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Q9JHP7

- KDEL1_MOUSE

UniProt

Q9JHP7 - KDEL1_MOUSE

Protein

KDEL motif-containing protein 1

Gene

Kdelc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    CAZyiGT90. Glycosyltransferase Family 90.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL motif-containing protein 1
    Alternative name(s):
    Endoplasmic reticulum resident protein 58
    Short name:
    ER protein 58
    Short name:
    ERp58
    Gene namesi
    Name:Kdelc1
    Synonyms:Ep58
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1919300. Kdelc1.

    Subcellular locationi

    Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 502483KDEL motif-containing protein 1PRO_0000247164Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JHP7.
    PaxDbiQ9JHP7.
    PRIDEiQ9JHP7.

    PTM databases

    PhosphoSiteiQ9JHP7.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Expressed in various fetal tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9JHP7.
    BgeeiQ9JHP7.
    GenevestigatoriQ9JHP7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000064500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHP7.
    SMRiQ9JHP7. Positions 25-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati24 – 130107FilaminAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi499 – 5024Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the KDELC family.Curated
    Contains 1 filamin repeat.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248922.
    GeneTreeiENSGT00530000063132.
    HOGENOMiHOG000286007.
    HOVERGENiHBG081852.
    InParanoidiQ9JHP7.
    OMAiLLLYCFF.
    PhylomeDBiQ9JHP7.
    TreeFamiTF323280.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view]
    PfamiPF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view]
    SMARTiSM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view]
    SUPFAMiSSF81296. SSF81296. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JHP7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSISLLSCL FLGTVPALAQ TGGERRLSPE KSEIWGPGLK AHVVLPARYF    50
    YIRAVDTSGE QFTSSPGEKV FQVKISAPDE QFTRVGVQVL DRKDGSFIVR 100
    YRMYASYRNL KIEVKHHGQH VAESPYVLRG PVYHENCDCP LEDSAAWLRE 150
    MNCSETISQI QKDLAHFPTV DPEKIAAEIP KRFGQRQSLC HYTLKDNKVY 200
    IKTHGEHVGF RIFMDAILLS LTRKVRMPDV EFFVNLGDWP LEKKKSNSNI 250
    QPIFSWCGST ESRDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES 300
    KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDESLYGPI 350
    VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN 400
    ELQPWKHYIP VKSNLSDLLE KLKWAKEHDA EAKKIAKAGQ EFARNNLMGD 450
    DIFCYYFKLF QGYANLQVSE PQIREGMKRV EPQSEDDLFP CTCHRRKAKD 500
    EL 502
    Length:502
    Mass (Da):57,985
    Last modified:October 1, 2000 - v1
    Checksum:iFFE80DF36765DB7E
    GO
    Isoform 2 (identifier: Q9JHP7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         362-431: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:432
    Mass (Da):49,668
    Checksum:i129D7176C148CF6C
    GO
    Isoform 3 (identifier: Q9JHP7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         283-502: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:282
    Mass (Da):32,136
    Checksum:i9E9AD362226CAAC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471A → V in BAB25294. (PubMed:16141072)Curated
    Sequence conflicti174 – 1741K → E in BAC35341. (PubMed:16141072)Curated
    Sequence conflicti313 – 3131R → H in BAC37727. (PubMed:16141072)Curated
    Sequence conflicti436 – 4361A → T in BAC37727. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei283 – 502220Missing in isoform 3. 1 PublicationVSP_019935Add
    BLAST
    Alternative sequencei362 – 43170Missing in isoform 2. 1 PublicationVSP_019936Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ404004 mRNA. Translation: CAC00650.1.
    AK007835 mRNA. Translation: BAB25294.1.
    AK035899 mRNA. Translation: BAC29235.1.
    AK053315 mRNA. Translation: BAC35341.1.
    AK079701 mRNA. Translation: BAC37727.1.
    AK170300 mRNA. Translation: BAE41698.1.
    BC023141 mRNA. Translation: AAH23141.1.
    CCDSiCCDS14929.1. [Q9JHP7-1]
    RefSeqiNP_076134.1. NM_023645.3. [Q9JHP7-1]
    XP_006496352.1. XM_006496289.1. [Q9JHP7-3]
    UniGeneiMm.281714.

