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Q9JHC9

- ELF2_MOUSE

UniProt

Q9JHC9 - ELF2_MOUSE

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Protein

ETS-related transcription factor Elf-2

Gene

Elf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi208 – 29083ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. negative regulation of transcription, DNA-templated Source: Ensembl
  3. positive regulation of transcription, DNA-templated Source: UniProtKB
  4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-2
Alternative name(s):
E74-like factor 2
New ETS-related factor
Gene namesi
Name:Elf2Imported
Synonyms:Nerf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1916507. Elf2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593ETS-related transcription factor Elf-2PRO_0000204088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851PhosphoserineBy similarity
Modified residuei191 – 1911PhosphoserineBy similarity
Modified residuei372 – 3721PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JHC9.
PaxDbiQ9JHC9.
PRIDEiQ9JHC9.

PTM databases

PhosphoSiteiQ9JHC9.

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels in thymocytes and bone marrow.1 Publication

Gene expression databases

BgeeiQ9JHC9.
CleanExiMM_ELF2.
ExpressionAtlasiQ9JHC9. baseline and differential.
GenevestigatoriQ9JHC9.

Interactioni

Subunit structurei

Interacts with LIM domains of LMO2. Interacts via its N-terminal region with RUNX1.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9JHC9. 1 interaction.
MINTiMINT-4129603.

Structurei

3D structure databases

ProteinModelPortaliQ9JHC9.
SMRiQ9JHC9. Positions 181-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Sequence Analysis
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG291231.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiQ9JHC9.
KOiK09428.
OMAiLTQCQLQ.
OrthoDBiEOG73RBD1.
PhylomeDBiQ9JHC9.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: Q9JHC9) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAVVDSGG SALELPSDGG ENQEGGDTGP DCPAVIVEPV PSARLEQGYA
60 70 80 90 100
AQVLVYDDET YMMQDVAEEQ EVETENSETV EASVHSSNAH CTDKTIEAAE
110 120 130 140 150
ALLHMESPTC LRDSRSPVEV FVPPCISTPE FIHAAMRPDV ITETVVEVST
160 170 180 190 200
EESEPMDASP IPTSPDSHEP MKKKKVGRKP KTQQSPVSNG SPELGIKKKA
210 220 230 240 250
REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
310 320 330 340 350
DDKSETCPED LAAAADDKSL ERVSLSAESL LKAATAVRGG KNSSPLNCSR
360 370 380 390 400
AEKGVARVVN ITSPTHDGSS RSPTTTAPVS AAAAPRTVRV AMQVPVVMTS
410 420 430 440 450
LGQKISAVAV QSVNAGTGSP LITSTSPASA SSPKVVIQTV PTVMPASTEN
460 470 480 490 500
GDRITMQPAK IITIPATQLA QCQLQAKSNL TGSGSINIVG TPLAVRALTP
510 520 530 540 550
VSIAHGTPVM RLSVPAQQAS GQTPPRVISA LLKGPEGKSE AKKQEHDVKT
560 570 580 590
LQLVEEKGAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK
Length:593
Mass (Da):63,203
Last modified:October 1, 2000 - v1
Checksum:iA6E67486141AB903
GO
Isoform 11 Publication (identifier: Q9JHC9-2) [UniParc]FASTAAdd to Basket

Also known as: elf-2a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-129: Missing.

Show »
Length:581
Mass (Da):61,933
Checksum:iA39A8AB0170504ED
GO
Isoform 21 Publication (identifier: Q9JHC9-3) [UniParc]FASTAAdd to Basket

Also known as: elf-2b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA
     118-129: Missing.

Show »
Length:521
Mass (Da):55,734
Checksum:i6CA5B402B609654F
GO
Isoform 3 (identifier: Q9JHC9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA

Show »
Length:533
Mass (Da):57,003
Checksum:i778C30AB03AE0CD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591S → W in BAC40346. (PubMed:16141072)Curated
Sequence conflicti171 – 1711M → K in AAH69901. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MASAV…ENSET → MATSLHEGPTNQLDLLIRA in isoform 2 and isoform 3. 3 PublicationsVSP_014159Add
BLAST
Alternative sequencei118 – 12912Missing in isoform 1 and isoform 2. 3 PublicationsVSP_014160Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF256216 mRNA. Translation: AAF67191.1.
AF256217 mRNA. Translation: AAF67192.1.
AF256218 mRNA. Translation: AAF67193.1.
AF256219 mRNA. Translation: AAF67194.1.
AK088422 mRNA. Translation: BAC40346.1.
BC069901 mRNA. Translation: AAH69901.1.
CCDSiCCDS17337.1. [Q9JHC9-1]
CCDS71240.1. [Q9JHC9-3]
CCDS71241.1. [Q9JHC9-4]
CCDS71242.1. [Q9JHC9-2]
RefSeqiNP_001277988.1. NM_001291059.1. [Q9JHC9-2]
NP_001277991.1. NM_001291062.1. [Q9JHC9-3]
NP_001277992.1. NM_001291063.1. [Q9JHC9-4]
NP_075991.1. NM_023502.2. [Q9JHC9-1]
XP_006502090.1. XM_006502027.1. [Q9JHC9-1]
UniGeneiMm.131038.

