Reviewed, UniProtKB/Swiss-Prot Q9JHC0 (GPX2_MOUSE)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 2
    EC=1.11.1.9
Alternative name(s):
    GSHPx-2
      Short name=GPx-2
    Glutathione peroxidase-gastrointestinal
    GSHPx-GI

Gene names

Name:

Gpx2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	interaction with symbiont Inferred from genetic interaction. Source: MGI negative regulation of inflammatory response to antigenic stimulus Inferred from genetic interaction. Source: MGI oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro response to symbiotic bacterium Inferred from genetic interaction. Source: MGI temperature homeostasis Inferred from genetic interaction. Source: MGI
Cellular component	cytosol Traceable author statement. Source: MGI
Molecular function	glutathione peroxidase activity Inferred from mutant phenotype. Source: MGI selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Glutathione peroxidase 2		PRO_0000066622
Sites
	Active site	40	1
Amino acid modifications
	Non-standard residue	40	1	Selenocysteine
Experimental info
	Sequence conflict	14	1	I → V in BAE20886. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JHC0-1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: F66BDD7A431E1A6D	FASTA	190	21,990
	10 20 30 40 50 60 MAYIAKSFYD LSAIGLDGEK IDFNTFRGRA VLIENVASLU GTTTRDYNQL NELQCRFPRR 70 80 90 100 110 120 LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFS LTQKCDVNGQ NEHPVFAYLK 130 140 150 160 170 180 DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV SWNFEKFLIG PEGEPFRRYS RSFQTINIEP 190 DIKRLLKVAI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12; its pseudogene Gpx2-ps maps to chromosome 7." Chu F.-F., Esworthy R.S., Burmeister M. Genomics 33:516-518(1996) [PubMed: 8661011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U62658 Genomic DNA. Translation: AAD41533.1. AK131940 mRNA. Translation: BAE20886.1. BC010823 mRNA. Translation: AAH10823.1. BC034335 mRNA. Translation: AAH34335.1. BC039658 mRNA. Translation: AAH39658.1. BC054848 mRNA. Translation: AAH54848.2.
IPI	IPI00119240.
RefSeq	NP_109602.2.
UniGene	Mm.441856
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
SMR	Q9JHC0. Positions 4-187.
ModBase	Search...
Protein family/group databases
PeroxiBase	3710. MmGPx02.
Genome annotation databases
Ensembl	ENSMUSG00000042808. Mus musculus. [Contig view]
GeneID	14776.
KEGG	mmu:14776.
Organism-specific databases
MGI	MGI:106609. Gpx2.
Phylogenomic databases
HOGENOM	Q9JHC0.
HOVERGEN	Q9JHC0.
Enzyme and pathway databases
BRENDA	1.11.1.9. 244.
Gene expression databases
ArrayExpress	Q9JHC0.
Bgee	Q9JHC0.
CleanEx	MM_GPX2.
GermOnline	ENSMUSG00000042808. Mus musculus.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286881.
SOURCE	Search...

Entry information

Entry name

GPX2_MOUSE

Accession

Primary (citable) accession number: Q9JHC0
Secondary accession number(s): Q3V2B2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 26, 2008
Last modified:	March 3, 2009
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)