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Protein

Apelin receptor

Gene

Aplnr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11359874). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (By similarity).By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • peptide binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processAngiogenesis, Gastrulation

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Apelin receptor
Alternative name(s):
Angiotensin receptor-like 1
B78
G-protein coupled receptor APJ
GPCR34
Gene namesi
Name:Aplnr
Synonyms:Agtrl1, Apj
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621645 Aplnr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 53Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini54 – 64CytoplasmicSequence analysisAdd BLAST11
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 106ExtracellularSequence analysisAdd BLAST19
Transmembranei107 – 129Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini130 – 141CytoplasmicSequence analysisAdd BLAST12
Transmembranei142 – 164Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini165 – 200ExtracellularSequence analysisAdd BLAST36
Transmembranei201 – 223Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini224 – 242CytoplasmicSequence analysisAdd BLAST19
Transmembranei243 – 265Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini266 – 284ExtracellularSequence analysisAdd BLAST19
Transmembranei285 – 307Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini308 – 377CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691761 – 377Apelin receptorAdd BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9JHG3
PRIDEiQ9JHG3

PTM databases

PhosphoSitePlusiQ9JHG3

Expressioni

Tissue specificityi

Widely expressed. Highest expression in the lung, lower in the heart, placenta, ovary, skeletal muscle, mammary gland, kidney and several structures in the brain as the hypothalamus (supraoptic and periventricular nuclei), pituitary, olfactory bulb and pineal gland.1 Publication

Developmental stagei

Higher expression in neonates than in adult.1 Publication

Gene expression databases

BgeeiENSRNOG00000009227
GenevisibleiQ9JHG3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012379

Structurei

3D structure databases

ProteinModelPortaliQ9JHG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000234122
HOVERGENiHBG104998
InParanoidiQ9JHG3
KOiK04174
OMAiVMVFRST
OrthoDBiEOG091G0BIX
PhylomeDBiQ9JHG3
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR020279 Apelin_receptor_C
IPR003904 APJ_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01416 APJRECEPTOR
PR00237 GPCRRHODOPSN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD061381 Apelin_receptor_C, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDDGYNYYG ADNQSECDYA DWTPSGALIP AIYILVFLLG TTGNGLVLWT
60 70 80 90 100
VFWSSREKRR SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC
110 120 130 140 150
KLSSYLIFVN MYASVFCLTG LSFDRYLAIV RPVANARLRL RVSGAVATAV
160 170 180 190 200
LWVLAALLAV PVMVFRSTDI PENSTKTQCY MDYSMVATSN SEWAWEVGLG
210 220 230 240 250
VSSTAVGFVV PFIIMLTCYF FIAQTIAGHF RKERIEGLRK RRRLLSIIVV
260 270 280 290 300
LVVTFALCWM PYHLVKTLYM LGNLLHWPCD FDSFLMNVFP YCTCISYVNS
310 320 330 340 350
CLNPFLYAFF DPRFRRACTS MLCCDQSGCK GSPHSSSAEK SASYSSGHSQ
360 370
GPGPNMCKGG EPMHEKSIPY SQETLVD
Length:377
Mass (Da):42,349
Last modified:October 1, 2000 - v1
Checksum:iC43F81EBC3855BB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117C → W in AAG24468 (Ref. 5) Curated1
Sequence conflicti187A → G in AAG24468 (Ref. 5) Curated1
Sequence conflicti198G → R in AAG24468 (Ref. 5) Curated1
Sequence conflicti251L → P in AAG24468 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033170 mRNA Translation: BAA95002.1
AF184883 mRNA Translation: AAF80860.1
BC072494 mRNA Translation: AAH72494.1
AF090346 mRNA Translation: AAG24468.1
RefSeqiNP_112639.1, NM_031349.2
UniGeneiRn.7965

Genome annotation databases

EnsembliENSRNOT00000012379; ENSRNOP00000012379; ENSRNOG00000009227
GeneIDi83518
KEGGirno:83518
UCSCiRGD:621645 rat

Similar proteinsi

Entry informationi

Entry nameiAPJ_RAT
AccessioniPrimary (citable) accession number: Q9JHG3
Secondary accession number(s): Q9ESK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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