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Protein

Solute carrier family 13 member 1

Gene

Slc13a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

GO - Molecular functioni

GO - Biological processi

  • sodium ion transmembrane transport Source: GO_Central
  • sulfate transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Sulfate transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 1
Alternative name(s):
NaSi-1
Renal sodium/sulfate cotransporter
Short name:
Na(+)/sulfate cotransporter
Gene namesi
Name:Slc13a1
Synonyms:Nas1, Nasi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1859937. Slc13a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei347 – 36721HelicalSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Transmembranei461 – 48121HelicalSequence analysisAdd
BLAST
Transmembranei487 – 50721HelicalSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Transmembranei552 – 57221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Solute carrier family 13 member 1PRO_0000172486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JHI4.
PRIDEiQ9JHI4.

PTM databases

iPTMnetiQ9JHI4.
PhosphoSiteiQ9JHI4.

Expressioni

Tissue specificityi

Highly expressed in kidney and ileum, detected at lower levels in duodenum/jejunum and colon, and at very low levels in cecum, testis, adrenal and adipose tissues. Expression of isoform 2 is very low.

Gene expression databases

BgeeiENSMUSG00000029700.
GenevisibleiQ9JHI4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031713.

Structurei

3D structure databases

ProteinModelPortaliQ9JHI4.
SMRiQ9JHI4. Positions 40-160, 242-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9JHI4.
KOiK14444.
OMAiLPMFGIM.
OrthoDBiEOG091G092X.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9JHI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLLNYALVY RRFLLVVFTI LVFLPLPLII RTKEAQCAYI LFVIAIFWIT
60 70 80 90 100
EALPLSITAL LPGLMFPMFG IMRSSQVASA YFKDFHLLLI GVICLATSIE
110 120 130 140 150
KWNLHKRIAL RMVMMVGVNP AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI
160 170 180 190 200
VEAVAQQIIS AEAEAEATQM TYFNESAAHG LDIDETVIGQ ETNEKKEKTK
210 220 230 240 250
PAPGSSHDKG KVSRKMETEK NAVTGAKYRS RKDHMMCKLM CLSVAYSSTI
260 270 280 290 300
GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VALILLLLSW
310 320 330 340 350
IWLQWLYLGF DFKMFKCGKT KTLKEKACAK VIKQEYEKLG PMRYQEIVTL
360 370 380 390 400
VIFIVMALLW FSRDPGFVTG WSVLFSEYPG YVTDSTVALV AGILFFLIPA
410 420 430 440 450
KKVTKMTSAG EIIAFDYTPL ITWKEFQSFM PWDIAILVGG GFALADGCQV
460 470 480 490 500
SGLSNWIGSK LSPLGSLPVW LIILISSLIV TSLTEVASNP ATITILFPIL
510 520 530 540 550
SPLAEAIQVN PLQILLPSTL CTSFAFLLPV ANPPNAIVFS YGHLKVIDMV
560 570 580 590
KAGLGVNILG VAVVMLGMFT WIEPMFNLHE YPSWASNFVN QTMP
Length:594
Mass (Da):66,084
Last modified:July 27, 2011 - v2
Checksum:i7B8C347B9DA8F3C6
GO
Isoform 2 (identifier: Q9JHI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-76: Missing.

Note: Inactive.
Show »
Length:551
Mass (Da):61,298
Checksum:iC4857567392AA181
GO
Isoform 3 (identifier: Q9JHI4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-594: Missing.

Note: Inactive.
Show »
Length:122
Mass (Da):14,004
Checksum:i73DAB3BC40C09870
GO

Sequence cautioni

The sequence AK019876 differs from that shown. Reason: Frameshift at position 111. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti470 – 4701W → R in AAF64648 (PubMed:10766815).Curated
Sequence conflicti470 – 4701W → R in AAF64649 (PubMed:10766815).Curated
Sequence conflicti470 – 4701W → R in AAF65231 (PubMed:10766815).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei34 – 7643Missing in isoform 2. 1 PublicationVSP_006121Add
BLAST
Alternative sequencei123 – 594472Missing in isoform 3. 1 PublicationVSP_006122Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199365 mRNA. Translation: AAF64648.1.
AF199366 mRNA. Translation: AAF64649.1.
AF200319
, AF200305, AF200306, AF200307, AF200308, AF200309, AF200310, AF200311, AF200312, AF200313, AF200314, AF200315, AF200316, AF200317, AF200318 Genomic DNA. Translation: AAF65231.1.
AK019876 mRNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13827.1.
BC049981 mRNA. Translation: AAH49981.1.
BC022672 mRNA. Translation: AAH22672.1.
CCDSiCCDS19940.1. [Q9JHI4-1]
RefSeqiNP_062354.2. NM_019481.2. [Q9JHI4-1]
UniGeneiMm.19299.

Genome annotation databases

EnsembliENSMUST00000031713; ENSMUSP00000031713; ENSMUSG00000029700. [Q9JHI4-1]
GeneIDi55961.
KEGGimmu:55961.
UCSCiuc009bbo.2. mouse. [Q9JHI4-1]
uc009bbq.1. mouse. [Q9JHI4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199365 mRNA. Translation: AAF64648.1.
AF199366 mRNA. Translation: AAF64649.1.
AF200319
, AF200305, AF200306, AF200307, AF200308, AF200309, AF200310, AF200311, AF200312, AF200313, AF200314, AF200315, AF200316, AF200317, AF200318 Genomic DNA. Translation: AAF65231.1.
AK019876 mRNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13827.1.
BC049981 mRNA. Translation: AAH49981.1.
BC022672 mRNA. Translation: AAH22672.1.
CCDSiCCDS19940.1. [Q9JHI4-1]
RefSeqiNP_062354.2. NM_019481.2. [Q9JHI4-1]
UniGeneiMm.19299.

3D structure databases

ProteinModelPortaliQ9JHI4.
SMRiQ9JHI4. Positions 40-160, 242-571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031713.

PTM databases

iPTMnetiQ9JHI4.
PhosphoSiteiQ9JHI4.

Proteomic databases

PaxDbiQ9JHI4.
PRIDEiQ9JHI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031713; ENSMUSP00000031713; ENSMUSG00000029700. [Q9JHI4-1]
GeneIDi55961.
KEGGimmu:55961.
UCSCiuc009bbo.2. mouse. [Q9JHI4-1]
uc009bbq.1. mouse. [Q9JHI4-3]

Organism-specific databases

CTDi6561.
MGIiMGI:1859937. Slc13a1.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9JHI4.
KOiK14444.
OMAiLPMFGIM.
OrthoDBiEOG091G092X.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

PROiQ9JHI4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029700.
GenevisibleiQ9JHI4. MM.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
IPR031312. Na/sul_symport_CS.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHI4
Secondary accession number(s): Q80YB5, Q8R208, Q9D2C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.