Q9J592 (DUSP_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable dual specificity protein phosphatase H1 homolog
EC=3.1.3.-
EC=3.1.3.48

Gene names

Ordered Locus Names:

FPV138

Organism

Fowlpox virus (strain NVSL) (FPV) [Reference proteome]

Taxonomic identifier

928301 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Avipoxvirus › Fowlpox virus

Virus host

Vertebrata [TaxID: 7742]

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated STAT1 and blocking interferon (IFN)-stimulated innate immune responses By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Protein serine phosphate + H2O = protein serine + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Virion By similarity. Host cytoplasm By similarity. Note: Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus By similarity.
Induction	Expressed in the late phase of the viral replicative cycle.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host STAT1 by virus Inhibition of host innate immune response by virus Inhibition of host interferon signaling pathway by virus Viral immunoevasion
Cellular component	Host cytoplasm Virion
Developmental stage	Late protein
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC suppression by virus of host STAT1 activity Inferred from electronic annotation. Source: UniProtKB-KW suppression by virus of host type I interferon-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Probable dual specificity protein phosphatase H1 homolog		PRO_0000094870
Sites
	Active site	108	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9J592 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D98A7C95DAB29BD6	FASTA	166	19,637
	10 20 30 40 50 60 MDEKQLYKHI ITKSTNTCVK FTPRDITKIT DYVYLGNYRN VIELPNKTFF KYIVNVSMLK 70 80 90 100 110 120 YKLKRTDITV LHFPLEDNDT VSISKHIDAV TYVLKKCESL KIPVLVHCMA GINRSSAMIM 130 140 150 160 GYLMEIRDKN IPFVIYFLYI YHELKYIRGA FIENKSFLNQ IIDKYI

References

[1]	"The genome of fowlpox virus." Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L. J. Virol. 74:3815-3831(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF198100 Genomic DNA. Translation: AAF44482.1.
RefSeq	NP_039101.1. NC_002188.1.
3D structure databases
ProteinModelPortal	Q9J592.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1486686.
Phylogenomic databases
ProtClustDB	CLSP2509785.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSP_FOWPN

Accession

Primary (citable) accession number: Q9J592

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program