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Protein

Cerebellin-3

Gene

Cbln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in synaptic functions in the CNS.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellin-3
Gene namesi
Name:Cbln3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1889286. Cbln3.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • extracellular space Source: MGI
  • Golgi apparatus Source: UniProtKB-SubCell
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Endoplasmic reticulum, Golgi apparatus, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi119 – 1191R → A: Promotes self-association and secretion independent of CBLN1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 197173Cerebellin-3PRO_0000003555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 – 37InterchainBy similarity
Disulfide bondi41 – 41InterchainBy similarity
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JHG0.
PaxDbiQ9JHG0.
PeptideAtlasiQ9JHG0.
PRIDEiQ9JHG0.

PTM databases

PhosphoSiteiQ9JHG0.

Expressioni

Tissue specificityi

Expressed in brain, restricted to the cerebellar cortex. Within the cerebellum, expressed in granule layers (at protein level). Also detected in postsynaptic Purkinje cell spines (at protein level).2 Publications

Developmental stagei

In the developing brain, selectively expressed as early as postnatal day 7-10 in cerebellar granule cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000040380.
CleanExiMM_CBLN3.
GenevisibleiQ9JHG0. MM.

Interactioni

Subunit structurei

Heterohexamer; disulfide-linked heterotrimers (By similarity). Interacts with CBLN1. May also form oligomers with CBLN2 AND CBLN4.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070494.

Structurei

3D structure databases

ProteinModelPortaliQ9JHG0.
SMRiQ9JHG0. Positions 63-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 197139C1qPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 197134Necessary for interaction with CBLN3, and homotrimerizationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J973. Eukaryota.
ENOG4111BES. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ9JHG0.
OMAiWAQEGTE.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ9JHG0.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTEWHKPKL SLALVLLTLE AGWAQEGSEP VLLEGECLVV CEPGRPTAGG
60 70 80 90 100
PGGAALGEAP PGRVAFAAVR SHHHEPAGET GNGTSGAIYF DQVLVNEGEG
110 120 130 140 150
FDRTSGCFVA PVRGVYSFRF HVVKVYNRQT VQVSLMLNTW PVISAFANDP
160 170 180 190
DVTREAATSS VLLPLDPGDR VSLRLRRGNL LGGWKYSSFS GFLIFPL
Length:197
Mass (Da):21,077
Last modified:October 1, 2000 - v1
Checksum:iDBA8925C9BB11B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218380 Genomic DNA. Translation: AAF32315.1.
AF218379 mRNA. Translation: AAF32314.1.
BC065108 mRNA. Translation: AAH65108.1.
CCDSiCCDS27133.1.
RefSeqiNP_062794.1. NM_019820.3.
UniGeneiMm.97163.

Genome annotation databases

EnsembliENSMUST00000063871; ENSMUSP00000070494; ENSMUSG00000040380.
ENSMUST00000172378; ENSMUSP00000127798; ENSMUSG00000040380.
GeneIDi56410.
KEGGimmu:56410.
UCSCiuc007uba.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218380 Genomic DNA. Translation: AAF32315.1.
AF218379 mRNA. Translation: AAF32314.1.
BC065108 mRNA. Translation: AAH65108.1.
CCDSiCCDS27133.1.
RefSeqiNP_062794.1. NM_019820.3.
UniGeneiMm.97163.

3D structure databases

ProteinModelPortaliQ9JHG0.
SMRiQ9JHG0. Positions 63-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070494.

PTM databases

PhosphoSiteiQ9JHG0.

Proteomic databases

MaxQBiQ9JHG0.
PaxDbiQ9JHG0.
PeptideAtlasiQ9JHG0.
PRIDEiQ9JHG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063871; ENSMUSP00000070494; ENSMUSG00000040380.
ENSMUST00000172378; ENSMUSP00000127798; ENSMUSG00000040380.
GeneIDi56410.
KEGGimmu:56410.
UCSCiuc007uba.1. mouse.

Organism-specific databases

CTDi643866.
MGIiMGI:1889286. Cbln3.

Phylogenomic databases

eggNOGiENOG410J973. Eukaryota.
ENOG4111BES. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085657.
HOVERGENiHBG108329.
InParanoidiQ9JHG0.
OMAiWAQEGTE.
OrthoDBiEOG091G0XK2.
PhylomeDBiQ9JHG0.
TreeFamiTF329591.

Miscellaneous databases

PROiQ9JHG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040380.
CleanExiMM_CBLN3.
GenevisibleiQ9JHG0. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBLN3_MOUSE
AccessioniPrimary (citable) accession number: Q9JHG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.