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Protein

C-X-C motif chemokine 11

Gene

Cxcl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 11
Alternative name(s):
Interferon-inducible T-cell alpha chemoattractant
Short name:
I-TAC
Small-inducible cytokine B11
Gene namesi
Name:Cxcl11
Synonyms:Scyb11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1860203. Cxcl11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 10079C-X-C motif chemokine 11PRO_0000005107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9JHH5.

PTM databases

PhosphoSiteiQ9JHH5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060183.
CleanExiMM_CXCL11.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9JHH5.
SMRiQ9JHH5. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107789.
InParanoidiQ9JHH5.
KOiK12672.
PhylomeDBiQ9JHH5.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRKVTAIAL AAIIWATAAQ GFLMFKQGRC LCIGPGMKAV KMAEIEKASV
60 70 80 90 100
IYPSNGCDKV EVIVTMKAHK RQRCLDPRSK QARLIMQAIE KKNFLRRQNM
Length:100
Mass (Da):11,266
Last modified:October 1, 2000 - v1
Checksum:i9932345FD5F1E5E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178672 mRNA. Translation: AAF79048.1.
AF167354 Genomic DNA. Translation: AAF71824.1.
AF179872 mRNA. Translation: AAF77095.1.
AF136449 mRNA. Translation: AAF79022.1.
RefSeqiNP_062367.1. NM_019494.1.
UniGeneiMm.131723.

Genome annotation databases

GeneIDi56066.
KEGGimmu:56066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178672 mRNA. Translation: AAF79048.1.
AF167354 Genomic DNA. Translation: AAF71824.1.
AF179872 mRNA. Translation: AAF77095.1.
AF136449 mRNA. Translation: AAF79022.1.
RefSeqiNP_062367.1. NM_019494.1.
UniGeneiMm.131723.

3D structure databases

ProteinModelPortaliQ9JHH5.
SMRiQ9JHH5. Positions 22-94.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9JHH5.

Proteomic databases

PRIDEiQ9JHH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56066.
KEGGimmu:56066.

Organism-specific databases

CTDi6373.
MGIiMGI:1860203. Cxcl11.

Phylogenomic databases

HOVERGENiHBG107789.
InParanoidiQ9JHH5.
KOiK12672.
PhylomeDBiQ9JHH5.

Miscellaneous databases

PROiQ9JHH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060183.
CleanExiMM_CXCL11.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027221. CXCL11.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF28. PTHR10179:SF28. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXL11_MOUSE
AccessioniPrimary (citable) accession number: Q9JHH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.