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Q9JHP7

- KDEL1_MOUSE

UniProt

Q9JHP7 - KDEL1_MOUSE

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Protein

KDEL motif-containing protein 1

Gene

Kdelc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name:
ER protein 58
Short name:
ERp58
Gene namesi
Name:Kdelc1
Synonyms:Ep58
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1919300. Kdelc1.

Subcellular locationi

Endoplasmic reticulum lumen 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 502483KDEL motif-containing protein 1PRO_0000247164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JHP7.
PaxDbiQ9JHP7.
PRIDEiQ9JHP7.

PTM databases

PhosphoSiteiQ9JHP7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed in various fetal tissues.1 Publication

Gene expression databases

BgeeiQ9JHP7.
ExpressionAtlasiQ9JHP7. baseline.
GenevestigatoriQ9JHP7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064500.

Structurei

3D structure databases

ProteinModelPortaliQ9JHP7.
SMRiQ9JHP7. Positions 25-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 130107FilaminAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi499 – 5024Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248922.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ9JHP7.
OMAiLLLYCFF.
PhylomeDBiQ9JHP7.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JHP7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSISLLSCL FLGTVPALAQ TGGERRLSPE KSEIWGPGLK AHVVLPARYF
60 70 80 90 100
YIRAVDTSGE QFTSSPGEKV FQVKISAPDE QFTRVGVQVL DRKDGSFIVR
110 120 130 140 150
YRMYASYRNL KIEVKHHGQH VAESPYVLRG PVYHENCDCP LEDSAAWLRE
160 170 180 190 200
MNCSETISQI QKDLAHFPTV DPEKIAAEIP KRFGQRQSLC HYTLKDNKVY
210 220 230 240 250
IKTHGEHVGF RIFMDAILLS LTRKVRMPDV EFFVNLGDWP LEKKKSNSNI
260 270 280 290 300
QPIFSWCGST ESRDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
310 320 330 340 350
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDESLYGPI
360 370 380 390 400
VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN
410 420 430 440 450
ELQPWKHYIP VKSNLSDLLE KLKWAKEHDA EAKKIAKAGQ EFARNNLMGD
460 470 480 490 500
DIFCYYFKLF QGYANLQVSE PQIREGMKRV EPQSEDDLFP CTCHRRKAKD

EL
Length:502
Mass (Da):57,985
Last modified:October 1, 2000 - v1
Checksum:iFFE80DF36765DB7E
GO
Isoform 2 (identifier: Q9JHP7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-431: Missing.

Note: No experimental confirmation available.

Show »
Length:432
Mass (Da):49,668
Checksum:i129D7176C148CF6C
GO
Isoform 3 (identifier: Q9JHP7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-502: Missing.

Note: No experimental confirmation available.

Show »
Length:282
Mass (Da):32,136
Checksum:i9E9AD362226CAAC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471A → V in BAB25294. (PubMed:16141072)Curated
Sequence conflicti174 – 1741K → E in BAC35341. (PubMed:16141072)Curated
Sequence conflicti313 – 3131R → H in BAC37727. (PubMed:16141072)Curated
Sequence conflicti436 – 4361A → T in BAC37727. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 502220Missing in isoform 3. 1 PublicationVSP_019935Add
BLAST
Alternative sequencei362 – 43170Missing in isoform 2. 1 PublicationVSP_019936Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404004 mRNA. Translation: CAC00650.1.
AK007835 mRNA. Translation: BAB25294.1.
AK035899 mRNA. Translation: BAC29235.1.
AK053315 mRNA. Translation: BAC35341.1.
AK079701 mRNA. Translation: BAC37727.1.
AK170300 mRNA. Translation: BAE41698.1.
BC023141 mRNA. Translation: AAH23141.1.
CCDSiCCDS14929.1. [Q9JHP7-1]
RefSeqiNP_076134.1. NM_023645.3. [Q9JHP7-1]
XP_006496352.1. XM_006496289.1. [Q9JHP7-3]
UniGeneiMm.281714.

Genome annotation databases

EnsembliENSMUST00000027213; ENSMUSP00000027213; ENSMUSG00000026047. [Q9JHP7-2]
ENSMUST00000065767; ENSMUSP00000064500; ENSMUSG00000026047. [Q9JHP7-1]
GeneIDi72050.
KEGGimmu:72050.
UCSCiuc007awb.1. mouse. [Q9JHP7-1]
uc011wkc.1. mouse. [Q9JHP7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404004 mRNA. Translation: CAC00650.1 .
AK007835 mRNA. Translation: BAB25294.1 .
AK035899 mRNA. Translation: BAC29235.1 .
AK053315 mRNA. Translation: BAC35341.1 .
AK079701 mRNA. Translation: BAC37727.1 .
AK170300 mRNA. Translation: BAE41698.1 .
BC023141 mRNA. Translation: AAH23141.1 .
CCDSi CCDS14929.1. [Q9JHP7-1 ]
RefSeqi NP_076134.1. NM_023645.3. [Q9JHP7-1 ]
XP_006496352.1. XM_006496289.1. [Q9JHP7-3 ]
UniGenei Mm.281714.

3D structure databases

ProteinModelPortali Q9JHP7.
SMRi Q9JHP7. Positions 25-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000064500.

Protein family/group databases

CAZyi GT90. Glycosyltransferase Family 90.

PTM databases

PhosphoSitei Q9JHP7.

Proteomic databases

MaxQBi Q9JHP7.
PaxDbi Q9JHP7.
PRIDEi Q9JHP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027213 ; ENSMUSP00000027213 ; ENSMUSG00000026047 . [Q9JHP7-2 ]
ENSMUST00000065767 ; ENSMUSP00000064500 ; ENSMUSG00000026047 . [Q9JHP7-1 ]
GeneIDi 72050.
KEGGi mmu:72050.
UCSCi uc007awb.1. mouse. [Q9JHP7-1 ]
uc011wkc.1. mouse. [Q9JHP7-2 ]

Organism-specific databases

CTDi 79070.
MGIi MGI:1919300. Kdelc1.

Phylogenomic databases

eggNOGi NOG248922.
GeneTreei ENSGT00530000063132.
HOGENOMi HOG000286007.
HOVERGENi HBG081852.
InParanoidi Q9JHP7.
OMAi LLLYCFF.
PhylomeDBi Q9JHP7.
TreeFami TF323280.

Miscellaneous databases

NextBioi 335316.
PROi Q9JHP7.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHP7.
ExpressionAtlasi Q9JHP7. baseline.
Genevestigatori Q9JHP7.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view ]
Pfami PF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view ]
SMARTi SM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search."
    Kimata Y., Ooboki K., Nomura-Furuwatari C., Hosoda A., Tsuru A., Kohno K.
    Gene 261:321-327(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic carcinoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Dendritic cell, Eye, Pancreas and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiKDEL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHP7
Secondary accession number(s): Q8BPU6
, Q8C528, Q8R591, Q9D8P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3