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Protein

tRNA-specific adenosine deaminase 1

Gene

Adat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specifically deaminates adenosine-37 to inosine in tRNA-Ala.1 Publication

Catalytic activityi

Adenine(37) in tRNA(Ala) + H2O = hypoxanthine(37) in tRNA(Ala) + NH3.1 Publication

Cofactori

1D-myo-inositol hexakisphosphateBy similarityNote: Binds 1 myo-inositol hexakisphosphate (IP6) per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87ZincPROSITE-ProRule annotation1
Active sitei89Proton donorPROSITE-ProRule annotation1
Binding sitei93Inositol hexakisphosphateBy similarity1
Binding sitei94Inositol hexakisphosphateBy similarity1
Metal bindingi142ZincPROSITE-ProRule annotation1
Metal bindingi294ZincPROSITE-ProRule annotation1
Binding sitei297Inositol hexakisphosphateBy similarity1
Binding sitei300Inositol hexakisphosphateBy similarity1
Binding sitei430Inositol hexakisphosphateBy similarity1
Binding sitei466Inositol hexakisphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-specific adenosine deaminase 1 (EC:3.5.4.34)
Short name:
mADAT1
Alternative name(s):
tRNA-specific adenosine-37 deaminase
Gene namesi
Name:Adat1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1353631. Adat1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876481 – 499tRNA-specific adenosine deaminase 1Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JHI2.
PaxDbiQ9JHI2.
PeptideAtlasiQ9JHI2.
PRIDEiQ9JHI2.

PTM databases

iPTMnetiQ9JHI2.
PhosphoSitePlusiQ9JHI2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031949.
CleanExiMM_ADAT1.
ExpressionAtlasiQ9JHI2. baseline and differential.
GenevisibleiQ9JHI2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034427.

Structurei

3D structure databases

ProteinModelPortaliQ9JHI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 498A to I editasePROSITE-ProRule annotationAdd BLAST436

Sequence similaritiesi

Belongs to the ADAT1 family.Curated
Contains 1 A to I editase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000237320.
HOVERGENiHBG059724.
InParanoidiQ9JHI2.
KOiK15440.
OMAiMRKNGDI.
OrthoDBiEOG091G0HDD.
PhylomeDBiQ9JHI2.
TreeFamiTF315806.

Family and domain databases

InterProiIPR002466. A_deamin.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JHI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWTADEIAQL CYAHYNVRLP KQGKPEPNRE WTLLAAVVKI QASANQACDI
60 70 80 90 100
PEKEVQVTKE VVSMGTGTKC IGQSKMRESG DILNDSHAEI IARRSFQRYL
110 120 130 140 150
LHQLHLAAVL KEDSIFVPGT QRGLWRLRPD LSFVFFSSHT PCGDASIIPM
160 170 180 190 200
LEFEEQPCCP VIRSWANNSP VQETENLEDS KDKRNCEDPA SPVAKKMRLG
210 220 230 240 250
TPARSLSNCV AHHGTQESGP VKPDVSSSDL TKEEPDAANG IASGSFRVVD
260 270 280 290 300
VYRTGAKCVP GETGDLREPG AAYHQVGLLR VKPGRGDRTC SMSCSDKMAR
310 320 330 340 350
WNVLGCQGAL LMHFLEKPIY LSAVVIGKCP YSQEAMRRAL TGRCEETLVL
360 370 380 390 400
PRGFGVQELE IQQSGLLFEQ SRCAVHRKRG DSPGRLVPCG AAISWSAVPQ
410 420 430 440 450
QPLDVTANGF PQGTTKKEIG SPRARSRISK VELFRSFQKL LSSIADDEQP
460 470 480 490
DSIRVTKKLD TYQEYKDAAS AYQEAWGALR RIQPFASWIR NPPDYHQFK
Length:499
Mass (Da):55,355
Last modified:October 1, 2000 - v1
Checksum:i8080BD40C1EE5E71
GO
Isoform 2 (identifier: Q9JHI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     455-499: Missing.

