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Q9J5U7

- RDRP_CARMS

UniProt

Q9J5U7 - RDRP_CARMS

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Protein

Probable RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation mottle virus (isolate China/Shanghai) (CarMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Cleaved into the following chain:
Gene namesi
ORF Names:ORF1
OrganismiCarnation mottle virus (isolate China/Shanghai) (CarMV)
Taxonomic identifieri652111 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeCarmovirus
Virus hostiDianthus barbatus [TaxID: 278075]
Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
Dianthus chinensis [TaxID: 118431]
Dianthus superbus [TaxID: 288950]
Saponaria officinalis (Common soapwort) (Lychnis saponaria) [TaxID: 3572]
ProteomesiUP000006709: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Probable RNA-directed RNA polymerasePRO_0000398302Add
BLAST
Chaini1 – 245245Protein p28PRO_0000398303Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9J5U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini467 – 580114RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9J5U7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLPSLLVEG VIGCTLVGGL VAVGSAALAV RATIGVVEFN RECVRGARRI
60 70 80 90 100
VSSGGRCLIV QSPYGNPNQG LIRGEDEEID NVEESTPEEL TQLIEVKAEV
110 120 130 140 150
DGKEVVVSKK RVVNRHLRQR FVRSIAIEAK NHFGGDISPS KANYLSVSKF
160 170 180 190 200
LTGKCKERHV VPAHTRDCVS AAMVLVFTPD VHEIRMMAGL ASDAAYARKI
210 220 230 240 250
AMASILNRKG WCWRLMVNPL DRARWWEMWC VVNGFDSNKP VTFPKXGGLF
260 270 280 290 300
YLNGVETKIR RGGHPSVIEV DGQCPPRERK LYVQNAITTG YEYRVHNHSY
310 320 330 340 350
ANLRRGLLER VFYVERNKEL VSCPQPEPGS FKEMGYLRRR FHRVCGNHTR
360 370 380 390 400
ISANDLVDCY QGRKRTIYEN AAASLLDRAI ERKDGDLKTF IKAEKFNVNL
410 420 430 440 450
KSDPAPRVIQ PRSPRYNVEL GRYLKKYEHH AYKALDKIWG GPTVMKGYTT
460 470 480 490 500
EEVAQHIWSA WNQFQTPVAI GFDMSRFDQH VSVAALEFEH SCYLACFEGD
510 520 530 540 550
AHLANLLKMQ LVNHGVGFAS NGMLRYTKEG CRMIGDMNTA LGNCLLACLI
560 570 580 590 600
TKHLMKIRSR LINNGDDCVL ICERTDIDYV VSNLTTGWSR FGFNCIAEEP
610 620 630 640 650
VYEMEKIRFC QMAPVFDGAG WLMVRDPLVS MSKDSHSLVH WNNETNAKQW
660 670 680 690 700
LKSVGMCGLR IAGGVPIVQE FYQKYVETAG NVKENKNITE KSSSGFFMMA
710 720 730 740 750
DRAKRGYSAV SEMCRFSFYQ AFGITPDQQI ALEGEIRSLT IDTNVGPQCE
760
AADSLWILNR KYQ
Length:763
Mass (Da):85,965
Last modified:October 1, 2000 - v1
Checksum:iECDBAC527714F3D1
GO

Sequence cautioni

The sequence AAF15527.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192772 Genomic RNA. Translation: AAF15524.1.
AF192772 Genomic RNA. Translation: AAF15525.1.
AF192772 Genomic RNA. Translation: AAF15527.1. Sequence problems.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF192772 Genomic RNA. Translation: AAF15524.1 .
AF192772 Genomic RNA. Translation: AAF15525.1 .
AF192772 Genomic RNA. Translation: AAF15527.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q9J5U7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Infectivity of full-length cDNA of carnation mottle virus."
    Zhang A.P., Yue Y., Ye R., Zhu H.Q., Xu L., Yu S.Q.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CARMS
AccessioniPrimary (citable) accession number: Q9J5U7
Secondary accession number(s): Q9J5U6, Q9Q6X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Readthrough of the terminator UAG occurs at position 246.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3