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Protein
Submitted name:

Inducible prostaglandin E synthase

Gene

Ptges

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glutathione binding Source: Ensembl
  2. prostaglandin-E synthase activity Source: RGD

GO - Biological processi

  1. acute inflammatory response Source: RGD
  2. chronic inflammatory response Source: RGD
  3. negative regulation of cell proliferation Source: Ensembl
  4. prostaglandin biosynthetic process Source: RGD
  5. response to calcium ion Source: RGD
  6. response to cytokine Source: RGD
  7. response to lipopolysaccharide Source: RGD
  8. response to organic cyclic compound Source: RGD
  9. response to retinoic acid Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_320384. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Submitted name:
Inducible prostaglandin E synthaseImported
Submitted name:
PGE synthaseImported
Submitted name:
PIG12 proteinImported
Submitted name:
Prostaglandin E synthaseImported
Submitted name:
Protein PtgesImported
Gene namesi
Name:PtgesImported
Synonyms:iPGESImported, PGESImported, PIG12Imported
ORF Names:rCG_45741Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi62076. Ptges.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: Ensembl
  2. intracellular membrane-bounded organelle Source: RGD
  3. nuclear envelope lumen Source: Ensembl
  4. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9JHF3. baseline and differential.
GenevestigatoriQ9JHF3.

Structurei

3D structure databases

ProteinModelPortaliQ9JHF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ9JHF3.
KOiK15729.
OMAiKMYVVAV.
OrthoDBiEOG7288T0.
PhylomeDBiQ9JHF3.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLGLVMEN SQVLPAFLLC STLLVIKMYA VAVITGQVRL RKKAFANPED
60 70 80 90 100
ALKRGGLQYC RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA
110 120 130 140 150
WIHFLVVLTG RVVHTVAYLG KMNPRIRSGA YVLAQFACFS MALQILWEVA

HHL
Length:153
Mass (Da):17,273
Last modified:September 30, 2000 - v1
Checksum:iEA2E91E143CD7886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06022145 Genomic DNA. No translation available.
AF280967 mRNA. Translation: AAG24803.1.
BC105858 mRNA. Translation: AAI05859.1.
AB035145 mRNA. Translation: BAA95808.1.
AB041998 mRNA. Translation: BAA96084.1.
AB048730 mRNA. Translation: BAB20597.1.
CH474001 Genomic DNA. Translation: EDL93288.1.
RefSeqiNP_067594.1. NM_021583.3.
UniGeneiRn.7730.

Genome annotation databases

EnsembliENSRNOT00000045993; ENSRNOP00000044191; ENSRNOG00000006320.
GeneIDi59103.
KEGGirno:59103.
UCSCiRGD:62076. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06022145 Genomic DNA. No translation available.
AF280967 mRNA. Translation: AAG24803.1.
BC105858 mRNA. Translation: AAI05859.1.
AB035145 mRNA. Translation: BAA95808.1.
AB041998 mRNA. Translation: BAA96084.1.
AB048730 mRNA. Translation: BAB20597.1.
CH474001 Genomic DNA. Translation: EDL93288.1.
RefSeqiNP_067594.1. NM_021583.3.
UniGeneiRn.7730.

3D structure databases

ProteinModelPortaliQ9JHF3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045993; ENSRNOP00000044191; ENSRNOG00000006320.
GeneIDi59103.
KEGGirno:59103.
UCSCiRGD:62076. rat.

Organism-specific databases

CTDi9536.
RGDi62076. Ptges.

Phylogenomic databases

GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
InParanoidiQ9JHF3.
KOiK15729.
OMAiKMYVVAV.
OrthoDBiEOG7288T0.
PhylomeDBiQ9JHF3.

Enzyme and pathway databases

ReactomeiREACT_320384. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi611727.

Gene expression databases

ExpressionAtlasiQ9JHF3. baseline and differential.
GenevestigatoriQ9JHF3.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2."
    Murakami M., Naraba H., Tanioka T., Semmyo N., Nakatani Y., Kojima F., Ikeda T., Fueki M., Ueno A., Oh S., Kudo I.
    J. Biol. Chem. 275:32783-32792(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
  2. "Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes."
    Satoh K., Nagano Y., Shimomura C., Suzuki N., Saeki Y., Yokota H.
    Neurosci. Lett. 283:221-223(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: BrainImported.
  3. "inducible prostaglandin E synthase mRNA."
    Yamagata K.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
    Tissue: TestisImported.
  4. "Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis."
    Mancini J.A., Blood K., Guay J., Gordon R., Claveau D., Chan C.C., Riendeau D.
    J. Biol. Chem. 276:4469-4475(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  6. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  9. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JHF3_RAT
AccessioniPrimary (citable) accession number: Q9JHF3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2000
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.