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Protein

Protein TSSC4

Gene

Tssc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TSSC4
Gene namesi
Name:Tssc4
ORF Names:MNCb-3063
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1861712. Tssc4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Protein TSSC4PRO_0000076361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571PhosphoserineCombined sources
Modified residuei64 – 641PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei124 – 1241PhosphothreonineCombined sources
Modified residuei214 – 2141N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9JHE7.
MaxQBiQ9JHE7.
PaxDbiQ9JHE7.
PRIDEiQ9JHE7.

PTM databases

iPTMnetiQ9JHE7.
PhosphoSiteiQ9JHE7.

Expressioni

Tissue specificityi

Expressed in placenta. Widely expressed in embryo and newborn.1 Publication

Developmental stagei

Expressed in embryo at 12.5 dpc and 16.5 dpc.1 Publication

Gene expression databases

BgeeiQ9JHE7.
ExpressionAtlasiQ9JHE7. baseline and differential.
GenevisibleiQ9JHE7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056582.

Family & Domainsi

Sequence similaritiesi

Belongs to the TSSC4 family.Curated

Phylogenomic databases

eggNOGiENOG410IIC0. Eukaryota.
ENOG41120VA. LUCA.
GeneTreeiENSGT00390000011846.
HOGENOMiHOG000154697.
HOVERGENiHBG059835.
InParanoidiQ9JHE7.
OMAiRDHFRNK.
OrthoDBiEOG7C8GHF.
PhylomeDBiQ9JHE7.
TreeFamiTF335741.

Family and domain databases

InterProiIPR029338. TSSC4.
[Graphical view]
PfamiPF15264. TSSC4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JHE7-1) [UniParc]FASTAAdd to basket

Also known as: Tssc4-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETEAGLEA DEPTEDDTLP SDTVSLSDSD SDLSLPSGVE VQVLSPERLS
60 70 80 90 100
EEGQEDSGPE DPPSPPTGTL TTAVQPFHLR GMSSTFSQRS HSIFDCLESA
110 120 130 140 150
ARQAPCSAPQ TSVSDNGSFR RPVTPPSQTP ARGLSRVHGN TGPTRVLPVP
160 170 180 190 200
DYVSHPERWT KYSLEDVSEA SEQSNRDAAL AFLSSRSQVS HTDYVPSFNQ
210 220 230 240 250
DPSSCGEGRV VFTKPVRDSE ARAERKRVLK KGVGSGAGGE AAVELAHLAG
260 270 280 290 300
PEAEEWSGHQ GQPEVVVPSE AAHPESSSGP IGVKAVGFHG SKKRSRDHFR
310
NRDGNPGGPG SERGPSV
Length:317
Mass (Da):33,569
Last modified:October 1, 2000 - v1
Checksum:iF0BC4EAEA7709342
GO
Isoform 2 (identifier: Q9JHE7-2) [UniParc]FASTAAdd to basket

Also known as: Tssc4-2

The sequence of this isoform differs from the canonical sequence as follows:
     113-114: VS → AP
     115-317: Missing.

Show »
Length:114
Mass (Da):11,947
Checksum:iEDE73978F0362346
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei113 – 1142VS → AP in isoform 2. 1 PublicationVSP_016562
Alternative sequencei115 – 317203Missing in isoform 2. 1 PublicationVSP_016563Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038011 mRNA. Translation: BAA96876.1.
AJ251835 Genomic DNA. Translation: CAB94775.1.
AJ279796 mRNA. Translation: CAB94724.1.
AB041597 mRNA. Translation: BAA95080.1.
CCDSiCCDS40195.1. [Q9JHE7-1]
CCDS40196.1. [Q9JHE7-2]
RefSeqiNP_001108557.1. NM_001115085.1. [Q9JHE7-1]
NP_064681.1. NM_020285.2. [Q9JHE7-1]
UniGeneiMm.139675.

Genome annotation databases

EnsembliENSMUST00000060433; ENSMUSP00000056582; ENSMUSG00000045752. [Q9JHE7-1]
ENSMUST00000105920; ENSMUSP00000101540; ENSMUSG00000045752. [Q9JHE7-2]
ENSMUST00000177841; ENSMUSP00000137399; ENSMUSG00000045752. [Q9JHE7-1]
ENSMUST00000208779; ENSMUSP00000146914; ENSMUSG00000045752. [Q9JHE7-2]
GeneIDi56844.
KEGGimmu:56844.
UCSCiuc009kow.1. mouse. [Q9JHE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038011 mRNA. Translation: BAA96876.1.
AJ251835 Genomic DNA. Translation: CAB94775.1.
AJ279796 mRNA. Translation: CAB94724.1.
AB041597 mRNA. Translation: BAA95080.1.
CCDSiCCDS40195.1. [Q9JHE7-1]
CCDS40196.1. [Q9JHE7-2]
RefSeqiNP_001108557.1. NM_001115085.1. [Q9JHE7-1]
NP_064681.1. NM_020285.2. [Q9JHE7-1]
UniGeneiMm.139675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056582.

PTM databases

iPTMnetiQ9JHE7.
PhosphoSiteiQ9JHE7.

Proteomic databases

EPDiQ9JHE7.
MaxQBiQ9JHE7.
PaxDbiQ9JHE7.
PRIDEiQ9JHE7.

Protocols and materials databases

DNASUi56844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060433; ENSMUSP00000056582; ENSMUSG00000045752. [Q9JHE7-1]
ENSMUST00000105920; ENSMUSP00000101540; ENSMUSG00000045752. [Q9JHE7-2]
ENSMUST00000177841; ENSMUSP00000137399; ENSMUSG00000045752. [Q9JHE7-1]
ENSMUST00000208779; ENSMUSP00000146914; ENSMUSG00000045752. [Q9JHE7-2]
GeneIDi56844.
KEGGimmu:56844.
UCSCiuc009kow.1. mouse. [Q9JHE7-1]

Organism-specific databases

CTDi10078.
MGIiMGI:1861712. Tssc4.

Phylogenomic databases

eggNOGiENOG410IIC0. Eukaryota.
ENOG41120VA. LUCA.
GeneTreeiENSGT00390000011846.
HOGENOMiHOG000154697.
HOVERGENiHBG059835.
InParanoidiQ9JHE7.
OMAiRDHFRNK.
OrthoDBiEOG7C8GHF.
PhylomeDBiQ9JHE7.
TreeFamiTF335741.

Miscellaneous databases

ChiTaRSiTssc4. mouse.
PROiQ9JHE7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JHE7.
ExpressionAtlasiQ9JHE7. baseline and differential.
GenevisibleiQ9JHE7. MM.

Family and domain databases

InterProiIPR029338. TSSC4.
[Graphical view]
PfamiPF15264. TSSC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human."
    Yatsuki H., Watanabe H., Hattori M., Joh K., Soejima H., Komoda H., Xin Z., Zhu X., Higashimoto K., Nishimura M., Kuratomi S., Sasaki H., Sakaki Y., Mukai T.
    DNA Res. 7:195-206(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
    Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
    Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Sv and C57BL/6.
  3. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-64; SER-92 AND THR-124, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTSSC4_MOUSE
AccessioniPrimary (citable) accession number: Q9JHE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.