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Protein

Leucine zipper transcription factor-like protein 1

Gene

Lztfl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.2 Publications

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5620922 BBSome-mediated cargo-targeting to cilium

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper transcription factor-like protein 1
Gene namesi
Name:Lztfl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1934860 Lztfl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003187601 – 299Leucine zipper transcription factor-like protein 1Add BLAST299

Proteomic databases

EPDiQ9JHQ5
MaxQBiQ9JHQ5
PaxDbiQ9JHQ5
PRIDEiQ9JHQ5

2D gel databases

REPRODUCTION-2DPAGEiIPI00458573
Q9JHQ5

PTM databases

iPTMnetiQ9JHQ5
PhosphoSitePlusiQ9JHQ5

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed in brain, cerebellum, eye, heart, kidney, liver, lung and trachea. In small intestine, graded expression along the crypt-villus axis with high levels in the villus apex and lower levels in the crypt stem cells (at protein level). Not expressed in skeletal muscle and white adipose tissue.4 Publications

Inductioni

In hippocampus, up-regulated by exercise training.1 Publication

Gene expression databases

BgeeiENSMUSG00000025245
CleanExiMM_LZTFL1
ExpressionAtlasiQ9JHQ5 baseline and differential
GenevisibleiQ9JHQ5 MM

Interactioni

Subunit structurei

Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352222EBI-6142879,EBI-491549From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JHQ5, 3 interactors
STRINGi10090.ENSMUSP00000026274

Structurei

3D structure databases

SMRiQ9JHQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 299Interaction with BSS9By similarityAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili96 – 299Sequence analysisAdd BLAST204

Sequence similaritiesi

Belongs to the LZTFL1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGWZ Eukaryota
ENOG410ZUNH LUCA
GeneTreeiENSGT00390000016415
HOGENOMiHOG000067838
HOVERGENiHBG054284
InParanoidiQ9JHQ5
KOiK19400
OMAiMQDAMND
OrthoDBiEOG091G0N7U
PhylomeDBiQ9JHQ5
TreeFamiTF329023

Family and domain databases

InterProiView protein in InterPro
IPR026157 LZTFL1
PANTHERiPTHR21635 PTHR21635, 1 hit
PfamiView protein in Pfam
PF15294 Leu_zip, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK DSRLVEETFT
60 70 80 90 100
IDEVSEVLNG LQAVVHSEVE SELINTAYTN VLLLRQLFSQ AEKWYLKLQT
110 120 130 140 150
DISELENREL LEQVAEFEKA EFVSSSKKPI IDITKPKLVP INEGGTTELL
160 170 180 190 200
NKEILRLQQE NEKLKSRLKT IEIQAVNALD EKSKLERVLQ DLQLDQENQQ
210 220 230 240 250
DLLKAQDLDD LENTVATLRS EFQKTLNDKT ENQKSLEENL AAAKHDLLRV
260 270 280 290
QEQLSMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAKYESED
Length:299
Mass (Da):34,773
Last modified:October 1, 2000 - v1
Checksum:i49F19871A72D48E7
GO

Sequence cautioni

The sequence BAC26556 differs from that shown. Reason: Frameshift at positions 268 and 270.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280K → E in BAC26556 (PubMed:16141072).Curated1
Sequence conflicti283D → G in BAC30817 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297352 mRNA Translation: CAB95845.1
AK029671 mRNA Translation: BAC26556.1 Frameshift.
AK041091 mRNA Translation: BAC30817.1
AK046515 mRNA Translation: BAC32764.1
AK054003 mRNA Translation: BAC35616.1
AK145263 mRNA Translation: BAE26331.1
AK157770 mRNA Translation: BAE34189.1
BC026840 mRNA Translation: AAH26840.1
BC098224 mRNA Translation: AAH98224.1
CCDSiCCDS40818.1
RefSeqiNP_201579.1, NM_033322.2
UniGeneiMm.378263
Mm.475504

Genome annotation databases

EnsembliENSMUST00000026274; ENSMUSP00000026274; ENSMUSG00000025245
GeneIDi93730
KEGGimmu:93730
UCSCiuc009sgm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLZTL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHQ5
Secondary accession number(s): Q8BRX8, Q8CDS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health