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Protein

ETS-related transcription factor Elf-2

Gene

Elf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8939245 RUNX1 regulates transcription of genes involved in BCR signaling

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-2
Alternative name(s):
E74-like factor 2
New ETS-related factor
Gene namesi
Name:Elf2Imported
Synonyms:Nerf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916507 Elf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040881 – 593ETS-related transcription factor Elf-2Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei185PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei363PhosphoserineBy similarity1
Modified residuei372PhosphoserineCombined sources1
Modified residuei376PhosphothreonineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei496Omega-N-methylarginineCombined sources1
Modified residuei523PhosphothreonineBy similarity1
Cross-linki538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JHC9
PeptideAtlasiQ9JHC9
PRIDEiQ9JHC9

PTM databases

iPTMnetiQ9JHC9
PhosphoSitePlusiQ9JHC9

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highest levels in thymocytes and bone marrow.1 Publication

Gene expression databases

BgeeiENSMUSG00000037174
CleanExiMM_ELF2
ExpressionAtlasiQ9JHC9 baseline and differential
GenevisibleiQ9JHC9 MM

Interactioni

Subunit structurei

Interacts with LIM domains of LMO2. Interacts via its N-terminal region with RUNX1.By similarity1 Publication

Protein-protein interaction databases

BioGridi213319, 5 interactors
IntActiQ9JHC9, 3 interactors
MINTiQ9JHC9
STRINGi10090.ENSMUSP00000088678

Structurei

3D structure databases

ProteinModelPortaliQ9JHC9
SMRiQ9JHC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000049253
HOVERGENiHBG007183
InParanoidiQ9JHC9
KOiK09428
OMAiGSNVHCT
OrthoDBiEOG091G04CD
PhylomeDBiQ9JHC9
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: Q9JHC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAVVDSGG SALELPSDGG ENQEGGDTGP DCPAVIVEPV PSARLEQGYA
60 70 80 90 100
AQVLVYDDET YMMQDVAEEQ EVETENSETV EASVHSSNAH CTDKTIEAAE
110 120 130 140 150
ALLHMESPTC LRDSRSPVEV FVPPCISTPE FIHAAMRPDV ITETVVEVST
160 170 180 190 200
EESEPMDASP IPTSPDSHEP MKKKKVGRKP KTQQSPVSNG SPELGIKKKA
210 220 230 240 250
REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL VDSKAVSKLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID
310 320 330 340 350
DDKSETCPED LAAAADDKSL ERVSLSAESL LKAATAVRGG KNSSPLNCSR
360 370 380 390 400
AEKGVARVVN ITSPTHDGSS RSPTTTAPVS AAAAPRTVRV AMQVPVVMTS
410 420 430 440 450
LGQKISAVAV QSVNAGTGSP LITSTSPASA SSPKVVIQTV PTVMPASTEN
460 470 480 490 500
GDRITMQPAK IITIPATQLA QCQLQAKSNL TGSGSINIVG TPLAVRALTP
510 520 530 540 550
VSIAHGTPVM RLSVPAQQAS GQTPPRVISA LLKGPEGKSE AKKQEHDVKT
560 570 580 590
LQLVEEKGAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK
Length:593
Mass (Da):63,203
Last modified:October 1, 2000 - v1
Checksum:iA6E67486141AB903
GO
Isoform 11 Publication (identifier: Q9JHC9-2) [UniParc]FASTAAdd to basket
Also known as: elf-2a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-129: Missing.

Show »
Length:581
Mass (Da):61,933
Checksum:iA39A8AB0170504ED
GO
Isoform 21 Publication (identifier: Q9JHC9-3) [UniParc]FASTAAdd to basket
Also known as: elf-2b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA
     118-129: Missing.

Show »
Length:521
Mass (Da):55,734
Checksum:i6CA5B402B609654F
GO
Isoform 3 (identifier: Q9JHC9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MASAVVDSGG...QEVETENSET → MATSLHEGPTNQLDLLIRA

Show »
Length:533
Mass (Da):57,003
Checksum:i778C30AB03AE0CD5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159S → W in BAC40346 (PubMed:16141072).Curated1
Sequence conflicti171M → K in AAH69901 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141591 – 79MASAV…ENSET → MATSLHEGPTNQLDLLIRA in isoform 2 and isoform 3. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_014160118 – 129Missing in isoform 1 and isoform 2. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF256216 mRNA Translation: AAF67191.1
AF256217 mRNA Translation: AAF67192.1
AF256218 mRNA Translation: AAF67193.1
AF256219 mRNA Translation: AAF67194.1
AK088422 mRNA Translation: BAC40346.1
BC069901 mRNA Translation: AAH69901.1
CCDSiCCDS17337.1 [Q9JHC9-1]
CCDS71240.1 [Q9JHC9-3]
CCDS71241.1 [Q9JHC9-4]
CCDS71242.1 [Q9JHC9-2]
RefSeqiNP_001277988.1, NM_001291059.1 [Q9JHC9-2]
NP_001277991.1, NM_001291062.1 [Q9JHC9-3]
NP_001277992.1, NM_001291063.1 [Q9JHC9-4]
NP_075991.1, NM_023502.2 [Q9JHC9-1]
UniGeneiMm.131038

Genome annotation databases

EnsembliENSMUST00000062009; ENSMUSP00000061076; ENSMUSG00000037174 [Q9JHC9-2]
ENSMUST00000108051; ENSMUSP00000103686; ENSMUSG00000037174 [Q9JHC9-3]
ENSMUST00000108053; ENSMUSP00000103688; ENSMUSG00000037174 [Q9JHC9-4]
ENSMUST00000163748; ENSMUSP00000126871; ENSMUSG00000037174 [Q9JHC9-1]
ENSMUST00000194641; ENSMUSP00000141197; ENSMUSG00000037174 [Q9JHC9-1]
GeneIDi69257
KEGGimmu:69257
UCSCiuc008pdo.2 mouse [Q9JHC9-3]
uc008pdp.2 mouse [Q9JHC9-4]
uc008pdq.2 mouse [Q9JHC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELF2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHC9
Secondary accession number(s): Q6NST2
, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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