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Protein

Coatomer subunit zeta-2

Gene

Copz2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit zeta-2
Alternative name(s):
Zeta-2-coat protein
Short name:
Zeta-2 COP
Gene namesi
Name:Copz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1929008. Copz2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938321 – 205Coatomer subunit zeta-2Add BLAST205

Proteomic databases

MaxQBiQ9JHH9.
PaxDbiQ9JHH9.
PeptideAtlasiQ9JHH9.
PRIDEiQ9JHH9.

PTM databases

PhosphoSitePlusiQ9JHH9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018672.
CleanExiMM_COPZ2.
ExpressionAtlasiQ9JHH9. baseline and differential.
GenevisibleiQ9JHH9. MM.

Interactioni

Subunit structurei

Oligomeric complex.

Protein-protein interaction databases

IntActiQ9JHH9. 1 interactor.
MINTiMINT-4091543.
STRINGi10090.ENSMUSP00000018816.

Structurei

3D structure databases

ProteinModelPortaliQ9JHH9.
SMRiQ9JHH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiQ9JHH9.
KOiK20472.
OMAiHVLRRNI.
OrthoDBiEOG091G0TM0.
PhylomeDBiQ9JHH9.
TreeFamiTF300262.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRPEAWPRP HPGEGASAAQ AGGAAPPTRA TEQREPSLYT IKAVFILDND
60 70 80 90 100
GRRLLAKYYD DTFPSVKEQM VFEKNVFNKT SRTESEIAFL GGMTIVYKSS
110 120 130 140 150
IDIFLYVVGS SSENELMLMS VLACLFDSLS HILRKNVEKR WLLENMDGAF
160 170 180 190 200
LVLDETVDGG VILESDPQQV IQKVNFRTDD SGLTEQSVAQ VLQSAKEQIK

WSLLK
Length:205
Mass (Da):22,934
Last modified:October 1, 2000 - v1
Checksum:i8BC358417A7F15D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047850 mRNA. Translation: BAB17661.1.
AB040137 mRNA. Translation: BAA92831.1.
AF237687 mRNA. Translation: AAF37723.1.
AL596384 Genomic DNA. Translation: CAM21891.1.
BC025122 mRNA. Translation: AAH25122.1.
CCDSiCCDS25305.1.
RefSeqiNP_063930.1. NM_019877.2.
UniGeneiMm.22144.

Genome annotation databases

EnsembliENSMUST00000018816; ENSMUSP00000018816; ENSMUSG00000018672.
GeneIDi56358.
KEGGimmu:56358.
UCSCiuc007lcu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047850 mRNA. Translation: BAB17661.1.
AB040137 mRNA. Translation: BAA92831.1.
AF237687 mRNA. Translation: AAF37723.1.
AL596384 Genomic DNA. Translation: CAM21891.1.
BC025122 mRNA. Translation: AAH25122.1.
CCDSiCCDS25305.1.
RefSeqiNP_063930.1. NM_019877.2.
UniGeneiMm.22144.

3D structure databases

ProteinModelPortaliQ9JHH9.
SMRiQ9JHH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JHH9. 1 interactor.
MINTiMINT-4091543.
STRINGi10090.ENSMUSP00000018816.

PTM databases

PhosphoSitePlusiQ9JHH9.

Proteomic databases

MaxQBiQ9JHH9.
PaxDbiQ9JHH9.
PeptideAtlasiQ9JHH9.
PRIDEiQ9JHH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018816; ENSMUSP00000018816; ENSMUSG00000018672.
GeneIDi56358.
KEGGimmu:56358.
UCSCiuc007lcu.1. mouse.

Organism-specific databases

CTDi51226.
MGIiMGI:1929008. Copz2.

Phylogenomic databases

eggNOGiKOG3343. Eukaryota.
COG5541. LUCA.
GeneTreeiENSGT00390000004405.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiQ9JHH9.
KOiK20472.
OMAiHVLRRNI.
OrthoDBiEOG091G0TM0.
PhylomeDBiQ9JHH9.
TreeFamiTF300262.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

ChiTaRSiCopz2. mouse.
PROiQ9JHH9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018672.
CleanExiMM_COPZ2.
ExpressionAtlasiQ9JHH9. baseline and differential.
GenevisibleiQ9JHH9. MM.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHH9
Secondary accession number(s): A2A6D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.