Show »
Length:454
Mass (Da):49,984
Checksum:i92AF500A9DE3D8A9
GO
Isoform 3 (identifier: Q9JHI2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-424: Missing.
     455-499: Missing.

Note: No experimental confirmation available.
Show »
Length:372
Mass (Da):41,143
Checksum:iE5C257214B3A6AA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201T → A in BAE36167 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025580343 – 424Missing in isoform 3. CuratedAdd BLAST82
Alternative sequenceiVSP_025581455 – 499Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192375 mRNA. Translation: AAF36820.1.
AF192374
, AF192367, AF192368, AF192369, AF192370, AF192371, AF192372, AF192373 Genomic DNA. Translation: AAF36821.1.
AK035614 mRNA. Translation: BAC29125.1.
AK039699 mRNA. Translation: BAC30422.1.
AK082399 mRNA. Translation: BAC38487.1.
AK161044 mRNA. Translation: BAE36167.1.
BC019976 mRNA. Translation: AAH19976.1.
CCDSiCCDS22684.1. [Q9JHI2-1]
RefSeqiNP_038953.1. NM_013925.4. [Q9JHI2-1]
UniGeneiMm.282162.

Genome annotation databases

EnsembliENSMUST00000034427; ENSMUSP00000034427; ENSMUSG00000031949. [Q9JHI2-1]
ENSMUST00000139820; ENSMUSP00000117279; ENSMUSG00000031949. [Q9JHI2-2]
GeneIDi30947.
KEGGimmu:30947.
UCSCiuc009nnc.1. mouse. [Q9JHI2-1]
uc012gkz.1. mouse. [Q9JHI2-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192375 mRNA. Translation: AAF36820.1.
AF192374
, AF192367, AF192368, AF192369, AF192370, AF192371, AF192372, AF192373 Genomic DNA. Translation: AAF36821.1.
AK035614 mRNA. Translation: BAC29125.1.
AK039699 mRNA. Translation: BAC30422.1.
AK082399 mRNA. Translation: BAC38487.1.
AK161044 mRNA. Translation: BAE36167.1.
BC019976 mRNA. Translation: AAH19976.1.
CCDSiCCDS22684.1. [Q9JHI2-1]
RefSeqiNP_038953.1. NM_013925.4. [Q9JHI2-1]
UniGeneiMm.282162.

3D structure databases

ProteinModelPortaliQ9JHI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034427.

PTM databases

iPTMnetiQ9JHI2.
PhosphoSitePlusiQ9JHI2.

Proteomic databases

EPDiQ9JHI2.
PaxDbiQ9JHI2.
PeptideAtlasiQ9JHI2.
PRIDEiQ9JHI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034427; ENSMUSP00000034427; ENSMUSG00000031949. [Q9JHI2-1]
ENSMUST00000139820; ENSMUSP00000117279; ENSMUSG00000031949. [Q9JHI2-2]
GeneIDi30947.
KEGGimmu:30947.
UCSCiuc009nnc.1. mouse. [Q9JHI2-1]
uc012gkz.1. mouse. [Q9JHI2-3]

Organism-specific databases

CTDi23536.
MGIiMGI:1353631. Adat1.

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000237320.
HOVERGENiHBG059724.
InParanoidiQ9JHI2.
KOiK15440.
OMAiMRKNGDI.
OrthoDBiEOG091G0HDD.
PhylomeDBiQ9JHI2.
TreeFamiTF315806.

Miscellaneous databases

PROiQ9JHI2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031949.
CleanExiMM_ADAT1.
ExpressionAtlasiQ9JHI2. baseline and differential.
GenevisibleiQ9JHI2. MM.

Family and domain databases

InterProiIPR002466. A_deamin.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADAT1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHI2
Secondary accession number(s): Q3TU04, Q8CBP0, Q8VE23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.