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Q9JHC6 (WISP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WNT1-inducible-signaling pathway protein 2

Short name=WISP-2
Alternative name(s):
CCN family member 5
CCN family protein COP-1
Connective tissue growth factor-like protein
Short name=CTGF-L
Gene names
Name:Wisp2
Synonyms:Ccn5, Cop1, Ctgfl
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the CCN family.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 250227WNT1-inducible-signaling pathway protein 2
PRO_0000014411

Regions

Domain24 – 9471IGFBP N-terminal
Domain98 – 16467VWFC
Domain194 – 23845TSP type-1

Amino acid modifications

Glycosylation1961N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JHC6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9A147074626BCA47

FASTA25027,005
        10         20         30         40         50         60 
MRGSPLIRLL ATSFLCLLSM VCAQLCRTPC TCPWTPPQCP QGVPLVLDGC GCCKVCARRL 

        70         80         90        100        110        120 
TESCEHLHVC EPSQGLVCQP GAGPGGHGAV CLLDEDDGDC EVNGRRYLDG ETFKPNCRVL 

       130        140        150        160        170        180 
CRCDDGGFTC LPLCSEDVTL PSWDCPRPKR IQVPGKCCPE WVCDQGVTPA IQRSAAQGHQ 

       190        200        210        220        230        240 
LSALVTPASA DAPWPNWSTA WGPCSTTCGL GIATRVSNQN RFCQLEIQRR LCLPRPCLAA 

       250 
RSHSSWNSAF 

« Hide

References

[1]"Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation."
Zhang R., Averboukh L., Zhu W., Zhang H., Jo H., Dempsey P.J., Coffey R.J., Pardee A.B., Liang P.
Mol. Cell. Biol. 18:6131-6141(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF259981 mRNA. Translation: AAF69011.1.
RefSeqNP_113778.1. NM_031590.1.
UniGeneRn.53991.

3D structure databases

ProteinModelPortalQ9JHC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014346.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29576.
KEGGrno:29576.
UCSCRGD:621867. rat.

Organism-specific databases

CTD8839.
RGD621867. Wisp2.

Phylogenomic databases

eggNOGNOG82184.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidQ9JHC6.
PhylomeDBQ9JHC6.

Gene expression databases

GenevestigatorQ9JHC6.

Family and domain databases

InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609670.
PROQ9JHC6.

Entry information

Entry nameWISP2_RAT
AccessionPrimary (citable) accession number: Q9JHC6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families