Genome annotation databases

EnsembliENSMUST00000062009; ENSMUSP00000061076; ENSMUSG00000037174. [Q9JHC9-2]
ENSMUST00000091144; ENSMUSP00000088678; ENSMUSG00000037174. [Q9JHC9-1]
ENSMUST00000108051; ENSMUSP00000103686; ENSMUSG00000037174. [Q9JHC9-3]
ENSMUST00000108053; ENSMUSP00000103688; ENSMUSG00000037174. [Q9JHC9-4]
ENSMUST00000163748; ENSMUSP00000126871; ENSMUSG00000037174. [Q9JHC9-1]
GeneIDi69257.
KEGGimmu:69257.
UCSCiuc008pdo.1. mouse. [Q9JHC9-3]
uc008pdp.1. mouse. [Q9JHC9-4]
uc008pdq.1. mouse. [Q9JHC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF256216 mRNA. Translation: AAF67191.1 .
AF256217 mRNA. Translation: AAF67192.1 .
AF256218 mRNA. Translation: AAF67193.1 .
AF256219 mRNA. Translation: AAF67194.1 .
AK088422 mRNA. Translation: BAC40346.1 .
BC069901 mRNA. Translation: AAH69901.1 .
CCDSi CCDS17337.1. [Q9JHC9-1 ]
CCDS71240.1. [Q9JHC9-3 ]
CCDS71241.1. [Q9JHC9-4 ]
CCDS71242.1. [Q9JHC9-2 ]
RefSeqi NP_001277988.1. NM_001291059.1. [Q9JHC9-2 ]
NP_001277991.1. NM_001291062.1. [Q9JHC9-3 ]
NP_001277992.1. NM_001291063.1. [Q9JHC9-4 ]
NP_075991.1. NM_023502.2. [Q9JHC9-1 ]
XP_006502090.1. XM_006502027.1. [Q9JHC9-1 ]
UniGenei Mm.131038.

3D structure databases

ProteinModelPortali Q9JHC9.
SMRi Q9JHC9. Positions 181-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JHC9. 1 interaction.
MINTi MINT-4129603.

PTM databases

PhosphoSitei Q9JHC9.

Proteomic databases

MaxQBi Q9JHC9.
PaxDbi Q9JHC9.
PRIDEi Q9JHC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062009 ; ENSMUSP00000061076 ; ENSMUSG00000037174 . [Q9JHC9-2 ]
ENSMUST00000091144 ; ENSMUSP00000088678 ; ENSMUSG00000037174 . [Q9JHC9-1 ]
ENSMUST00000108051 ; ENSMUSP00000103686 ; ENSMUSG00000037174 . [Q9JHC9-3 ]
ENSMUST00000108053 ; ENSMUSP00000103688 ; ENSMUSG00000037174 . [Q9JHC9-4 ]
ENSMUST00000163748 ; ENSMUSP00000126871 ; ENSMUSG00000037174 . [Q9JHC9-1 ]
GeneIDi 69257.
KEGGi mmu:69257.
UCSCi uc008pdo.1. mouse. [Q9JHC9-3 ]
uc008pdp.1. mouse. [Q9JHC9-4 ]
uc008pdq.1. mouse. [Q9JHC9-1 ]

Organism-specific databases

CTDi 1998.
MGIi MGI:1916507. Elf2.

Phylogenomic databases

eggNOGi NOG291231.
GeneTreei ENSGT00760000118996.
HOGENOMi HOG000049253.
HOVERGENi HBG007183.
InParanoidi Q9JHC9.
KOi K09428.
OMAi LTQCQLQ.
OrthoDBi EOG73RBD1.
PhylomeDBi Q9JHC9.
TreeFami TF318679.

Miscellaneous databases

NextBioi 328977.
PROi Q9JHC9.
SOURCEi Search...

Gene expression databases

Bgeei Q9JHC9.
CleanExi MM_ELF2.
ExpressionAtlasi Q9JHC9. baseline and differential.
Genevestigatori Q9JHC9.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia."
    Wilkinson D.A., Neale G.A.M., Mao S., Naeve C.W., Goorha R.M.
    Leukemia 11:86-96(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH LMO2.
    Tissue: T-cell1 Publication.
  2. Wilkinson D.A., Neale G.A.M., Mao S., Fernandes E.R., Davenport J.W., Naeve C.W., Goorha R.M.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1).
    Strain: NMRIImported.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiELF2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHC9
Secondary accession number(s): Q6NST2
, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3