Reviewed,
UniProtKB/Swiss-Prot Q9JHD1 (KAT2B_MOUSE)
Last modified
November 3, 2009.
Version 52.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase KAT2B EC=2.3.1.48 Alternative name(s): Lysine acetyltransferase 2B Histone acetyltransferase PCAF Short name=Histone acetylase PCAF P300/CBP-associated factor Short name=P/CAF | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 813 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles By similarity. |
| Catalytic activity | Acetyl-CoA + histone = CoA + acetylhistone. |
| Subunit structure | Interacts with SIRT1. Interacts with EP300 and CREBBP. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4 By similarity. |
| Subcellular location | Nucleus By similarity. |
| Domain | The bromodomain mediates binding to HIV-1 Tat. |
| Sequence similarities | Belongs to the GCN5 family. Contains 1 bromo domain. Contains 1 N-acetyltransferase domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 813 | 813 | Histone acetyltransferase KAT2B | PRO_0000322986 | |||||
Regions | |||||||||
| Domain | 484 – 632 | 149 | N-acetyltransferase | ||||||
| Domain | 721 – 791 | 71 | Bromo | ||||||
| Compositional bias | 48 – 53 | 6 | Poly-Gly | ||||||
Amino acid modifications | |||||||||
| Modified residue | 20 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 710 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 714 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 293 – 294 | 2 | LL → FV in AAF70498. Ref.1 | ||||||
| Sequence conflict | 319 | 1 | E → G in BAE33658. Ref.2 | ||||||
| Sequence conflict | 459 | 1 | H → L in AAF70498. Ref.1 | ||||||
| Sequence conflict | 548 | 1 | G → A in AAF70498. Ref.1 | ||||||
| Sequence conflict | 554 | 1 | F → L in AAF70498. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates." Xu W., Edmondson D.G., Roth S.Y. Mol. Cell. Biol. 18:5659-5669(1998) [PubMed: 9742083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NOD. Tissue: Spleen. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Eye. |
| [4] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, MASS SPECTROMETRY. Tissue: Liver. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF254442 mRNA. Translation: AAF70498.1. AK156290 mRNA. Translation: BAE33658.1. BC082581 mRNA. Translation: AAH82581.1. BC145896 mRNA. Translation: AAI45897.1. | |
| IPI | IPI00471164. |
| RefSeq | NP_064389.2. |
| UniGene | Mm.255025 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CM0 based on UniProtKB Q92831. |
| SMR | Q9JHD1. Positions 474-634, 696-813. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9JHD1. |
Proteomic databases | |
| PRIDE | Q9JHD1. |
Genome annotation databases | |
| Ensembl | ENSMUST00000000724; ENSMUSP00000000724; ENSMUSG00000000708; Mus musculus. [Genome view] |
| GeneID | 18519. |
| KEGG | mmu:18519. |
| UCSC | uc008czp.1. mouse. |
Organism-specific databases | |
| CTD | 18519. |
| MGI | MGI:1343094. Kat2b. |
Phylogenomic databases | |
| HOVERGEN | Q9JHD1. |
| OMA | YKENYTR. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 244. |
Gene expression databases | |
| ArrayExpress | Q9JHD1. |
| Bgee | Q9JHD1. |
| Genevestigator | Q9JHD1. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR001487. Bromodomain. IPR018359. Bromodomain_CS. IPR000182. GCN5-rel_AcTrfase. IPR016376. Hist_acetylase_PCAF. IPR009464. PCAF_N. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.20.920.10. Bromodomain. 1 hit. |
| Pfam | PF00583. Acetyltransf_1. 1 hit. PF00439. Bromodomain. 1 hit. PF06466. PCAF_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF003048. Histone_acetylase_PCAF. 1 hit. |
| PRINTS | PR00503. BROMODOMAIN. |
| SMART | SM00297. BROMO. 1 hit. [Graphical view] |
| PROSITE | PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS51186. GNAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 294272. |
| SOURCE | Search... |
Entry information
| Entry name | KAT2B_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9JHD1 Secondary accession number(s): Q3U142, Q640M9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


