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Protein

Dihydropyrimidinase-related protein 5

Gene

Dpysl5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a function in neuronal differentiation and/or axon growth.

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: InterPro
  • neuron differentiation Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-399956 CRMPs in Sema3A signaling

Protein family/group databases

MEROPSiM38.978

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 5
Short name:
DRP-5
Alternative name(s):
UNC33-like phosphoprotein 6
Short name:
ULIP-6
Gene namesi
Name:Dpysl5
Synonyms:Ulip6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620467 Dpysl5

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659261 – 564Dihydropyrimidinase-related protein 5Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei509PhosphothreonineBy similarity1
Modified residuei514PhosphothreonineBy similarity1
Modified residuei532PhosphoserineBy similarity1
Modified residuei538PhosphoserineBy similarity1
Modified residuei559Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JHU0
PRIDEiQ9JHU0

2D gel databases

World-2DPAGEi0004:Q9JHU0

PTM databases

iPTMnetiQ9JHU0
PhosphoSitePlusiQ9JHU0

Expressioni

Tissue specificityi

Highly expressed in embryonic and early postnatal brain and spinal cord.

Gene expression databases

BgeeiENSRNOG00000008996
GenevisibleiQ9JHU0 RN

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249320, 1 interactor
STRINGi10116.ENSRNOP00000012274

Structurei

3D structure databases

ProteinModelPortaliQ9JHU0
SMRiQ9JHU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ9JHU0
KOiK07529
OMAiLHACKDI
OrthoDBiEOG091G05F3
PhylomeDBiQ9JHU0
TreeFamiTF314706

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030626 DRP5
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF58 PTHR11647:SF58, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANSASVRI LIKGGKVVND DCTHEADVYI ENGIIQQVGR ELMIPGGAKV
60 70 80 90 100
IDATGKLVIP GGIDTSTHFH QTFMNATCVD DFYHGTKAAL VGGTTMIIGH
110 120 130 140 150
VLPDKETSLV EAYEKCRALA DPKVCCDYAL HVGITWWAPK VKAEMETLVR
160 170 180 190 200
EKGVNSFQMF MTYKDLYMLR DSELYQVFHA CRDFGAIPRV HAENGELVAE
210 220 230 240 250
GAKEALDLGI TGPEGIEISH PEELEAEATH RVITIANRTH CPIYLVNVSS
260 270 280 290 300
ISAGDVIAAA KMQGKVVLAE TTNAHATLTG LHYYHQDWSH AAAYVTVPPL
310 320 330 340 350
RLDTNTSTYL MSLLANDTLN IVASDHRPFT TKQKAMGKED FTKIPHGVSG
360 370 380 390 400
VQDRMSVVWE RGVVGGKMDE NRFVAVTSSN AAKILNLYPR KGRIIPGADA
410 420 430 440 450
DVVVWDPEAT KTISASTQVQ GGDFNLYENM RCHGVPLVTI SRGRVVYENG
460 470 480 490 500
VFMCAEGTGK FCPLRSFPDI VYKKLVQREK TLKVRGVDRT PYLGDVAVVV
510 520 530 540 550
NPGKKEMGTP LADTPTRPVT RHGGMRDLHE SSFSLSGSQI DDHVPKRASA
560
RILAPPGGRS SGIW
Length:564
Mass (Da):61,540
Last modified:October 1, 2000 - v1
Checksum:iE078B9002F54975E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131436 mRNA Translation: CAB95193.1
RefSeqiNP_075412.1, NM_023023.1
XP_017449839.1, XM_017594350.1
UniGeneiRn.44871

Genome annotation databases

EnsembliENSRNOT00000012273; ENSRNOP00000012274; ENSRNOG00000008996
GeneIDi65208
KEGGirno:65208

Similar proteinsi

Entry informationi

Entry nameiDPYL5_RAT
AccessioniPrimary (citable) accession number: Q9JHU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health