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Protein
Submitted name:

Inducible prostaglandin E synthase

Gene

Ptges

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • glutathione binding Source: Ensembl
  • prostaglandin-E synthase activity Source: RGD

GO - Biological processi

  • acute inflammatory response Source: RGD
  • chronic inflammatory response Source: RGD
  • negative regulation of cell proliferation Source: Ensembl
  • prostaglandin biosynthetic process Source: RGD
  • response to calcium ion Source: RGD
  • response to cytokine Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to retinoic acid Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Submitted name:
Inducible prostaglandin E synthaseImported
Submitted name:
PGE synthaseImported
Submitted name:
PIG12 proteinImported
Submitted name:
Prostaglandin E synthaseImported
Gene namesi
Name:PtgesImported
Synonyms:iPGESImported, PGESImported, PIG12Imported
ORF Names:rCG_45741Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi62076 Ptges

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei131 – 150HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000006320

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044191

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IY81 Eukaryota
ENOG4111VJG LUCA
GeneTreeiENSGT00390000011980
HOGENOMiHOG000231759
HOVERGENiHBG052470
KOiK15729
OMAiCFSMALQ
OrthoDBiEOG091G14I4

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JHF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLGLVMEN SQVLPAFLLC STLLVIKMYA VAVITGQVRL RKKAFANPED
60 70 80 90 100
ALKRGGLQYC RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA
110 120 130 140 150
WIHFLVVLTG RVVHTVAYLG KMNPRIRSGA YVLAQFACFS MALQILWEVA

HHL
Length:153
Mass (Da):17,273
Last modified:October 1, 2000 - v1
Checksum:iEA2E91E143CD7886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125306 Genomic DNA No translation available.
AF280967 mRNA Translation: AAG24803.1
BC105858 mRNA Translation: AAI05859.1
AB035145 mRNA Translation: BAA95808.1
AB041998 mRNA Translation: BAA96084.1
AB048730 mRNA Translation: BAB20597.1
CH474001 Genomic DNA Translation: EDL93288.1
RefSeqiNP_067594.1, NM_021583.3
UniGeneiRn.7730

Genome annotation databases

EnsembliENSRNOT00000045993; ENSRNOP00000044191; ENSRNOG00000006320
GeneIDi59103
KEGGirno:59103
UCSCiRGD:62076 rat

Similar proteinsi

Entry informationi

Entry nameiQ9JHF3_RAT
AccessioniPrimary (citable) accession number: Q9JHF3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health