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Q9J5B8

- PAP1_FOWPN

UniProt

Q9J5B8 - PAP1_FOWPN

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei194 – 1941By similarity
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    VP55
    Gene namesi
    Name:PAPL
    Ordered Locus Names:FPV102
    OrganismiFowlpox virus (strain NVSL) (FPV)
    Taxonomic identifieri928301 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
    Virus hostiVertebrata [TaxID: 7742]
    ProteomesiUP000008597: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000099109Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9J5B8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9J5B8-1 [UniParc]FASTAAdd to Basket

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    MERSRQVYYI INEYLGRHPS STEYQVLKHQ VEKISKINNF NKETFFFLLK    50
    KNKNKFFKDL ELSDDLLKKR IDEYFSKQKH AKRLGNLFAI MELQKILISS 100
    FTKTIGILTT KVPEYYHSTI KLEYSSMEKI ADDILDSYNV VEPSKEVKGR 150
    HKVSDLVGHV YKIMEEYLRR HSNSCLCYGS YSLHFLNNKI EYGDIDVLQT 200
    NARTFLINIA FLIKFITGRR IVLLKVPFLK NYVIMHDEET NHVMDTFNIR 250
    EKTMNMIPKI MIDNMYIVDP CIQLLNMIKM LSQIDRLEEL QAKFEKLSVR 300
    LGTLLEYTRY RYSIPLDSES ILEVRAKLDK DKRKITVDFK KYKLNYIKCY 350
    FYLDEVELKK FISKNSGLDE YEDFEAVTNS EYAIRNKTMY TYFSNTALMR 400
    SENEIHPITI NALTSHALLY HVITRKFYDD LLGDLVRSLM IVEKVPVFKI 450
    IPRDKKQGRH TIIDIEKDII FH 472
    Length:472
    Mass (Da):56,081
    Last modified:October 1, 2000 - v1
    Checksum:iADDD6F39EC84DC22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198100 Genomic DNA. Translation: AAF44446.1.
    AJ581527 Genomic DNA. Translation: CAE52643.1.
    RefSeqiNP_039065.1. NC_002188.1.

    Genome annotation databases

    GeneIDi1486650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198100 Genomic DNA. Translation: AAF44446.1 .
    AJ581527 Genomic DNA. Translation: CAE52643.1 .
    RefSeqi NP_039065.1. NC_002188.1.

    3D structure databases

    ProteinModelPortali Q9J5B8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486650.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European fowlpox virus, with those of virulent American and European viruses."
      Skinner M.A., Laidlaw S.M.
      J. Gen. Virol. 85:305-322(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HP1-438 Munich.

    Entry informationi

    Entry nameiPAP1_FOWPN
    AccessioniPrimary (citable) accession number: Q9J5B8
    Secondary accession number(s): Q70H53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3