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Q9JHH2

- TSN32_MOUSE

UniProt

Q9JHH2 - TSN32_MOUSE

Protein

Tetraspanin-32

Gene

Tspan32

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. blood coagulation Source: MGI
    2. cytoskeleton organization Source: MGI
    3. defense response to protozoan Source: MGI
    4. hemostasis Source: MGI
    5. integrin-mediated signaling pathway Source: MGI
    6. negative regulation of cell proliferation Source: MGI
    7. negative regulation of myeloid dendritic cell activation Source: MGI
    8. platelet aggregation Source: MGI
    9. regulation of defense response to virus Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-32
    Short name:
    Tspan-32
    Alternative name(s):
    AML1-regulated transmembrane protein 1
    Protein Phemx
    Gene namesi
    Name:Tspan32
    Synonyms:Art1, Phemx, Tssc6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1350360. Tspan32.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integrin alphaIIb-beta3 complex Source: MGI
    3. intracellular Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Tetraspanin-32PRO_0000219279Add
    BLAST

    Proteomic databases

    PRIDEiQ9JHH2.

    Expressioni

    Tissue specificityi

    Expressed exclusively in hematopoietic tissues. Expression detected in spleen, thymus, bone marrow and peripheral blood leukocytes but not in heart, brain, lung, liver, kidney or testis.1 Publication

    Developmental stagei

    Expressed from early embryogenesis through to adulthood.1 Publication

    Gene expression databases

    ArrayExpressiQ9JHH2.
    BgeeiQ9JHH2.
    CleanExiMM_ART1.
    MM_TSPAN32.
    GenevestigatoriQ9JHH2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41704.
    GeneTreeiENSGT00390000003287.
    HOVERGENiHBG053580.
    InParanoidiQ9JHH2.
    KOiK17359.
    OMAiAARQDCL.
    OrthoDBiEOG7XDBH0.
    PhylomeDBiQ9JHH2.
    TreeFamiTF336277.

    Family and domain databases

    Gene3Di1.10.1450.10. 1 hit.
    InterProiIPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    SUPFAMiSSF48652. SSF48652. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 6 (identifier: Q9JHH2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGHWNRIKIA KCQILITNFL VLLLGLSMAT MVVVIHFGDH FTVIGHASLE    50
    RNPYETLRYW AFYVGISLAG LLSLGAALST IATVREAHGL MAAGFLCFAL 100
    SFCILVQVAF WRFYNPTQVE DAVLDTYDFV YDQAMKSPSS NWWQELAVIQ 150
    DTFLCCGKKS PFGLLVSTGA IMCQGREAMR EDCLQSIRNV LWTHYSIASI 200
    LTCTSLALTV YAMMLCAFLW FAIHSYHGLD RKGRYSLTPP RSHGFQTQEP 250
    SLFRWT 256
    Length:256
    Mass (Da):28,906
    Last modified:March 27, 2002 - v2
    Checksum:iA20EF0F6248FF67A
    GO
    Isoform 1 (identifier: Q9JHH2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.

    Show »
    Length:226
    Mass (Da):25,525
    Checksum:iAD5AE6916BD14BD2
    GO
    Isoform 2 (identifier: Q9JHH2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.
         182-209: Missing.

    Show »
    Length:198
    Mass (Da):22,419
    Checksum:i3399ADE104D69B49
    GO
    Isoform 3 (identifier: Q9JHH2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.
         182-206: DCLQSIRNVLWTHYSIASILTCTSL → IPWFPDPGTQPLQMDLGWAGASMPC
         207-236: Missing.

    Show »
    Length:196
    Mass (Da):21,898
    Checksum:iD7CFC3B0510C7157
    GO
    Isoform 4 (identifier: Q9JHH2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.
         119-152: Missing.
         182-209: Missing.

    Show »
    Length:164
    Mass (Da):18,472
    Checksum:i23E2CAF9AC04D11F
    GO
    Isoform 5 (identifier: Q9JHH2-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-30: Missing.
         119-152: Missing.
         182-206: DCLQSIRNVLWTHYSIASILTCTSL → IPWFPDPGTQPLQMDLGWAGASMPC

