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Q9JHG6

- RCAN1_MOUSE

UniProt

Q9JHG6 - RCAN1_MOUSE

Protein

Calcipressin-1

Gene

Rcan1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. calcineurin-NFAT signaling cascade Source: MGI
    2. locomotion involved in locomotory behavior Source: MGI
    3. regulation of phosphoprotein phosphatase activity Source: MGI
    4. response to ischemia Source: MGI
    5. response to oxidative stress Source: MGI
    6. short-term memory Source: MGI
    7. skeletal muscle fiber development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcipressin-1
    Alternative name(s):
    Down syndrome critical region protein 1 homolog
    Myocyte-enriched calcineurin-interacting protein 1
    Short name:
    MCIP1
    Regulator of calcineurin 1
    Gene namesi
    Name:Rcan1
    Synonyms:Dscr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1890564. Rcan1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Calcipressin-1PRO_0000211415Add
    BLAST

    Proteomic databases

    MaxQBiQ9JHG6.
    PaxDbiQ9JHG6.
    PRIDEiQ9JHG6.

    PTM databases

    PhosphoSiteiQ9JHG6.

    Expressioni

    Tissue specificityi

    Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.

    Gene expression databases

    ArrayExpressiQ9JHG6.
    BgeeiQ9JHG6.
    CleanExiMM_RCAN1.
    GenevestigatoriQ9JHG6.

    Interactioni

    Subunit structurei

    Interacts with RAF1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dyrk1aQ612142EBI-644061,EBI-80344
    Fmr1P359223EBI-644061,EBI-645094

    Protein-protein interaction databases

    BioGridi207725. 1 interaction.
    IntActiQ9JHG6. 4 interactions.
    MINTiMINT-1678164.

    Structurei

    Secondary structure

    1
    198
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi29 – 379
    Beta strandi44 – 485
    Turni49 – 524
    Beta strandi53 – 575
    Helixi63 – 697
    Beta strandi74 – 763
    Beta strandi82 – 843

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WEYNMR-A29-103[»]
    ProteinModelPortaliQ9JHG6.
    SMRiQ9JHG6. Positions 11-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9JHG6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RCAN family.Curated

    Phylogenomic databases

    eggNOGiNOG87330.
    GeneTreeiENSGT00400000022053.
    HOGENOMiHOG000254788.
    HOVERGENiHBG018932.
    InParanoidiQ9JHG6.
    KOiK17901.
    OMAiACVANSE.
    PhylomeDBiQ9JHG6.

    Family and domain databases

    InterProiIPR006931. Calcipressin.
    [Graphical view]
    PANTHERiPTHR10300. PTHR10300. 1 hit.
    PfamiPF04847. Calcipressin. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform A (identifier: Q9JHG6-1) [UniParc]FASTAAdd to Basket

    Also known as: 1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEVDLQDLP SATIACHLDP RVFVDGLCRA KFESLFRTYD KDTTFQYFKS    50
    FKRVRINFSN PLSAADARLR LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN 100
    PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT 150
    DTTPSVVVHV CESDQENEEE EEEMERMKRP KPKIIQTRRP EYTPIHLS 198
    Length:198
    Mass (Da):22,706
    Last modified:October 1, 2000 - v1
    Checksum:iBA35340AFD6F0582
    GO
    Isoform B (identifier: Q9JHG6-2) [UniParc]FASTAAdd to Basket

    Also known as: 4

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: MEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET

    Show »
    Length:198
    Mass (Da):22,851
    Checksum:iF017C68F18ACC187
    GO
    Isoform C (identifier: Q9JHG6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-80: Missing.

    Show »
    Length:118
    Mass (Da):13,378
    Checksum:iDC4A1EE03245E50B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521T → P in AAF63485. (PubMed:10722714)Curated
    Sequence conflicti152 – 1521T → P in AAF63486. (PubMed:10722714)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8080Missing in isoform C. 2 PublicationsVSP_001318Add
    BLAST
    Alternative sequencei1 – 2828MEEVD…VDGLC → MHFRDFSYNFSSLIACVAND DVFSESET in isoform B. 3 PublicationsVSP_001317Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282255 mRNA. Translation: AAF91461.1.
    AF237789 mRNA. Translation: AAF63485.1.
    AF237790 mRNA. Translation: AAF63486.1.
    AF260717 mRNA. Translation: AAF70343.1.
    AF263239 mRNA. Translation: AAF72701.1.
    AF263240 mRNA. Translation: AAF72702.1.
    AK010696 mRNA. Translation: BAB27128.1.
    BC013551 mRNA. Translation: AAH13551.1.
    CCDSiCCDS28337.1. [Q9JHG6-2]
    RefSeqiNP_062339.2. NM_019466.4. [Q9JHG6-2]
    UniGeneiMm.265744.

