Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione peroxidase 2

Gene

Gpx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei401

GO - Molecular functioni

  • glutathione peroxidase activity Source: MGI

GO - Biological processi

  • interaction with symbiont Source: MGI
  • negative regulation of inflammatory response to antigenic stimulus Source: MGI
  • response to oxidative stress Source: InterPro
  • response to symbiotic bacterium Source: MGI
  • temperature homeostasis Source: MGI

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei3710. MmGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Short name:
GPx-2
Short name:
GSHPx-2
Alternative name(s):
Glutathione peroxidase-gastrointestinal
Short name:
GPx-GI
Short name:
GSHPx-GI
Gene namesi
Name:Gpx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:106609. Gpx2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666221 – 190Glutathione peroxidase 2Add BLAST190

Proteomic databases

MaxQBiQ9JHC0.
PaxDbiQ9JHC0.
PeptideAtlasiQ9JHC0.
PRIDEiQ9JHC0.

PTM databases

iPTMnetiQ9JHC0.
PhosphoSitePlusiQ9JHC0.

Expressioni

Gene expression databases

CleanExiMM_GPX2.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081012.

Structurei

3D structure databases

ProteinModelPortaliQ9JHC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiQ9JHC0.
KOiK00432.
PhylomeDBiQ9JHC0.
TreeFamiTF105318.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
InterProiView protein in InterPro
IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiView protein in Pfam
PF00255. GSHPx. 1 hit.
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYIAKSFYD LSAIGLDGEK IDFNTFRGRA VLIENVASLU GTTTRDYNQL
60 70 80 90 100
NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFS
110 120 130 140 150
LTQKCDVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV
160 170 180 190
SWNFEKFLIG PEGEPFRRYS RSFQTINIEP DIKRLLKVAI
Length:190
Mass (Da):21,990
Last modified:February 26, 2008 - v3
Checksum:iF66BDD7A431E1A6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14I → V in BAE20886 (PubMed:16141072).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei40Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62658 Genomic DNA. Translation: AAD41533.1.
AK131940 mRNA. Translation: BAE20886.1.
BC010823 mRNA. Translation: AAH10823.1.
BC034335 mRNA. Translation: AAH34335.1.
BC039658 mRNA. Translation: AAH39658.1.
BC054848 mRNA. Translation: AAH54848.2.
CCDSiCCDS25996.1.
RefSeqiNP_109602.2. NM_030677.2.
UniGeneiMm.441856.

Genome annotation databases

GeneIDi14776.
KEGGimmu:14776.
UCSCiuc007nys.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiGPX2_MOUSE
AccessioniPrimary (citable) accession number: Q9JHC0
Secondary accession number(s): Q3V2B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families