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Q9JHI9

- S40A1_MOUSE

UniProt

Q9JHI9 - S40A1_MOUSE

Protein

Solute carrier family 40 member 1

Gene

Slc40a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

    GO - Molecular functioni

    1. iron ion transmembrane transporter activity Source: MGI
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cellular iron ion homeostasis Source: Ensembl
    2. endothelium development Source: MGI
    3. iron ion transport Source: MGI
    4. lymphocyte homeostasis Source: MGI
    5. multicellular organismal iron ion homeostasis Source: MGI
    6. negative regulation of apoptotic process Source: MGI
    7. regulation of transcription from RNA polymerase II promoter in response to iron Source: MGI
    8. spleen development Source: MGI
    9. spleen trabecula formation Source: MGI

    Keywords - Biological processi

    Ion transport, Iron transport, Transport

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    ReactomeiREACT_205755. Iron uptake and transport.

    Protein family/group databases

    TCDBi2.A.100.1.1. the ferroportin (fpn) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 40 member 1
    Alternative name(s):
    Ferroportin-1
    Iron-regulated transporter 1
    Metal transporter protein 1
    Short name:
    MTP1
    Gene namesi
    Name:Slc40a1
    Synonyms:Fpn1, Ireg1, Slc11a3, Slc39a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1315204. Slc40a1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: Localized to the basolateral membrane of polarized epithelial cells.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. multivesicular body Source: MGI
    3. plasma membrane Source: MGI
    4. synaptic vesicle Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Solute carrier family 40 member 1PRO_0000191311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JHI9.
    PaxDbiQ9JHI9.
    PRIDEiQ9JHI9.

    PTM databases

    PhosphoSiteiQ9JHI9.

    Expressioni

    Tissue specificityi

    High expression in spleen, liver, kidney, heart and duodenum.

    Gene expression databases

    ArrayExpressiQ9JHI9.
    BgeeiQ9JHI9.
    GenevestigatoriQ9JHI9.

    Interactioni

    Subunit structurei

    Identified in a complex with STOM.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AppP120232EBI-2931424,EBI-78814

    Protein-protein interaction databases

    DIPiDIP-58649N.
    IntActiQ9JHI9. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHI9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 8023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei339 – 36123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39523HelicalSequence AnalysisAdd
    BLAST
    Transmembranei449 – 47123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei518 – 54023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG273752.
    GeneTreeiENSGT00390000015143.
    HOGENOMiHOG000234273.
    HOVERGENiHBG055582.
    InParanoidiQ9JHI9.
    KOiK14685.
    OMAiLHKETEP.
    OrthoDBiEOG72NRPT.
    PhylomeDBiQ9JHI9.
    TreeFamiTF313463.

    Family and domain databases

    InterProiIPR009716. Ferroportin-1.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF06963. FPN1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9JHI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL    50
    VELYGNSLLL TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN 100
    VSVILCGIIL MMVFLHKNEL LTMYHGWVLT VCYILIITIA NIANLASTAT 150
    AITIQRDWIV VVAGENRSRL ADMNATIRRI DQLTNILAPM AVGQIMTFGS 200
    PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK VEESELKQLT 250
    SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 300
    SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA 350
    ITGIMGTVAF TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL 400
    SVSPFEDIRS RFVNVEPVSP TTKIPETVFT TEMHMSNMSN VHEMSTKPIP 450
    IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ ENVIESERGI INGVQNSMNY 500
    LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF AQKTLGNQIF 550
    VCGPDEKEVT DENQPNTSVV 570
    Length:570
    Mass (Da):62,702
    Last modified:October 1, 2000 - v1
    Checksum:i7125CC6171394A0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215637 mRNA. Translation: AAF80987.1.
    AF216834 Genomic DNA. Translation: AAF82036.1.
    AF226613 mRNA. Translation: AAF36696.1.
    AF231120 mRNA. Translation: AAF44329.1.
    AK008700 mRNA. Translation: BAB25840.1.
    AK032732 mRNA. Translation: BAC28001.1.
    AK083288 mRNA. Translation: BAC38844.1.
    AK144780 mRNA. Translation: BAE26063.1.
    AK147137 mRNA. Translation: BAE27707.1.
    AK159294 mRNA. Translation: BAE34969.1.
    AK159855 mRNA. Translation: BAE35431.1.
    BC003438 mRNA. Translation: AAH03438.1.
    CCDSiCCDS14933.1.
    RefSeqiNP_058613.2. NM_016917.2.
    XP_006496200.1. XM_006496137.1.
    UniGeneiMm.28756.

    Genome annotation databases

    EnsembliENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993.
    GeneIDi53945.
    KEGGimmu:53945.
    UCSCiuc007awu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215637 mRNA. Translation: AAF80987.1 .
    AF216834 Genomic DNA. Translation: AAF82036.1 .
    AF226613 mRNA. Translation: AAF36696.1 .
    AF231120 mRNA. Translation: AAF44329.1 .
    AK008700 mRNA. Translation: BAB25840.1 .
    AK032732 mRNA. Translation: BAC28001.1 .
    AK083288 mRNA. Translation: BAC38844.1 .
    AK144780 mRNA. Translation: BAE26063.1 .
    AK147137 mRNA. Translation: BAE27707.1 .
    AK159294 mRNA. Translation: BAE34969.1 .
    AK159855 mRNA. Translation: BAE35431.1 .
    BC003438 mRNA. Translation: AAH03438.1 .
    CCDSi CCDS14933.1.
    RefSeqi NP_058613.2. NM_016917.2.
    XP_006496200.1. XM_006496137.1.
    UniGenei Mm.28756.

    3D structure databases

    ProteinModelPortali Q9JHI9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-58649N.
    IntActi Q9JHI9. 2 interactions.

    Protein family/group databases

    TCDBi 2.A.100.1.1. the ferroportin (fpn) family.

    PTM databases

    PhosphoSitei Q9JHI9.

    Proteomic databases

    MaxQBi Q9JHI9.
    PaxDbi Q9JHI9.
    PRIDEi Q9JHI9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027137 ; ENSMUSP00000027137 ; ENSMUSG00000025993 .
    GeneIDi 53945.
    KEGGi mmu:53945.
    UCSCi uc007awu.1. mouse.

    Organism-specific databases

    CTDi 30061.
    MGIi MGI:1315204. Slc40a1.

    Phylogenomic databases

    eggNOGi NOG273752.
    GeneTreei ENSGT00390000015143.
    HOGENOMi HOG000234273.
    HOVERGENi HBG055582.
    InParanoidi Q9JHI9.
    KOi K14685.
    OMAi LHKETEP.
    OrthoDBi EOG72NRPT.
    PhylomeDBi Q9JHI9.
    TreeFami TF313463.

    Enzyme and pathway databases

    Reactomei REACT_205755. Iron uptake and transport.

    Miscellaneous databases

    NextBioi 310827.
    PROi Q9JHI9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHI9.
    Bgeei Q9JHI9.
    Genevestigatori Q9JHI9.

    Family and domain databases

    InterProi IPR009716. Ferroportin-1.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF06963. FPN1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A novel mammalian iron-regulated protein involved in intracellular iron metabolism."
      Abboud S., Haile D.J.
      J. Biol. Chem. 275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Liver.
    3. "A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."
      McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., Simpson R.J.
      Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Liver, Lung and Stomach.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS40A1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHI9
    Secondary accession number(s): Q3UHZ9
    , Q8BME5, Q8BUM5, Q9JIM9, Q9JKP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3