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Q9JHP7 (KDEL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name=ER protein 58
Short name=ERp58
Gene names
Name:Kdelc1
Synonyms:Ep58
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Ref.1.

Tissue specificity

Widely expressed. Ref.1

Developmental stage

Expressed in various fetal tissues. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Sequence similarities

Belongs to the KDELC family.

Contains 1 filamin repeat.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   Coding sequence diversityAlternative splicing
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JHP7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JHP7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     362-431: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9JHP7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     283-502: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 502483KDEL motif-containing protein 1
PRO_0000247164

Regions

Repeat24 – 130107Filamin
Motif499 – 5024Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence283 – 502220Missing in isoform 3.
VSP_019935
Alternative sequence362 – 43170Missing in isoform 2.
VSP_019936

Experimental info

Sequence conflict471A → V in BAB25294. Ref.2
Sequence conflict1741K → E in BAC35341. Ref.2
Sequence conflict3131R → H in BAC37727. Ref.2
Sequence conflict4361A → T in BAC37727. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FFE80DF36765DB7E

FASTA50257,985
        10         20         30         40         50         60 
MFSISLLSCL FLGTVPALAQ TGGERRLSPE KSEIWGPGLK AHVVLPARYF YIRAVDTSGE 

        70         80         90        100        110        120 
QFTSSPGEKV FQVKISAPDE QFTRVGVQVL DRKDGSFIVR YRMYASYRNL KIEVKHHGQH 

       130        140        150        160        170        180 
VAESPYVLRG PVYHENCDCP LEDSAAWLRE MNCSETISQI QKDLAHFPTV DPEKIAAEIP 

       190        200        210        220        230        240 
KRFGQRQSLC HYTLKDNKVY IKTHGEHVGF RIFMDAILLS LTRKVRMPDV EFFVNLGDWP 

       250        260        270        280        290        300 
LEKKKSNSNI QPIFSWCGST ESRDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES 

       310        320        330        340        350        360 
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDESLYGPI VKHISFFDFF 

       370        380        390        400        410        420 
KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN ELQPWKHYIP VKSNLSDLLE 

       430        440        450        460        470        480 
KLKWAKEHDA EAKKIAKAGQ EFARNNLMGD DIFCYYFKLF QGYANLQVSE PQIREGMKRV 

       490        500 
EPQSEDDLFP CTCHRRKAKD EL 

« Hide

Isoform 2 [UniParc].

Checksum: 129D7176C148CF6C
Show »

FASTA43249,668
Isoform 3 [UniParc].

Checksum: 9E9AD362226CAAC0
Show »

FASTA28232,136

References

« Hide 'large scale' references
[1]"Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search."
Kimata Y., Ooboki K., Nomura-Furuwatari C., Hosoda A., Tsuru A., Kohno K.
Gene 261:321-327(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Embryonic carcinoma.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J and NOD.
Tissue: Cerebellum, Dendritic cell, Eye, Pancreas and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ404004 mRNA. Translation: CAC00650.1.
AK007835 mRNA. Translation: BAB25294.1.
AK035899 mRNA. Translation: BAC29235.1.
AK053315 mRNA. Translation: BAC35341.1.
AK079701 mRNA. Translation: BAC37727.1.
AK170300 mRNA. Translation: BAE41698.1.
BC023141 mRNA. Translation: AAH23141.1.
CCDSCCDS14929.1. [Q9JHP7-1]
RefSeqNP_076134.1. NM_023645.3. [Q9JHP7-1]
XP_006496352.1. XM_006496289.1. [Q9JHP7-3]
UniGeneMm.281714.

3D structure databases

ProteinModelPortalQ9JHP7.
SMRQ9JHP7. Positions 25-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000064500.

Protein family/group databases

CAZyGT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSiteQ9JHP7.

Proteomic databases

MaxQBQ9JHP7.
PaxDbQ9JHP7.
PRIDEQ9JHP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027213; ENSMUSP00000027213; ENSMUSG00000026047. [Q9JHP7-2]
ENSMUST00000065767; ENSMUSP00000064500; ENSMUSG00000026047. [Q9JHP7-1]
GeneID72050.
KEGGmmu:72050.
UCSCuc007awb.1. mouse. [Q9JHP7-1]
uc011wkc.1. mouse. [Q9JHP7-2]

Organism-specific databases

CTD79070.
MGIMGI:1919300. Kdelc1.

Phylogenomic databases

eggNOGNOG248922.
GeneTreeENSGT00530000063132.
HOGENOMHOG000286007.
HOVERGENHBG081852.
InParanoidQ9JHP7.
OMALLLYCFF.
PhylomeDBQ9JHP7.
TreeFamTF323280.

Gene expression databases

ArrayExpressQ9JHP7.
BgeeQ9JHP7.
GenevestigatorQ9JHP7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMSSF81296. SSF81296. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335316.
PROQ9JHP7.
SOURCESearch...

Entry information

Entry nameKDEL1_MOUSE
AccessionPrimary (citable) accession number: Q9JHP7
Secondary accession number(s): Q8BPU6 expand/collapse secondary AC list , Q8C528, Q8R591, Q9D8P1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot