Reviewed, UniProtKB/Swiss-Prot Q9JHI5 (IVD_MOUSE)

Names and origin

Protein names

Recommended name:
    Isovaleryl-CoA dehydrogenase, mitochondrial
      Short name=IVD
    EC=1.3.99.10

Gene names

Name:

Ivd

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor.
Cofactor	FAD.
Pathway	Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix.
Post-translational modification	Acetylation of Lys-76 is observed in liver mitochondria from fasted mice but not from fed mice.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Acetylation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro isovaleryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 30	30	Mitochondrion By similarity
	Chain	31 – 424	394	Isovaleryl-CoA dehydrogenase, mitochondrial		PRO_0000000532
Sites
	Active site	284	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	76	1	N6-acetyllysine Ref.5
Experimental info
	Sequence conflict	29	1	R → G in BAB23751. Ref.2
	Sequence conflict	41	1	N → K in BAB30859. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JHI5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 7B8A556A9E73B0B6	FASTA	424	46,325
	10 20 30 40 50 60 MATAIRLLGR RVSSWRLRPS PSPLAVPRRA HSILPVDDDI NGLNEEQKQL RHTISKFLQE 70 80 90 100 110 120 NLAPKAQEID QTNDFKNLRE FWKQLGSLGV LGITAPVQYG GSGLGYLEHV LVMEEISRAS 130 140 150 160 170 180 GAVGLSYGAH SNLCVNQIVR NGNEAQKEKY LPKLISGEFI GALAMSEPNA GSDVVSMKLK 190 200 210 220 230 240 AEKKGDHYVL NGNKFWITNG PDADILVVYA KTDLTAVPAS RGITAFIVEK GMPGFSTSKK 250 260 270 280 290 300 LDKLGMRGSN TCELVFEDCK VPAANVLSQE SKGVYVLMSG LDLERLVLAG GPLGIMQAVL 310 320 330 340 350 360 DHTIPYLHVR EAFGQKIGQF QLMQGKMADM YTRLMASRQY VYNVAKACDE GHIIPKDCAG 370 380 390 400 410 420 VILYAAECAT QVALDGIQCL GGNGYINDFP MGRFLRDAKL YEIGAGTSEV RRLVIGRAFN ADFR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of genomic and cDNA for mouse isovaleryl-CoA dehydrogenase (IVD) and evolutionary comparison to other known IVDs." Willard J.M., Reinard T., Mohsen A.W., Vockley J. Gene 270:253-257(2001) [PubMed: 11404023] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Ola.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney and Salivary gland.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 57-76; 154-178; 212-221; 231-239; 273-285; 339-346; 400-411 AND 418-424, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[5]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-76, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF225989 mRNA. Translation: AAF35888.1. AF226043 , AF226039, AF226041, AF226040, AF226042 Genomic DNA. Translation: AAF67667.1. AK005024 mRNA. Translation: BAB23751.1. AK017660 mRNA. Translation: BAB30859.1. BC018325 mRNA. Translation: AAH18325.1. BC027198 mRNA. Translation: AAH27198.1.
IPI	IPI00471246.
RefSeq	NP_062800.1.
UniGene	Mm.6635
3D structure databases
HSSP	HSSP built from PDB template 1IVH based on UniProtKB P26440.
SMR	Q9JHI5. Positions 36-422.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9JHI5.
PTM databases
PhosphoSite	Q9JHI5.
2-D gel databases
REPRODUCTION-2DPAGE	Q9JHI5.
Proteomic databases
PRIDE	Q9JHI5.
Genome annotation databases
Ensembl	ENSMUST00000028807; ENSMUSP00000028807; ENSMUSG00000027332; Mus musculus. [Genome view]
GeneID	56357.
KEGG	mmu:56357.
NMPDR	fig|10090.3.peg.6671.
UCSC	uc008lsv.1. mouse.
Organism-specific databases
CTD	56357.
MGI	MGI:1929242. Ivd.
Phylogenomic databases
HOGENOM	Q9JHI5.
HOVERGEN	Q9JHI5.
OMA	KHAREDD.
Enzyme and pathway databases
BRENDA	1.3.99.10. 244.
Gene expression databases
ArrayExpress	Q9JHI5.
Bgee	Q9JHI5.
CleanEx	MM_IVD.
Genevestigator	Q9JHI5.
GermOnline	ENSMUSG00000027332. Mus musculus.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	312370.
SOURCE	Search...

Entry information

Entry name

IVD_MOUSE

Accession

Primary (citable) accession number: Q9JHI5
Secondary accession number(s): Q9CYI3, Q9DBD7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)