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Q9JHC6

- WISP2_RAT

UniProt

Q9JHC6 - WISP2_RAT

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Protein

WNT1-inducible-signaling pathway protein 2

Gene
Wisp2, Ccn5, Cop1, Ctgfl
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. negative regulation of cell proliferation Source: RGD
  3. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
WNT1-inducible-signaling pathway protein 2
Short name:
WISP-2
Alternative name(s):
CCN family member 5
CCN family protein COP-1
Connective tissue growth factor-like protein
Short name:
CTGF-L
Gene namesi
Name:Wisp2
Synonyms:Ccn5, Cop1, Ctgfl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621867. Wisp2.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. cell surface Source: RGD
  2. cytoplasm Source: RGD
  3. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 250227WNT1-inducible-signaling pathway protein 2PRO_0000014411Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriQ9JHC6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014346.

Structurei

3D structure databases

ProteinModelPortaliQ9JHC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9471IGFBP N-terminalAdd
BLAST
Domaini98 – 16467VWFCAdd
BLAST
Domaini194 – 23845TSP type-1Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82184.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9JHC6.
PhylomeDBiQ9JHC6.

Family and domain databases

InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JHC6-1 [UniParc]FASTAAdd to Basket

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MRGSPLIRLL ATSFLCLLSM VCAQLCRTPC TCPWTPPQCP QGVPLVLDGC    50
GCCKVCARRL TESCEHLHVC EPSQGLVCQP GAGPGGHGAV CLLDEDDGDC 100
EVNGRRYLDG ETFKPNCRVL CRCDDGGFTC LPLCSEDVTL PSWDCPRPKR 150
IQVPGKCCPE WVCDQGVTPA IQRSAAQGHQ LSALVTPASA DAPWPNWSTA 200
WGPCSTTCGL GIATRVSNQN RFCQLEIQRR LCLPRPCLAA RSHSSWNSAF 250
Length:250
Mass (Da):27,005
Last modified:October 1, 2000 - v1
Checksum:i9A147074626BCA47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259981 mRNA. Translation: AAF69011.1.
RefSeqiNP_113778.1. NM_031590.1.
UniGeneiRn.53991.

Genome annotation databases

GeneIDi29576.
KEGGirno:29576.
UCSCiRGD:621867. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF259981 mRNA. Translation: AAF69011.1 .
RefSeqi NP_113778.1. NM_031590.1.
UniGenei Rn.53991.

3D structure databases

ProteinModelPortali Q9JHC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29576.
KEGGi rno:29576.
UCSCi RGD:621867. rat.

Organism-specific databases

CTDi 8839.
RGDi 621867. Wisp2.

Phylogenomic databases

eggNOGi NOG82184.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi Q9JHC6.
PhylomeDBi Q9JHC6.

Miscellaneous databases

NextBioi 609670.
PROi Q9JHC6.

Gene expression databases

Genevestigatori Q9JHC6.

Family and domain databases

InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation."
    Zhang R., Averboukh L., Zhu W., Zhang H., Jo H., Dempsey P.J., Coffey R.J., Pardee A.B., Liang P.
    Mol. Cell. Biol. 18:6131-6141(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWISP2_RAT
AccessioniPrimary (citable) accession number: Q9JHC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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