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Q9JHE6

- HES6_MOUSE

UniProt

Q9JHE6 - HES6_MOUSE

Protein

Transcription cofactor HES-6

Gene

Hes6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation.1 Publication

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: MGI
    3. transcription cofactor activity Source: MGI
    4. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. nervous system development Source: MGI
    3. regulation of transcription from RNA polymerase II promoter Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription cofactor HES-6
    Alternative name(s):
    Hairy and enhancer of split 6
    Gene namesi
    Name:Hes6Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1859852. Hes6.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Transcription cofactor HES-6PRO_0000127215Add
    BLAST

    Proteomic databases

    PRIDEiQ9JHE6.

    PTM databases

    PhosphoSiteiQ9JHE6.

    Expressioni

    Tissue specificityi

    Expressed in both undifferentiated and differentiated cells. High levels of expression are observed in several embryonic tissues including the nervous system, muscle and thymus. In the nervous system, initially expressed in the closing neural tube, then in the spinal cord, cranial and dorsal root ganglia, and brain neuroepithelium. Also expressed in epithelial cells of the embryonic respiratory, urinary and digestive systems. In the limb buds, expressed in skeletal muscle and presumptive tendons.2 Publications

    Developmental stagei

    Expressed in both embryo and adult. Expression in the embryo is detected from E8.5. In the retina, expressed at high levels at postnatal E0. Expression in brain and retina decreases postnatally but still detectable in adult.1 Publication

    Gene expression databases

    BgeeiQ9JHE6.
    CleanExiMM_HES6.
    GenevestigatoriQ9JHE6.

    Interactioni

    Subunit structurei

    Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family By similarity. Interacts with HES1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi207731. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHE6.
    SMRiQ9JHE6. Positions 26-81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 7753bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini96 – 12934OrangePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi221 – 2244WRPW motif

    Domaini

    The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity
    Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 1 Orange domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG241578.
    GeneTreeiENSGT00700000104168.
    HOGENOMiHOG000236346.
    HOVERGENiHBG107098.
    InParanoidiQ9JHE6.
    KOiK09087.
    OMAiREDEDGC.
    OrthoDBiEOG7GBFXZ.
    PhylomeDBiQ9JHE6.
    TreeFamiTF351373.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR003650. Orange.
    [Graphical view]
    PfamiPF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JHE6-1 [UniParc]FASTAAdd to Basket

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    MAPSQAPSRD RAGQEDEDRW EARGDRKARK PLVEKKRRAR INESLQELRL    50
    LLAGTEVQAK LENAEVLELT VRRVQGALRG RAREREQLQA EASERFAAGY 100
    IQCMHEVHTF VSTCQAIDAT VSAELLNHLL ESMPLREGSS FQDLLGDSLA 150
    GLPGGSGRSS WPPGGSPESP LSSPPGPGDD LCSDLEEIPE AELNRVPAEG 200
    PDLVSTSLGS LTAARRAQSV WRPW 224
    Length:224
    Mass (Da):24,454
    Last modified:October 1, 2000 - v1
    Checksum:iF5160A69D913DBE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035178 mRNA. Translation: BAA96081.1.
    AF247040 mRNA. Translation: AAF63757.1.
    AF260236 mRNA. Translation: AAK51633.1.
    AK013443 mRNA. Translation: BAB28856.1.
    AK076135 mRNA. Translation: BAC36210.1.
    AK155340 mRNA. Translation: BAE33204.1.
    BC012897 mRNA. Translation: AAH12897.1.
    CCDSiCCDS15163.1.
    RefSeqiNP_062352.1. NM_019479.3.
    UniGeneiMm.280029.

    Genome annotation databases

    EnsembliENSMUST00000086851; ENSMUSP00000084062; ENSMUSG00000067071.
    GeneIDi55927.
    KEGGimmu:55927.
    UCSCiuc007cau.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035178 mRNA. Translation: BAA96081.1 .
    AF247040 mRNA. Translation: AAF63757.1 .
    AF260236 mRNA. Translation: AAK51633.1 .
    AK013443 mRNA. Translation: BAB28856.1 .
    AK076135 mRNA. Translation: BAC36210.1 .
    AK155340 mRNA. Translation: BAE33204.1 .
    BC012897 mRNA. Translation: AAH12897.1 .
    CCDSi CCDS15163.1.
    RefSeqi NP_062352.1. NM_019479.3.
    UniGenei Mm.280029.

    3D structure databases

    ProteinModelPortali Q9JHE6.
    SMRi Q9JHE6. Positions 26-81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207731. 5 interactions.

    PTM databases

    PhosphoSitei Q9JHE6.

    Proteomic databases

    PRIDEi Q9JHE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086851 ; ENSMUSP00000084062 ; ENSMUSG00000067071 .
    GeneIDi 55927.
    KEGGi mmu:55927.
    UCSCi uc007cau.1. mouse.

    Organism-specific databases

    CTDi 55502.
    MGIi MGI:1859852. Hes6.

    Phylogenomic databases

    eggNOGi NOG241578.
    GeneTreei ENSGT00700000104168.
    HOGENOMi HOG000236346.
    HOVERGENi HBG107098.
    InParanoidi Q9JHE6.
    KOi K09087.
    OMAi REDEDGC.
    OrthoDBi EOG7GBFXZ.
    PhylomeDBi Q9JHE6.
    TreeFami TF351373.

    Miscellaneous databases

    ChiTaRSi HES6. mouse.
    NextBioi 311596.
    PROi Q9JHE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JHE6.
    CleanExi MM_HES6.
    Genevestigatori Q9JHE6.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR003650. Orange.
    [Graphical view ]
    Pfami PF07527. Hairy_orange. 1 hit.
    PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS51054. ORANGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation."
      Bae S.-K., Bessho Y., Hojo M., Kageyama R.
      Development 127:2933-2943(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH HES1, DEVELOPMENTAL STAGE.
      Tissue: Embryo1 Publication.
    2. "Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development."
      Pissarra L., Henrique D., Duarte A.
      Mech. Dev. 95:275-278(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors."
      Vasiliauskas D., Stern C.D.
      Mech. Dev. 98:133-137(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: C57BL/6JImported.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech IIImported.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiHES6_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHE6
    Secondary accession number(s): Q3U2D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3