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Q9JHG6 (RCAN1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcipressin-1
Alternative name(s):
Down syndrome critical region protein 1 homolog
Myocyte-enriched calcineurin-interacting protein 1
Short name=MCIP1
Regulator of calcineurin 1
Gene names
Name:Rcan1
Synonyms:Dscr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Ref.3

Subunit structure

Interacts with RAF1 By similarity.

Tissue specificity

Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.

Sequence similarities

Belongs to the RCAN family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dyrk1aQ612142EBI-644061,EBI-80344
Fmr1P359223EBI-644061,EBI-645094

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform A (identifier: Q9JHG6-1)

Also known as: 1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9JHG6-2)

Also known as: 4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MEEVDLQDLPSATIACHLDPRVFVDGLC → MHFRDFSYNFSSLIACVANDDVFSESET
Isoform C (identifier: Q9JHG6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Calcipressin-1
PRO_0000211415

Natural variations

Alternative sequence1 – 8080Missing in isoform C.
VSP_001318
Alternative sequence1 – 2828MEEVD…VDGLC → MHFRDFSYNFSSLIACVAND DVFSESET in isoform B.
VSP_001317

Experimental info

Sequence conflict1521T → P in AAF63485. Ref.2
Sequence conflict1521T → P in AAF63486. Ref.2

Secondary structure

............. 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform A (1) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: BA35340AFD6F0582

FASTA19822,706
        10         20         30         40         50         60 
MEEVDLQDLP SATIACHLDP RVFVDGLCRA KFESLFRTYD KDTTFQYFKS FKRVRINFSN 

        70         80         90        100        110        120 
PLSAADARLR LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV 

       130        140        150        160        170        180 
EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQENEEE EEEMERMKRP 

       190 
KPKIIQTRRP EYTPIHLS 

« Hide

Isoform B (4) [UniParc].

Checksum: F017C68F18ACC187
Show »

FASTA19822,851
Isoform C [UniParc].

Checksum: DC4A1EE03245E50B
Show »

FASTA11813,378

References

« Hide 'large scale' references
[1]"The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes."
Strippoli P., Petrini M., Lenzi L., Carinci P., Zannotti M.
Gene 257:223-232(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
Strain: BALB/c.
Tissue: Brain.
[2]"A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling."
Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., Williams R.S.
J. Biol. Chem. 275:8719-8725(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
[3]"Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis."
Casas C., Martinez S., Pritchard M.A., Fuentes J.J., Nadal M., Guimera J., Arbones M., Florez J., Soriano E., Estivill X., Alcantara S.
Mech. Dev. 101:289-292(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
Tissue: Fetal brain.
[4]"Down syndrome candidate region 1 (Dscr1), one of three alternatively spliced exon 1 transcripts."
Fuentes J.J., Pritchard M.A., Pucharcos C., Estivill X.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B AND C).
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
Strain: C57BL/6J.
Tissue: Embryonic stem cell.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Tissue: Kidney.
[7]"Solution structure of RRM domain in calcipressin 1."
RIKEN structural genomics initiative (RSGI)
Submitted (MAY-2004) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 14-103.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF282255 mRNA. Translation: AAF91461.1.
AF237789 mRNA. Translation: AAF63485.1.
AF237790 mRNA. Translation: AAF63486.1.
AF260717 mRNA. Translation: AAF70343.1.
AF263239 mRNA. Translation: AAF72701.1.
AF263240 mRNA. Translation: AAF72702.1.
AK010696 mRNA. Translation: BAB27128.1.
BC013551 mRNA. Translation: AAH13551.1.
RefSeqNP_062339.2. NM_019466.4.
UniGeneMm.265744.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WEYNMR-A29-103[»]
ProteinModelPortalQ9JHG6.
SMRQ9JHG6. Positions 11-103.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207725. 1 interaction.
IntActQ9JHG6. 4 interactions.
MINTMINT-1678164.

PTM databases

PhosphoSiteQ9JHG6.

Proteomic databases

PaxDbQ9JHG6.
PRIDEQ9JHG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023672; ENSMUSP00000023672; ENSMUSG00000022951. [Q9JHG6-2]
GeneID54720.
KEGGmmu:54720.

Organism-specific databases

CTD1827.
MGIMGI:1890564. Rcan1.

Phylogenomic databases

eggNOGNOG87330.
GeneTreeENSGT00400000022053.
HOGENOMHOG000254788.
HOVERGENHBG018932.
InParanoidQ9JHG6.
KOK17901.
OMAACVANSE.
PhylomeDBQ9JHG6.

Gene expression databases

ArrayExpressQ9JHG6.
BgeeQ9JHG6.
CleanExMM_RCAN1.
GenevestigatorQ9JHG6.

Family and domain databases

InterProIPR006931. Calcipressin.
[Graphical view]
PANTHERPTHR10300. PTHR10300. 1 hit.
PfamPF04847. Calcipressin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRCAN1. mouse.
EvolutionaryTraceQ9JHG6.
NextBio311564.
PROQ9JHG6.
SOURCESearch...

Entry information

Entry nameRCAN1_MOUSE
AccessionPrimary (citable) accession number: Q9JHG6
Secondary accession number(s): Q91WQ4 expand/collapse secondary AC list , Q9JK50, Q9JK51, Q9JKK2, Q9JKK3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot