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Q9JHC6

- WISP2_RAT

UniProt

Q9JHC6 - WISP2_RAT

Protein

WNT1-inducible-signaling pathway protein 2

Gene

Wisp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. negative regulation of cell proliferation Source: RGD
    3. regulation of cell growth Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WNT1-inducible-signaling pathway protein 2
    Short name:
    WISP-2
    Alternative name(s):
    CCN family member 5
    CCN family protein COP-1
    Connective tissue growth factor-like protein
    Short name:
    CTGF-L
    Gene namesi
    Name:Wisp2
    Synonyms:Ccn5, Cop1, Ctgfl
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621867. Wisp2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. cytoplasm Source: RGD
    3. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 250227WNT1-inducible-signaling pathway protein 2PRO_0000014411Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JHC6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014346.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JHC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 23845TSP type-1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82184.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ9JHC6.
    PhylomeDBiQ9JHC6.

    Family and domain databases

    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JHC6-1 [UniParc]FASTAAdd to Basket

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    MRGSPLIRLL ATSFLCLLSM VCAQLCRTPC TCPWTPPQCP QGVPLVLDGC    50
    GCCKVCARRL TESCEHLHVC EPSQGLVCQP GAGPGGHGAV CLLDEDDGDC 100
    EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVTL PSWDCPRPKR 150
    IQVPGKCCPE WVCDQGVTPA IQRSAAQGHQ LSALVTPASA DAPWPNWSTA 200
    WGPCSTTCGL GIATRVSNQN RFCQLEIQRR LCLPRPCLAA RSHSSWNSAF 250
    Length:250
    Mass (Da):27,005
    Last modified:October 1, 2000 - v1
    Checksum:i9A147074626BCA47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259981 mRNA. Translation: AAF69011.1.
    RefSeqiNP_113778.1. NM_031590.1.
    UniGeneiRn.53991.

    Genome annotation databases

    GeneIDi29576.
    KEGGirno:29576.
    UCSCiRGD:621867. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF259981 mRNA. Translation: AAF69011.1 .
    RefSeqi NP_113778.1. NM_031590.1.
    UniGenei Rn.53991.

    3D structure databases

    ProteinModelPortali Q9JHC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29576.
    KEGGi rno:29576.
    UCSCi RGD:621867. rat.

    Organism-specific databases

    CTDi 8839.
    RGDi 621867. Wisp2.

    Phylogenomic databases

    eggNOGi NOG82184.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q9JHC6.
    PhylomeDBi Q9JHC6.

    Miscellaneous databases

    NextBioi 609670.
    PROi Q9JHC6.

    Gene expression databases

    Genevestigatori Q9JHC6.

    Family and domain databases

    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation."
      Zhang R., Averboukh L., Zhu W., Zhang H., Jo H., Dempsey P.J., Coffey R.J., Pardee A.B., Liang P.
      Mol. Cell. Biol. 18:6131-6141(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiWISP2_RAT
    AccessioniPrimary (citable) accession number: Q9JHC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3