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Protein

Stathmin-3

Gene

Stmn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • tubulin binding Source: RGD

GO - Biological processi

  • cytoplasmic microtubule organization Source: HGNC
  • microtubule depolymerization Source: GO_Central
  • negative regulation of Rac protein signal transduction Source: HGNC
  • neuron projection development Source: HGNC
  • regulation of cytoskeleton organization Source: HGNC
  • regulation of GTPase activity Source: HGNC
  • regulation of microtubule polymerization or depolymerization Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-3
Alternative name(s):
SCG10-like protein
Gene namesi
Name:Stmn3
Synonyms:Sclip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3628. Stmn3.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • cytoplasm Source: HGNC
  • Golgi apparatus Source: UniProtKB-SubCell
  • growth cone Source: UniProtKB-SubCell
  • neuron projection Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824041 – 180Stathmin-3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22S-palmitoyl cysteineBy similarity1
Lipidationi24S-palmitoyl cysteineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei65PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1
Modified residuei81PhosphoserineCombined sources1

Post-translational modificationi

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ9JHU6.

PTM databases

iPTMnetiQ9JHU6.
PhosphoSitePlusiQ9JHU6.

Expressioni

Tissue specificityi

Neuron specific.

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi247922. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9JHU6.
SMRiQ9JHU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 180SLDPROSITE-ProRule annotationAdd BLAST143

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 179Sequence analysisAdd BLAST105

Sequence similaritiesi

Belongs to the stathmin family.Curated
Contains 1 SLD (stathmin-like) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9JHU6.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTVSAYKE KMKELSVLSL ICSCFYSQPH PNTIYQYGDM EVKQLDKRAS
60 70 80 90 100
GQSFEVILKS PSDLSPESPV LSSPPKRKDA SLEELQKRLE AAEERRKTQE
110 120 130 140 150
AQVLKQLAER REHEREVLHK ALEENNNFSP LAEEKLNYKM ELSKEIREAH
160 170 180
LAALRERLRE KELHAAEVRR NKEQREEMSG
Length:180
Mass (Da):20,895
Last modified:October 1, 2000 - v1
Checksum:iA7C0D0D7DCB0A765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004290 mRNA. Translation: AAF86617.1.
RefSeqiNP_077322.1. NM_024346.1.
UniGeneiRn.14961.

Genome annotation databases

GeneIDi29246.
KEGGirno:29246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004290 mRNA. Translation: AAF86617.1.
RefSeqiNP_077322.1. NM_024346.1.
UniGeneiRn.14961.

3D structure databases

ProteinModelPortaliQ9JHU6.
SMRiQ9JHU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247922. 2 interactors.

PTM databases

iPTMnetiQ9JHU6.
PhosphoSitePlusiQ9JHU6.

Proteomic databases

PRIDEiQ9JHU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29246.
KEGGirno:29246.

Organism-specific databases

CTDi50861.
RGDi3628. Stmn3.

Phylogenomic databases

HOGENOMiHOG000013197.
HOVERGENiHBG054037.
InParanoidiQ9JHU6.

Miscellaneous databases

PROiQ9JHU6.

Family and domain databases

InterProiIPR028835. Stathmin-3.
IPR030514. Stathmin_CS.
IPR000956. Stathmin_fam.
[Graphical view]
PANTHERiPTHR10104. PTHR10104. 1 hit.
PTHR10104:SF17. PTHR10104:SF17. 1 hit.
PfamiPF00836. Stathmin. 1 hit.
[Graphical view]
PIRSFiPIRSF002285. Stathmin. 1 hit.
PRINTSiPR00345. STATHMIN.
SUPFAMiSSF101494. SSF101494. 1 hit.
PROSITEiPS00563. STATHMIN_1. 1 hit.
PS01041. STATHMIN_2. 1 hit.
PS51663. STATHMIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN3_RAT
AccessioniPrimary (citable) accession number: Q9JHU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.