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Protein

KDEL motif-containing protein 1

Gene

Kdelc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name:
ER protein 58
Short name:
ERp58
Gene namesi
Name:Kdelc1
Synonyms:Ep58
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919300. Kdelc1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024716420 – 502KDEL motif-containing protein 1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JHP7.
PeptideAtlasiQ9JHP7.
PRIDEiQ9JHP7.

PTM databases

iPTMnetiQ9JHP7.
PhosphoSitePlusiQ9JHP7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed in various fetal tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026047.
ExpressionAtlasiQ9JHP7. baseline and differential.
GenevisibleiQ9JHP7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064500.

Structurei

3D structure databases

ProteinModelPortaliQ9JHP7.
SMRiQ9JHP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 130FilaminAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi499 – 502Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the KDELC family.Curated
Contains 1 filamin repeat.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ9JHP7.
OMAiCPLQDSA.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ9JHP7.
TreeFamiTF323280.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JHP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSISLLSCL FLGTVPALAQ TGGERRLSPE KSEIWGPGLK AHVVLPARYF
60 70 80 90 100
YIRAVDTSGE QFTSSPGEKV FQVKISAPDE QFTRVGVQVL DRKDGSFIVR
110 120 130 140 150
YRMYASYRNL KIEVKHHGQH VAESPYVLRG PVYHENCDCP LEDSAAWLRE
160 170 180 190 200
MNCSETISQI QKDLAHFPTV DPEKIAAEIP KRFGQRQSLC HYTLKDNKVY
210 220 230 240 250
IKTHGEHVGF RIFMDAILLS LTRKVRMPDV EFFVNLGDWP LEKKKSNSNI
260 270 280 290 300
QPIFSWCGST ESRDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
310 320 330 340 350
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDESLYGPI
360 370 380 390 400
VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN
410 420 430 440 450
ELQPWKHYIP VKSNLSDLLE KLKWAKEHDA EAKKIAKAGQ EFARNNLMGD
460 470 480 490 500
DIFCYYFKLF QGYANLQVSE PQIREGMKRV EPQSEDDLFP CTCHRRKAKD

EL
Length:502
Mass (Da):57,985
Last modified:October 1, 2000 - v1
Checksum:iFFE80DF36765DB7E
GO
Isoform 2 (identifier: Q9JHP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     362-431: Missing.

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):49,668
Checksum:i129D7176C148CF6C
GO
Isoform 3 (identifier: Q9JHP7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-502: Missing.

Note: No experimental confirmation available.
Show »
Length:282
Mass (Da):32,136
Checksum:i9E9AD362226CAAC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47A → V in BAB25294 (PubMed:16141072).Curated1
Sequence conflicti174K → E in BAC35341 (PubMed:16141072).Curated1
Sequence conflicti313R → H in BAC37727 (PubMed:16141072).Curated1
Sequence conflicti436A → T in BAC37727 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019935283 – 502Missing in isoform 3. 1 PublicationAdd BLAST220
Alternative sequenceiVSP_019936362 – 431Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404004 mRNA. Translation: CAC00650.1.
AK007835 mRNA. Translation: BAB25294.1.
AK035899 mRNA. Translation: BAC29235.1.
AK053315 mRNA. Translation: BAC35341.1.
AK079701 mRNA. Translation: BAC37727.1.
AK170300 mRNA. Translation: BAE41698.1.
BC023141 mRNA. Translation: AAH23141.1.
CCDSiCCDS14929.1. [Q9JHP7-1]
RefSeqiNP_076134.1. NM_023645.3. [Q9JHP7-1]
XP_006496352.1. XM_006496289.3. [Q9JHP7-3]
UniGeneiMm.281714.

Genome annotation databases

EnsembliENSMUST00000027213; ENSMUSP00000027213; ENSMUSG00000026047. [Q9JHP7-2]
ENSMUST00000065767; ENSMUSP00000064500; ENSMUSG00000026047. [Q9JHP7-1]
GeneIDi72050.
KEGGimmu:72050.
UCSCiuc007awb.1. mouse. [Q9JHP7-1]
uc011wkc.1. mouse. [Q9JHP7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ404004 mRNA. Translation: CAC00650.1.
AK007835 mRNA. Translation: BAB25294.1.
AK035899 mRNA. Translation: BAC29235.1.
AK053315 mRNA. Translation: BAC35341.1.
AK079701 mRNA. Translation: BAC37727.1.
AK170300 mRNA. Translation: BAE41698.1.
BC023141 mRNA. Translation: AAH23141.1.
CCDSiCCDS14929.1. [Q9JHP7-1]
RefSeqiNP_076134.1. NM_023645.3. [Q9JHP7-1]
XP_006496352.1. XM_006496289.3. [Q9JHP7-3]
UniGeneiMm.281714.

3D structure databases

ProteinModelPortaliQ9JHP7.
SMRiQ9JHP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064500.

Protein family/group databases

CAZyiGT90. Glycosyltransferase Family 90.

PTM databases

iPTMnetiQ9JHP7.
PhosphoSitePlusiQ9JHP7.

Proteomic databases

PaxDbiQ9JHP7.
PeptideAtlasiQ9JHP7.
PRIDEiQ9JHP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027213; ENSMUSP00000027213; ENSMUSG00000026047. [Q9JHP7-2]
ENSMUST00000065767; ENSMUSP00000064500; ENSMUSG00000026047. [Q9JHP7-1]
GeneIDi72050.
KEGGimmu:72050.
UCSCiuc007awb.1. mouse. [Q9JHP7-1]
uc011wkc.1. mouse. [Q9JHP7-2]

Organism-specific databases

CTDi79070.
MGIiMGI:1919300. Kdelc1.

Phylogenomic databases

eggNOGiKOG2458. Eukaryota.
ENOG410XT5U. LUCA.
GeneTreeiENSGT00530000063132.
HOGENOMiHOG000286007.
HOVERGENiHBG081852.
InParanoidiQ9JHP7.
OMAiCPLQDSA.
OrthoDBiEOG091G04SJ.
PhylomeDBiQ9JHP7.
TreeFamiTF323280.

Miscellaneous databases

PROiQ9JHP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026047.
ExpressionAtlasiQ9JHP7. baseline and differential.
GenevisibleiQ9JHP7. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR006598. LipoPS_modifying.
[Graphical view]
PfamiPF00630. Filamin. 1 hit.
PF05686. Glyco_transf_90. 1 hit.
[Graphical view]
SMARTiSM00672. CAP10. 1 hit.
SM00557. IG_FLMN. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50194. FILAMIN_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKDEL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHP7
Secondary accession number(s): Q8BPU6
, Q8C528, Q8R591, Q9D8P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.