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Protein

Solute carrier organic anion transporter family member 2B1

Gene

Slco2b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

GO - Molecular functioni

  • bile acid transmembrane transporter activity Source: RGD
  • sodium-independent organic anion transmembrane transporter activity Source: RGD

GO - Biological processi

  • bile acid and bile salt transport Source: RGD
  • liver development Source: RGD
  • sodium-independent icosanoid transport Source: RGD
  • sodium-independent organic anion transport Source: GO_Central

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.7 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2B1
Alternative name(s):
Organic anion transporter moatp1
Solute carrier family 21 member 9
Gene namesi
Name:Slco2b1
Synonyms:Oatp2b1, Slc21a9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621391 Slco2b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 61Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini62 – 80ExtracellularSequence analysisAdd BLAST19
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 107CytoplasmicSequence analysis6
Transmembranei108 – 132Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini133 – 176ExtracellularSequence analysisAdd BLAST44
Transmembranei177 – 206Helical; Name=4Sequence analysisAdd BLAST30
Topological domaini207 – 225CytoplasmicSequence analysisAdd BLAST19
Transmembranei226 – 246Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini247 – 264ExtracellularSequence analysisAdd BLAST18
Transmembranei265 – 289Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini290 – 354CytoplasmicSequence analysisAdd BLAST65
Transmembranei355 – 376Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini377 – 396ExtracellularSequence analysisAdd BLAST20
Transmembranei397 – 420Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini421 – 424CytoplasmicSequence analysis4
Transmembranei425 – 448Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini449 – 552ExtracellularSequence analysisAdd BLAST104
Transmembranei553 – 575Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini576 – 584CytoplasmicSequence analysis9
Transmembranei585 – 610Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini611 – 643ExtracellularSequence analysisAdd BLAST33
Transmembranei644 – 661Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini662 – 682CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073698

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910631 – 682Solute carrier organic anion transporter family member 2B1Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei311PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Disulfide bondi477 ↔ 504PROSITE-ProRule annotation
Disulfide bondi481 ↔ 492PROSITE-ProRule annotation
Disulfide bondi483 ↔ 508PROSITE-ProRule annotation
Glycosylationi526N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi533N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JHI3
PRIDEiQ9JHI3

PTM databases

iPTMnetiQ9JHI3
PhosphoSitePlusiQ9JHI3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000017976
ExpressionAtlasiQ9JHI3 baseline and differential
GenevisibleiQ9JHI3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024281

Chemistry databases

BindingDBiQ9JHI3

Structurei

3D structure databases

ProteinModelPortaliQ9JHI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 531Kazal-likePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiQ9JHI3
KOiK14352
OMAiVHRPRMI
OrthoDBiEOG091G08QD
PhylomeDBiQ9JHI3

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF03137 OATP, 1 hit
SUPFAMiSSF103473 SSF103473, 5 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRSTKATM GAEDIHERKV SMEPRDSHQD AQPRGMFQNI KFFVLCHSIL
60 70 80 90 100
QLAQLMISGY LKSSISTVEK RFGLSSQTSG LLAAFNEVGN ISLILFVSYF
110 120 130 140 150
GSRVHRPRMI GCGAILVAVA GLLMALPHFI SEPYRYDHSS PDRSQDFEAS
160 170 180 190 200
LCLPTTMAPA SALSNDSCSS RTETKHLTMV GIMFTAQTLL GIGGVPIQPF
210 220 230 240 250
GISYIDDFAH HSNSPLYLGI LFAITMMGPG LAYGLGSLML RLYVDIDRMP
260 270 280 290 300
EGGINLTTKD PRWVGAWWLG FLISAGLVVL AASPYFFFPR EMPKEKYELH
310 320 330 340 350
FRQKVLAGGA SIGSKGEELS SQHEPLKKQA GLPQIAPDLT VVQFIKVFPR
360 370 380 390 400
VLLRTLRHPI FLLVVLSQVC TSSMVAGTAT FLPKFLERQF SITASFANLL
410 420 430 440 450
LGCLTIPLAI VGIVVGGVLV KRLHLSPMQC SALCLLGSLL CLLLSLPLFF
460 470 480 490 500
IGCSTHHIAG ITQDLGAQPG PSLFPGCSEP CSCQSDDFNP VCDTSAYVEY
510 520 530 540 550
TTPCHAGCTG RVVQEALDKS QVFYTNCSCV AGNGTISAGS CESACSRLVL
560 570 580 590 600
PFILLISLGA AVASITHTPS FMLILRGVKK EDKTLAVGMQ FMLLRVLAWM
610 620 630 640 650
PSPVIHGSAI DTTCVHWALT CGRRAVCRYY DHDLLRNRFI GLQFFFKSGS
660 670 680
LVCFALVLAI LRQQSREAST KATVKSSDLQ EL
Length:682
Mass (Da):74,215
Last modified:October 1, 2000 - v1
Checksum:i7CA4BBEAE21DE8C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169410 mRNA Translation: AAF89671.1
AF169409 mRNA Translation: AAF89670.1
PIRiJC7385
RefSeqiNP_542964.1, NM_080786.1
XP_006229789.1, XM_006229727.3
XP_006229790.1, XM_006229728.3
UniGeneiRn.44538

Genome annotation databases

EnsembliENSRNOT00000024281; ENSRNOP00000024281; ENSRNOG00000017976
GeneIDi140860
KEGGirno:140860
UCSCiRGD:621391 rat

Similar proteinsi

Entry informationi

Entry nameiSO2B1_RAT
AccessioniPrimary (citable) accession number: Q9JHI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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