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Protein

Serine/threonine-protein kinase 19

Gene

Stk19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be a protein kinase.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarityNote: Divalent metal cations. Has a preference for Mn2+.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 19 (EC:2.7.11.1)
Alternative name(s):
Protein RP1
Gene namesi
Name:Stk19
Synonyms:Rp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1860085. Stk19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Serine/threonine-protein kinase 19PRO_0000072276Add
BLAST

Proteomic databases

EPDiQ9JHN8.
MaxQBiQ9JHN8.
PaxDbiQ9JHN8.
PRIDEiQ9JHN8.

PTM databases

PhosphoSiteiQ9JHN8.

Expressioni

Gene expression databases

BgeeiQ9JHN8.
CleanExiMM_STK19.
ExpressionAtlasiQ9JHN8. baseline.
GenevisibleiQ9JHN8. MM.

Interactioni

Subunit structurei

The N-terminus interacts with BAG1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076686.

Structurei

3D structure databases

ProteinModelPortaliQ9JHN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STK19 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVV. Eukaryota.
ENOG410YGZ8. LUCA.
GeneTreeiENSGT00390000018295.
HOGENOMiHOG000272639.
HOVERGENiHBG056144.
InParanoidiQ9JHN8.
KOiK08880.
OMAiQEQMTQT.
OrthoDBiEOG7GQXVT.
PhylomeDBiQ9JHN8.
TreeFamiTF105332.

Family and domain databases

InterProiIPR018865. Ser/Thr_kinase_19.
[Graphical view]
PfamiPF10494. Stk19. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRKRRLLAS EAFGVKRRRA PGPVRADPLR TRAGSAREAI EELVKLFPRG
60 70 80 90 100
LFEDALPPIA LRSQVYSLVP DRTVADLQLK ELQELGEIRI IQLGFDLDAH
110 120 130 140 150
GIVFTEDYRT RVLKACDGRP CAGAVQKFLA SVLPACGDLS FQQDQMTQTY
160 170 180 190 200
GFRDPEITQL VNAGVLTVRD AGSWWLAVPG AGRFIKCFVK GRQAVLSMVR
210 220 230 240 250
KAKYRELALS ELLGRRAPLA VRLGLAYHVH DLIGAQLVDC VPTTSGTLLR

LPDT
Length:254
Mass (Da):28,104
Last modified:October 18, 2001 - v2
Checksum:i9F7BEAEC06DCC9D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049850 Genomic DNA. Translation: AAC05280.1.
BC022681 mRNA. Translation: AAH22681.1.
AF099934 mRNA. Translation: AAF26174.1.
CCDSiCCDS28659.1.
RefSeqiNP_062315.1. NM_019442.3.
UniGeneiMm.440064.

Genome annotation databases

EnsembliENSMUST00000077477; ENSMUSP00000076686; ENSMUSG00000061207.
GeneIDi54402.
KEGGimmu:54402.
UCSCiuc008cdq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049850 Genomic DNA. Translation: AAC05280.1.
BC022681 mRNA. Translation: AAH22681.1.
AF099934 mRNA. Translation: AAF26174.1.
CCDSiCCDS28659.1.
RefSeqiNP_062315.1. NM_019442.3.
UniGeneiMm.440064.

3D structure databases

ProteinModelPortaliQ9JHN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076686.

PTM databases

PhosphoSiteiQ9JHN8.

Proteomic databases

EPDiQ9JHN8.
MaxQBiQ9JHN8.
PaxDbiQ9JHN8.
PRIDEiQ9JHN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077477; ENSMUSP00000076686; ENSMUSG00000061207.
GeneIDi54402.
KEGGimmu:54402.
UCSCiuc008cdq.1. mouse.

Organism-specific databases

CTDi8859.
MGIiMGI:1860085. Stk19.

Phylogenomic databases

eggNOGiENOG410IEVV. Eukaryota.
ENOG410YGZ8. LUCA.
GeneTreeiENSGT00390000018295.
HOGENOMiHOG000272639.
HOVERGENiHBG056144.
InParanoidiQ9JHN8.
KOiK08880.
OMAiQEQMTQT.
OrthoDBiEOG7GQXVT.
PhylomeDBiQ9JHN8.
TreeFamiTF105332.

Miscellaneous databases

NextBioi311264.
PROiQ9JHN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JHN8.
CleanExiMM_STK19.
ExpressionAtlasiQ9JHN8. baseline.
GenevisibleiQ9JHN8. MM.

Family and domain databases

InterProiIPR018865. Ser/Thr_kinase_19.
[Graphical view]
PfamiPF10494. Stk19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. "Conservation and polymorphism of the DOM3Z-RP1 gene pair located at the RD-SKI2W-DOM3Z-RP1 complex of the MHC complement gene cluster."
    Yang Z., Shen L., Yu C.Y.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 14-254.
    Strain: BALB/cJ.
    Tissue: Brain.

Entry informationi

Entry nameiSTK19_MOUSE
AccessioniPrimary (citable) accession number: Q9JHN8
Secondary accession number(s): O70347
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: March 16, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.