9JHW9.
    SMRi Q9JHW9. Positions 20-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208193. 1 interaction.

    PTM databases

    PhosphoSitei Q9JHW9.

    Proteomic databases

    MaxQBi Q9JHW9.
    PaxDbi Q9JHW9.
    PRIDEi Q9JHW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015278 ; ENSMUSP00000015278 ; ENSMUSG00000015134 .
    GeneIDi 56847.
    KEGGi mmu:56847.
    UCSCi uc009hhi.2. mouse.

    Organism-specific databases

    CTDi 220.
    MGIi MGI:1861722. Aldh1a3.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00550000074289.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q9JHW9.
    KOi K00129.
    OMAi HAQTPFG.
    OrthoDBi EOG7PS1F7.
    PhylomeDBi Q9JHW9.
    TreeFami TF300455.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BRENDAi 1.2.1.36. 3474.
    SABIO-RK Q9JHW9.

    Miscellaneous databases

    NextBioi 313405.
    PROi Q9JHW9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHW9.
    Bgeei Q9JHW9.
    CleanExi MM_ALDH1A3.
    Genevestigatori Q9JHW9.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse."
      Li H., Wagner E., McCaffery P., Smith D., Andreadis A., Drager U.C.
      Mech. Dev. 95:283-289(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: B6/D2.
    2. "RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development."
      Mic F.A., Molotkov A., Fan X., Cuenca A.E., Duester G.
      Mech. Dev. 97:227-230(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
      Strain: C57BL/6 X 129/SvJ.
      Tissue: Kidney.
    3. "Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina."
      Suzuki R., Shintani T., Sakuta H., Kato A., Ohkawara T., Osumi N., Noda M.
      Mech. Dev. 98:37-50(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
      Tissue: Retina.
    4. "Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development."
      Grun F., Hirose Y., Kawauchi S., Ogura T., Umesono K.
      J. Biol. Chem. 275:41210-41218(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiAL1A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHW9
    Secondary accession number(s): Q9EQP7, Q9JI72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3