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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

Rabggta

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Enzyme regulationi

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.By similarity

GO - Molecular functioni

  • Rab geranylgeranyltransferase activity Source: MGI
  • Rab GTPase binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • protein geranylgeranylation Source: MGI

Keywordsi

Molecular functionPrenyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Short name:
Rab GG transferase alpha
Short name:
Rab GGTase alpha
Rab geranylgeranyltransferase subunit alpha
Gene namesi
Name:Rabggta
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1860443 Rabggta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197581 – 567Geranylgeranyl transferase type-2 subunit alphaAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JHK4
PaxDbiQ9JHK4
PeptideAtlasiQ9JHK4
PRIDEiQ9JHK4

PTM databases

iPTMnetiQ9JHK4
PhosphoSitePlusiQ9JHK4
SwissPalmiQ9JHK4

Expressioni

Gene expression databases

BgeeiENSMUSG00000040472
CleanExiMM_RABGGTA
GenevisibleiQ9JHK4 MM

Interactioni

Subunit structurei

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207827, 1 interactor
IntActiQ9JHK4, 1 interactor
STRINGi10090.ENSMUSP00000061498

Structurei

3D structure databases

ProteinModelPortaliQ9JHK4
SMRiQ9JHK4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JHK4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 78PFTA 1Add BLAST35
Repeati88 – 122PFTA 2Add BLAST35
Repeati124 – 158PFTA 3Add BLAST35
Repeati159 – 193PFTA 4Add BLAST35
Repeati207 – 241PFTA 5Add BLAST35
Repeati363 – 397PFTA 6Add BLAST35
Repeati442 – 463LRR 1Add BLAST22
Repeati464 – 486LRR 2Add BLAST23
Repeati487 – 508LRR 3Add BLAST22
Repeati509 – 530LRR 4Add BLAST22
Repeati534 – 555LRR 5Add BLAST22

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0529 Eukaryota
COG5536 LUCA
GeneTreeiENSGT00550000075121
HOGENOMiHOG000007845
HOVERGENiHBG002171
InParanoidiQ9JHK4
KOiK14050
OMAiMRAAYLD
OrthoDBiEOG091G0L9H
PhylomeDBiQ9JHK4
TreeFamiTF315057

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
IPR002088 Prenyl_trans_a
IPR036254 RabGGT_asu_insert-dom_sf
IPR009087 RabGGT_asu_insert-domain
IPR032955 RabGGTase_alpha
PANTHERiPTHR11129:SF2 PTHR11129:SF2, 1 hit
PfamiView protein in Pfam
PF01239 PPTA, 4 hits
PF07711 RabGGT_insert, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331837 RabGG_trans_A, 1 hit
SUPFAMiSSF49594 SSF49594, 1 hit
PROSITEiView protein in PROSITE
PS51147 PFTA, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JHK4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRE AGELDESVLE
60 70 80 90 100
LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL
110 120 130 140 150
RVNPKSYGTW HHRCWLLSRL PEPNWARELE LCARFLEADE RNFHCWDYRR
160 170 180 190 200
FVAAQAAVAP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ
210 220 230 240 250
GRLPENVLLR ELELVQNAFF TDPNDQSAWF YHRWLLGRAE PHDVLCCLHV
260 270 280 290 300
SREEACLSVC FSRPLIVGSK MGTLLLTVDE APLSVEWRTP DGRNRPSHVW
310 320 330 340 350
LCDLPAASLN DHLPQHTFRV IWTGSDTQKE CVLLKGHQEC WCRDSATDEQ
360 370 380 390 400
LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY
410 420 430 440 450
EKETLEYFST LKAVDPMRAA YLDDLRSKFL VENSVLKMEY ADVRVLHLAH
460 470 480 490 500
KDLTVLCHLE QLLLVTHLDL SHNRLRALPP ALAALRCLEV LQASDNVLEN
510 520 530 540 550
LDGVANLPRL RELLLCNNRL QQSAALQTLA SCPRLVFLNL QGNSLCQEEG
560
IRERLAEMLP SVSSILT
Length:567
Mass (Da):64,989
Last modified:October 1, 2000 - v1
Checksum:i387DA2DAC12C4C0D
GO
Isoform 2 (identifier: Q9JHK4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-339: HQE → DAV
     340-567: Missing.

Show »
Length:339
Mass (Da):38,943
Checksum:iB68BCAADA15ED4D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009113337 – 339HQE → DAV in isoform 2. 1 Publication3
Alternative sequenceiVSP_009114340 – 567Missing in isoform 2. 1 PublicationAdd BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127654 Genomic DNA Translation: AAF65918.1
AF127655 Genomic DNA Translation: AAF65919.1
AF127656 mRNA Translation: AAF65920.1
AF127658 mRNA Translation: AAF65921.1
AF127659 mRNA Translation: AAF65922.1
AF127660 mRNA Translation: AAF65923.1
AF127662 mRNA Translation: AAF65924.1
AK002625 mRNA Translation: BAB22240.1
CCDSiCCDS36933.1 [Q9JHK4-1]
RefSeqiNP_062392.1, NM_019519.2 [Q9JHK4-1]
XP_006519357.1, XM_006519294.2 [Q9JHK4-1]
XP_006519358.1, XM_006519295.1 [Q9JHK4-1]
UniGeneiMm.87216

Genome annotation databases

EnsembliENSMUST00000163889; ENSMUSP00000128668; ENSMUSG00000040472 [Q9JHK4-1]
ENSMUST00000169237; ENSMUSP00000133032; ENSMUSG00000040472 [Q9JHK4-1]
ENSMUST00000227061; ENSMUSP00000154725; ENSMUSG00000040472 [Q9JHK4-1]
GeneIDi56187
KEGGimmu:56187
UCSCiuc007uai.1 mouse [Q9JHK4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPGTA_MOUSE
AccessioniPrimary (citable) accession number: Q9JHK4
Secondary accession number(s): Q9JLX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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