Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JHQ5

- LZTL1_MOUSE

UniProt

Q9JHQ5 - LZTL1_MOUSE

Protein

Leucine zipper transcription factor-like protein 1

Gene

Lztfl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.2 Publications

    GO - Molecular functioni

    1. identical protein binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. establishment of protein localization to organelle Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine zipper transcription factor-like protein 1
    Gene namesi
    Name:Lztfl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1934860. Lztfl1.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. BBSome Source: UniProtKB
    2. cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Leucine zipper transcription factor-like protein 1PRO_0000318760Add
    BLAST

    Proteomic databases

    MaxQBiQ9JHQ5.
    PaxDbiQ9JHQ5.
    PRIDEiQ9JHQ5.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00458573.
    Q9JHQ5.

    PTM databases

    PhosphoSiteiQ9JHQ5.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Expressed in brain, cerebellum, eye, heart, kidney, liver, lung and trachea. In small intestine, graded expression along the crypt-villus axis with high levels in the villus apex and lower levels in the crypt stem cells (at protein level). Not expressed in skeletal muscle and white adipose tissue.4 Publications

    Inductioni

    In hippocampus, up-regulated by exercise training.1 Publication

    Gene expression databases

    BgeeiQ9JHQ5.
    CleanExiMM_LZTFL1.
    GenevestigatoriQ9JHQ5.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

    Protein-protein interaction databases

    IntActiQ9JHQ5. 2 interactions.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 299155Interaction with BSS9By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili96 – 299204Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LZTFL1 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG68368.
    GeneTreeiENSGT00390000016415.
    HOGENOMiHOG000067838.
    HOVERGENiHBG054284.
    InParanoidiQ9JHQ5.
    OMAiGFNEHHQ.
    PhylomeDBiQ9JHQ5.
    TreeFamiTF329023.

    Family and domain databases

    InterProiIPR026157. LZTFL1.
    [Graphical view]
    PANTHERiPTHR21635. PTHR21635. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JHQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK DSRLVEETFT    50
    IDEVSEVLNG LQAVVHSEVE SELINTAYTN VLLLRQLFSQ AEKWYLKLQT 100
    DISELENREL LEQVAEFEKA EFVSSSKKPI IDITKPKLVP INEGGTTELL 150
    NKEILRLQQE NEKLKSRLKT IEIQAVNALD EKSKLERVLQ DLQLDQENQQ 200
    DLLKAQDLDD LENTVATLRS EFQKTLNDKT ENQKSLEENL AAAKHDLLRV 250
    QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED 299
    Length:299
    Mass (Da):34,773
    Last modified:October 1, 2000 - v1
    Checksum:i49F19871A72D48E7
    GO

    Sequence cautioni

    The sequence BAC26556.1 differs from that shown. Reason: Frameshift at positions 268 and 270.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti280 – 2801K → E in BAC26556. (PubMed:16141072)Curated
    Sequence conflicti283 – 2831D → G in BAC30817. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297352 mRNA. Translation: CAB95845.1.
    AK029671 mRNA. Translation: BAC26556.1. Frameshift.
    AK041091 mRNA. Translation: BAC30817.1.
    AK046515 mRNA. Translation: BAC32764.1.
    AK054003 mRNA. Translation: BAC35616.1.
    AK145263 mRNA. Translation: BAE26331.1.
    AK157770 mRNA. Translation: BAE34189.1.
    BC026840 mRNA. Translation: AAH26840.1.
    BC098224 mRNA. Translation: AAH98224.1.
    CCDSiCCDS40818.1.
    RefSeqiNP_201579.1. NM_033322.2.
    UniGeneiMm.378263.
    Mm.475504.

    Genome annotation databases

    EnsembliENSMUST00000026274; ENSMUSP00000026274; ENSMUSG00000025245.
    GeneIDi93730.
    KEGGimmu:93730.
    UCSCiuc009sgm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ297352 mRNA. Translation: CAB95845.1 .
    AK029671 mRNA. Translation: BAC26556.1 . Frameshift.
    AK041091 mRNA. Translation: BAC30817.1 .
    AK046515 mRNA. Translation: BAC32764.1 .
    AK054003 mRNA. Translation: BAC35616.1 .
    AK145263 mRNA. Translation: BAE26331.1 .
    AK157770 mRNA. Translation: BAE34189.1 .
    BC026840 mRNA. Translation: AAH26840.1 .
    BC098224 mRNA. Translation: AAH98224.1 .
    CCDSi CCDS40818.1.
    RefSeqi NP_201579.1. NM_033322.2.
    UniGenei Mm.378263.
    Mm.475504.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JHQ5. 2 interactions.

    PTM databases

    PhosphoSitei Q9JHQ5.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00458573.
    Q9JHQ5.

    Proteomic databases

    MaxQBi Q9JHQ5.
    PaxDbi Q9JHQ5.
    PRIDEi Q9JHQ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026274 ; ENSMUSP00000026274 ; ENSMUSG00000025245 .
    GeneIDi 93730.
    KEGGi mmu:93730.
    UCSCi uc009sgm.1. mouse.

    Organism-specific databases

    CTDi 54585.
    MGIi MGI:1934860. Lztfl1.

    Phylogenomic databases

    eggNOGi NOG68368.
    GeneTreei ENSGT00390000016415.
    HOGENOMi HOG000067838.
    HOVERGENi HBG054284.
    InParanoidi Q9JHQ5.
    OMAi GFNEHHQ.
    PhylomeDBi Q9JHQ5.
    TreeFami TF329023.

    Miscellaneous databases

    NextBioi 351571.
    PROi Q9JHQ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JHQ5.
    CleanExi MM_LZTFL1.
    Genevestigatori Q9JHQ5.

    Family and domain databases

    InterProi IPR026157. LZTFL1.
    [Graphical view ]
    PANTHERi PTHR21635. PTHR21635. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3."
      Kiss H., Kedra D., Kiss C., Kost-Alimova M., Yang Y., Klein G., Imreh S., Dumanski J.P.
      Genomics 73:10-19(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adrenal gland, Aorta, Embryo, Mammary gland, Oviduct and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and FVB/N.
      Tissue: Salivary gland and Thymus.
    4. "Tumor-suppressive functions of leucine zipper transcription factor-like 1."
      Wei Q., Zhou W., Wang W., Gao B., Wang L., Cao J., Liu Z.P.
      Cancer Res. 70:2942-2950(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TUMOR SUPPRESSOR, TISSUE SPECIFICITY.
    5. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
      Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
      PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH THE BBSOME COMPLEX, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    6. "Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training."
      Sakurai T., Ogasawara J., Kizaki T., Ishibashi Y., Fujiwara T., Akagawa K., Izawa T., Oh-ishi S., Haga S., Ohno H.
      Biochem. Biophys. Res. Commun. 416:125-129(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN NEURITE OUTGROWTH, INDUCTION BY EXERCISE TRAINING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLZTL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHQ5
    Secondary accession number(s): Q8BRX8, Q8CDS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3