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Protein

Translin-associated protein X

Gene

Tsnax

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129MagnesiumBy similarity1
Metal bindingi197MagnesiumBy similarity1

GO - Molecular functioni

  • A2A adenosine receptor binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • protein complex binding Source: RGD
  • RNA binding Source: RGD
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-426486. Small interfering RNA (siRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:Tsnax
Synonyms:Trax
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621574. Tsnax.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916891 – 290Translin-associated protein XAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9JHB5.
PRIDEiQ9JHB5.

PTM databases

iPTMnetiQ9JHB5.
PhosphoSitePlusiQ9JHB5.

Expressioni

Tissue specificityi

Detected in cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000049784.
GenevisibleiQ9JHB5. RN.

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).By similarity

GO - Molecular functioni

  • A2A adenosine receptor binding Source: RGD
  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiQ9JHB5. 1 interactor.
STRINGi10116.ENSRNOP00000063911.

Structurei

3D structure databases

ProteinModelPortaliQ9JHB5.
SMRiQ9JHB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 208Interaction with C1DBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOVERGENiHBG059067.
InParanoidiQ9JHB5.
OMAiAYTYMEY.
OrthoDBiEOG091G0JHU.
PhylomeDBiQ9JHB5.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
InterProiView protein in InterPro
IPR002848. Translin_fam.
IPR016068. Translin_N.
IPR036081. Translin_sf.
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiView protein in Pfam
PF01997. Translin. 1 hit.
SUPFAMiSSF74784. SSF74784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKEGPGGF RKRKHDNFPH NQRREGKDAS SSSPVMLAFK SFQQELDTRH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEEILTES ESKLDGVRQK
110 120 130 140 150
MLQVAQELSG EDMHQFHRAV TTGLQEYVEA VSFQHFIRTR SLISMEEINR
160 170 180 190 200
QLTFTTDDSG KESKAPPADG QDKQLVTWRL KITPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
SKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEESIS
Length:290
Mass (Da):33,005
Last modified:October 1, 2000 - v1
Checksum:i22233361904A5882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262357 mRNA. Translation: AAF76149.1.
BC081715 mRNA. Translation: AAH81715.1.
RefSeqiNP_071598.1. NM_022262.3.
UniGeneiRn.2315.

Genome annotation databases

EnsembliENSRNOT00000071827; ENSRNOP00000063911; ENSRNOG00000049784.
GeneIDi64028.
KEGGirno:64028.

Similar proteinsi

Entry informationi

Entry nameiTSNAX_RAT
AccessioniPrimary (citable) accession number: Q9JHB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families