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Q9IZU7

- VP2_CAVCA

UniProt

Q9IZU7 - VP2_CAVCA

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Protein
Dual specificity protein phosphatase VP2
Gene
VP2
Organism
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a scaffold protein in virion assembly. May also play a role in intracellular signaling during viral replication.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediate Inferred

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase VP2 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:VP2
    OrganismiChicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
    Taxonomic identifieri486492 [NCBI]
    Taxonomic lineageiVirusesssDNA virusesCircoviridaeGyrovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    ProteomesiUP000007539: Genome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi95 – 951C → S: Complete loss of phosphatase activity. Reduced cytopathogenicity and marked inhibition of viral growth in cell culture. 1 Publication
    Mutagenesisi97 – 971C → S: 70% loss of phosphotyrosine activity. 700% increase of phosphoserine/phosphothreonine phosphatase activity. Reduced cytopathogenicity and marked inhibition of viral growth in cell culture. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Dual specificity protein phosphatase VP2
    PRO_0000314474Add
    BLAST

    Expressioni

    Inductioni

    VP1 and VP2 are detected 12 hours post infection, while VP3 only after 24 hours.

    Keywords - Developmental stagei

    Early protein

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view]
    PfamiPF02957. TT_ORF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9IZU7-1 [UniParc]FASTAAdd to Basket

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    MHGNGGQPAA GGSESALSRE GQPGPSGAAQ GQVISNERSP RRYSTRTING    50
    VQATNKFTAV GNPSLQRDPD WYRWNYSHSI AVWLRECSRS HAKICNCGQF 100
    RKHWFQECAG LEDRSTQASL EEAILRPLRV QGKRAKRKLD YHYSQPTPNR 150
    KKVYKTVRWQ DELADREADF TPSEEDGGTT SSDFDEDINF DIGGDSGIVD 200
    ELLGRPFTTP APVRIV 216
    Length:216
    Mass (Da):24,112
    Last modified:October 1, 2000 - v1
    Checksum:iF83EB3D07B97F752
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227982 Genomic DNA. Translation: AAF34787.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF227982 Genomic DNA. Translation: AAF34787.1 .

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR004118. HEV_TT_virus_Orf2/Gyrovir_Vp2.
    [Graphical view ]
    Pfami PF02957. TT_ORF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Full-length infectious clone of a pathogenic Australian isolate of chicken anaemia virus."
      Brown H.K., Browning G.F., Scott P.C., Crabb B.S., Brown K.
      Aust. Vet. J. 78:637-640(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Chicken anemia virus VP2 is a novel dual specificity protein phosphatase."
      Peters M.A., Jackson D.C., Crabb B.S., Browning G.F.
      J. Biol. Chem. 277:39566-39573(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF CYS-95.
    3. "Mutation of chicken anemia virus VP2 differentially affects serine/threonine and tyrosine protein phosphatase activities."
      Peters M.A., Jackson D.C., Crabb B.S., Browning G.F.
      J. Gen. Virol. 86:623-630(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF CYS-97.

    Entry informationi

    Entry nameiVP2_CAVCA
    AccessioniPrimary (citable) accession number: Q9IZU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 1, 2000
    Last modified: April 16, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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