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Q9J592 (DUSP_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dual specificity protein phosphatase H1 homolog

EC=3.1.3.-
EC=3.1.3.48
Gene names
Ordered Locus Names:FPV138
OrganismFowlpox virus (strain NVSL) (FPV) [Reference proteome]
Taxonomic identifier928301 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostVertebrata [TaxID: 7742]

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated STAT1 and blocking interferon (IFN)-stimulated innate immune responses By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Protein serine phosphate + H2O = protein serine + phosphate.

Subunit structure

Homodimer By similarity.

Subcellular location

Virion By similarity. Host cytoplasm By similarity. Note: Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus By similarity.

Induction

Expressed in the late phase of the viral replicative cycle.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Probable dual specificity protein phosphatase H1 homolog
PRO_0000094870

Sites

Active site1081Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9J592 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D98A7C95DAB29BD6

FASTA16619,637
        10         20         30         40         50         60 
MDEKQLYKHI ITKSTNTCVK FTPRDITKIT DYVYLGNYRN VIELPNKTFF KYIVNVSMLK 

        70         80         90        100        110        120 
YKLKRTDITV LHFPLEDNDT VSISKHIDAV TYVLKKCESL KIPVLVHCMA GINRSSAMIM 

       130        140        150        160 
GYLMEIRDKN IPFVIYFLYI YHELKYIRGA FIENKSFLNQ IIDKYI 

« Hide

References

[1]"The genome of fowlpox virus."
Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.
J. Virol. 74:3815-3831(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF198100 Genomic DNA. Translation: AAF44482.1.
RefSeqNP_039101.1. NC_002188.1.

3D structure databases

ProteinModelPortalQ9J592.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1486686.

Phylogenomic databases

ProtClustDBCLSP2509785.

Family and domain databases

InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSP_FOWPN
AccessionPrimary (citable) accession number: Q9J592
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families