Solute carrier family 40 member 1 - Mus musculus (Mouse)

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Q9JHI9 (S40A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 40 member 1

Alternative name(s):
Ferroportin-1
Iron-regulated transporter 1
Metal transporter protein 1
Short name=MTP1

Gene names

Name:	Slc40a1
Synonyms:	Fpn1, Ireg1, Slc11a3, Slc39a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Localized to the basolateral membrane of polarized epithelial cells.
Tissue specificity	High expression in spleen, liver, kidney, heart and duodenum.
Sequence similarities	Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Iron
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from mutant phenotype PubMed 15342464. Source: MGI cellular iron ion homeostasis Inferred from electronic annotation. Source: Compara endothelium development Inferred from mutant phenotype PubMed 15342464. Source: MGI lymphocyte homeostasis Inferred from mutant phenotype PubMed 15888661. Source: MGI multicellular organismal iron ion homeostasis Inferred from mutant phenotype PubMed 15342464. Source: MGI spleen trabecula formation Inferred from mutant phenotype PubMed 15342464. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW multivesicular body Inferred from direct assay PubMed 22019085. Source: MGI plasma membrane Inferred from direct assay PubMed 22019085. Source: MGI synaptic vesicle Inferred from direct assay PubMed 14972659. Source: MGI
Molecular_function	iron ion transmembrane transporter activity Inferred from direct assay PubMed 10828623. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
App	P12023	2	EBI-2931424,EBI-78814

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 570

570

Solute carrier family 40 member 1

PRO_0000191311

Regions

Transmembrane

12 – 34

Helical; Potential

Transmembrane

58 – 80

Helical; Potential

Transmembrane

93 – 115

Helical; Potential

Transmembrane

125 – 147

Helical; Potential

Transmembrane

302 – 324

Helical; Potential

Transmembrane

339 – 361

Helical; Potential

Transmembrane

373 – 395

Helical; Potential

Transmembrane

449 – 471

Helical; Potential

Transmembrane

491 – 513

Helical; Potential

Transmembrane

518 – 540

Helical; Potential

Amino acid modifications

Glycosylation

166

N-linked (GlcNAc...) Potential

Glycosylation

174

N-linked (GlcNAc...) Potential

Glycosylation

437

N-linked (GlcNAc...) Potential

Glycosylation

566

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JHI9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7125CC6171394A0A
Show »

FASTA

570

62,702

        10         20         30         40         50         60 
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 

        70         80         90        100        110        120 
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 

       130        140        150        160        170        180 
LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 

       190        200        210        220        230        240 
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 

       250        260        270        280        290        300 
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 

       310        320        330        340        350        360 
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 

       370        380        390        400        410        420 
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP 

       430        440        450        460        470        480 
TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ 

       490        500        510        520        530        540 
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 

       550        560        570 
AQKTLGNQIF VCGPDEKEVT DENQPNTSVV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel mammalian iron-regulated protein involved in intracellular iron metabolism." Abboud S., Haile D.J. J. Biol. Chem. 275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter." Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., Paw B.H., Drejer A., Barut B., Zapata A., Law T.C., Brugnara C., Lux S.E. IV, Pinkus G.S., Pinkus J.L., Kingsley P.D., Palis J., Fleming M.D., Andrews N.C., Zon L.I. Nature 403:776-781(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver.
[3]	"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation." McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., Simpson R.J. Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo, Liver, Lung and Stomach.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF215637 mRNA. Translation: AAF80987.1. AF216834 Genomic DNA. Translation: AAF82036.1. AF226613 mRNA. Translation: AAF36696.1. AF231120 mRNA. Translation: AAF44329.1. AK008700 mRNA. Translation: BAB25840.1. AK032732 mRNA. Translation: BAC28001.1. AK083288 mRNA. Translation: BAC38844.1. AK144780 mRNA. Translation: BAE26063.1. AK147137 mRNA. Translation: BAE27707.1. AK159294 mRNA. Translation: BAE34969.1. AK159855 mRNA. Translation: BAE35431.1. BC003438 mRNA. Translation: AAH03438.1.
IPI	IPI00225883.
RefSeq	NP_058613.2. NM_016917.2.
UniGene	Mm.28756.
3D structure databases
ProteinModelPortal	Q9JHI9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-58649N.
IntAct	Q9JHI9. 2 interactions.
Protein family/group databases
TCDB	2.A.100.1.1. ferroportin (FP) family.
PTM databases
PhosphoSite	Q9JHI9.
Proteomic databases
PaxDb	Q9JHI9.
PRIDE	Q9JHI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993.
GeneID	53945.
KEGG	mmu:53945.
UCSC	uc007awu.1. mouse.
Organism-specific databases
CTD	30061.
MGI	MGI:1315204. Slc40a1.
Phylogenomic databases
eggNOG	NOG273752.
GeneTree	ENSGT00390000015143.
HOGENOM	HOG000234273.
HOVERGEN	HBG055582.
InParanoid	Q9JHI9.
KO	K14685.
OMA	FRFAQKT.
OrthoDB	EOG4PRSQJ.
Gene expression databases
ArrayExpress	Q9JHI9.
Bgee	Q9JHI9.
Genevestigator	Q9JHI9.
GermOnline	ENSMUSG00000025993. Mus musculus.
Family and domain databases
InterPro	IPR009716. Ferroportin-1. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF06963. FPN1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
ProtoNet	Search...
Other
NextBio	310827.
SOURCE	Search...

Entry information

Entry name

S40A1_MOUSE

Accession

Primary (citable) accession number: Q9JHI9
Secondary accession number(s): Q3UHZ9

Q9JKP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents