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Q9JHG6

- RCAN1_MOUSE

UniProt

Q9JHG6 - RCAN1_MOUSE

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Protein

Calcipressin-1

Gene
Rcan1, Dscr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. calcineurin-NFAT signaling cascade Source: MGI
  2. locomotion involved in locomotory behavior Source: MGI
  3. regulation of phosphoprotein phosphatase activity Source: MGI
  4. response to ischemia Source: MGI
  5. response to oxidative stress Source: MGI
  6. short-term memory Source: MGI
  7. skeletal muscle fiber development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-1
Alternative name(s):
Down syndrome critical region protein 1 homolog
Myocyte-enriched calcineurin-interacting protein 1
Short name:
MCIP1
Regulator of calcineurin 1
Gene namesi
Name:Rcan1
Synonyms:Dscr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1890564. Rcan1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Calcipressin-1PRO_0000211415Add
BLAST

Proteomic databases

MaxQBiQ9JHG6.
PaxDbiQ9JHG6.
PRIDEiQ9JHG6.

PTM databases

PhosphoSiteiQ9JHG6.

Expressioni

Tissue specificityi

Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.

Gene expression databases

ArrayExpressiQ9JHG6.
BgeeiQ9JHG6.
CleanExiMM_RCAN1.
GenevestigatoriQ9JHG6.

Interactioni

Subunit structurei

Interacts with RAF1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Dyrk1aQ612142EBI-644061,EBI-80344
Fmr1P359223EBI-644061,EBI-645094

Protein-protein interaction databases

BioGridi207725. 1 interaction.
IntActiQ9JHG6. 4 interactions.
MINTiMINT-1678164.

Structurei

Secondary structure

1
198
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 379
Beta strandi44 – 485
Turni49 – 524
Beta strandi53 – 575
Helixi63 – 697
Beta strandi74 – 763
Beta strandi82 – 843

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WEYNMR-A29-103[»]
ProteinModelPortaliQ9JHG6.
SMRiQ9JHG6. Positions 11-103.

Miscellaneous databases

EvolutionaryTraceiQ9JHG6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.

Phylogenomic databases

eggNOGiNOG87330.
GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ9JHG6.
KOiK17901.
OMAiACVANSE.
PhylomeDBiQ9JHG6.

Family and domain databases

InterProiIPR006931. Calcipressin.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform A (identifier: Q9JHG6-1) [UniParc]FASTAAdd to Basket

Also known as: 1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEVDLQDLP SATIACHLDP RVFVDGLCRA KFESLFRTYD KDTTFQYFKS    50
FKRVRINFSN PLSAADARLR LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN 100
PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT 150
DTTPSVVVHV CESDQENEEE EEEMERMKRP KPKIIQTRRP EYTPIHLS 198
Length:198
Mass (Da):22,706
Last modified:October 1, 2000 - v1
Checksum:iBA35340AFD6F0582
GO
Isoform B (identifier: Q9JHG6-2) [UniParc]FASTAAdd to Basket

Also known as: 4

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET

Show »
Length:198
Mass (Da):22,851
Checksum:iF017C68F18ACC187
GO
Isoform C (identifier: Q9JHG6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:118
Mass (Da):13,378
Checksum:iDC4A1EE03245E50B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8080Missing in isoform C. VSP_001318Add
BLAST
Alternative sequencei1 – 2828MEEVD…VDGLC → MHFRDFSYNFSSLIACVAND DVFSESET in isoform B. VSP_001317Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521T → P in AAF63485. 1 Publication
Sequence conflicti152 – 1521T → P in AAF63486. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282255 mRNA. Translation: AAF91461.1.
AF237789 mRNA. Translation: AAF63485.1.
AF237790 mRNA. Translation: AAF63486.1.
AF260717 mRNA. Translation: AAF70343.1.
AF263239 mRNA. Translation: AAF72701.1.
AF263240 mRNA. Translation: AAF72702.1.
AK010696 mRNA. Translation: BAB27128.1.
BC013551 mRNA. Translation: AAH13551.1.
CCDSiCCDS28337.1. [Q9JHG6-2]
RefSeqiNP_062339.2. NM_019466.4. [Q9JHG6-2]
UniGeneiMm.265744.

Genome annotation databases

EnsembliENSMUST00000023672; ENSMUSP00000023672; ENSMUSG00000022951. [Q9JHG6-2]
GeneIDi54720.
KEGGimmu:54720.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF282255 mRNA. Translation: AAF91461.1 .
AF237789 mRNA. Translation: AAF63485.1 .
AF237790 mRNA. Translation: AAF63486.1 .
AF260717 mRNA. Translation: AAF70343.1 .
AF263239 mRNA. Translation: AAF72701.1 .
AF263240 mRNA. Translation: AAF72702.1 .
AK010696 mRNA. Translation: BAB27128.1 .
BC013551 mRNA. Translation: AAH13551.1 .
CCDSi CCDS28337.1. [Q9JHG6-2 ]
RefSeqi NP_062339.2. NM_019466.4. [Q9JHG6-2 ]
UniGenei Mm.265744.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WEY NMR - A 29-103 [» ]
ProteinModelPortali Q9JHG6.
SMRi Q9JHG6. Positions 11-103.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207725. 1 interaction.
IntActi Q9JHG6. 4 interactions.
MINTi MINT-1678164.

PTM databases

PhosphoSitei Q9JHG6.

Proteomic databases

MaxQBi Q9JHG6.
PaxDbi Q9JHG6.
PRIDEi Q9JHG6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023672 ; ENSMUSP00000023672 ; ENSMUSG00000022951 . [Q9JHG6-2 ]
GeneIDi 54720.
KEGGi mmu:54720.

Organism-specific databases

CTDi 1827.
MGIi MGI:1890564. Rcan1.

Phylogenomic databases

eggNOGi NOG87330.
GeneTreei ENSGT00400000022053.
HOGENOMi HOG000254788.
HOVERGENi HBG018932.
InParanoidi Q9JHG6.
KOi K17901.
OMAi ACVANSE.
PhylomeDBi Q9JHG6.

Miscellaneous databases

ChiTaRSi RCAN1. mouse.
EvolutionaryTracei Q9JHG6.
NextBioi 311564.
PROi Q9JHG6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JHG6.
Bgeei Q9JHG6.
CleanExi MM_RCAN1.
Genevestigatori Q9JHG6.

Family and domain databases

InterProi IPR006931. Calcipressin.
[Graphical view ]
PANTHERi PTHR10300. PTHR10300. 1 hit.
Pfami PF04847. Calcipressin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes."
    Strippoli P., Petrini M., Lenzi L., Carinci P., Zannotti M.
    Gene 257:223-232(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    Strain: BALB/c.
    Tissue: Brain.
  2. "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling."
    Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., Williams R.S.
    J. Biol. Chem. 275:8719-8725(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
  3. "Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis."
    Casas C., Martinez S., Pritchard M.A., Fuentes J.J., Nadal M., Guimera J., Arbones M., Florez J., Soriano E., Estivill X., Alcantara S.
    Mech. Dev. 101:289-292(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
    Tissue: Fetal brain.
  4. "Down syndrome candidate region 1 (Dscr1), one of three alternatively spliced exon 1 transcripts."
    Fuentes J.J., Pritchard M.A., Pucharcos C., Estivill X.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Tissue: Kidney.
  7. "Solution structure of RRM domain in calcipressin 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2004) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 14-103.

Entry informationi

Entry nameiRCAN1_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG6
Secondary accession number(s): Q91WQ4
, Q9JK50, Q9JK51, Q9JKK2, Q9JKK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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