Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JHF3

- Q9JHF3_RAT

UniProt

Q9JHF3 - Q9JHF3_RAT

Protein
Submitted name:

Inducible prostaglandin E synthase

Gene

Ptges

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. glutathione binding Source: Ensembl
    2. prostaglandin-E synthase activity Source: RGD

    GO - Biological processi

    1. acute inflammatory response Source: RGD
    2. chronic inflammatory response Source: RGD
    3. negative regulation of cell proliferation Source: Ensembl
    4. prostaglandin biosynthetic process Source: RGD
    5. response to calcium ion Source: RGD
    6. response to cytokine Source: RGD
    7. response to lipopolysaccharide Source: RGD
    8. response to organic cyclic compound Source: RGD
    9. response to retinoic acid Source: RGD

    Enzyme and pathway databases

    ReactomeiREACT_194948. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Inducible prostaglandin E synthaseImported
    Submitted name:
    PGE synthaseImported
    Submitted name:
    PIG12 proteinImported
    Submitted name:
    Prostaglandin E synthaseImported
    Submitted name:
    Protein PtgesImported
    Gene namesi
    Name:PtgesImported
    Synonyms:iPGESImported, PGESImported, PIG12Imported
    ORF Names:rCG_45741Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi62076. Ptges.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: Ensembl
    2. intracellular membrane-bounded organelle Source: RGD
    3. nuclear envelope lumen Source: Ensembl
    4. perinuclear region of cytoplasm Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JHF3.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000011980.
    HOGENOMiHOG000231759.
    HOVERGENiHBG052470.
    KOiK15729.
    OMAiGLQYCRS.
    OrthoDBiEOG7288T0.

    Family and domain databases

    Gene3Di1.20.120.550. 1 hit.
    InterProiIPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view]
    PfamiPF01124. MAPEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JHF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSLGLVMEN SQVLPAFLLC STLLVIKMYA VAVITGQVRL RKKAFANPED    50
    ALKRGGLQYC RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA 100
    WIHFLVVLTG RVVHTVAYLG KMNPRIRSGA YVLAQFACFS MALQILWEVA 150
    HHL 153
    Length:153
    Mass (Da):17,273
    Last modified:October 1, 2000 - v1
    Checksum:iEA2E91E143CD7886
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06022145 Genomic DNA. No translation available.
    AF280967 mRNA. Translation: AAG24803.1.
    BC105858 mRNA. Translation: AAI05859.1.
    AB035145 mRNA. Translation: BAA95808.1.
    AB041998 mRNA. Translation: BAA96084.1.
    AB048730 mRNA. Translation: BAB20597.1.
    CH474001 Genomic DNA. Translation: EDL93288.1.
    RefSeqiNP_067594.1. NM_021583.3.
    UniGeneiRn.7730.

    Genome annotation databases

    EnsembliENSRNOT00000045993; ENSRNOP00000044191; ENSRNOG00000006320.
    GeneIDi59103.
    KEGGirno:59103.
    UCSCiRGD:62076. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06022145 Genomic DNA. No translation available.
    AF280967 mRNA. Translation: AAG24803.1 .
    BC105858 mRNA. Translation: AAI05859.1 .
    AB035145 mRNA. Translation: BAA95808.1 .
    AB041998 mRNA. Translation: BAA96084.1 .
    AB048730 mRNA. Translation: BAB20597.1 .
    CH474001 Genomic DNA. Translation: EDL93288.1 .
    RefSeqi NP_067594.1. NM_021583.3.
    UniGenei Rn.7730.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000045993 ; ENSRNOP00000044191 ; ENSRNOG00000006320 .
    GeneIDi 59103.
    KEGGi rno:59103.
    UCSCi RGD:62076. rat.

    Organism-specific databases

    CTDi 9536.
    RGDi 62076. Ptges.

    Phylogenomic databases

    GeneTreei ENSGT00390000011980.
    HOGENOMi HOG000231759.
    HOVERGENi HBG052470.
    KOi K15729.
    OMAi GLQYCRS.
    OrthoDBi EOG7288T0.

    Enzyme and pathway databases

    Reactomei REACT_194948. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

    Miscellaneous databases

    NextBioi 611727.

    Gene expression databases

    Genevestigatori Q9JHF3.

    Family and domain databases

    Gene3Di 1.20.120.550. 1 hit.
    InterProi IPR023352. MAPEG-like_dom.
    IPR001129. Membr-assoc_MAPEG.
    [Graphical view ]
    Pfami PF01124. MAPEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2."
      Murakami M., Naraba H., Tanioka T., Semmyo N., Nakatani Y., Kojima F., Ikeda T., Fueki M., Ueno A., Oh S., Kudo I.
      J. Biol. Chem. 275:32783-32792(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague DawleyImported.
    2. "Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes."
      Satoh K., Nagano Y., Shimomura C., Suzuki N., Saeki Y., Yokota H.
      Neurosci. Lett. 283:221-223(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: WistarImported.
      Tissue: BrainImported.
    3. "inducible prostaglandin E synthase mRNA."
      Yamagata K.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague DawleyImported.
      Tissue: TestisImported.
    4. "Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis."
      Mancini J.A., Blood K., Guay J., Gordon R., Claveau D., Chan C.C., Riendeau D.
      J. Biol. Chem. 276:4469-4475(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.
    6. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    9. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9JHF3_RAT
    AccessioniPrimary (citable) accession number: Q9JHF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3