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Protein

WNT1-inducible-signaling pathway protein 2

Gene

Wisp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production (By similarity).By similarity

GO - Molecular functioni

  1. heparin binding Source: GO_Central
  2. integrin binding Source: GO_Central

GO - Biological processi

  1. cell adhesion Source: GO_Central
  2. cell-cell signaling Source: GO_Central
  3. negative regulation of cell death Source: GO_Central
  4. negative regulation of cell proliferation Source: RGD
  5. regulation of cell growth Source: InterPro
  6. signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
CCN family protein COP-1
Connective tissue growth factor-like protein
Short name:
CTGF-L
Gene namesi
Name:Wisp2
Synonyms:Ccn5, Cop1, Ctgfl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621867. Wisp2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 250227WNT1-inducible-signaling pathway protein 2PRO_0000014411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ9JHC6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014346.

Structurei

3D structure databases

ProteinModelPortaliQ9JHC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9471IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini194 – 23845TSP type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9JHC6.
PhylomeDBiQ9JHC6.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGSPLIRLL ATSFLCLLSM VCAQLCRTPC TCPWTPPQCP QGVPLVLDGC
60 70 80 90 100
GCCKVCARRL TESCEHLHVC EPSQGLVCQP GAGPGGHGAV CLLDEDDGDC
110 120 130 140 150
EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVTL PSWDCPRPKR
160 170 180 190 200
IQVPGKCCPE WVCDQGVTPA IQRSAAQGHQ LSALVTPASA DAPWPNWSTA
210 220 230 240 250
WGPCSTTCGL GIATRVSNQN RFCQLEIQRR LCLPRPCLAA RSHSSWNSAF
Length:250
Mass (Da):27,005
Last modified:October 1, 2000 - v1
Checksum:i9A147074626BCA47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259981 mRNA. Translation: AAF69011.1.
RefSeqiNP_113778.1. NM_031590.1.
UniGeneiRn.53991.

Genome annotation databases

GeneIDi29576.
KEGGirno:29576.
UCSCiRGD:621867. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259981 mRNA. Translation: AAF69011.1.
RefSeqiNP_113778.1. NM_031590.1.
UniGeneiRn.53991.

3D structure databases

ProteinModelPortaliQ9JHC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29576.
KEGGirno:29576.
UCSCiRGD:621867. rat.

Organism-specific databases

CTDi8839.
RGDi621867. Wisp2.

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9JHC6.
PhylomeDBiQ9JHC6.

Miscellaneous databases

NextBioi609670.
PROiQ9JHC6.

Gene expression databases

GenevestigatoriQ9JHC6.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation."
    Zhang R., Averboukh L., Zhu W., Zhang H., Jo H., Dempsey P.J., Coffey R.J., Pardee A.B., Liang P.
    Mol. Cell. Biol. 18:6131-6141(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWISP2_RAT
AccessioniPrimary (citable) accession number: Q9JHC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.