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Q9JHI9

- S40A1_MOUSE

UniProt

Q9JHI9 - S40A1_MOUSE

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Protein

Solute carrier family 40 member 1

Gene

Slc40a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

GO - Molecular functioni

  1. iron ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. endothelium development Source: MGI
  3. iron ion transmembrane transport Source: MGI
  4. iron ion transport Source: MGI
  5. lymphocyte homeostasis Source: MGI
  6. multicellular organismal iron ion homeostasis Source: MGI
  7. negative regulation of apoptotic process Source: MGI
  8. regulation of transcription from RNA polymerase II promoter in response to iron Source: MGI
  9. spleen development Source: MGI
  10. spleen trabecula formation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiREACT_205755. Iron uptake and transport.
REACT_251299. Metal ion SLC transporters.

Protein family/group databases

TCDBi2.A.100.1.1. the ferroportin (fpn) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 40 member 1
Alternative name(s):
Ferroportin-1
Iron-regulated transporter 1
Metal transporter protein 1
Short name:
MTP1
Gene namesi
Name:Slc40a1
Synonyms:Fpn1, Ireg1, Slc11a3, Slc39a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1315204. Slc40a1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Localized to the basolateral membrane of polarized epithelial cells.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 8023HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11523HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14723HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32423HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 36123HelicalSequence AnalysisAdd
BLAST
Transmembranei373 – 39523HelicalSequence AnalysisAdd
BLAST
Transmembranei449 – 47123HelicalSequence AnalysisAdd
BLAST
Transmembranei491 – 51323HelicalSequence AnalysisAdd
BLAST
Transmembranei518 – 54023HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. multivesicular body Source: MGI
  4. plasma membrane Source: MGI
  5. synaptic vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Solute carrier family 40 member 1PRO_0000191311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JHI9.
PaxDbiQ9JHI9.
PRIDEiQ9JHI9.

PTM databases

PhosphoSiteiQ9JHI9.

Expressioni

Tissue specificityi

High expression in spleen, liver, kidney, heart and duodenum.

Gene expression databases

BgeeiQ9JHI9.
ExpressionAtlasiQ9JHI9. baseline and differential.
GenevestigatoriQ9JHI9.

Interactioni

Subunit structurei

Identified in a complex with STOM.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AppP120232EBI-2931424,EBI-78814

Protein-protein interaction databases

DIPiDIP-58649N.
IntActiQ9JHI9. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9JHI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG273752.
GeneTreeiENSGT00390000015143.
HOGENOMiHOG000234273.
HOVERGENiHBG055582.
InParanoidiQ9JHI9.
KOiK14685.
OMAiLHKETEP.
OrthoDBiEOG72NRPT.
PhylomeDBiQ9JHI9.
TreeFamiTF313463.

Family and domain databases

InterProiIPR009716. Ferroportin-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9JHI9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL
60 70 80 90 100
VELYGNSLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN
110 120 130 140 150
VSVILCGIIL MMVFLHKNEL LTMYHGWVLT VCYILIITIA NIANLASTAT
160 170 180 190 200
AITIQRDWIV VVAGENRSRL ADMNATIRRI DQLTNILAPM AVGQIMTFGS
210 220 230 240 250
PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK VEESELKQLT
260 270 280 290 300
SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV
310 320 330 340 350
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA
360 370 380 390 400
ITGIMGTVAF TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL
410 420 430 440 450
SVSPFEDIRS RFVNVEPVSP TTKIPETVFT TEMHMSNMSN VHEMSTKPIP
460 470 480 490 500
IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ ENVIESERGI INGVQNSMNY
510 520 530 540 550
LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF AQKTLGNQIF
560 570
VCGPDEKEVT DENQPNTSVV
Length:570
Mass (Da):62,702
Last modified:October 1, 2000 - v1
Checksum:i7125CC6171394A0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215637 mRNA. Translation: AAF80987.1.
AF216834 Genomic DNA. Translation: AAF82036.1.
AF226613 mRNA. Translation: AAF36696.1.
AF231120 mRNA. Translation: AAF44329.1.
AK008700 mRNA. Translation: BAB25840.1.
AK032732 mRNA. Translation: BAC28001.1.
AK083288 mRNA. Translation: BAC38844.1.
AK144780 mRNA. Translation: BAE26063.1.
AK147137 mRNA. Translation: BAE27707.1.
AK159294 mRNA. Translation: BAE34969.1.
AK159855 mRNA. Translation: BAE35431.1.
BC003438 mRNA. Translation: AAH03438.1.
CCDSiCCDS14933.1.
RefSeqiNP_058613.2. NM_016917.2.
XP_006496200.1. XM_006496137.1.
UniGeneiMm.28756.

Genome annotation databases

EnsembliENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993.
GeneIDi53945.
KEGGimmu:53945.
UCSCiuc007awu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215637 mRNA. Translation: AAF80987.1 .
AF216834 Genomic DNA. Translation: AAF82036.1 .
AF226613 mRNA. Translation: AAF36696.1 .
AF231120 mRNA. Translation: AAF44329.1 .
AK008700 mRNA. Translation: BAB25840.1 .
AK032732 mRNA. Translation: BAC28001.1 .
AK083288 mRNA. Translation: BAC38844.1 .
AK144780 mRNA. Translation: BAE26063.1 .
AK147137 mRNA. Translation: BAE27707.1 .
AK159294 mRNA. Translation: BAE34969.1 .
AK159855 mRNA. Translation: BAE35431.1 .
BC003438 mRNA. Translation: AAH03438.1 .
CCDSi CCDS14933.1.
RefSeqi NP_058613.2. NM_016917.2.
XP_006496200.1. XM_006496137.1.
UniGenei Mm.28756.

3D structure databases

ProteinModelPortali Q9JHI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-58649N.
IntActi Q9JHI9. 2 interactions.

Protein family/group databases

TCDBi 2.A.100.1.1. the ferroportin (fpn) family.

PTM databases

PhosphoSitei Q9JHI9.

Proteomic databases

MaxQBi Q9JHI9.
PaxDbi Q9JHI9.
PRIDEi Q9JHI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027137 ; ENSMUSP00000027137 ; ENSMUSG00000025993 .
GeneIDi 53945.
KEGGi mmu:53945.
UCSCi uc007awu.1. mouse.

Organism-specific databases

CTDi 30061.
MGIi MGI:1315204. Slc40a1.

Phylogenomic databases

eggNOGi NOG273752.
GeneTreei ENSGT00390000015143.
HOGENOMi HOG000234273.
HOVERGENi HBG055582.
InParanoidi Q9JHI9.
KOi K14685.
OMAi LHKETEP.
OrthoDBi EOG72NRPT.
PhylomeDBi Q9JHI9.
TreeFami TF313463.

Enzyme and pathway databases

Reactomei REACT_205755. Iron uptake and transport.
REACT_251299. Metal ion SLC transporters.

Miscellaneous databases

NextBioi 310827.
PROi Q9JHI9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHI9.
ExpressionAtlasi Q9JHI9. baseline and differential.
Genevestigatori Q9JHI9.

Family and domain databases

InterProi IPR009716. Ferroportin-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF06963. FPN1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel mammalian iron-regulated protein involved in intracellular iron metabolism."
    Abboud S., Haile D.J.
    J. Biol. Chem. 275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Liver.
  3. "A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."
    McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., Simpson R.J.
    Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Liver, Lung and Stomach.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS40A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHI9
Secondary accession number(s): Q3UHZ9
, Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3