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Protein
Submitted name:

MHC class I protein

Gene

RT1-A3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I proteinImported
Submitted name:
RT1 class I, A3Imported
Gene namesi
Name:RT1-A3Imported
Synonyms:AA926063Imported, B3galt4Imported, Cdk2ap1-ps1Imported, Col11a2Imported, DaxxImported, Hsd17b8Imported, Kifc1Imported, LOC224733l-1Imported, LOC224733l-2Imported, Phf1Imported, Rps25-ps1Imported, RT1-A1Imported, RT1-A2Imported, RT1-DOaImported, RT1-HbImported, RT1-Ke4Imported, RxrbImported, Sacm2l-ps1Imported, Sacm2l-ps2Imported, Sec61-psImported, Syngap1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1359610. RT1-A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei312 – 333HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501014822322 – 369Sequence analysisAdd BLAST348

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 292Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRTLLLLL AAALAPTQTQ AGSHSLRYFD IAVSRPGLGE PRFIIVGYVD
60 70 80 90 100
DREVMRFDSD AENPRMKPRA RWMEREGPEY WERQTRKVKE KEQIFRDNLR
110 120 130 140 150
TLLRYYNQSE GGSHTVQRLS GCDVGSDGSL LRGYNQHAYD GRDYIALNED
160 170 180 190 200
LKTWTAADTA AQITKNKWER DGEAERRRAY LEGECVEWLR SYLAPRKETL
210 220 230 240 250
LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME
260 270 280 290 300
FVETRPAGDG TFQKWASVVV PSGEEQNYTC LVEHEGLPKP LTQRWEPSPS
310 320 330 340 350
TNTNMGIDVT SVVLGAVAVF VVLAIIGAVV CVVRRRRRRR NTGGKGDYTP
360
ARGRDSSQSS DVSLPDCKA
Length:369
Mass (Da):41,717
Last modified:October 1, 2000 - v1
Checksum:i86FE99B5BAEAF90A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277139 Genomic DNA. Translation: CAB86389.1.
BX883042 Genomic DNA. Translation: CAE83929.1.
RefSeqiNP_001008830.1. NM_001008830.1.
UniGeneiRn.116787.
Rn.217243.
Rn.234338.

Genome annotation databases

GeneIDi309627.
KEGGirno:309627.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ9JHM2_RAT
AccessioniPrimary (citable) accession number: Q9JHM2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)