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Q9JHD2

- KAT2A_MOUSE

UniProt

Q9JHD2 - KAT2A_MOUSE

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Protein

Histone acetyltransferase KAT2A

Gene

Kat2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei568 – 5681Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. H3 histone acetyltransferase activity Source: MGI
  3. histone acetyltransferase activity Source: MGI
  4. histone acetyltransferase activity (H4-K12 specific) Source: MGI
  5. N-acetyltransferase activity Source: MGI
  6. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. cell proliferation Source: MGI
  2. histone deubiquitination Source: Ensembl
  3. histone H3-K14 acetylation Source: MGI
  4. histone H4-K12 acetylation Source: MGI
  5. in utero embryonic development Source: MGI
  6. metencephalon development Source: MGI
  7. midbrain development Source: MGI
  8. multicellular organism growth Source: MGI
  9. nervous system development Source: MGI
  10. neural tube closure Source: MGI
  11. positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. regulation of protein stability Source: Ensembl
  13. somitogenesis Source: MGI
  14. telencephalon development Source: MGI
  15. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_226917. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase KAT2A (EC:2.3.1.48)
Alternative name(s):
General control of amino acid synthesis protein 5-like 2
Histone acetyltransferase GCN5
Short name:
MmGCN5
Lysine acetyltransferase 2A
Gene namesi
Name:Kat2a
Synonyms:Gcn5l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1343101. Kat2a.

Subcellular locationi

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  2. extracellular space Source: Ensembl
  3. histone acetyltransferase complex Source: MGI
  4. mitotic spindle Source: MGI
  5. nucleus Source: MGI
  6. STAGA complex Source: MGI
  7. transcription factor TFTC complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 830829Histone acetyltransferase KAT2APRO_0000211203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JHD2.
PaxDbiQ9JHD2.
PRIDEiQ9JHD2.

PTM databases

PhosphoSiteiQ9JHD2.

Expressioni

Gene expression databases

BgeeiQ9JHD2.
ExpressionAtlasiQ9JHD2. baseline and differential.
GenevestigatoriQ9JHD2.

Interactioni

Subunit structurei

Interacts with EP300, CREBBP and ADA2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, KAT2A/GCN5L2, TAF10 and TRRAP. Interacts with TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, KAT2A, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (By similarity). Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity). In the complex, it probably interacts directly with CSRP2BP, MBIP and WDR5 (By similarity). Interacts with PML.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TrrapQ80YV33EBI-2943116,EBI-2942477

Protein-protein interaction databases

BioGridi199867. 10 interactions.
DIPiDIP-29180N.
IntActiQ9JHD2. 54 interactions.
MINTiMINT-4617449.
STRINGi10090.ENSMUSP00000099407.

