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Q9J5G5 (DUT_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT
Ordered Locus Names:FPV038
OrganismFowlpox virus (strain NVSL) (FPV) [Reference proteome]
Taxonomic identifier928301 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostVertebrata [TaxID: 7742]

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182947

Sequences

Sequence LengthMass (Da)Tools
Q9J5G5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 94CF5F6963B47D08

FASTA14516,253
        10         20         30         40         50         60 
MEEVTVYKIS DRAKLPYKQT SYSAGYDLYS AYDYVIEPMN KELIKTDIIL KIPNGYYGRI 

        70         80         90        100        110        120 
APRSGLAYNY FIDVGAGVID SDYRGNVGVL LFNFGSTQFN VCKGDRIAQI IFEKIAYPKI 

       130        140 
IEVTTLEEIN ITDRGNSGFG STGLK 

« Hide

References

[1]"The genome of fowlpox virus."
Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.
J. Virol. 74:3815-3831(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF198100 Genomic DNA. Translation: AAF44382.1.
RefSeqNP_039001.1. NC_002188.1.

3D structure databases

ProteinModelPortalQ9J5G5.
SMRQ9J5G5. Positions 8-143.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1486586.

Phylogenomic databases

ProtClustDBCLSP2510971.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_FOWPN
AccessionPrimary (citable) accession number: Q9J5G5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: October 16, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families