    Genome annotation databases

    EnsembliENSMUST00000023672; ENSMUSP00000023672; ENSMUSG00000022951. [Q9JHG6-2]
    GeneIDi54720.
    KEGGimmu:54720.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF282255 mRNA. Translation: AAF91461.1 .
    AF237789 mRNA. Translation: AAF63485.1 .
    AF237790 mRNA. Translation: AAF63486.1 .
    AF260717 mRNA. Translation: AAF70343.1 .
    AF263239 mRNA. Translation: AAF72701.1 .
    AF263240 mRNA. Translation: AAF72702.1 .
    AK010696 mRNA. Translation: BAB27128.1 .
    BC013551 mRNA. Translation: AAH13551.1 .
    CCDSi CCDS28337.1. [Q9JHG6-2 ]
    RefSeqi NP_062339.2. NM_019466.4. [Q9JHG6-2 ]
    UniGenei Mm.265744.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WEY NMR - A 29-103 [» ]
    ProteinModelPortali Q9JHG6.
    SMRi Q9JHG6. Positions 11-103.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207725. 1 interaction.
    IntActi Q9JHG6. 4 interactions.
    MINTi MINT-1678164.

    PTM databases

    PhosphoSitei Q9JHG6.

    Proteomic databases

    MaxQBi Q9JHG6.
    PaxDbi Q9JHG6.
    PRIDEi Q9JHG6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023672 ; ENSMUSP00000023672 ; ENSMUSG00000022951 . [Q9JHG6-2 ]
    GeneIDi 54720.
    KEGGi mmu:54720.

    Organism-specific databases

    CTDi 1827.
    MGIi MGI:1890564. Rcan1.

    Phylogenomic databases

    eggNOGi NOG87330.
    GeneTreei ENSGT00400000022053.
    HOGENOMi HOG000254788.
    HOVERGENi HBG018932.
    InParanoidi Q9JHG6.
    KOi K17901.
    OMAi ACVANSE.
    PhylomeDBi Q9JHG6.

    Miscellaneous databases

    ChiTaRSi RCAN1. mouse.
    EvolutionaryTracei Q9JHG6.
    NextBioi 311564.
    PROi Q9JHG6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHG6.
    Bgeei Q9JHG6.
    CleanExi MM_RCAN1.
    Genevestigatori Q9JHG6.

    Family and domain databases

    InterProi IPR006931. Calcipressin.
    [Graphical view ]
    PANTHERi PTHR10300. PTHR10300. 1 hit.
    Pfami PF04847. Calcipressin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes."
      Strippoli P., Petrini M., Lenzi L., Carinci P., Zannotti M.
      Gene 257:223-232(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
      Strain: BALB/c.
      Tissue: Brain.
    2. "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling."
      Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., Williams R.S.
      J. Biol. Chem. 275:8719-8725(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
    3. "Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis."
      Casas C., Martinez S., Pritchard M.A., Fuentes J.J., Nadal M., Guimera J., Arbones M., Florez J., Soriano E., Estivill X., Alcantara S.
      Mech. Dev. 101:289-292(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
      Tissue: Fetal brain.
    4. "Down syndrome candidate region 1 (Dscr1), one of three alternatively spliced exon 1 transcripts."
      Fuentes J.J., Pritchard M.A., Pucharcos C., Estivill X.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Kidney.
    7. "Solution structure of RRM domain in calcipressin 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAY-2004) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 14-103.

    Entry informationi

    Entry nameiRCAN1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHG6
    Secondary accession number(s): Q91WQ4
    , Q9JK50, Q9JK51, Q9JKK2, Q9JKK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3