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Q9JHI9 (S40A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 40 member 1
Alternative name(s):
Ferroportin-1
Iron-regulated transporter 1
Metal transporter protein 1
Short name=MTP1
Gene names
Name:Slc40a1
Synonyms:Fpn1, Ireg1, Slc11a3, Slc39a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Localized to the basolateral membrane of polarized epithelial cells.

Tissue specificity

High expression in spleen, liver, kidney, heart and duodenum.

Sequence similarities

Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

AppP120232EBI-2931424,EBI-78814

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Solute carrier family 40 member 1
PRO_0000191311

Regions

Transmembrane12 – 3423Helical; Potential
Transmembrane58 – 8023Helical; Potential
Transmembrane93 – 11523Helical; Potential
Transmembrane125 – 14723Helical; Potential
Transmembrane302 – 32423Helical; Potential
Transmembrane339 – 36123Helical; Potential
Transmembrane373 – 39523Helical; Potential
Transmembrane449 – 47123Helical; Potential
Transmembrane491 – 51323Helical; Potential
Transmembrane518 – 54023Helical; Potential

Amino acid modifications

Glycosylation1661N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JHI9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7125CC6171394A0A

FASTA57062,702
        10         20         30         40         50         60 
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 

        70         80         90        100        110        120 
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 

       130        140        150        160        170        180 
LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 

       190        200        210        220        230        240 
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 

       250        260        270        280        290        300 
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 

       310        320        330        340        350        360 
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 

       370        380        390        400        410        420 
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP 

       430        440        450        460        470        480 
TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ 

       490        500        510        520        530        540 
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 

       550        560        570 
AQKTLGNQIF VCGPDEKEVT DENQPNTSVV 

« Hide

References

« Hide 'large scale' references
[1]"A novel mammalian iron-regulated protein involved in intracellular iron metabolism."
Abboud S., Haile D.J.
J. Biol. Chem. 275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter."
Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., Paw B.H., Drejer A., Barut B., Zapata A., Law T.C., Brugnara C., Lux S.E. IV, Pinkus G.S., Pinkus J.L., Kingsley P.D., Palis J., Fleming M.D., Andrews N.C., Zon L.I.
Nature 403:776-781(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[3]"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."
McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., Simpson R.J.
Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo, Liver, Lung and Stomach.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF215637 mRNA. Translation: AAF80987.1.
AF216834 Genomic DNA. Translation: AAF82036.1.
AF226613 mRNA. Translation: AAF36696.1.
AF231120 mRNA. Translation: AAF44329.1.
AK008700 mRNA. Translation: BAB25840.1.
AK032732 mRNA. Translation: BAC28001.1.
AK083288 mRNA. Translation: BAC38844.1.
AK144780 mRNA. Translation: BAE26063.1.
AK147137 mRNA. Translation: BAE27707.1.
AK159294 mRNA. Translation: BAE34969.1.
AK159855 mRNA. Translation: BAE35431.1.
BC003438 mRNA. Translation: AAH03438.1.
RefSeqNP_058613.2. NM_016917.2.
XP_006496200.1. XM_006496137.1.
UniGeneMm.28756.

3D structure databases

ProteinModelPortalQ9JHI9.
SMRQ9JHI9. Positions 341-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-58649N.
IntActQ9JHI9. 2 interactions.

Protein family/group databases

TCDB2.A.100.1.1. the ferroportin (fpn) family.

PTM databases

PhosphoSiteQ9JHI9.

Proteomic databases

PaxDbQ9JHI9.
PRIDEQ9JHI9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993.
GeneID53945.
KEGGmmu:53945.
UCSCuc007awu.1. mouse.

Organism-specific databases

CTD30061.
MGIMGI:1315204. Slc40a1.

Phylogenomic databases

eggNOGNOG273752.
GeneTreeENSGT00390000015143.
HOGENOMHOG000234273.
HOVERGENHBG055582.
InParanoidQ9JHI9.
KOK14685.
OMALHKETEP.
OrthoDBEOG72NRPT.
PhylomeDBQ9JHI9.
TreeFamTF313463.

Gene expression databases

ArrayExpressQ9JHI9.
BgeeQ9JHI9.
GenevestigatorQ9JHI9.

Family and domain databases

InterProIPR009716. Ferroportin-1.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF06963. FPN1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

NextBio310827.
PROQ9JHI9.
SOURCESearch...

Entry information

Entry nameS40A1_MOUSE
AccessionPrimary (citable) accession number: Q9JHI9
Secondary accession number(s): Q3UHZ9 expand/collapse secondary AC list , Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot