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Reviewed, UniProtKB/Swiss-Prot Q9JHU3 (CDK20_MOUSE)

Last modified February 9, 2010. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division protein kinase 20
    EC=2.7.11.22
Alternative name(s):
    Cell cycle-related kinase
    Cyclin-kinase-activating kinase p42
    CDK-activating kinase p42
      Short name=CAK-kinase p42
    CDK-related protein kinase PNQLARE
    Cyclin-dependent protein kinase H
Gene names
Name: Cdk20
Synonyms: Ccrk, Cdch
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
Gene Ontology (GO)
   Biological processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

protein amino acid phosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JHU3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JHU3-2)

Also known as: Cardiac CCRK;

The sequence of this isoform differs from the canonical sequence as follows:
     168-243: WYRAPELLYG...LPDYNKISFK → SSLSCRTTTR...IHLSCRFLSV
     244-346: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Cell division protein kinase 20
PRO_0000085703

Regions

Domain4 – 288285Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Natural variations

Alternative sequence168 – 24376WYRAP…KISFK → SSLSCRTTTRSPLRSRCPCP WRRCCLTSLPRHWICWVNSF STLLTSASQLPRLSSISTSS QLPCLPIHLSCRFLSV in isoform 2.
VSP_016753
Alternative sequence244 – 346103Missing in isoform 2.
VSP_016754

Experimental info

Sequence conflict441I → F in AAW82351. Ref.2
Sequence conflict581I → M in AAW82351. Ref.2
Sequence conflict611S → N in AAW82351. Ref.2
Sequence conflict751A → G in AAW82351. Ref.2
Sequence conflict1011P → Q in AAW82351. Ref.2
Sequence conflict1571G → S in AAW82351. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: ACCACE0C3FC4B833

FASTA34638,379
        10         20         30         40         50         60 
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 

        70         80         90        100        110        120 
SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 

       130        140        150        160        170        180 
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 

       190        200        210        220        230        240 
YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 

       250        260        270        280        290        300 
SFKEQAPVPL EEVLPDASPQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 

       310        320        330        340 
PIPQRPGGPA PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 

« Hide

Isoform 2 (Cardiac CCRK).

Checksum: B9EFCE73BAC18AC0
Show »

FASTA24326,974

References

« Hide 'large scale' references
[1]"PNQALRE a novel member of the CDK family."
Liao J.C., Fisher R.P.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: 129/SvJ.
[2]"Mouse p42(CCRK), cardiac variant."
Qiu H., Depre C.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY005133 mRNA. Translation: AAF89089.1.
AY904369 mRNA. Translation: AAW82351.1.
BC031907 mRNA. Translation: AAH31907.1.
IPIIPI00119872.
IPI00553299.
RefSeqNP_444410.1.
UniGeneMm.74982

3D structure databases

SMRQ9JHU3. Positions 6-303.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9JHU3.

PTM databases

PhosphoSiteQ9JHU3.

Proteomic databases

PRIDEQ9JHU3.

Genome annotation databases

EnsemblENSMUST00000021939; ENSMUSP00000021939; ENSMUSG00000021483; Mus musculus. [Genome view]
GeneID105278.
KEGGmmu:105278.
UCSCuc007qyx.1. mouse.

Organism-specific databases

CTD105278.
MGIMGI:2145349. Cdk20.

Phylogenomic databases

eggNOGroNOG11932.
HOGENOMHBG755340.
HOVERGENQ9JHU3.
InParanoidQ9JHU3.
OMAQRIAASK.
PhylomeDBQ9JHU3.

Enzyme and pathway databases

BRENDA2.7.11.22. 244.

Gene expression databases

ArrayExpressQ9JHU3.
BgeeQ9JHU3.
CleanExMM_CCRK.
GenevestigatorQ9JHU3.
GermOnlineENSMUSG00000021483. Mus musculus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio357580.
SOURCESearch...

Entry information

Entry nameCDK20_MOUSE
AccessionPrimary (citable) accession number: Q9JHU3
Secondary accession number(s): Q5EDC2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: February 9, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents