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Q9JFM9 (FLSO_ASFM2) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAD-linked sulfhydryl oxidase

EC=1.8.3.2
Alternative name(s):
p14
Gene names
Ordered Locus Names:Mal-081
ORF Names:L09GL
OrganismAfrican swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV) [Complete proteome]
Taxonomic identifier10500 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Phacochoerus aethiopicus (Warthog) [TaxID: 85517]
Phacochoerus africanus (Warthog) [TaxID: 41426]
Potamochoerus larvatus (Bushpig) [TaxID: 273792]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Involved in virion maturation and virulence By similarity. Ref.1

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

FAD By similarity.

Subunit structure

Interacts with A151R By similarity.

Subcellular location

Host cytoplasm By similarity.

Induction

Expressed late in the infection cycle.

Sequence similarities

Belongs to the asfivirus B119L family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentHost cytoplasm
   Developmental stageLate protein
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionthiol oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119FAD-linked sulfhydryl oxidase
PRO_0000355536

Regions

Domain1 – 9797ERV/ALR sulfhydryl oxidase

Amino acid modifications

Disulfide bond44 ↔ 47Redox-active Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JFM9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F6694FFC67A282E2

FASTA11914,379
        10         20         30         40         50         60 
MLHWGPKFWR TLHLYAIFFS DTPGWKEKYE AIQWILNFIE SLPCTMCRHH AFSYLTKNPL 

        70         80         90        100        110 
TLNNSEDFQY WTFAFHNNVN KRLNKKIISW SEYKNIYEQS ILNTIEYGKT DFIGAWSSL 

« Hide

References

« Hide 'large scale' references
[1]"An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine."
Lewis T., Zsak L., Burrage T.G., Lu Z., Kutish G.F., Neilan J.G., Rock D.L.
J. Virol. 74:1275-1285(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"Nucleotide sequence and analysis of 16.25 kilobase pairs of the African swine fever virus genome that span the central variable region."
Roberts P.C., Lu Z., Rock D.L.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"African swine fever virus genomes."
Kutish G.F., Rock D.L.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081174 Genomic DNA. Translation: AAF27970.1.
L00966 Genomic DNA. Translation: AAL31324.1.
AY261361 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalQ9JFM9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.310. 1 hit.
InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view]
PfamPF04777. Evr1_Alr. 1 hit.
[Graphical view]
SUPFAMSSF69000. SSF69000. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFLSO_ASFM2
AccessionPrimary (citable) accession number: Q9JFM9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 1, 2000
Last modified: October 16, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families