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Protein
Submitted name:

MHC class I protein

Gene

RT1-A3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I proteinImported
Submitted name:
RT1 class I, A3Imported
Gene namesi
Name:RT1-A3Imported
Synonyms:AA926063Imported, B3galt4Imported, Cdk2ap1-ps1Imported, Col11a2Imported, DaxxImported, Hsd17b8Imported, Kifc1Imported, LOC224733l-1Imported, LOC224733l-2Imported, Phf1Imported, Rps25-ps1Imported, RT1-A1Imported, RT1-A2Imported, RT1-DOaImported, RT1-HbImported, RT1-Ke4Imported, RxrbImported, Sacm2l-ps1Imported, Sacm2l-ps2Imported, Sec61-psImported, Syngap1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1359610. RT1-A3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class I protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 PotentialImportedAdd
BLAST
Chaini22 – 369348MHC class I proteinImportedPRO_5000066050Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ9JHM2.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000544.

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiNOG42056.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRTLLLLL AAALAPTQTQ AGSHSLRYFD IAVSRPGLGE PRFIIVGYVD
60 70 80 90 100
DREVMRFDSD AENPRMKPRA RWMEREGPEY WERQTRKVKE KEQIFRDNLR
110 120 130 140 150
TLLRYYNQSE GGSHTVQRLS GCDVGSDGSL LRGYNQHAYD GRDYIALNED
160 170 180 190 200
LKTWTAADTA AQITKNKWER DGEAERRRAY LEGECVEWLR SYLAPRKETL
210 220 230 240 250
LRSDPPKAHV TLHPRPEGDV TLRCWALGFY PADITLTWQL NGEDLTQDME
260 270 280 290 300
FVETRPAGDG TFQKWASVVV PSGEEQNYTC LVEHEGLPKP LTQRWEPSPS
310 320 330 340 350
TNTNMGIDVT SVVLGAVAVF VVLAIIGAVV CVVRRRRRRR NTGGKGDYTP
360
ARGRDSSQSS DVSLPDCKA
Length:369
Mass (Da):41,717
Last modified:October 1, 2000 - v1
Checksum:i86FE99B5BAEAF90A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277139 Genomic DNA. Translation: CAB86389.1.
BX883042 Genomic DNA. Translation: CAE83929.1.
RefSeqiNP_001008830.1. NM_001008830.1.
UniGeneiRn.116787.
Rn.217243.
Rn.234338.

Genome annotation databases

GeneIDi309627.
KEGGirno:309627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277139 Genomic DNA. Translation: CAB86389.1.
BX883042 Genomic DNA. Translation: CAE83929.1.
RefSeqiNP_001008830.1. NM_001008830.1.
UniGeneiRn.116787.
Rn.217243.
Rn.234338.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi309627.
KEGGirno:309627.

Organism-specific databases

CTDi309627.
RGDi1359610. RT1-A3.

Phylogenomic databases

eggNOGiNOG42056.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
KOiK06751.

Miscellaneous databases

NextBioi661080.

Gene expression databases

GenevestigatoriQ9JHM2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC."
    Walter L., Gunther E.
    Immunogenetics 51:829-837(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.
  3. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JHM2_RAT
AccessioniPrimary (citable) accession number: Q9JHM2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.