Q9JHC6 (WISP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name=WISP-2

Alternative name(s):
CCN family member 5
CCN family protein COP-1
Connective tissue growth factor-like protein
Short name=CTGF-L

Gene names

Name:	Wisp2
Synonyms:	Ccn5, Cop1, Ctgfl

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the CCN family. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of cell proliferation Inferred from direct assay Ref.1. Source: RGD regulation of cell growth Inferred from electronic annotation. Source: InterPro
Cellular_component	cell surface Inferred from direct assay Ref.1. Source: RGD cytoplasm Inferred from direct assay Ref.1. Source: RGD extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 250	227	WNT1-inducible-signaling pathway protein 2		PRO_0000014411
Regions
	Domain	24 – 94	71	IGFBP N-terminal
	Domain	98 – 164	67	VWFC
	Domain	194 – 238	45	TSP type-1
Amino acid modifications
	Glycosylation	196	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9JHC6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9A147074626BCA47	FASTA	250	27,005
	10 20 30 40 50 60 MRGSPLIRLL ATSFLCLLSM VCAQLCRTPC TCPWTPPQCP QGVPLVLDGC GCCKVCARRL 70 80 90 100 110 120 TESCEHLHVC EPSQGLVCQP GAGPGGHGAV CLLDEDDGDC EVNGRRYLDG ETFKPNCRVL 130 140 150 160 170 180 CRCDDGGFTC LPLCSEDVTL PSWDCPRPKR IQVPGKCCPE WVCDQGVTPA IQRSAAQGHQ 190 200 210 220 230 240 LSALVTPASA DAPWPNWSTA WGPCSTTCGL GIATRVSNQN RFCQLEIQRR LCLPRPCLAA 250 RSHSSWNSAF

References

[1]

"Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation." Zhang R., Averboukh L., Zhu W., Zhang H., Jo H., Dempsey P.J., Coffey R.J., Pardee A.B., Liang P. Mol. Cell. Biol. 18:6131-6141(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF259981 mRNA. Translation: AAF69011.1.
IPI	IPI00199447.
RefSeq	NP_113778.1. NM_031590.1.
UniGene	Rn.53991.
3D structure databases
ProteinModelPortal	Q9JHC6.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014346.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29576.
KEGG	rno:29576.
UCSC	RGD:621867. rat.
Organism-specific databases
CTD	8839.
RGD	621867. Wisp2.
Phylogenomic databases
eggNOG	NOG82184.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	Q9JHC6.
OrthoDB	EOG4XPQGQ.
Gene expression databases
Genevestigator	Q9JHC6.
GermOnline	ENSRNOG00000010666. Rattus norvegicus.
Family and domain databases
InterPro	IPR000867. IGFBP-like. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
SMART	SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	609670.

Entry information

Entry name

WISP2_RAT

Accession

Primary (citable) accession number: Q9JHC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program