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Q9JHM2

- Q9JHM2_RAT

UniProt

Q9JHM2 - Q9JHM2_RAT

Protein
Submitted name:

MHC class I protein

Gene

RT1-A3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.SAAS annotation

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro
    2. protein binding Source: RGD

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class I proteinImported
    Submitted name:
    RT1 class I, A3Imported
    Gene namesi
    Name:RT1-A3Imported
    Synonyms:AA926063Imported, B3galt4Imported, Cdk2ap1-ps1Imported, Col11a2Imported, DaxxImported, Hsd17b8Imported, Kifc1Imported, LOC224733l-1Imported, LOC224733l-2Imported, Phf1Imported, Rps25-ps1Imported, RT1-A1Imported, RT1-A2Imported, RT1-DOaImported, RT1-HbImported, RT1-Ke4Imported, RxrbImported, Sacm2l-ps1Imported, Sacm2l-ps2Imported, Sec61-psImported, Syngap1Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi1359610. RT1-A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC ISAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121 PotentialImportedAdd
    BLAST
    Chaini22 – 369348MHC class I proteinImportedPRO_5000066050Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JHM2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000544.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    eggNOGiNOG42056.
    HOGENOMiHOG000296917.
    HOVERGENiHBG016709.
    KOiK06751.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JHM2-1 [UniParc]FASTAAdd to Basket

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    MAPRTLLLLL AAALAPTQTQ AGSHSLRYFD IAVSRPGLGE PRFIIVGYVD    50
    DREVMRFDSD AENPRMKPRA RWMEREGPEY WERQTRKVKE KEQIFRDNLR 100
    TLLRYYNQSE GGSHTVQRLS GCDVGSDGSL LRGYNQHAYD GRDYIALNED 150
    LKTWTAADTA AQITKNKWER DGEAERRRAY LEGECVEWLR SYLAPRKETL 200
    LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME 250
    FVETRPAGDG TFQKWASVVV PSGEEQNYTC LVEHEGLPKP LTQRWEPSPS 300
    TNTNMGIDVT SVVLGAVAVF VVLAIIGAVV CVVRRRRRRR NTGGKGDYTP 350
    ARGRDSSQSS DVSLPDCKA 369
    Length:369
    Mass (Da):41,717
    Last modified:October 1, 2000 - v1
    Checksum:i86FE99B5BAEAF90A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277139 Genomic DNA. Translation: CAB86389.1.
    BX883042 Genomic DNA. Translation: CAE83929.1.
    RefSeqiNP_001008830.1. NM_001008830.1.
    UniGeneiRn.116787.
    Rn.217243.
    Rn.234338.

    Genome annotation databases

    GeneIDi309627.
    KEGGirno:309627.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277139 Genomic DNA. Translation: CAB86389.1 .
    BX883042 Genomic DNA. Translation: CAE83929.1 .
    RefSeqi NP_001008830.1. NM_001008830.1.
    UniGenei Rn.116787.
    Rn.217243.
    Rn.234338.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 309627.
    KEGGi rno:309627.

    Organism-specific databases

    CTDi 309627.
    RGDi 1359610. RT1-A3.

    Phylogenomic databases

    eggNOGi NOG42056.
    HOGENOMi HOG000296917.
    HOVERGENi HBG016709.
    KOi K06751.

    Miscellaneous databases

    NextBioi 661080.

    Gene expression databases

    Genevestigatori Q9JHM2.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC."
      Walter L., Gunther E.
      Immunogenetics 51:829-837(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.
    3. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
      Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
      Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9JHM2_RAT
    AccessioniPrimary (citable) accession number: Q9JHM2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)