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Q9JHW9

- AL1A3_MOUSE

UniProt

Q9JHW9 - AL1A3_MOUSE

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Protein

Aldehyde dehydrogenase family 1 member A3

Gene

Aldh1a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.4 Publications

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei181 – 1811Transition state stabilizerBy similarity
Active sitei280 – 2801Proton acceptorPROSITE-ProRule annotation
Active sitei314 – 3141NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2626NADBy similarity

GO - Molecular functioni

  1. 3-chloroallyl aldehyde dehydrogenase activity Source: MGI
  2. aldehyde dehydrogenase (NAD) activity Source: MGI
  3. aldehyde dehydrogenase [NAD(P)+] activity Source: MGI
  4. NAD+ binding Source: MGI
  5. thyroid hormone binding Source: MGI

GO - Biological processi

  1. embryonic camera-type eye development Source: MGI
  2. embryonic eye morphogenesis Source: MGI
  3. face development Source: MGI
  4. inner ear morphogenesis Source: MGI
  5. locomotory behavior Source: MGI
  6. neuromuscular process controlling balance Source: MGI
  7. nucleus accumbens development Source: MGI
  8. olfactory pit development Source: MGI
  9. optic cup morphogenesis involved in camera-type eye development Source: MGI
  10. positive regulation of apoptotic process Source: MGI
  11. positive regulation of retinoic acid receptor signaling pathway Source: MGI
  12. retinal metabolic process Source: Ensembl
  13. retinoic acid biosynthetic process Source: MGI
  14. retinoic acid metabolic process Source: MGI
  15. retinol metabolic process Source: UniProtKB-UniPathway
  16. righting reflex Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 3474.
SABIO-RKQ9JHW9.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 1 member A3 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 6
Retinaldehyde dehydrogenase 3
Short name:
RALDH-3
Short name:
RalDH3
Gene namesi
Name:Aldh1a3
Synonyms:Aldh6, Raldh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1861722. Aldh1a3.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 512511Aldehyde dehydrogenase family 1 member A3PRO_0000056479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JHW9.
PaxDbiQ9JHW9.
PRIDEiQ9JHW9.

PTM databases

PhosphoSiteiQ9JHW9.

Expressioni

Tissue specificityi

Ventral retina.4 Publications

Developmental stagei

In mouse embryos, RALDH3 expression is first noticed in the ventral optic eminence at E8.75, then in the optic vesicle/cup, otic vesicle and olfactory placode/pit from E9.5 to E11.5.1 Publication

Gene expression databases

BgeeiQ9JHW9.
CleanExiMM_ALDH1A3.
ExpressionAtlasiQ9JHW9. baseline and differential.
GenevestigatoriQ9JHW9.

Interactioni

Protein-protein interaction databases

BioGridi208193. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JHW9.
SMRiQ9JHW9. Positions 20-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ9JHW9.
KOiK00129.
OMAiHAQTPFG.
OrthoDBiEOG7PS1F7.
PhylomeDBiQ9JHW9.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATTNGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HESKSGRKFA
60 70 80 90 100
TYNPSTLEKI CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL
110 120 130 140 150
HQLADLVERD RAILATLETM DTGKPFLHAF FVDLEGCIKT FRYFAGWADK
160 170 180 190 200
IQGRTIPTDD NVVCFTRHEP IGVCGAITPW NFPLLMLAWK LAPALCCGNT
210 220 230 240 250
VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV GAAISSHPQI
260 270 280 290 300
NKIAFTGSTE VGKLVREAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE
310 320 330 340 350
CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK
360 370 380 390 400
TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD
410 420 430 440 450
VTDNMRIAKE EIFGPVQPIL KFKNLEEVIK RANSTDYGLT AAVFTKNLDK
460 470 480 490 500
ALKLAAALES GTVWINCYNA FYAQAPFGGF KMSGNGRELG EYALAEYTEV
510
KTVTIKLEEK NP
Length:512
Mass (Da):56,157
Last modified:October 1, 2000 - v1
Checksum:i5BBC6DEE41E58CFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911L → V in AAF67736. (PubMed:10906479)Curated
Sequence conflicti208 – 2081Q → R in AAG33935. (PubMed:11013254)Curated
Sequence conflicti223 – 2231V → E in AAF67736. (PubMed:10906479)Curated
Sequence conflicti341 – 3411R → S in AAG33935. (PubMed:11013254)Curated
Sequence conflicti407 – 4071I → R in AAF67736. (PubMed:10906479)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253409 mRNA. Translation: AAF67736.1.
AF280404 mRNA. Translation: AAF86980.1.
AF246711 mRNA. Translation: AAG38488.1.
AF152359 mRNA. Translation: AAG33935.1.
BC058277 mRNA. Translation: AAH58277.1.
CCDSiCCDS21345.1.
RefSeqiNP_444310.3. NM_053080.3.
UniGeneiMm.140988.

Genome annotation databases

EnsembliENSMUST00000015278; ENSMUSP00000015278; ENSMUSG00000015134.
GeneIDi56847.
KEGGimmu:56847.
UCSCiuc009hhi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253409 mRNA. Translation: AAF67736.1 .
AF280404 mRNA. Translation: AAF86980.1 .
AF246711 mRNA. Translation: AAG38488.1 .
AF152359 mRNA. Translation: AAG33935.1 .
BC058277 mRNA. Translation: AAH58277.1 .
CCDSi CCDS21345.1.
RefSeqi NP_444310.3. NM_053080.3.
UniGenei Mm.140988.

3D structure databases

ProteinModelPortali Q9JHW9.
SMRi Q9JHW9. Positions 20-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208193. 1 interaction.

PTM databases

PhosphoSitei Q9JHW9.

Proteomic databases

MaxQBi Q9JHW9.
PaxDbi Q9JHW9.
PRIDEi Q9JHW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015278 ; ENSMUSP00000015278 ; ENSMUSG00000015134 .
GeneIDi 56847.
KEGGi mmu:56847.
UCSCi uc009hhi.2. mouse.

Organism-specific databases

CTDi 220.
MGIi MGI:1861722. Aldh1a3.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00760000118999.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q9JHW9.
KOi K00129.
OMAi HAQTPFG.
OrthoDBi EOG7PS1F7.
PhylomeDBi Q9JHW9.
TreeFami TF300455.

Enzyme and pathway databases

UniPathwayi UPA00912 .
BRENDAi 1.2.1.36. 3474.
SABIO-RK Q9JHW9.

Miscellaneous databases

NextBioi 313405.
PROi Q9JHW9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHW9.
CleanExi MM_ALDH1A3.
ExpressionAtlasi Q9JHW9. baseline and differential.
Genevestigatori Q9JHW9.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse."
    Li H., Wagner E., McCaffery P., Smith D., Andreadis A., Drager U.C.
    Mech. Dev. 95:283-289(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: B6/D2.
  2. "RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development."
    Mic F.A., Molotkov A., Fan X., Cuenca A.E., Duester G.
    Mech. Dev. 97:227-230(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Strain: C57BL/6 X 129/SvJ.
    Tissue: Kidney.
  3. "Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina."
    Suzuki R., Shintani T., Sakuta H., Kato A., Ohkawara T., Osumi N., Noda M.
    Mech. Dev. 98:37-50(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Retina.
  4. "Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development."
    Grun F., Hirose Y., Kawauchi S., Ogura T., Umesono K.
    J. Biol. Chem. 275:41210-41218(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiAL1A3_MOUSE
AccessioniPrimary (citable) accession number: Q9JHW9
Secondary accession number(s): Q9EQP7, Q9JI72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3