    Show »
    Length:192
    Mass (Da):21,455
    Checksum:i93092F6EF11DF439
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741Q → L in AAG27268. (PubMed:10950922)Curated
    Sequence conflicti235 – 2351Y → F in AAG27268. (PubMed:10950922)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3030Missing in isoform 1, isoform 2, isoform 3, isoform 4 and isoform 5. 3 PublicationsVSP_003939Add
    BLAST
    Alternative sequencei119 – 15234Missing in isoform 4 and isoform 5. 1 PublicationVSP_003940Add
    BLAST
    Alternative sequencei182 – 20928Missing in isoform 2 and isoform 4. 1 PublicationVSP_003941Add
    BLAST
    Alternative sequencei182 – 20625DCLQS…TCTSL → IPWFPDPGTQPLQMDLGWAG ASMPC in isoform 3 and isoform 5. 1 PublicationVSP_003942Add
    BLAST
    Alternative sequencei207 – 23630Missing in isoform 3. 1 PublicationVSP_003943Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175771 mRNA. Translation: AAG27268.1.
    AJ251788 Genomic DNA. Translation: CAB94716.1.
    AJ251835 Genomic DNA. Translation: CAB94777.1.
    AJ279791 mRNA. Translation: CAB94719.1.
    AJ279792 mRNA. Translation: CAB94720.1.
    AJ279793 mRNA. Translation: CAB94721.1.
    AJ279794 mRNA. Translation: CAB94722.1.
    AJ279795 mRNA. Translation: CAB94723.1.
    AY039000 mRNA. Translation: AAK84430.1.
    AF291425 mRNA. Translation: AAK83110.1.
    CCDSiCCDS52459.1. [Q9JHH2-1]
    RefSeqiNP_001121552.1. NM_001128080.2. [Q9JHH2-1]
    NP_001121553.1. NM_001128081.1.
    NP_001121554.1. NM_001128082.1.
    NP_064682.1. NM_020286.3.
    UniGeneiMm.28172.

    Genome annotation databases

    EnsembliENSMUST00000009396; ENSMUSP00000009396; ENSMUSG00000000244. [Q9JHH2-1]
    GeneIDi27027.
    KEGGimmu:27027.
    UCSCiuc009kom.2. mouse. [Q9JHH2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF175771 mRNA. Translation: AAG27268.1 .
    AJ251788 Genomic DNA. Translation: CAB94716.1 .
    AJ251835 Genomic DNA. Translation: CAB94777.1 .
    AJ279791 mRNA. Translation: CAB94719.1 .
    AJ279792 mRNA. Translation: CAB94720.1 .
    AJ279793 mRNA. Translation: CAB94721.1 .
    AJ279794 mRNA. Translation: CAB94722.1 .
    AJ279795 mRNA. Translation: CAB94723.1 .
    AY039000 mRNA. Translation: AAK84430.1 .
    AF291425 mRNA. Translation: AAK83110.1 .
    CCDSi CCDS52459.1. [Q9JHH2-1 ]
    RefSeqi NP_001121552.1. NM_001128080.2. [Q9JHH2-1 ]
    NP_001121553.1. NM_001128081.1.
    NP_001121554.1. NM_001128082.1.
    NP_064682.1. NM_020286.3.
    UniGenei Mm.28172.

    3D structure databases

    ProteinModelPortali Q9JHH2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9JHH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009396 ; ENSMUSP00000009396 ; ENSMUSG00000000244 . [Q9JHH2-1 ]
    GeneIDi 27027.
    KEGGi mmu:27027.
    UCSCi uc009kom.2. mouse. [Q9JHH2-1 ]

    Organism-specific databases

    CTDi 10077.
    MGIi MGI:1350360. Tspan32.

    Phylogenomic databases

    eggNOGi NOG41704.
    GeneTreei ENSGT00390000003287.
    HOVERGENi HBG053580.
    InParanoidi Q9JHH2.
    KOi K17359.
    OMAi AARQDCL.
    OrthoDBi EOG7XDBH0.
    PhylomeDBi Q9JHH2.
    TreeFami TF336277.

    Miscellaneous databases

    NextBioi 304953.
    PROi Q9JHH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHH2.
    Bgeei Q9JHH2.
    CleanExi MM_ART1.
    MM_TSPAN32.
    Genevestigatori Q9JHH2.

    Family and domain databases

    Gene3Di 1.10.1450.10. 1 hit.
    InterProi IPR028977. CD81_LEL.
    IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7."
      Nicholson R.H., Pantano S., Eliason J.F., Galy A., Weiler S., Kaplan J., Hughes M.R., Ko M.S.H.
      Genomics 68:13-21(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6J.
    2. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
      Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
      Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4 AND 5).
      Strain: 129/Sv and C57BL/6.
    3. "Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs."
      Robb L., Tarrant J., Groom J., Ibrahim M., Li R., Borobakas B., Wright M.D.
      Biochim. Biophys. Acta 1522:31-41(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 6).
    4. "A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by aml1."
      Harada Y., Harada H., Downing J.R., Kimura A.
      Biochem. Biophys. Res. Commun. 284:714-722(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Spleen.

    Entry informationi

    Entry nameiTSN32_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHH2
    Secondary accession number(s): Q923G9
    , Q9ESH0, Q9JHQ9, Q9JHR0, Q9JHR1, Q9JHR2, Q9JHS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3