SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JHF9

- LY96_MOUSE

UniProt

Q9JHF9 - LY96_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Lymphocyte antigen 96
Gene
Ly96, Esop1, Md2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS By similarity.

GO - Molecular functioni

  1. lipopolysaccharide receptor activity Source: UniProtKB
  2. protein binding Source: IntAct

GO - Biological processi

  1. detection of lipopolysaccharide Source: UniProtKB
  2. inflammatory response Source: UniProtKB-KW
  3. innate immune response Source: UniProtKB-KW
  4. positive regulation of lipopolysaccharide-mediated signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_196636. TRIF-mediated programmed cell death.
REACT_198539. TRAF6 mediated induction of TAK1 complex.
REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_226192. IKK complex recruitment mediated by RIP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 96
Short name:
Ly-96
Alternative name(s):
ESOP-1
Protein MD-2
Gene namesi
Name:Ly96
Synonyms:Esop1, Md2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1341909. Ly96.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
  2. lipopolysaccharide receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 160142Lymphocyte antigen 96
PRO_0000018620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 511 Publication
Glycosylationi26 – 261N-linked (GlcNAc...)1 Publication
Disulfide bondi37 ↔ 1481 Publication
Disulfide bondi95 ↔ 1051 Publication
Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication
Glycosylationi150 – 1501N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JHF9.

PTM databases

PhosphoSiteiQ9JHF9.

Expressioni

Tissue specificityi

Highly expressed in spleen, bone marrow, thymus, liver, kidney, ovary and decidua. Detected at lower levels in testis, small intestine and skin.

Gene expression databases

ArrayExpressiQ9JHF9.
BgeeiQ9JHF9.
CleanExiMM_LY96.
GenevestigatoriQ9JHF9.

Interactioni

Subunit structurei

Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tlr4Q9QUK63EBI-1534566,EBI-1534575

Protein-protein interaction databases

DIPiDIP-38572N.
IntActiQ9JHF9. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 264
Beta strandi31 – 377
Beta strandi44 – 507
Beta strandi57 – 659
Beta strandi74 – 829
Beta strandi90 – 945
Beta strandi97 – 993
Helixi103 – 1064
Beta strandi113 – 1219
Beta strandi128 – 13912
Turni140 – 1423
Beta strandi145 – 15410

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z64X-ray2.84C21-155[»]
3VQ1X-ray2.70C/D17-160[»]
3VQ2X-ray2.48C/D17-160[»]
ProteinModelPortaliQ9JHF9.
SMRiQ9JHF9. Positions 21-155.

Miscellaneous databases

EvolutionaryTraceiQ9JHF9.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46291.
GeneTreeiENSGT00390000000742.
HOGENOMiHOG000001152.
HOVERGENiHBG032514.
InParanoidiQ9JHF9.
KOiK05400.
OMAiIPRRDIK.
OrthoDBiEOG7QG45N.
PhylomeDBiQ9JHF9.
TreeFamiTF335876.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHF9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPFILFSTL LSPILTESEK QQWFCNSSDA IISYSYCDHL KFPISISSEP    50
CIRLRGTNGF VHVEFIPRGN LKYLYFNLFI SVNSIELPKR KEVLCHGHDD 100
DYSFCRALKG ETVNTSIPFS FEGILFPKGH YRCVAEAIAG DTEEKLFCLN 150
FTIIHRRDVN 160
Length:160
Mass (Da):18,394
Last modified:October 1, 2000 - v1
Checksum:iE224D17E5D5429E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168120 mRNA. Translation: AAF89634.1.
AB018550 mRNA. Translation: BAA93619.1.
AK019283 mRNA. Translation: BAB31645.1.
CCDSiCCDS14832.1.
RefSeqiNP_001153183.1. NM_001159711.1.
NP_058619.1. NM_016923.2.
XP_006495518.1. XM_006495455.1.
XP_006495519.1. XM_006495456.1.
UniGeneiMm.116844.

Genome annotation databases

EnsembliENSMUST00000026881; ENSMUSP00000026881; ENSMUSG00000025779.
GeneIDi17087.
KEGGimmu:17087.
UCSCiuc007ajz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF168120 mRNA. Translation: AAF89634.1 .
AB018550 mRNA. Translation: BAA93619.1 .
AK019283 mRNA. Translation: BAB31645.1 .
CCDSi CCDS14832.1.
RefSeqi NP_001153183.1. NM_001159711.1.
NP_058619.1. NM_016923.2.
XP_006495518.1. XM_006495455.1.
XP_006495519.1. XM_006495456.1.
UniGenei Mm.116844.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Z64 X-ray 2.84 C 21-155 [» ]
3VQ1 X-ray 2.70 C/D 17-160 [» ]
3VQ2 X-ray 2.48 C/D 17-160 [» ]
ProteinModelPortali Q9JHF9.
SMRi Q9JHF9. Positions 21-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-38572N.
IntActi Q9JHF9. 1 interaction.

Chemistry

ChEMBLi CHEMBL3038514.

PTM databases

PhosphoSitei Q9JHF9.

Proteomic databases

PRIDEi Q9JHF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026881 ; ENSMUSP00000026881 ; ENSMUSG00000025779 .
GeneIDi 17087.
KEGGi mmu:17087.
UCSCi uc007ajz.2. mouse.

Organism-specific databases

CTDi 23643.
MGIi MGI:1341909. Ly96.

Phylogenomic databases

eggNOGi NOG46291.
GeneTreei ENSGT00390000000742.
HOGENOMi HOG000001152.
HOVERGENi HBG032514.
InParanoidi Q9JHF9.
KOi K05400.
OMAi IPRRDIK.
OrthoDBi EOG7QG45N.
PhylomeDBi Q9JHF9.
TreeFami TF335876.

Enzyme and pathway databases

Reactomei REACT_196636. TRIF-mediated programmed cell death.
REACT_198539. TRAF6 mediated induction of TAK1 complex.
REACT_225463. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
REACT_226192. IKK complex recruitment mediated by RIP1.

Miscellaneous databases

ChiTaRSi LY96. mouse.
EvolutionaryTracei Q9JHF9.
NextBioi 291228.
PROi Q9JHF9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JHF9.
Bgeei Q9JHF9.
CleanExi MM_LY96.
Genevestigatori Q9JHF9.

Family and domain databases

Gene3Di 2.60.40.770. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view ]
Pfami PF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view ]
SMARTi SM00737. ML. 1 hit.
[Graphical view ]
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice."
    Kato K., Morrison A.M., Nakano T., Tashiro K., Honjo T.
    Blood 96:362-364(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cell surface expression and lipopolysaccaride signaling via the Toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages."
    Akashi S., Shimazu R., Ogata H., Nagai Y., Takeda K., Kimoto M., Miyake K.
    J. Immunol. 164:3471-3475(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran."
    Kim H.M., Park B.S., Kim J.-I., Kim S.E., Lee J., Oh S.C., Enkhbayar P., Matsushima N., Lee H., Yoo O.J., Lee J.-O.
    Cell 130:906-917(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.84 ANGSTROMS) OF 21-155 IN COMPLEX WITH TLR4, GLYCOSYLATION AT ASN-26; ASN-114 AND ASN-150, DISULFIDE BONDS.

Entry informationi

Entry nameiLY96_MOUSE
AccessioniPrimary (citable) accession number: Q9JHF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi