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Protein

Receptor activity-modifying protein 2

Gene

Ramp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

  • amylin receptor activity Source: Ensembl
  • coreceptor activity Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 2
Gene namesi
Name:Ramp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61872. Ramp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 152ExtracellularSequence analysisAdd BLAST107
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Topological domaini174 – 182CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi52.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_000003017446 – 182Receptor activity-modifying protein 2Add BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi76 ↔ 106By similarity
Disulfide bondi91 ↔ 138By similarity
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JHJ1.
PRIDEiQ9JHJ1.

PTM databases

iPTMnetiQ9JHJ1.
PhosphoSitePlusiQ9JHJ1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020415.
ExpressionAtlasiQ9JHJ1. baseline and differential.
GenevisibleiQ9JHJ1. RN.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP2.By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043210.

Structurei

3D structure databases

ProteinModelPortaliQ9JHJ1.
SMRiQ9JHJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYPR. Eukaryota.
ENOG4112A9G. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000230963.
HOVERGENiHBG067366.
InParanoidiQ9JHJ1.
KOiK08448.
OMAiDLGFPNP.
OrthoDBiEOG091G0RMZ.
PhylomeDBiQ9JHJ1.

Family and domain databases

InterProiView protein in InterPro
IPR006985. RAMP.
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiView protein in Pfam
PF04901. RAMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRVERAP GGSQLAVTSA QRPAALRLPP LLLLLLLLLL GAVSTSPESL
60 70 80 90 100
NQSHPTEDSL LSKGKMEDYE TNVLPCWYYY KTSMDSVKDW CNWTLISRYY
110 120 130 140 150
SNLRYCLEYE ADKFGLGFPN PLAESIILEA HLIHFANCSL VQPTFSDPPE
160 170 180
DVLLAMIIAP ICLIPFLVTL VVWRSKDGDA QA
Length:182
Mass (Da):20,300
Last modified:October 1, 2000 - v1
Checksum:i6A506053D7EE0748
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042888 mRNA. Translation: BAB03505.1.
AB030943 mRNA. Translation: BAA94426.1.
AF181551 mRNA. Translation: AAG09435.1.
PIRiJC7236.
RefSeqiNP_113834.1. NM_031646.1.
UniGeneiRn.107168.

Genome annotation databases

EnsembliENSRNOT00000043953; ENSRNOP00000043210; ENSRNOG00000020415.
GeneIDi58966.
KEGGirno:58966.
UCSCiRGD:61872. rat.

Similar proteinsi

Entry informationi

Entry nameiRAMP2_RAT
AccessioniPrimary (citable) accession number: Q9JHJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families