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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei194 – 1941By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
VP55
Gene namesi
Name:PAPL
Ordered Locus Names:FPV102
OrganismiFowlpox virus (strain NVSL) (FPV)
Taxonomic identifieri928301 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostiVertebrata [TaxID: 7742]
ProteomesiUP000008597 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Poly(A) polymerase catalytic subunitPRO_0000099109Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9J5B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSRQVYYI INEYLGRHPS STEYQVLKHQ VEKISKINNF NKETFFFLLK
60 70 80 90 100
KNKNKFFKDL ELSDDLLKKR IDEYFSKQKH AKRLGNLFAI MELQKILISS
110 120 130 140 150
FTKTIGILTT KVPEYYHSTI KLEYSSMEKI ADDILDSYNV VEPSKEVKGR
160 170 180 190 200
HKVSDLVGHV YKIMEEYLRR HSNSCLCYGS YSLHFLNNKI EYGDIDVLQT
210 220 230 240 250
NARTFLINIA FLIKFITGRR IVLLKVPFLK NYVIMHDEET NHVMDTFNIR
260 270 280 290 300
EKTMNMIPKI MIDNMYIVDP CIQLLNMIKM LSQIDRLEEL QAKFEKLSVR
310 320 330 340 350
LGTLLEYTRY RYSIPLDSES ILEVRAKLDK DKRKITVDFK KYKLNYIKCY
360 370 380 390 400
FYLDEVELKK FISKNSGLDE YEDFEAVTNS EYAIRNKTMY TYFSNTALMR
410 420 430 440 450
SENEIHPITI NALTSHALLY HVITRKFYDD LLGDLVRSLM IVEKVPVFKI
460 470
IPRDKKQGRH TIIDIEKDII FH
Length:472
Mass (Da):56,081
Last modified:October 1, 2000 - v1
Checksum:iADDD6F39EC84DC22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198100 Genomic DNA. Translation: AAF44446.1.
AJ581527 Genomic DNA. Translation: CAE52643.1.
RefSeqiNP_039065.1. NC_002188.1.

Genome annotation databases

GeneIDi1486650.
KEGGivg:1486650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF198100 Genomic DNA. Translation: AAF44446.1.
AJ581527 Genomic DNA. Translation: CAE52643.1.
RefSeqiNP_039065.1. NC_002188.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1486650.
KEGGivg:1486650.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Comparison of the genome sequence of FP9, an attenuated, tissue culture-adapted European fowlpox virus, with those of virulent American and European viruses."
    Skinner M.A., Laidlaw S.M.
    J. Gen. Virol. 85:305-322(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HP1-438 Munich.

Entry informationi

Entry nameiPAP1_FOWPN
AccessioniPrimary (citable) accession number: Q9J5B8
Secondary accession number(s): Q70H53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: April 1, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.