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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Pariacoto virus (PaV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiPariacoto virus (PaV)
Taxonomic identifieri103782 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiSpodoptera eridania (Southern armyworm) [TaxID: 37547]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 973973RNA-directed RNA polymerasePRO_0000222449Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9J7Z2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini558 – 683126RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi962 – 9665Poly-Thr

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9J7Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEHIPLPSQ YESPKALPPR VPSSRWLRSL RPRLANSCLA LKIRAHESLV
60 70 80 90 100
KIRLCKPYDA QSRSKIIEKV IERRETRKTL AHQLKDLKLV PVARDHTHGR
110 120 130 140 150
AAKFRTSANI WMNEAMRAAG YEPYNVSMSN HDIERGNRYF YFAKDLTIPY
160 170 180 190 200
RNDPVSDNTG FVFCDVDYYA DMEKWMQHFK PMLLYTLVPE SLSYHCDDHS
210 220 230 240 250
FHVNDDRVFF DVRGGASYSH QLWDYTGDTI CVRGKNKELL VFTIEQKCIQ
260 270 280 290 300
GDPHRRIIFL EPAARVAWPF YKPMKVEVGL KRKCMTAGQV NVLYEPIDDK
310 320 330 340 350
ISLSASGSRH TVETTGRTLA AITARMKNKT SPPMVADVER ILRDAGDKEA
360 370 380 390 400
CVNAPILFEL IPEAKFRVNV VKTTATPTHF QPLGPLRTED GETCGHAVTT
410 420 430 440 450
TLATAPALLP MRGVNSDVAT VNGRVKKPAN TVIPFKEYKE YASEFVEFLV
460 470 480 490 500
PEPGVGHPWD TAAVREVQDN RQQKARINMV AATVSTHSSN RLKAFIKAEA
510 520 530 540 550
YAATNDPRNI TTMAPELTLM MSCFTYAFKE KILYEQPWYG PGKTPKQVGR
560 570 580 590 600
RLQSIAKHGT LESDYSRFDG SISEWLQKNV VKAAYMRFFK EHQRTEFQSW
610 620 630 640 650
FSKVFMQMGT TTAGVRYEAG WGTRSGSPIT TDGNTMLNAF VVYCCYRKLC
660 670 680 690 700
HTPAEAWRKL SQGALLTGDD AVLAHENGLE PALLDVVKNL GLKVEAKVNG
710 720 730 740 750
PDDPVSFCGR IYPRLSDCIT SFQDPLRTIP KLHLTTNKGV SPEQAAANRA
760 770 780 790 800
HGYLATDKAT PIIGTWARRV IELTGDLKVK GATREEQYKL SNAHQQLDPS
810 820 830 840 850
LIETAMANIL GIDVGELKAL DKAVSEAKAL DQMPVVLGNC YKHKIEAVVG
860 870 880 890 900
GEVVGPGPRV ETVEPNHEQS SGTPEVVPEM AGHSERRDKS SNPRPGGKAE
910 920 930 940 950
GLSSKAGKPR VPTRPAADRK AAAGSGNRRG PTNGRRPIRD RAPRGGGRPN
960 970
PGTTPPVSNS ETTTTTAVVH ASA
Length:973
Mass (Da):108,099
Last modified:October 1, 2000 - v1
Checksum:iC08835451D46EA1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171942 Genomic RNA. Translation: AAF71691.1.
RefSeqiNP_620109.1. NC_003691.1.

Genome annotation databases

GeneIDi956347.
KEGGivg:956347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171942 Genomic RNA. Translation: AAF71691.1.
RefSeqiNP_620109.1. NC_003691.1.

3D structure databases

ProteinModelPortaliQ9J7Z2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956347.
KEGGivg:956347.

Family and domain databases

InterProiIPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00680. RdRP_1. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and construction of functional cDNA clones of Pariacoto virus, the first Alphanodavirus isolated outside Australasia."
    Johnson K.N., Zeddam J.-L., Ball L.A.
    J. Virol. 74:5123-5132(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_PAV
AccessioniPrimary (citable) accession number: Q9J7Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: October 1, 2000
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.