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Q9JHC9

- ELF2_MOUSE

UniProt

Q9JHC9 - ELF2_MOUSE

Protein

ETS-related transcription factor Elf-2

Gene

Elf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi208 – 29083ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. negative regulation of transcription, DNA-templated Source: Ensembl
    3. positive regulation of transcription, DNA-templated Source: UniProtKB
    4. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-2
    Alternative name(s):
    E74-like factor 2
    New ETS-related factor
    Gene namesi
    Name:Elf2Imported
    Synonyms:Nerf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1916507. Elf2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593ETS-related transcription factor Elf-2PRO_0000204088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851PhosphoserineBy similarity
    Modified residuei191 – 1911PhosphoserineBy similarity
    Modified residuei372 – 3721PhosphoserineBy similarity
    Modified residuei432 – 4321PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9JHC9.
    PRIDEiQ9JHC9.

    PTM databases

    PhosphoSiteiQ9JHC9.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined. Highest levels in thymocytes and bone marrow.1 Publication

    Gene expression databases

    ArrayExpressiQ9JHC9.
    BgeeiQ9JHC9.
    CleanExiMM_ELF2.
    GenevestigatoriQ9JHC9.

    Interactioni

    Subunit structurei

    Interacts with LIM domains of LMO2. Interacts via its N-terminal region with RUNX1.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9JHC9. 1 interaction.
    MINTiMINT-4129603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHC9.
    SMRiQ9JHC9. Positions 210-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Sequence Analysis
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG291231.
    GeneTreeiENSGT00750000117299.
    HOGENOMiHOG000049253.
    HOVERGENiHBG007183.
    InParanoidiQ9JHC9.
    KOiK09428.
    OMAiLTQCQLQ.
    OrthoDBiEOG73RBD1.
    PhylomeDBiQ9JHC9.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 4 (identifier: Q9JHC9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASAVVDSGG SALELPSDGG ENQEGGDTGP DCPAVIVEPV PSARLEQGYA    50
    AQVLVYDDET YMMQDVAEEQ EVETENSETV EASVHSSNAH CTDKTIEAAE 100
    ALLHMESPTC LRDSRSPVEV FVPPCISTPE FIHAAMRPDV ITETVVEVST 150
    EESEPMDASP IPTSPDSHEP MKKKKVGRKP KTQQSPVSNG SPELGIKKKA 200
    REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW 250
    GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID 300
    DDKSETCPED LAAAADDKSL ERVSLSAESL LKAATAVRGG KNSSPLNCSR 350
    AEKGVARVVN ITSPTHDGSS RSPTTTAPVS AAAAPRTVRV AMQVPVVMTS 400
    LGQKISAVAV QSVNAGTGSP LITSTSPASA SSPKVVIQTV PTVMPASTEN 450
    GDRITMQPAK IITIPATQLA QCQLQAKSNL TGSGSINIVG TPLAVRALTP 500
    VSIAHGTPVM RLSVPAQQAS GQTPPRVISA LLKGPEGKSE AKKQEHDVKT 550
    LQLVEEKGAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK 593
    Length:593
    Mass (Da):63,203
    Last modified:October 1, 2000 - v1
    Checksum:iA6E67486141AB903
    GO
    Isoform 11 Publication (identifier: Q9JHC9-2) [UniParc]FASTAAdd to Basket

    Also known as: elf-2a1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         118-129: Missing.

    Show »
    Length:581
    Mass (Da):61,933
    Checksum:iA39A8AB0170504ED
    GO
    Isoform 21 Publication (identifier: Q9JHC9-3) [UniParc]FASTAAdd to Basket

    Also known as: elf-2b1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA
         118-129: Missing.

    Show »
    Length:521
    Mass (Da):55,734
    Checksum:i6CA5B402B609654F
    GO
    Isoform 3 (identifier: Q9JHC9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA

    Show »
    Length:533
    Mass (Da):57,003
    Checksum:i778C30AB03AE0CD5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591S → W in BAC40346. (PubMed:16141072)Curated
    Sequence conflicti171 – 1711M → K in AAH69901. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979MASAV…ENSET → MATSLHEGPTNQLDLLIRA in isoform 2 and isoform 3. 3 PublicationsVSP_014159Add
    BLAST
    Alternative sequencei118 – 12912Missing in isoform 1 and isoform 2. 3 PublicationsVSP_014160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF256216 mRNA. Translation: AAF67191.1.
    AF256217 mRNA. Translation: AAF67192.1.
    AF256218 mRNA. Translation: AAF67193.1.
    AF256219 mRNA. Translation: AAF67194.1.
    AK088422 mRNA. Translation: BAC40346.1.
    BC069901 mRNA. Translation: AAH69901.1.
    CCDSiCCDS17337.1. [Q9JHC9-1]
    CCDS71240.1. [Q9JHC9-3]
    CCDS71241.1. [Q9JHC9-4]
    CCDS71242.1. [Q9JHC9-2]
    RefSeqiNP_001277988.1. NM_001291059.1. [Q9JHC9-2]
    NP_001277991.1. NM_001291062.1. [Q9JHC9-3]
    NP_001277992.1. NM_001291063.1. [Q9JHC9-4]
    NP_075991.1. NM_023502.2. [Q9JHC9-1]
    XP_006502090.1. XM_006502027.1. [Q9JHC9-1]
    UniGeneiMm.131038.