    Genome annotation databases

    EnsembliENSMUST00000027213; ENSMUSP00000027213; ENSMUSG00000026047. [Q9JHP7-2]
    ENSMUST00000065767; ENSMUSP00000064500; ENSMUSG00000026047. [Q9JHP7-1]
    GeneIDi72050.
    KEGGimmu:72050.
    UCSCiuc007awb.1. mouse. [Q9JHP7-1]
    uc011wkc.1. mouse. [Q9JHP7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ404004 mRNA. Translation: CAC00650.1 .
    AK007835 mRNA. Translation: BAB25294.1 .
    AK035899 mRNA. Translation: BAC29235.1 .
    AK053315 mRNA. Translation: BAC35341.1 .
    AK079701 mRNA. Translation: BAC37727.1 .
    AK170300 mRNA. Translation: BAE41698.1 .
    BC023141 mRNA. Translation: AAH23141.1 .
    CCDSi CCDS14929.1. [Q9JHP7-1 ]
    RefSeqi NP_076134.1. NM_023645.3. [Q9JHP7-1 ]
    XP_006496352.1. XM_006496289.1. [Q9JHP7-3 ]
    UniGenei Mm.281714.

    3D structure databases

    ProteinModelPortali Q9JHP7.
    SMRi Q9JHP7. Positions 25-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000064500.

    Protein family/group databases

    CAZyi GT90. Glycosyltransferase Family 90.

    PTM databases

    PhosphoSitei Q9JHP7.

    Proteomic databases

    MaxQBi Q9JHP7.
    PaxDbi Q9JHP7.
    PRIDEi Q9JHP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027213 ; ENSMUSP00000027213 ; ENSMUSG00000026047 . [Q9JHP7-2 ]
    ENSMUST00000065767 ; ENSMUSP00000064500 ; ENSMUSG00000026047 . [Q9JHP7-1 ]
    GeneIDi 72050.
    KEGGi mmu:72050.
    UCSCi uc007awb.1. mouse. [Q9JHP7-1 ]
    uc011wkc.1. mouse. [Q9JHP7-2 ]

    Organism-specific databases

    CTDi 79070.
    MGIi MGI:1919300. Kdelc1.

    Phylogenomic databases

    eggNOGi NOG248922.
    GeneTreei ENSGT00530000063132.
    HOGENOMi HOG000286007.
    HOVERGENi HBG081852.
    InParanoidi Q9JHP7.
    OMAi LLLYCFF.
    PhylomeDBi Q9JHP7.
    TreeFami TF323280.

    Miscellaneous databases

    NextBioi 335316.
    PROi Q9JHP7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHP7.
    Bgeei Q9JHP7.
    Genevestigatori Q9JHP7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR017868. Filamin/ABP280_repeat-like.
    IPR001298. Filamin/ABP280_rpt.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR006598. LipoPS_modifying.
    [Graphical view ]
    Pfami PF00630. Filamin. 1 hit.
    PF05686. Glyco_transf_90. 1 hit.
    [Graphical view ]
    SMARTi SM00672. CAP10. 1 hit.
    SM00557. IG_FLMN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81296. SSF81296. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50194. FILAMIN_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search."
      Kimata Y., Ooboki K., Nomura-Furuwatari C., Hosoda A., Tsuru A., Kohno K.
      Gene 261:321-327(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Embryonic carcinoma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J and NOD.
      Tissue: Cerebellum, Dendritic cell, Eye, Pancreas and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiKDEL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHP7
    Secondary accession number(s): Q8BPU6
    , Q8C528, Q8R591, Q9D8P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3