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Protein

Ninjurin-2

Gene

Ninj2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Ninjurin-2
Alternative name(s):
Nerve injury-induced protein 2
Gene namesi
Name:Ninj2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620552. Ninj2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767ExtracellularSequence analysisAdd
BLAST
Transmembranei68 – 9023HelicalSequence analysisAdd
BLAST
Topological domaini91 – 10818CytoplasmicSequence analysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence analysisAdd
BLAST
Topological domaini130 – 14415ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Ninjurin-2PRO_0000159648Add
BLAST

Proteomic databases

PaxDbiQ9JHE8.
PRIDEiQ9JHE8.

Expressioni

Inductioni

By nerve injury; in Schwann cells.

Gene expression databases

BgeeiENSRNOG00000010282.
GenevisibleiQ9JHE8. RN.

Family & Domainsi

Sequence similaritiesi

Belongs to the ninjurin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9JHE8.
OMAiLSHPKKA.
OrthoDBiEOG091G0TAH.
PhylomeDBiQ9JHE8.
TreeFamiTF323538.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JHE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESDREIIHL QHRHSTPGGN QRHINLNHYA TKKSVAESML DVALFMSNAM
60 70 80 90 100
RLKSVLEQGP FSQYYTTLLT LISASLLLQV VIGILLVVIA RLNLNEVENQ
110 120 130 140
WRLNQLNNAA TTLVFITVVI NIFITAFGAH KTGSVAARTS SNPI
Length:144
Mass (Da):15,996
Last modified:October 1, 2000 - v1
Checksum:iEED7A2ACA61A838D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040815 mRNA. Translation: BAA94291.1.
AF250322 mRNA. Translation: AAF65567.1.
RefSeqiNP_067606.1. NM_021595.2.
UniGeneiRn.162768.

Genome annotation databases

EnsembliENSRNOT00000013721; ENSRNOP00000013721; ENSRNOG00000010282.
GeneIDi59115.
KEGGirno:59115.
UCSCiRGD:620552. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040815 mRNA. Translation: BAA94291.1.
AF250322 mRNA. Translation: AAF65567.1.
RefSeqiNP_067606.1. NM_021595.2.
UniGeneiRn.162768.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9JHE8.
PRIDEiQ9JHE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013721; ENSRNOP00000013721; ENSRNOG00000010282.
GeneIDi59115.
KEGGirno:59115.
UCSCiRGD:620552. rat.

Organism-specific databases

CTDi4815.
RGDi620552. Ninj2.

Phylogenomic databases

eggNOGiENOG410J0D7. Eukaryota.
ENOG4111YA5. LUCA.
GeneTreeiENSGT00390000012754.
HOGENOMiHOG000037625.
HOVERGENiHBG052622.
InParanoidiQ9JHE8.
OMAiLSHPKKA.
OrthoDBiEOG091G0TAH.
PhylomeDBiQ9JHE8.
TreeFamiTF323538.

Miscellaneous databases

PROiQ9JHE8.

Gene expression databases

BgeeiENSRNOG00000010282.
GenevisibleiQ9JHE8. RN.

Family and domain databases

InterProiIPR007007. Ninjurin.
[Graphical view]
PANTHERiPTHR12316. PTHR12316. 1 hit.
PfamiPF04923. Ninjurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNINJ2_RAT
AccessioniPrimary (citable) accession number: Q9JHE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.