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Q9J5U7

- RDRP_CARMS

UniProt

Q9J5U7 - RDRP_CARMS

Protein

Probable RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation mottle virus (isolate China/Shanghai) (CarMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p88
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiCarnation mottle virus (isolate China/Shanghai) (CarMV)
    Taxonomic identifieri652111 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
    Virus hostiDianthus barbatus [TaxID: 278075]
    Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
    Dianthus chinensis [TaxID: 118431]
    Dianthus superbus [TaxID: 288950]
    Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]
    ProteomesiUP000006709: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Probable RNA-directed RNA polymerasePRO_0000398302Add
    BLAST
    Chaini1 – 245245Protein p28PRO_0000398303Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9J5U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini467 – 580114RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9J5U7-1 [UniParc]FASTAAdd to Basket

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    MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI    50
    VSSGGRCLIV QSPYGNPNQG LIRGEDEEID NVEESTPEEL TQLIEVKAEV 100
    DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF 150
    LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYARKI 200
    AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF 250
    YLNGVETKIR RGGHPSVIEV DGQCPPRERK LYVQNAITTG YEYRVHNHSY 300
    ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR 350
    ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL 400
    KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT 450
    EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD 500
    AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMIGDMNTA LGNCLLACLI 550
    TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP 600
    VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW 650
    LKSVGMCGLR IAGGVPIVQE FYQKYVETAG NVKENKNITE KSSSGFFMMA 700
    DRAKRGYSAV SEMCRFSFYQ AFGITPDQQI ALEGEIRSLT IDTNVGPQCE 750
    AADSLWILNR KYQ 763
    Length:763
    Mass (Da):85,965
    Last modified:October 1, 2000 - v1
    Checksum:iECDBAC527714F3D1
    GO

    Sequence cautioni

    The sequence AAF15527.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192772 Genomic RNA. Translation: AAF15524.1.
    AF192772 Genomic RNA. Translation: AAF15525.1.
    AF192772 Genomic RNA. Translation: AAF15527.1. Sequence problems.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF192772 Genomic RNA. Translation: AAF15524.1 .
    AF192772 Genomic RNA. Translation: AAF15525.1 .
    AF192772 Genomic RNA. Translation: AAF15527.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q9J5U7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Infectivity of full-length cDNA of carnation mottle virus."
      Zhang A.P., Yue Y., Ye R., Zhu H.Q., Xu L., Yu S.Q.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_CARMS
    AccessioniPrimary (citable) accession number: Q9J5U7
    Secondary accession number(s): Q9J5U6, Q9Q6X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 246.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3