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Protein

Receptor activity-modifying protein 2

Gene

Ramp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein transporter activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor activity-modifying protein 2
Gene namesi
Name:Ramp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi61872. Ramp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini46 – 152107ExtracellularSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 1829CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2103731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4545Sequence analysisAdd
BLAST
Chaini46 – 182137Receptor activity-modifying protein 2PRO_0000030174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi76 ↔ 106By similarity
Disulfide bondi91 ↔ 138By similarity
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JHJ1.
PRIDEiQ9JHJ1.

PTM databases

iPTMnetiQ9JHJ1.
PhosphoSiteiQ9JHJ1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020415.
ExpressionAtlasiQ9JHJ1. baseline.
GenevisibleiQ9JHJ1. RN.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP2.By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043210.

Structurei

3D structure databases

ProteinModelPortaliQ9JHJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYPR. Eukaryota.
ENOG4112A9G. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000230963.
HOVERGENiHBG067366.
InParanoidiQ9JHJ1.
KOiK08448.
OMAiDLGFPNP.
OrthoDBiEOG091G0RMZ.
PhylomeDBiQ9JHJ1.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRVERAP GGSQLAVTSA QRPAALRLPP LLLLLLLLLL GAVSTSPESL
60 70 80 90 100
NQSHPTEDSL LSKGKMEDYE TNVLPCWYYY KTSMDSVKDW CNWTLISRYY
110 120 130 140 150
SNLRYCLEYE ADKFGLGFPN PLAESIILEA HLIHFANCSL VQPTFSDPPE
160 170 180
DVLLAMIIAP ICLIPFLVTL VVWRSKDGDA QA
Length:182
Mass (Da):20,300
Last modified:October 1, 2000 - v1
Checksum:i6A506053D7EE0748
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042888 mRNA. Translation: BAB03505.1.
AB030943 mRNA. Translation: BAA94426.1.
AF181551 mRNA. Translation: AAG09435.1.
PIRiJC7236.
RefSeqiNP_113834.1. NM_031646.1.
UniGeneiRn.107168.

Genome annotation databases

EnsembliENSRNOT00000043953; ENSRNOP00000043210; ENSRNOG00000020415.
GeneIDi58966.
KEGGirno:58966.
UCSCiRGD:61872. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042888 mRNA. Translation: BAB03505.1.
AB030943 mRNA. Translation: BAA94426.1.
AF181551 mRNA. Translation: AAG09435.1.
PIRiJC7236.
RefSeqiNP_113834.1. NM_031646.1.
UniGeneiRn.107168.

3D structure databases

ProteinModelPortaliQ9JHJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043210.

Chemistry

ChEMBLiCHEMBL2103731.

PTM databases

iPTMnetiQ9JHJ1.
PhosphoSiteiQ9JHJ1.

Proteomic databases

PaxDbiQ9JHJ1.
PRIDEiQ9JHJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043953; ENSRNOP00000043210; ENSRNOG00000020415.
GeneIDi58966.
KEGGirno:58966.
UCSCiRGD:61872. rat.

Organism-specific databases

CTDi10266.
RGDi61872. Ramp2.

Phylogenomic databases

eggNOGiENOG410IYPR. Eukaryota.
ENOG4112A9G. LUCA.
GeneTreeiENSGT00390000016200.
HOGENOMiHOG000230963.
HOVERGENiHBG067366.
InParanoidiQ9JHJ1.
KOiK08448.
OMAiDLGFPNP.
OrthoDBiEOG091G0RMZ.
PhylomeDBiQ9JHJ1.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ9JHJ1.

Gene expression databases

BgeeiENSRNOG00000020415.
ExpressionAtlasiQ9JHJ1. baseline.
GenevisibleiQ9JHJ1. RN.

Family and domain databases

InterProiIPR006985. RAMP.
[Graphical view]
PANTHERiPTHR14076. PTHR14076. 1 hit.
PfamiPF04901. RAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAMP2_RAT
AccessioniPrimary (citable) accession number: Q9JHJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.