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Q9J592

- DUSP_FOWPN

UniProt

Q9J592 - DUSP_FOWPN

Protein

Probable dual specificity protein phosphatase H1 homolog

Gene

FPV138

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated STAT1 and blocking interferon (IFN)-stimulated innate immune responses.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    Protein serine phosphate + H2O = protein serine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. suppression by virus of host STAT1 activity Source: UniProtKB-KW
    2. suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dual specificity protein phosphatase H1 homolog (EC:3.1.3.-, EC:3.1.3.48)
    Gene namesi
    Ordered Locus Names:FPV138
    OrganismiFowlpox virus (strain NVSL) (FPV)
    Taxonomic identifieri928301 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
    Virus hostiVertebrata [TaxID: 7742]
    ProteomesiUP000008597: Genome

    Subcellular locationi

    Virion By similarity. Host cytoplasm By similarity
    Note: Approximately 200 molecules of H1 are packaged within the virion and are essential for the viability of the virus.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell
    2. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Probable dual specificity protein phosphatase H1 homologPRO_0000094870Add
    BLAST

    Expressioni

    Inductioni

    Expressed in the late phase of the viral replicative cycle.

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9J592.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9J592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEKQLYKHI ITKSTNTCVK FTPRDITKIT DYVYLGNYRN VIELPNKTFF    50
    KYIVNVSMLK YKLKRTDITV LHFPLEDNDT VSISKHIDAV TYVLKKCESL 100
    KIPVLVHCMA GINRSSAMIM GYLMEIRDKN IPFVIYFLYI YHELKYIRGA 150
    FIENKSFLNQ IIDKYI 166
    Length:166
    Mass (Da):19,637
    Last modified:October 1, 2000 - v1
    Checksum:iD98A7C95DAB29BD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198100 Genomic DNA. Translation: AAF44482.1.
    RefSeqiNP_039101.1. NC_002188.1.

    Genome annotation databases

    GeneIDi1486686.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198100 Genomic DNA. Translation: AAF44482.1 .
    RefSeqi NP_039101.1. NC_002188.1.

    3D structure databases

    ProteinModelPortali Q9J592.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1486686.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUSP_FOWPN
    AccessioniPrimary (citable) accession number: Q9J592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3