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Protein

Calcipressin-2

Gene

Rcan2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

GO - Molecular functioni

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: MGI
  • locomotion involved in locomotory behavior Source: MGI
  • Notch signaling pathway Source: MGI
  • response to oxidative stress Source: MGI
  • short-term memory Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Calcineurin inhibitory protein ZAKI-4
Down syndrome candidate region 1-like protein 1
Myocyte-enriched calcineurin-interacting protein 2
Short name:
MCIP2
Regulator of calcineurin 2
Gene namesi
Name:Rcan2
Synonyms:Dscr1l1, Zaki4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1858219. Rcan2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Calcipressin-2PRO_0000211418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JHG2.
PRIDEiQ9JHG2.

PTM databases

iPTMnetiQ9JHG2.
PhosphoSiteiQ9JHG2.

Expressioni

Tissue specificityi

Highest expression in heart, skeletal muscle and brain. Lower expression in all other tissues.

Gene expression databases

BgeeiQ9JHG2.
CleanExiMM_RCAN2.
ExpressionAtlasiQ9JHG2. baseline and differential.
GenevisibleiQ9JHG2. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9JHG2.
SMRiQ9JHG2. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ9JHG2.
KOiK17903.
PhylomeDBiQ9JHG2.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS
60 70 80 90 100
FRRVRINFSH PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WKPISDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDME EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):22,025
Last modified:October 1, 2000 - v1
Checksum:iCE1306B7B03E70F1
GO

Sequence cautioni

The sequence BAB71955.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771R → K in BAB71955 (Ref. 3) Curated
Sequence conflicti132 – 1321N → K in BAB71955 (Ref. 3) Curated
Sequence conflicti177 – 1771T → N in BAB71955 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237791 mRNA. Translation: AAF63487.1.
AF237887 mRNA. Translation: AAF62538.1.
AB061524 mRNA. Translation: BAB71955.1. Different initiation.
BC047153 mRNA. Translation: AAH47153.1.
BC049096 mRNA. Translation: AAH49096.1.
BC062141 mRNA. Translation: AAH62141.1.
CCDSiCCDS28801.1.
RefSeqiNP_001273583.1. NM_001286654.1.
NP_085101.1. NM_030598.2.
NP_997532.1. NM_207649.1.
UniGeneiMm.251242.

Genome annotation databases

EnsembliENSMUST00000044792; ENSMUSP00000048013; ENSMUSG00000039601.
ENSMUST00000177857; ENSMUSP00000137211; ENSMUSG00000039601.
GeneIDi53901.
KEGGimmu:53901.
UCSCiuc008cpp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237791 mRNA. Translation: AAF63487.1.
AF237887 mRNA. Translation: AAF62538.1.
AB061524 mRNA. Translation: BAB71955.1. Different initiation.
BC047153 mRNA. Translation: AAH47153.1.
BC049096 mRNA. Translation: AAH49096.1.
BC062141 mRNA. Translation: AAH62141.1.
CCDSiCCDS28801.1.
RefSeqiNP_001273583.1. NM_001286654.1.
NP_085101.1. NM_030598.2.
NP_997532.1. NM_207649.1.
UniGeneiMm.251242.

3D structure databases

ProteinModelPortaliQ9JHG2.
SMRiQ9JHG2. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9JHG2.
PhosphoSiteiQ9JHG2.

Proteomic databases

MaxQBiQ9JHG2.
PRIDEiQ9JHG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044792; ENSMUSP00000048013; ENSMUSG00000039601.
ENSMUST00000177857; ENSMUSP00000137211; ENSMUSG00000039601.
GeneIDi53901.
KEGGimmu:53901.
UCSCiuc008cpp.1. mouse.

Organism-specific databases

CTDi10231.
MGIiMGI:1858219. Rcan2.

Phylogenomic databases

GeneTreeiENSGT00400000022053.
HOGENOMiHOG000254788.
HOVERGENiHBG018932.
InParanoidiQ9JHG2.
KOiK17903.
PhylomeDBiQ9JHG2.

Miscellaneous databases

ChiTaRSiRcan2. mouse.
PROiQ9JHG2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JHG2.
CleanExiMM_RCAN2.
ExpressionAtlasiQ9JHG2. baseline and differential.
GenevisibleiQ9JHG2. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling."
    Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., Williams R.S.
    J. Biol. Chem. 275:8719-8725(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes."
    Strippoli P., Petrini M., Lenzi L., Carinci P., Zannotti M.
    Gene 257:223-232(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  3. "Calcineurin inhibitory protein ZAKI-4."
    Kanou Y., Miyazaki T., Seo H., Murata Y.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Eye.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRCAN2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG2
Secondary accession number(s): Q8VIP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.