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Q9IZU7

- VP2_CAVCA

UniProt

Q9IZU7 - VP2_CAVCA

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Protein

Dual specificity protein phosphatase VP2

Gene

VP2

Organism
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediateCurated

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:VP2
OrganismiChicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
Taxonomic identifieri486492 [NCBI]
Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000007539: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi95 – 951C → S: Complete loss of phosphatase activity. Reduced cytopathogenicity and marked inhibition of viral growth in cell culture. 1 Publication
Mutagenesisi97 – 971C → S: 70% loss of phosphotyrosine activity. 700% increase of phosphoserine/phosphothreonine phosphatase activity. Reduced cytopathogenicity and marked inhibition of viral growth in cell culture. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Dual specificity protein phosphatase VP2PRO_0000314474Add
BLAST

Expressioni

Inductioni

VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

Keywords - Developmental stagei

Early protein

Family & Domainsi

Sequence similaritiesi

Belongs to the gyrovirus protein VP2 family.Curated

Family and domain databases

InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view]
PfamiPF02957. TT_ORF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9IZU7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING
60 70 80 90 100
VQATNKFTAV GNPSLQRDPD WYRWNYSHSI AVWLRECSRS HAKICNCGQF
110 120 130 140 150
RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR
160 170 180 190 200
KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD
210
ELLGRPFTTP APVRIV
Length:216
Mass (Da):24,112
Last modified:October 1, 2000 - v1
Checksum:iF83EB3D07B97F752
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227982 Genomic DNA. Translation: AAF34787.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF227982 Genomic DNA. Translation: AAF34787.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
[Graphical view ]
Pfami PF02957. TT_ORF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-length infectious clone of a pathogenic Australian isolate of chicken anaemia virus."
    Brown H.K., Browning G.F., Scott P.C., Crabb B.S., Brown K.
    Aust. Vet. J. 78:637-640(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Chicken anemia virus VP2 is a novel dual specificity protein phosphatase."
    Peters M.A., Jackson D.C., Crabb B.S., Browning G.F.
    J. Biol. Chem. 277:39566-39573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-95.
  3. "Mutation of chicken anemia virus VP2 differentially affects serine/threonine and tyrosine protein phosphatase activities."
    Peters M.A., Jackson D.C., Crabb B.S., Browning G.F.
    J. Gen. Virol. 86:623-630(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-97.

Entry informationi

Entry nameiVP2_CAVCA
AccessioniPrimary (citable) accession number: Q9IZU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3