Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier organic anion transporter family member 2B1

Gene

Slco2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: RGD
  • sodium-independent organic anion transmembrane transporter activity Source: RGD

GO - Biological processi

  • bile acid and bile salt transport Source: RGD
  • liver development Source: RGD
  • sodium-independent icosanoid transport Source: RGD
  • sodium-independent organic anion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.7. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter moatp1
Solute carrier family 21 member 9
Gene namesi
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621391. Slco2b1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141CytoplasmicSequence analysisAdd
BLAST
Transmembranei42 – 6120Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini62 – 8019ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 1076CytoplasmicSequence analysis
Transmembranei108 – 13225Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 17644ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 20630Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini207 – 22519CytoplasmicSequence analysisAdd
BLAST
Transmembranei226 – 24621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini247 – 26418ExtracellularSequence analysisAdd
BLAST
Transmembranei265 – 28925Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini290 – 35465CytoplasmicSequence analysisAdd
BLAST
Transmembranei355 – 37622Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini377 – 39620ExtracellularSequence analysisAdd
BLAST
Transmembranei397 – 42024Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini421 – 4244CytoplasmicSequence analysis
Transmembranei425 – 44824Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini449 – 552104ExtracellularSequence analysisAdd
BLAST
Transmembranei553 – 57523Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini576 – 5849CytoplasmicSequence analysis
Transmembranei585 – 61026Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini611 – 64333ExtracellularSequence analysisAdd
BLAST
Transmembranei644 – 66118Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini662 – 68221CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073698.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 682682Solute carrier organic anion transporter family member 2B1PRO_0000191063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Modified residuei311 – 3111PhosphoserineCombined sources
Modified residuei314 – 3141PhosphoserineCombined sources
Disulfide bondi477 ↔ 504PROSITE-ProRule annotation
Disulfide bondi481 ↔ 492PROSITE-ProRule annotation
Disulfide bondi483 ↔ 508PROSITE-ProRule annotation
Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence analysis
Glycosylationi533 – 5331N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JHI3.
PRIDEiQ9JHI3.

PTM databases

iPTMnetiQ9JHI3.
PhosphoSiteiQ9JHI3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000017976.
ExpressionAtlasiQ9JHI3. baseline and differential.
GenevisibleiQ9JHI3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024281.

Chemistry

BindingDBiQ9JHI3.

Structurei

3D structure databases

ProteinModelPortaliQ9JHI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 53161Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9JHI3.
KOiK14352.
OMAiICISENG.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9JHI3.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRSTKATM GAEDIHERKV SMEPRDSHQD AQPRGMFQNI KFFVLCHSIL
60 70 80 90 100
QLAQLMISGY LKSSISTVEK RFGLSSQTSG LLAAFNEVGN ISLILFVSYF
110 120 130 140 150
GSRVHRPRMI GCGAILVAVA GLLMALPHFI SEPYRYDHSS PDRSQDFEAS
160 170 180 190 200
LCLPTTMAPA SALSNDSCSS RTETKHLTMV GIMFTAQTLL GIGGVPIQPF
210 220 230 240 250
GISYIDDFAH HSNSPLYLGI LFAITMMGPG LAYGLGSLML RLYVDIDRMP
260 270 280 290 300
EGGINLTTKD PRWVGAWWLG FLISAGLVVL AASPYFFFPR EMPKEKYELH
310 320 330 340 350
FRQKVLAGGA SIGSKGEELS SQHEPLKKQA GLPQIAPDLT VVQFIKVFPR
360 370 380 390 400
VLLRTLRHPI FLLVVLSQVC TSSMVAGTAT FLPKFLERQF SITASFANLL
410 420 430 440 450
LGCLTIPLAI VGIVVGGVLV KRLHLSPMQC SALCLLGSLL CLLLSLPLFF
460 470 480 490 500
IGCSTHHIAG ITQDLGAQPG PSLFPGCSEP CSCQSDDFNP VCDTSAYVEY
510 520 530 540 550
TTPCHAGCTG RVVQEALDKS QVFYTNCSCV AGNGTISAGS CESACSRLVL
560 570 580 590 600
PFILLISLGA AVASITHTPS FMLILRGVKK EDKTLAVGMQ FMLLRVLAWM
610 620 630 640 650
PSPVIHGSAI DTTCVHWALT CGRRAVCRYY DHDLLRNRFI GLQFFFKSGS
660 670 680
LVCFALVLAI LRQQSREAST KATVKSSDLQ EL
Length:682
Mass (Da):74,215
Last modified:October 1, 2000 - v1
Checksum:i7CA4BBEAE21DE8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169410 mRNA. Translation: AAF89671.1.
AF169409 mRNA. Translation: AAF89670.1.
PIRiJC7385.
RefSeqiNP_542964.1. NM_080786.1.
XP_006229789.1. XM_006229727.2.
XP_006229790.1. XM_006229728.2.
UniGeneiRn.44538.

Genome annotation databases

EnsembliENSRNOT00000024281; ENSRNOP00000024281; ENSRNOG00000017976.
GeneIDi140860.
KEGGirno:140860.
UCSCiRGD:621391. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169410 mRNA. Translation: AAF89671.1.
AF169409 mRNA. Translation: AAF89670.1.
PIRiJC7385.
RefSeqiNP_542964.1. NM_080786.1.
XP_006229789.1. XM_006229727.2.
XP_006229790.1. XM_006229728.2.
UniGeneiRn.44538.

3D structure databases

ProteinModelPortaliQ9JHI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024281.

Chemistry

BindingDBiQ9JHI3.
ChEMBLiCHEMBL2073698.

Protein family/group databases

TCDBi2.A.60.1.7. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ9JHI3.
PhosphoSiteiQ9JHI3.

Proteomic databases

PaxDbiQ9JHI3.
PRIDEiQ9JHI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024281; ENSRNOP00000024281; ENSRNOG00000017976.
GeneIDi140860.
KEGGirno:140860.
UCSCiRGD:621391. rat.

Organism-specific databases

CTDi11309.
RGDi621391. Slco2b1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9JHI3.
KOiK14352.
OMAiICISENG.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9JHI3.

Enzyme and pathway databases

ReactomeiR-RNO-879518. Transport of organic anions.

Miscellaneous databases

PROiQ9JHI3.

Gene expression databases

BgeeiENSRNOG00000017976.
ExpressionAtlasiQ9JHI3. baseline and differential.
GenevisibleiQ9JHI3. RN.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2B1_RAT
AccessioniPrimary (citable) accession number: Q9JHI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.