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Protein

Translin-associated protein X

Gene

Tsnax

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291MagnesiumBy similarity
Metal bindingi197 – 1971MagnesiumBy similarity

GO - Molecular functioni

  • A2A adenosine receptor binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • protein complex binding Source: RGD
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-426486. Small interfering RNA (siRNA) biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated protein X
Alternative name(s):
Translin-associated factor X
Gene namesi
Name:Tsnax
Synonyms:Trax
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621574. Tsnax.

Subcellular locationi

  • Cytoplasmperinuclear region By similarity
  • Golgi apparatus 1 Publication
  • Nucleus By similarity

  • Note: Expressed in the cytoplasm in the presence of TSN. Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Translin-associated protein XPRO_0000191689Add
BLAST

Post-translational modificationi

Sumoylated with SUMO1.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9JHB5.
PRIDEiQ9JHB5.

PTM databases

iPTMnetiQ9JHB5.

Expressioni

Tissue specificityi

Detected in cerebellum.1 Publication

Gene expression databases

GenevisibleiQ9JHB5. RN.

Interactioni

Subunit structurei

Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner (By similarity).By similarity

GO - Molecular functioni

  • A2A adenosine receptor binding Source: RGD
  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiQ9JHB5. 1 interaction.
STRINGi10116.ENSRNOP00000063911.

Structurei

3D structure databases

ProteinModelPortaliQ9JHB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 208136Interaction with C1DBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the translin family.Curated

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOVERGENiHBG059067.
InParanoidiQ9JHB5.
OMAiCISSVGN.
OrthoDBiEOG7XWPPR.
PhylomeDBiQ9JHB5.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProiIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMiSSF74784. SSF74784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JHB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGKEGPGGF RKRKHDNFPH NQRREGKDAS SSSPVMLAFK SFQQELDTRH
60 70 80 90 100
DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEEILTES ESKLDGVRQK
110 120 130 140 150
MLQVAQELSG EDMHQFHRAV TTGLQEYVEA VSFQHFIRTR SLISMEEINR
160 170 180 190 200
QLTFTTDDSG KESKAPPADG QDKQLVTWRL KITPVDYLLG VADLTGELMR
210 220 230 240 250
MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL
260 270 280 290
SKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEESIS
Length:290
Mass (Da):33,005
Last modified:October 1, 2000 - v1
Checksum:i22233361904A5882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262357 mRNA. Translation: AAF76149.1.
BC081715 mRNA. Translation: AAH81715.1.
RefSeqiNP_071598.1. NM_022262.3.
UniGeneiRn.2315.

Genome annotation databases

EnsembliENSRNOT00000071827; ENSRNOP00000063911; ENSRNOG00000049784.
GeneIDi64028.
KEGGirno:64028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF262357 mRNA. Translation: AAF76149.1.
BC081715 mRNA. Translation: AAH81715.1.
RefSeqiNP_071598.1. NM_022262.3.
UniGeneiRn.2315.

3D structure databases

ProteinModelPortaliQ9JHB5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JHB5. 1 interaction.
STRINGi10116.ENSRNOP00000063911.

PTM databases

iPTMnetiQ9JHB5.

Proteomic databases

PaxDbiQ9JHB5.
PRIDEiQ9JHB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071827; ENSRNOP00000063911; ENSRNOG00000049784.
GeneIDi64028.
KEGGirno:64028.

Organism-specific databases

CTDi7257.
RGDi621574. Tsnax.

Phylogenomic databases

eggNOGiKOG3066. Eukaryota.
COG2178. LUCA.
GeneTreeiENSGT00390000014716.
HOVERGENiHBG059067.
InParanoidiQ9JHB5.
OMAiCISSVGN.
OrthoDBiEOG7XWPPR.
PhylomeDBiQ9JHB5.

Enzyme and pathway databases

ReactomeiR-RNO-426486. Small interfering RNA (siRNA) biogenesis.

Miscellaneous databases

PROiQ9JHB5.

Gene expression databases

GenevisibleiQ9JHB5. RN.

Family and domain databases

Gene3Di1.20.58.190. 1 hit.
1.20.58.200. 1 hit.
InterProiIPR002848. Translin.
IPR016069. Translin_C.
IPR016068. Translin_N.
[Graphical view]
PANTHERiPTHR10741. PTHR10741. 1 hit.
PfamiPF01997. Translin. 1 hit.
[Graphical view]
SUPFAMiSSF74784. SSF74784. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of translin and trax as components of the GS1 strand-specific DNA binding complex enriched in brain."
    Taira E., Finkenstadt P.M., Baraban J.M.
    J. Neurochem. 71:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION IN A DNA-BINDING COMPLEX WITH TSN.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTSNAX_RAT
AccessioniPrimary (citable) accession number: Q9JHB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.