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Protein
Submitted name:

Caspase 9, isoform CRA_a

Gene

Casp9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • aging Source: RGD
  • apoptotic process Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to DNA damage stimulus Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to UV Source: RGD
  • execution phase of apoptosis Source: GO_Central
  • glial cell apoptotic process Source: RGD
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: RGD
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of neuron apoptotic process Source: RGD
  • proteolysis Source: RGD
  • regulation of response to DNA damage stimulus Source: RGD
  • response to antibiotic Source: RGD
  • response to cobalt ion Source: RGD
  • response to estradiol Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to UV Source: RGD
  • signal transduction in response to DNA damage Source: RGD

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-111458. Formation of apoptosome.
R-RNO-111459. Activation of caspases through apoptosome-mediated cleavage.
R-RNO-198323. AKT phosphorylates targets in the cytosol.
R-RNO-418889. Ligand-independent caspase activation via DCC.

Protein family/group databases

MEROPSiC14.010.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 9, isoform CRA_aImported
Submitted name:
Caspase-9Imported
Submitted name:
Caspase-9 long isoformImported
Gene namesi
Name:Casp9Imported
Synonyms:RNCASP9Imported
ORF Names:rCG_30964Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61867. Casp9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000012944.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-3369959.
STRINGi10116.ENSRNOP00000017972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDInterPro annotationAdd BLAST92
Domaini197 – 329CASPASE_P20InterPro annotationAdd BLAST133
Domaini369 – 453CASPASE_P10InterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000231878.
HOVERGENiHBG059022.
KOiK04399.
OMAiGSWYIET.
TreeFamiTF102023.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR033171. Caspase-9.
IPR029030. Caspase-like_dom_sf.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom_sf.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PANTHERiPTHR10454:SF157. PTHR10454:SF157. 1 hit.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEADRQLLR RCRVRLVREL QVAELWDALL SRELFTRDMI EDIQRAGSGS
60 70 80 90 100
RRDQARQLVI DLETRGRQAL PRFISCLEDT GQGSLASFLQ SSGQAAKQDP
110 120 130 140 150
EAVTPLDHLV PVVLGPMGLK SKEQKVVKLD PSQPALGNLT PVVLGPEELW
160 170 180 190 200
PTRLRPEVLT PETPRPVDIG SGRAHDVCTP GKIERHADMA YTLDSDPCGH
210 220 230 240 250
CLIINNVNFC PSSGLSTRIG SHVDCEKLQH RFCWLRFMVE VKNDLTAKKM
260 270 280 290 300
VTALMEMAHR DHRALDCFVV VILSHGCQAS HLQFPGAVYG TDGCSVSIER
310 320 330 340 350
IVNIFNGTGC PSLGGKPKLF FIQACGGEQK DHGFEVAFTS SQDKAFDSDS
360 370 380 390 400
EPDAVPYQEG PRTLDQLDAV SSLPTPSDIL VSYSTFPGFV SWRDKKSGSW
410 420 430 440 450
YIETLDGVLE QWARSEDLQS LLLRVANAVS EKGVYKQIPG CFNFLRKKLF

FKTS
Length:454
Mass (Da):50,400
Last modified:October 1, 2000 - v1
Checksum:i501623B29E6ED6FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07050305 Genomic DNA. No translation available.
AF271996 mRNA. Translation: AAF76217.1.
AF262319 mRNA. Translation: AAF85658.1.
AF286006 mRNA. Translation: AAF99705.1.
AY027667 mRNA. Translation: AAK26235.1.
AF308469 mRNA. Translation: AAK35159.1.
CH473968 Genomic DNA. Translation: EDL81013.1.
RefSeqiNP_113820.1. NM_031632.1.
UniGeneiRn.32199.

Genome annotation databases

EnsembliENSRNOT00000017972; ENSRNOP00000017972; ENSRNOG00000012944.
ENSRNOT00000085378; ENSRNOP00000072710; ENSRNOG00000012944.
GeneIDi58918.
KEGGirno:58918.
UCSCiRGD:61867. rat.

Similar proteinsi

Entry informationi

Entry nameiQ9JHK1_RAT
AccessioniPrimary (citable) accession number: Q9JHK1
Secondary accession number(s): F1M776
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported