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Protein

Spliceosome-associated protein CWC15 homolog

Gene

Cwc15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC15 homolog
Alternative name(s):
Embryonic development factor 1
Short name:
mED1
Gene namesi
Name:Cwc15
Synonyms:Ed1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1913320 Cwc15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002915442 – 229Spliceosome-associated protein CWC15 homologAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei18N6-acetyllysineCombined sources1
Modified residuei47PhosphothreonineBy similarity1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei121PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JHS9
MaxQBiQ9JHS9
PaxDbiQ9JHS9
PeptideAtlasiQ9JHS9
PRIDEiQ9JHS9

PTM databases

iPTMnetiQ9JHS9
PhosphoSitePlusiQ9JHS9

Expressioni

Gene expression databases

BgeeiENSMUSG00000004096
CleanExiMM_CWC15
ExpressionAtlasiQ9JHS9 baseline and differential
GenevisibleiQ9JHS9 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.By similarity

Protein-protein interaction databases

BioGridi211192, 1 interactor
IntActiQ9JHS9, 3 interactors
MINTiQ9JHS9
STRINGi10090.ENSMUSP00000004200

Structurei

3D structure databases

ProteinModelPortaliQ9JHS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili123 – 165Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the CWC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3228 Eukaryota
ENOG410Z258 LUCA
GeneTreeiENSGT00390000012084
HOGENOMiHOG000214250
HOVERGENiHBG107412
InParanoidiQ9JHS9
KOiK12863
OMAiFKNCARS
OrthoDBiEOG091G0TA6
PhylomeDBiQ9JHS9
TreeFamiTF321323

Family and domain databases

InterProiView protein in InterPro
IPR006973 Cwf_Cwc_15
PANTHERiPTHR12718 PTHR12718, 1 hit
PfamiView protein in Pfam
PF04889 Cwf_Cwc_15, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA
60 70 80 90 100
PEEVRNRDFR RELEERERAA ARDKNRDRPT REHTTSSSVS KKPRLDQIPA
110 120 130 140 150
ANLDADDPLT DEEDEDFEEE SDDDDTAALL AELEKIKKER AEEQARKEQE
160 170 180 190 200
QKAEEERIRM ENILSGNPLL NLTGPSQPQA NFKVKRRWDD DVVFKNCAKG
210 220
IDDQKKDKRF VNDTLRSEFH KKFMEKYIK
Length:229
Mass (Da):26,624
Last modified:October 1, 2000 - v1
Checksum:iA8AE6F44423EA7DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223F → L in BAE40300 (PubMed:16141072).Curated1
Sequence conflicti223F → L in BAE39808 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250394 mRNA Translation: CAB96547.1
AY842452 mRNA Translation: AAW32096.1
AK002864 mRNA Translation: BAB22414.1
AK003202 mRNA Translation: BAB22638.1
AK003591 mRNA Translation: BAB22880.1
AK003834 mRNA Translation: BAB23026.1
AK145249 mRNA Translation: BAE26327.1
AK167776 mRNA Translation: BAE39808.1
AK168365 mRNA Translation: BAE40300.1
BC004726 mRNA Translation: AAH04726.1
CCDSiCCDS22823.1
RefSeqiNP_075642.1, NM_023153.3
XP_006510600.1, XM_006510537.3
UniGeneiMm.245938

Genome annotation databases

EnsembliENSMUST00000004200; ENSMUSP00000004200; ENSMUSG00000004096
ENSMUST00000213913; ENSMUSP00000149476; ENSMUSG00000004096
GeneIDi66070
KEGGimmu:66070
UCSCiuc009oeo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCWC15_MOUSE
AccessioniPrimary (citable) accession number: Q9JHS9
Secondary accession number(s): Q3TH98, Q9CTH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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