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Protein

C-X-C motif chemokine 11

Gene

Cxcl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 11
Alternative name(s):
Interferon-inducible T-cell alpha chemoattractant
Short name:
I-TAC
Small-inducible cytokine B11
Gene namesi
Name:Cxcl11
Synonyms:Scyb11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1860203. Cxcl11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000510722 – 100C-X-C motif chemokine 11Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 74By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9JHH5.

PTM databases

PhosphoSitePlusiQ9JHH5.

Expressioni

Gene expression databases

CleanExiMM_CXCL11.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9JHH5.
SMRiQ9JHH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG107789.
InParanoidiQ9JHH5.
KOiK12672.
PhylomeDBiQ9JHH5.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiView protein in InterPro
IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027221. CXCL11.
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF54. PTHR10179:SF54. 1 hit.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00471. SMALL_CYTOKINES_CXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRKVTAIAL AAIIWATAAQ GFLMFKQGRC LCIGPGMKAV KMAEIEKASV
60 70 80 90 100
IYPSNGCDKV EVIVTMKAHK RQRCLDPRSK QARLIMQAIE KKNFLRRQNM
Length:100
Mass (Da):11,266
Last modified:October 1, 2000 - v1
Checksum:i9932345FD5F1E5E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178672 mRNA. Translation: AAF79048.1.
AF167354 Genomic DNA. Translation: AAF71824.1.
AF179872 mRNA. Translation: AAF77095.1.
AF136449 mRNA. Translation: AAF79022.1.
RefSeqiNP_062367.1. NM_019494.1.
UniGeneiMm.131723.

Genome annotation databases

GeneIDi56066.
KEGGimmu:56066.

Similar proteinsi

Entry informationi

Entry nameiCXL11_MOUSE
AccessioniPrimary (citable) accession number: Q9JHH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families