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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Gene

Pigp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi2.4.1.198. 3474.
ReactomeiR-MMU-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC:2.4.1.198)
Alternative name(s):
Down syndrome critical region protein 5 homolog
Phosphatidylinositol-glycan biosynthesis class P protein
Short name:
PIG-P
Gene namesi
Name:Pigp
Synonyms:Dcrc, Dscr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1860433. Pigp.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Phosphatidylinositol N-acetylglucosaminyltransferase subunit PPRO_0000191784Add
BLAST

Proteomic databases

PaxDbiQ9JHG1.
PRIDEiQ9JHG1.

PTM databases

iPTMnetiQ9JHG1.
PhosphoSiteiQ9JHG1.

Expressioni

Tissue specificityi

Expressed in tongue.1 Publication

Gene expression databases

BgeeiQ9JHG1.
ExpressionAtlasiQ9JHG1. baseline.
GenevisibleiQ9JHG1. MM.

Interactioni

Subunit structurei

Associates with PIGA, PIGC, PIGH, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109547.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2257. Eukaryota.
ENOG41121KH. LUCA.
GeneTreeiENSGT00390000013771.
HOGENOMiHOG000007030.
HOVERGENiHBG000430.
InParanoidiQ9JHG1.
KOiK03861.
PhylomeDBiQ9JHG1.

Family and domain databases

InterProiIPR013717. PIG-P.
IPR016542. PIG-P_GPI19.
[Graphical view]
PfamiPF08510. PIG-P. 1 hit.
[Graphical view]
PIRSFiPIRSF008765. PIG-P_GPI19. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVENSPSPLP ERAIYGFVLF LSSQFGFILY LVWAFVPESW LNSLGLTYWP
60 70 80 90 100
QKYWAVALPV YLLITVVIGY VLLFGINMMS TSPLDSIHTI TDNYAKNQQR
110 120 130
KNYQEDAIPA LRDVPISEVN KMFFLGAKEL NT
Length:132
Mass (Da):15,101
Last modified:October 1, 2000 - v1
Checksum:iD21472651F850F9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216306 mRNA. Translation: AAF32294.1.
AF216307 mRNA. Translation: AAF32295.1.
AF216308 mRNA. Translation: AAF32296.1.
AF216309 mRNA. Translation: AAF32297.1.
AK004169 mRNA. Translation: BAB23204.1.
BC038252 mRNA. Translation: AAH38252.1.
BC061116 mRNA. Translation: AAH61116.1.
BC096569 mRNA. Translation: AAH96569.1.
CCDSiCCDS28348.1.
RefSeqiNP_001153088.1. NM_001159616.1.
NP_001153089.1. NM_001159617.1.
NP_001153090.1. NM_001159618.1.
NP_001153091.1. NM_001159619.1.
NP_062416.1. NM_019543.3.
UniGeneiMm.474449.

Genome annotation databases

EnsembliENSMUST00000113905; ENSMUSP00000109538; ENSMUSG00000022940.
ENSMUST00000113906; ENSMUSP00000109539; ENSMUSG00000022940.
GeneIDi56176.
KEGGimmu:56176.
UCSCiuc008aan.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

PIG-P_DCRC-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216306 mRNA. Translation: AAF32294.1.
AF216307 mRNA. Translation: AAF32295.1.
AF216308 mRNA. Translation: AAF32296.1.
AF216309 mRNA. Translation: AAF32297.1.
AK004169 mRNA. Translation: BAB23204.1.
BC038252 mRNA. Translation: AAH38252.1.
BC061116 mRNA. Translation: AAH61116.1.
BC096569 mRNA. Translation: AAH96569.1.
CCDSiCCDS28348.1.
RefSeqiNP_001153088.1. NM_001159616.1.
NP_001153089.1. NM_001159617.1.
NP_001153090.1. NM_001159618.1.
NP_001153091.1. NM_001159619.1.
NP_062416.1. NM_019543.3.
UniGeneiMm.474449.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109547.

PTM databases

iPTMnetiQ9JHG1.
PhosphoSiteiQ9JHG1.

Proteomic databases

PaxDbiQ9JHG1.
PRIDEiQ9JHG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113905; ENSMUSP00000109538; ENSMUSG00000022940.
ENSMUST00000113906; ENSMUSP00000109539; ENSMUSG00000022940.
GeneIDi56176.
KEGGimmu:56176.
UCSCiuc008aan.2. mouse.

Organism-specific databases

CTDi51227.
MGIiMGI:1860433. Pigp.

Phylogenomic databases

eggNOGiKOG2257. Eukaryota.
ENOG41121KH. LUCA.
GeneTreeiENSGT00390000013771.
HOGENOMiHOG000007030.
HOVERGENiHBG000430.
InParanoidiQ9JHG1.
KOiK03861.
PhylomeDBiQ9JHG1.

Enzyme and pathway databases

UniPathwayiUPA00196.
BRENDAi2.4.1.198. 3474.
ReactomeiR-MMU-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

PROiQ9JHG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JHG1.
ExpressionAtlasiQ9JHG1. baseline.
GenevisibleiQ9JHG1. MM.

Family and domain databases

InterProiIPR013717. PIG-P.
IPR016542. PIG-P_GPI19.
[Graphical view]
PfamiPF08510. PIG-P. 1 hit.
[Graphical view]
PIRSFiPIRSF008765. PIG-P_GPI19. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome critical region gene 5)."
    Choi D.K., Suzuki Y., Yoshimura S., Togashi T., Hida M., Taylor T.D., Wang Y., Sugano S., Hattori M., Sakaki Y.
    Mamm. Genome 12:347-351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain, Salivary gland and Thymus.

Entry informationi

Entry nameiPIGP_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.