Structurei

3D structure databases

ProteinModelPortaliQ9JHD2.
SMRiQ9JHD2. Positions 490-651, 723-828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini496 – 649154N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST
Domaini738 – 80871BromoPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni572 – 5743Acetyl-CoA bindingBy similarity
Regioni579 – 5857Acetyl-CoA bindingBy similarity
Regioni610 – 6134Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiCOG5076.
GeneTreeiENSGT00760000119099.
HOGENOMiHOG000007151.
HOVERGENiHBG051710.
InParanoidiQ9JHD2.
KOiK06062.
OMAiNSPIWES.
TreeFamiTF105399.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP
60 70 80 90 100
AAAPAGSTGS GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK
110 120 130 140 150
LGVFSACKAN ETCKCNGWKN PKPPTAPRMD LQQPAANLSE LCRSCEHPLA
160 170 180 190 200
DHVSHLENVS EDEINRLLGM VVDVENLFMS VHKEEDTDTK QVYFYLFKLL
210 220 230 240 250
RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH LAPRERQTMF
260 270 280 290 300
ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC
310 320 330 340 350
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH
360 370 380 390 400
FPKFLSMLEE EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS
410 420 430 440 450
PSMGGGSNSS LSLDSAGTEP MPAGEKRKLP ENLTLEDAKR LRVMGDIPME
460 470 480 490 500
LVNEVMLTIT DPAAMLGPET SLLSANAARD ETARLEERRG IIEFHVIGNS
510 520 530 540 550
LTPKANRRVL LWLVGLQNVF SHQLPRMPKE YIARLVFDPK HKTLALIKDG
560 570 580 590 600
RVIGGICFRM FPTQGFTEIV FCAVTSNEQV KGYGTHLMNH LKEYHIKHSI
610 620 630 640 650
LYFLTYADEY AIGYFKKQGF SKDIKVPKSR YLGYIKDYEG ATLMECELNP
660 670 680 690 700
RIPYTELSHI IKKQKEIIKK LIERKQAQIR KVYPGLSCFK EGVRQIPVES
710 720 730 740 750
VPGIRETGWK PLGKEKGKEL KDPDQLYTTL KNLLAQIKSH PSAWPFMEPV
760 770 780 790 800
KKSEAPDYYE VIRFPIDLKT MTERLRSRYY VTRKLFVADL QRVIANCREY
810 820 830
NPPDSEYCRC ASALEKFFYF KLKEGGLIDK
Length:830
Mass (Da):93,394
Last modified:July 27, 2011 - v2
Checksum:i7993CFFEA4734174
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti804 – 8041D → N in AAF70497. (PubMed:9742083)Curated
Sequence conflicti815 – 8151E → K in AAF70497. (PubMed:9742083)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254441 mRNA. Translation: AAF70497.1.
AK158079 mRNA. Translation: BAE34351.1.
AL591469 Genomic DNA. Translation: CAM22909.1.
CH466662 Genomic DNA. Translation: EDL02541.1.
CCDSiCCDS25433.1.
RefSeqiNP_064388.2. NM_020004.5.
UniGeneiMm.218837.

Genome annotation databases

EnsembliENSMUST00000103118; ENSMUSP00000099407; ENSMUSG00000020918.
GeneIDi14534.
KEGGimmu:14534.
UCSCiuc007lma.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254441 mRNA. Translation: AAF70497.1 .
AK158079 mRNA. Translation: BAE34351.1 .
AL591469 Genomic DNA. Translation: CAM22909.1 .
CH466662 Genomic DNA. Translation: EDL02541.1 .
CCDSi CCDS25433.1.
RefSeqi NP_064388.2. NM_020004.5.
UniGenei Mm.218837.

3D structure databases

ProteinModelPortali Q9JHD2.
SMRi Q9JHD2. Positions 490-651, 723-828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199867. 10 interactions.
DIPi DIP-29180N.
IntActi Q9JHD2. 54 interactions.
MINTi MINT-4617449.
STRINGi 10090.ENSMUSP00000099407.

PTM databases

PhosphoSitei Q9JHD2.

Proteomic databases

MaxQBi Q9JHD2.
PaxDbi Q9JHD2.
PRIDEi Q9JHD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103118 ; ENSMUSP00000099407 ; ENSMUSG00000020918 .
GeneIDi 14534.
KEGGi mmu:14534.
UCSCi uc007lma.2. mouse.

Organism-specific databases

CTDi 2648.
MGIi MGI:1343101. Kat2a.

Phylogenomic databases

eggNOGi COG5076.
GeneTreei ENSGT00760000119099.
HOGENOMi HOG000007151.
HOVERGENi HBG051710.
InParanoidi Q9JHD2.
KOi K06062.
OMAi NSPIWES.
TreeFami TF105399.

Enzyme and pathway databases

Reactomei REACT_226917. HATs acetylate histones.

Miscellaneous databases

ChiTaRSi Kat2a. mouse.
NextBioi 286188.
PROi Q9JHD2.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHD2.
ExpressionAtlasi Q9JHD2. baseline and differential.
Genevestigatori Q9JHD2.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
IPR016376. Hist_acetylase_PCAF.
IPR009464. PCAF_N.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
PF06466. PCAF_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003048. Histone_acetylase_PCAF. 1 hit.
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates."
    Xu W., Edmondson D.G., Roth S.Y.
    Mol. Cell. Biol. 18:5659-5669(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Inner ear.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: INTERACTION WITH PML.

Entry informationi

Entry nameiKAT2A_MOUSE
AccessioniPrimary (citable) accession number: Q9JHD2
Secondary accession number(s): Q3TZ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3