    Genome annotation databases

    EnsembliENSMUST00000062009; ENSMUSP00000061076; ENSMUSG00000037174. [Q9JHC9-2]
    ENSMUST00000091144; ENSMUSP00000088678; ENSMUSG00000037174. [Q9JHC9-1]
    ENSMUST00000108051; ENSMUSP00000103686; ENSMUSG00000037174. [Q9JHC9-3]
    ENSMUST00000108053; ENSMUSP00000103688; ENSMUSG00000037174. [Q9JHC9-4]
    ENSMUST00000163748; ENSMUSP00000126871; ENSMUSG00000037174. [Q9JHC9-1]
    GeneIDi69257.
    KEGGimmu:69257.
    UCSCiuc008pdo.1. mouse. [Q9JHC9-3]
    uc008pdp.1. mouse. [Q9JHC9-4]
    uc008pdq.1. mouse. [Q9JHC9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF256216 mRNA. Translation: AAF67191.1 .
    AF256217 mRNA. Translation: AAF67192.1 .
    AF256218 mRNA. Translation: AAF67193.1 .
    AF256219 mRNA. Translation: AAF67194.1 .
    AK088422 mRNA. Translation: BAC40346.1 .
    BC069901 mRNA. Translation: AAH69901.1 .
    CCDSi CCDS17337.1. [Q9JHC9-1 ]
    CCDS71240.1. [Q9JHC9-3 ]
    CCDS71241.1. [Q9JHC9-4 ]
    CCDS71242.1. [Q9JHC9-2 ]
    RefSeqi NP_001277988.1. NM_001291059.1. [Q9JHC9-2 ]
    NP_001277991.1. NM_001291062.1. [Q9JHC9-3 ]
    NP_001277992.1. NM_001291063.1. [Q9JHC9-4 ]
    NP_075991.1. NM_023502.2. [Q9JHC9-1 ]
    XP_006502090.1. XM_006502027.1. [Q9JHC9-1 ]
    UniGenei Mm.131038.

    3D structure databases

    ProteinModelPortali Q9JHC9.
    SMRi Q9JHC9. Positions 210-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JHC9. 1 interaction.
    MINTi MINT-4129603.

    PTM databases

    PhosphoSitei Q9JHC9.

    Proteomic databases

    PaxDbi Q9JHC9.
    PRIDEi Q9JHC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062009 ; ENSMUSP00000061076 ; ENSMUSG00000037174 . [Q9JHC9-2 ]
    ENSMUST00000091144 ; ENSMUSP00000088678 ; ENSMUSG00000037174 . [Q9JHC9-1 ]
    ENSMUST00000108051 ; ENSMUSP00000103686 ; ENSMUSG00000037174 . [Q9JHC9-3 ]
    ENSMUST00000108053 ; ENSMUSP00000103688 ; ENSMUSG00000037174 . [Q9JHC9-4 ]
    ENSMUST00000163748 ; ENSMUSP00000126871 ; ENSMUSG00000037174 . [Q9JHC9-1 ]
    GeneIDi 69257.
    KEGGi mmu:69257.
    UCSCi uc008pdo.1. mouse. [Q9JHC9-3 ]
    uc008pdp.1. mouse. [Q9JHC9-4 ]
    uc008pdq.1. mouse. [Q9JHC9-1 ]

    Organism-specific databases

    CTDi 1998.
    MGIi MGI:1916507. Elf2.

    Phylogenomic databases

    eggNOGi NOG291231.
    GeneTreei ENSGT00750000117299.
    HOGENOMi HOG000049253.
    HOVERGENi HBG007183.
    InParanoidi Q9JHC9.
    KOi K09428.
    OMAi LTQCQLQ.
    OrthoDBi EOG73RBD1.
    PhylomeDBi Q9JHC9.
    TreeFami TF318679.

    Miscellaneous databases

    NextBioi 328977.
    PROi Q9JHC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JHC9.
    Bgeei Q9JHC9.
    CleanExi MM_ELF2.
    Genevestigatori Q9JHC9.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR022084. TF_Elf_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF12310. Elf-1_N. 1 hit.
    PF00178. Ets. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia."
      Wilkinson D.A., Neale G.A.M., Mao S., Naeve C.W., Goorha R.M.
      Leukemia 11:86-96(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INTERACTION WITH LMO2.
      Tissue: T-cell1 Publication.
    2. Wilkinson D.A., Neale G.A.M., Mao S., Fernandes E.R., Davenport J.W., Naeve C.W., Goorha R.M.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: NOD.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1).
      Strain: NMRIImported.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiELF2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JHC9
    Secondary accession number(s): Q6NST2
    , Q8BTX8, Q9JHC7, Q9JHC8, Q9JHD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3