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Q9JHF3

- Q9JHF3_RAT

UniProt

Q9JHF3 - Q9JHF3_RAT

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Protein
Submitted name:

Inducible prostaglandin E synthase

Gene
Ptges, iPGES, PGES, PIG12, rCG_45741
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glutathione binding Source: Ensembl
  2. prostaglandin-E synthase activity Source: RGD

GO - Biological processi

  1. acute inflammatory response Source: RGD
  2. chronic inflammatory response Source: RGD
  3. negative regulation of cell proliferation Source: Ensembl
  4. prostaglandin biosynthetic process Source: RGD
  5. response to calcium ion Source: RGD
  6. response to cytokine Source: RGD
  7. response to lipopolysaccharide Source: RGD
  8. response to organic cyclic compound Source: RGD
  9. response to retinoic acid Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_194948. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Submitted name:
Inducible prostaglandin E synthaseImported
Submitted name:
PGE synthaseImported
Submitted name:
PIG12 proteinImported
Submitted name:
Prostaglandin E synthaseImported
Submitted name:
Protein PtgesImported
Gene namesi
Name:PtgesImported
Synonyms:iPGESImported, PGESImported, PIG12Imported
ORF Names:rCG_45741Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi62076. Ptges.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: Ensembl
  2. intracellular membrane-bounded organelle Source: RGD
  3. nuclear envelope lumen Source: Ensembl
  4. perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9JHF3.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011980.
HOGENOMiHOG000231759.
HOVERGENiHBG052470.
KOiK15729.
OMAiGLQYCRS.
OrthoDBiEOG7288T0.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHF3-1 [UniParc]FASTAAdd to Basket

« Hide

MTSLGLVMEN SQVLPAFLLC STLLVIKMYA VAVITGQVRL RKKAFANPED    50
ALKRGGLQYC RSDPDVERCL RAHRNDMETI YPFLFLGFVY SFLGPNPLIA 100
WIHFLVVLTG RVVHTVAYLG KMNPRIRSGA YVLAQFACFS MALQILWEVA 150
HHL 153
Length:153
Mass (Da):17,273
Last modified:October 1, 2000 - v1
Checksum:iEA2E91E143CD7886
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06022145 Genomic DNA. No translation available.
AF280967 mRNA. Translation: AAG24803.1.
BC105858 mRNA. Translation: AAI05859.1.
AB035145 mRNA. Translation: BAA95808.1.
AB041998 mRNA. Translation: BAA96084.1.
AB048730 mRNA. Translation: BAB20597.1.
CH474001 Genomic DNA. Translation: EDL93288.1.
RefSeqiNP_067594.1. NM_021583.3.
UniGeneiRn.7730.

Genome annotation databases

EnsembliENSRNOT00000045993; ENSRNOP00000044191; ENSRNOG00000006320.
GeneIDi59103.
KEGGirno:59103.
UCSCiRGD:62076. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06022145 Genomic DNA. No translation available.
AF280967 mRNA. Translation: AAG24803.1 .
BC105858 mRNA. Translation: AAI05859.1 .
AB035145 mRNA. Translation: BAA95808.1 .
AB041998 mRNA. Translation: BAA96084.1 .
AB048730 mRNA. Translation: BAB20597.1 .
CH474001 Genomic DNA. Translation: EDL93288.1 .
RefSeqi NP_067594.1. NM_021583.3.
UniGenei Rn.7730.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000045993 ; ENSRNOP00000044191 ; ENSRNOG00000006320 .
GeneIDi 59103.
KEGGi rno:59103.
UCSCi RGD:62076. rat.

Organism-specific databases

CTDi 9536.
RGDi 62076. Ptges.

Phylogenomic databases

GeneTreei ENSGT00390000011980.
HOGENOMi HOG000231759.
HOVERGENi HBG052470.
KOi K15729.
OMAi GLQYCRS.
OrthoDBi EOG7288T0.

Enzyme and pathway databases

Reactomei REACT_194948. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi 611727.

Gene expression databases

Genevestigatori Q9JHF3.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2."
    Murakami M., Naraba H., Tanioka T., Semmyo N., Nakatani Y., Kojima F., Ikeda T., Fueki M., Ueno A., Oh S., Kudo I.
    J. Biol. Chem. 275:32783-32792(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
  2. "Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes."
    Satoh K., Nagano Y., Shimomura C., Suzuki N., Saeki Y., Yokota H.
    Neurosci. Lett. 283:221-223(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: BrainImported.
  3. "inducible prostaglandin E synthase mRNA."
    Yamagata K.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
    Tissue: TestisImported.
  4. "Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis."
    Mancini J.A., Blood K., Guay J., Gordon R., Claveau D., Chan C.C., Riendeau D.
    J. Biol. Chem. 276:4469-4475(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  6. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  7. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ9JHF3_RAT
AccessioniPrimary (citable) accession number: Q9JHF3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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