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Protein

Dihydropyrimidinase-related protein 5

Gene

Dpysl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a function in neuronal differentiation and/or axon growth.

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: InterPro
  • neuron differentiation Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-399956. CRMPs in Sema3A signaling.

Protein family/group databases

MEROPSiM38.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 5
Short name:
DRP-5
Alternative name(s):
UNC33-like phosphoprotein 6
Short name:
ULIP-6
Gene namesi
Name:Dpysl5
Synonyms:Ulip6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620467. Dpysl5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659261 – 564Dihydropyrimidinase-related protein 5Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei509PhosphothreonineBy similarity1
Modified residuei514PhosphothreonineBy similarity1
Modified residuei532PhosphoserineBy similarity1
Modified residuei538PhosphoserineBy similarity1
Modified residuei559Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JHU0.
PRIDEiQ9JHU0.

2D gel databases

World-2DPAGE0004:Q9JHU0.

PTM databases

iPTMnetiQ9JHU0.
PhosphoSitePlusiQ9JHU0.

Expressioni

Tissue specificityi

Highly expressed in embryonic and early postnatal brain and spinal cord.

Gene expression databases

BgeeiENSRNOG00000008996.
GenevisibleiQ9JHU0. RN.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249320. 1 interactor.
STRINGi10116.ENSRNOP00000012274.

Structurei

3D structure databases

ProteinModelPortaliQ9JHU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ9JHU0.
KOiK07529.
OMAiCRGLADP.
OrthoDBiEOG091G05F3.
PhylomeDBiQ9JHU0.
TreeFamiTF314706.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030626. DRP5.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF58. PTHR11647:SF58. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV
60 70 80 90 100
IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH
110 120 130 140 150
VLPDKETSLV EAYEKCRALA DPKVCCDYAL HVGITWWAPK VKAEMETLVR
160 170 180 190 200
EKGVNSFQMF MTYKDLYMLR DSELYQVFHA CRDFGAIPRV HAENGELVAE
210 220 230 240 250
GAKEALDLGI TGPEGIEISH PEELEAEATH RVITIANRTH CPIYLVNVSS
260 270 280 290 300
ISAGDVIAAA KMQGKVVLAE TTNAHATLTG LHYYHQDWSH AAAYVTVPPL
310 320 330 340 350
RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG
360 370 380 390 400
VQDRMSVVWE RGVVGGKMDE NRFVAVTSSN AAKILNLYPR KGRIIPGADA
410 420 430 440 450
DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG
460 470 480 490 500
VFMCAEGTGK FCPLRSFPDI VYKKLVQREK TLKVRGVDRT PYLGDVAVVV
510 520 530 540 550
NPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA
560
RILAPPGGRS SGIW
Length:564
Mass (Da):61,540
Last modified:October 1, 2000 - v1
Checksum:iE078B9002F54975E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131436 mRNA. Translation: CAB95193.1.
RefSeqiNP_075412.1. NM_023023.1.
XP_017449839.1. XM_017594350.1.
UniGeneiRn.44871.

Genome annotation databases

EnsembliENSRNOT00000012273; ENSRNOP00000012274; ENSRNOG00000008996.
GeneIDi65208.
KEGGirno:65208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131436 mRNA. Translation: CAB95193.1.
RefSeqiNP_075412.1. NM_023023.1.
XP_017449839.1. XM_017594350.1.
UniGeneiRn.44871.

3D structure databases

ProteinModelPortaliQ9JHU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249320. 1 interactor.
STRINGi10116.ENSRNOP00000012274.

Protein family/group databases

MEROPSiM38.978.

PTM databases

iPTMnetiQ9JHU0.
PhosphoSitePlusiQ9JHU0.

2D gel databases

World-2DPAGE0004:Q9JHU0.

Proteomic databases

PaxDbiQ9JHU0.
PRIDEiQ9JHU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012273; ENSRNOP00000012274; ENSRNOG00000008996.
GeneIDi65208.
KEGGirno:65208.

Organism-specific databases

CTDi56896.
RGDi620467. Dpysl5.

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ9JHU0.
KOiK07529.
OMAiCRGLADP.
OrthoDBiEOG091G05F3.
PhylomeDBiQ9JHU0.
TreeFamiTF314706.

Enzyme and pathway databases

ReactomeiR-RNO-399956. CRMPs in Sema3A signaling.

Miscellaneous databases

PROiQ9JHU0.

Gene expression databases

BgeeiENSRNOG00000008996.
GenevisibleiQ9JHU0. RN.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030626. DRP5.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF58. PTHR11647:SF58. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL5_RAT
AccessioniPrimary (citable) accession number: Q9JHU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.